Regulation of Homologous Recombination in Eukaryotes

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939 · see citing works

Multiple Pathways of Recombination Induced by Double-Strand Breaks in <i>Saccharomyces cerevisiae</i>

Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120 · see citing works

Rates of spontaneous mutation

Drake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932 · see citing works

Mechanism of Eukaryotic Homologous Recombination

Filippo, J. S., Sung, P., & Klein, H. L. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061306.125255 · Cited by 1,686 · see citing works

Human CtIP promotes DNA end resection

Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature · doi:10.1038/nature06337 · Cited by 1,362 · see citing works

Regulation of DNA double-strand break repair pathway choice

Shrivastav, M., De Haro, L. P., & Nickoloff, J. A. (2008) · Cell Research · doi:10.1038/cr.2007.111 · Cited by 1,329 · see citing works

Mammalian cyclin-dependent kinases

Malumbres, M., & Barbacid, M. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.09.005 · Cited by 1,294 · see citing works

Regulation of DNA repair throughout the cell cycle

Branzei, D., & Foiani, M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2351 · Cited by 1,228 · see citing works

Homologous recombination in DNA repair and DNA damage tolerance

Li, X., & Heyer, W. (2008) · Cell Research · doi:10.1038/cr.2008.1 · Cited by 1,203 · see citing works

The Bloom's syndrome helicase suppresses crossing over during homologous recombination

Wu, L., & Hickson, I. D. (2003) · Nature · doi:10.1038/nature02253 · Cited by 1,087 · see citing works

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,071 · see citing works

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

Zhu, Z., Chung, W.-H., Shim, E. Y., Lee, S. E., & Ira, G. (2008) · Cell · doi:10.1016/j.cell.2008.08.037 · Cited by 1,041 · see citing works

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

Mimitou, E. P., & Symington, L. S. (2008) · Nature · doi:10.1038/nature07312 · Cited by 1,009 · see citing works

EUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function

Prakash, S., Johnson, R. E., & Prakash, L. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133250 · Cited by 999 · see citing works

Cohesin: Its Roles and Mechanisms

Nasmyth, K., & Haering, C. H. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134233 · Cited by 967 · see citing works

Molecular views of recombination proteins and their control

West, S. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1127 · Cited by 947 · see citing works

Choreography of the DNA Damage Response

Lisby, M., Barlow, J. H., Burgess, R. C., & Rothstein, R. (2004) · Cell · doi:10.1016/j.cell.2004.08.015 · Cited by 891 · see citing works

Comparative Gene Expression Profiles Following UV Exposure in Wild-Type and SOS-Deficient <i>Escherichia coli</i>

Courcelle, J., Khodursky, A., Peter, B., Brown, P. O., & Hanawalt, P. C. (2001) · Genetics · doi:10.1093/genetics/158.1.41 · Cited by 853 · see citing works

Recombination Proteins in Yeast

Krogh, B. O., & Symington, L. S. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.091500 · Cited by 804 · see citing works

Saccharomyces Ku70, Mre11/Rad50, and RPA Proteins Regulate Adaptation to G2/M Arrest after DNA Damage

Lee, S. E., Moore, J. K., Holmes, A. M., Umezu, K., Kolodner, R. D., & Haber, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81482-8 · Cited by 775 · see citing works

Toward Maintaining the Genome: DNA Damage and Replication Checkpoints

Nyberg, K. A., Michelson, R. J., Putnam, C. W., & Weinert, T. A. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.060402.113540 · Cited by 770 · see citing works

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

Ira, G., Pellicioli, A., Balijja, A., Wang, X., Fiorani, S., Carotenuto, W., Liberi, G., Bressan, D., Wan, L., Hollingsworth, N. M., et al. (2004) · Nature · doi:10.1038/nature02964 · Cited by 722 · see citing works

Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein

Davies, A. A., Masson, J., McIlwraith, M. J., Stasiak, A. Z., Stasiak, A., Venkitaraman, A. R., & West, S. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00175-7 · Cited by 720 · see citing works

Biological networks: the tinkerer as an engineer

Alon, U. (2003) · Science · doi:10.1126/science.1089072 · Cited by 706 · see citing works

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Sørensen, C. S., Hansen, L. T., Dziegielewski, J., Syljuåsen, R. G., Lundin, C., Bartek, J., & Helleday, T. (2005) · Nature Cell Biology · doi:10.1038/ncb1212 · Cited by 666 · see citing works

The Single-End Invasion

Hunter, N. M., & Kleckner, N. E. (2001) · Cell · doi:10.1016/s0092-8674(01)00430-5 · Cited by 663 · see citing works

Reading protein modifications with interaction domains

Seet, B. T., Đikić, I., Zhou, M., & Pawson, T. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1960 · Cited by 662 · see citing works

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

Pfander, B., Moldovan, G., Sacher, M., Hoege, C., & Jentsch, S. (2005) · Nature · doi:10.1038/nature03665 · Cited by 626 · see citing works

DNA helicase Srs2 disrupts the Rad51 presynaptic filament

Krejčí, L., Komen, S. V., Li, Y., Villemain, J. L., Reddy, M. S., Klein, H. L., Ellenberger, T. E., & Sung, P. (2003) · Nature · doi:10.1038/nature01577 · Cited by 624 · see citing works

The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments

Veaute, X., Jeusset, J., Soustelle, C., Kowalczykowski, S. C., Cam, É. L., & Fabre, F. (2003) · Nature · doi:10.1038/nature01585 · Cited by 612 · see citing works

DNA MISMATCH REPAIR AND GENETIC INSTABILITY

Harfe, B. D., & Jinks-Robertson, S. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.359 · Cited by 605 · see citing works

How the Fanconi Anemia Pathway Guards the Genome

Moldovan, G., & D’Andrea, A. D. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134222 · Cited by 586 · see citing works

Srs2 and Sgs1–Top3 Suppress Crossovers during Double-Strand Break Repair in Yeast

Ira, G., Malkova, A., Liberi, G., Foiani, M., & Haber, J. E. (2003) · Cell · doi:10.1016/s0092-8674(03)00886-9 · Cited by 571 · see citing works

A dynamic model for replication protein A (RPA) function in DNA processing pathways

Fanning, E. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl550 · Cited by 565 · see citing works

Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions

Lopes, M., Foiani, M., & Sogo, J. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.015 · Cited by 563 · see citing works

DNA helicases Sgs1 and BLM promote DNA double-strand break resectionPreprint

Gravel, S., Chapman, J. R., Magill, C. P., & Jackson, S. P. (2008) · Genes & Development · doi:10.1101/gad.503108 · Cited by 562 · see citing works

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Yun, M. H., & Hiom, K. (2009) · Nature · doi:10.1038/nature07955 · Cited by 556 · see citing works

Mus81-Eme1 Are Essential Components of a Holliday Junction Resolvase

Boddy, M. N., Gaillard, P.-H. L., McDonald, W. H., Shanahan, P., Yates, J. R., & Russell, P. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00536-0 · Cited by 545 · see citing works

Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.

Sung, P. (1997) · Genes &amp; Development · doi:10.1101/gad.11.9.1111 · Cited by 540 · see citing works

Principles of ubiquitin and SUMO modifications in DNA repair

Bergink, S., & Jentsch, S. (2009) · Nature · doi:10.1038/nature07963 · Cited by 525 · see citing works

Crosstalk between SUMO and Ubiquitin on PCNA Is Mediated by Recruitment of the Helicase Srs2p

Papouli, E., Chen, S., Davies, A. A., Huttner, D., Krejčí, L., Sung, P., & Ulrich, H. D. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.06.001 · Cited by 522 · see citing works

Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae.

Kadyk, L. C., & Hartwell, L. H. (1992) · Genetics · doi:10.1093/genetics/132.2.387 · Cited by 522 · see citing works

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

Galanty, Y., Belotserkovskaya, R., Coates, J., Polo, S. E., Miller, K. M., & Jackson, S. P. (2009) · Nature · doi:10.1038/nature08657 · Cited by 520 · see citing works

Crosstalk between histone modifications during the DNA damage response

van Attikum, H., & Gasser, S. M. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.03.001 · Cited by 515 · see citing works

Human Rad50/Mre11 Is a Flexible Complex that Can Tether DNA Ends

de Jager, M., van Noort, J., van Gent, D. C., Dekker, C., Kanaar, R., & Wyman, C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00381-1 · Cited by 512 · see citing works

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

Huertas, P., & Jackson, S. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808906200 · Cited by 511 · see citing works

Genetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences

Stark, J. M., Pierce, A. J., Oh, J., Pastink, A., & Jasin, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9305-9316.2004 · Cited by 501 · see citing works

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

Esashi, F., Christ, N., Gannon, J., Liu, Y., Hunt, T., Jasin, M., & West, S. C. (2005) · Nature · doi:10.1038/nature03404 · Cited by 473 · see citing works

Maintenance of Genome Stability in Saccharomyces cerevisiae

Kolodner, R. D., Putnam, C. D., & Myung, K. (2002) · Science · doi:10.1126/science.1075277 · Cited by 464 · see citing works

CDK targets Sae2 to control DNA-end resection and homologous recombination

Huertas, P., Cortés‐Ledesma, F., Sartori, A. A., Aguilera, A., & Jackson, S. P. (2008) · Nature · doi:10.1038/nature07215 · Cited by 456 · see citing works

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

Morris, J. R., Boutell, C., Epple, M., Densham, R. M., Weekes, D. B., Alamshah, A., Butler, L. R., Galanty, Y., Pangon, L., Kiuchi, T., et al. (2009) · Nature · doi:10.1038/nature08593 · Cited by 434 · see citing works

Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

Trujillo, K. M., Yuan, S. F., Lee, E. Y.-H. P., & Sung, P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.21447 · Cited by 417 · see citing works

DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

Yu, X., & Chen, J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9478-9486.2004 · Cited by 410 · see citing works

The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

Hanada, K., Budzowska, M., Davies, S. L., van Drunen, E., Onizawa, H., Beverloo, H. B., Maas, A., Essers, J., Hickson, I. D., & Kanaar, R. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1313 · Cited by 392 · see citing works

Genetic Requirements for the Single-Strand Annealing Pathway of Double-Strand Break Repair in Saccharomyces cerevisiae

Ivanov, E. L., Sugawara, N., Fishman‐Lobell, J., & Haber, J. E. (1996) · Genetics · doi:10.1093/genetics/142.3.693 · Cited by 390 · see citing works

The CDK regulates repair of double‐strand breaks by homologous recombination during the cell cycle

Aylon, Y., Liefshitz, B., & Kupiec, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600469 · Cited by 387 · see citing works

The Smc5–Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus

Torres‐Rosell, J., Šunjevarić, I., Piccoli, G. D., Sacher, M., Eckert‐Boulet, N., Reid, R. J. D., Jentsch, S., Rothstein, R. J., Aragón, L., & Lisby, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1619 · Cited by 379 · see citing works

RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination

Barber, L. J., Youds, J. L., Ward, J. D., McIlwraith, M. J., O'Neil, N. J., Petalcorin, M. I. R., Martin, J. S., Collis, S. J., Cantor, S. B., Auclair, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.08.016 · Cited by 369 · see citing works

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases

Gangloff, S., Soustelle, C., & Fabre, F. (2000) · Nature Genetics · doi:10.1038/76055 · Cited by 363 · see citing works

In Vivo Roles of Rad52, Rad54, and Rad55 Proteins in Rad51-Mediated Recombination

Sugawara, N., Wang, X., & Haber, J. E. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00269-7 · Cited by 354 · see citing works

Semidominant Suppressors of Srs2 Helicase Mutations of Saccharomyces cerevisiae Map in the RAD51 Gene, Whose Sequence Predicts a Protein with Similarities to Procaryotic RecA Proteins

Aboussekhra, A., Chanet, R., Adjiri, A., & Fabre, F. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.7.3224-3234.1992 · Cited by 345 · see citing works

Template switching during break-induced replication

Smith, C. E., Llorente, B., & Symington, L. S. (2007) · Nature · doi:10.1038/nature05723 · Cited by 342 · see citing works

Mutational robustness can facilitate adaptation

Draghi, J. A., Parsons, T. L., Wagner, G. P., & Plotkin, J. B. (2010) · Nature · doi:10.1038/nature08694 · Cited by 336 · see citing works

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA–ssDNA junction

Yang, H., Li, Q., Fan, J., Holloman, W. K., & Pavletich, N. P. (2005) · Nature · doi:10.1038/nature03234 · Cited by 335 · see citing works

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filamentsPreprint

Hu, Y., Raynard, S. J., Sehorn, M. G., Lu, X., Bussen, W., Zheng, L., Stark, J. M., Barnes, E. L., Chi, P., Janščák, P., et al. (2007) · Genes & Development · doi:10.1101/gad.1609107 · Cited by 322 · see citing works

Replication fork reactivation downstream of a blocked nascent leading strand

Heller, R. C., & Marians, K. J. (2006) · Nature · doi:10.1038/nature04329 · Cited by 318 · see citing works

Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication

Fabre, F., Chan, A., Heyer, W., & Gangloff, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252652399 · Cited by 318 · see citing works

SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination

Myung, K., Datta, A., Chen, C., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/83673 · Cited by 316 · see citing works

Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.

Lengsfeld, B., Rattray, A., Bhaskara, V., Ghirlando, R., & Paull, T. (2007) · Molecules and Cells · doi:10.1016/j.molcel.2007.11.001 · Cited by 316 · see citing works

The controlling role of ATM in homologous recombinational repair of DNA damage

Morrison, C., Sonoda, E., Takao, N., Shinohara, A., Yamamoto, K., & Takeda, S. (2000) · The EMBO Journal · doi:10.1093/emboj/19.3.463 · Cited by 312 · cited 1× · see citing works

Novel pro- and anti-recombination activities of the Bloom’s syndrome helicasePreprint

Bugreev, D. V., Yu, X., Egelman, E. H., & Mazin, A. V. (2007) · Genes & Development · doi:10.1101/gad.1609007 · Cited by 297 · see citing works

The RecQ DNA Helicases in DNA Repair

Bernstein, K. A., Gangloff, S., & Rothstein, R. J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-102209-163602 · Cited by 297 · see citing works

Potential Role for the BLM Helicase in Recombinational Repair via a Conserved Interaction with RAD51

Wu, L., Davies, S. L., Levitt, N. C., & Hickson, I. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009471200 · Cited by 296 · see citing works

Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins.

Hays, S. L., Firmenich, A. A., & Berg, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6925 · Cited by 296 · see citing works

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

Nimonkar, A. V., Özsoy, A. Z., Genschel, J., Modrich, P. L., & Kowalczykowski, S. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809380105 · Cited by 295 · see citing works

Ubc9- and Mms21-Mediated Sumoylation Counteracts Recombinogenic Events at Damaged Replication Forks

Branzei, D., Sollier, J., Liberi, G., Zhao, X., Maeda, D., Seki, M., Enomoto, T., Ohta, K., & Foiani, M. (2006) · Cell · doi:10.1016/j.cell.2006.08.050 · Cited by 291 · see citing works

The structure‐specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double‐strands breaks

Hanada, K., Budzowska, M., Modesti, M., Maas, A., Wyman, C., Essers, J., & Kanaar, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601344 · Cited by 290 · see citing works

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIPPreprint

Yu, X., Fu, S., Lai, M., Baer, R. J., & Chen, J. (2006) · Genes & Development · doi:10.1101/gad.1431006 · Cited by 283 · see citing works

Activation of Ubiquitin-Dependent DNA Damage Bypass Is Mediated by Replication Protein A

Davies, A. A., Huttner, D., Daigaku, Y., Chen, S., & Ulrich, H. D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.016 · Cited by 281 · see citing works

Exo1 Processes Stalled Replication Forks and Counteracts Fork Reversal in Checkpoint-Defective Cells

Cotta‐Ramusino, C., Fachinetti, D., Lucca, C., Doksani, Y., Lopes, M., Sogo, J. M., & Foiani, M. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.11.032 · Cited by 281 · see citing works

BLM Ortholog, Sgs1, Prevents Aberrant Crossing-over by Suppressing Formation of Multichromatid Joint Molecules

Oh, S. D., Lao, J. P., Hwang, P. Y.-H., Taylor, A. F., Smith, G. R., & Hunter, N. (2007) · Cell · doi:10.1016/j.cell.2007.05.035 · Cited by 278 · see citing works

The Fanconi Anemia Protein FANCM Can Promote Branch Migration of Holliday Junctions and Replication Forks

Gari, K., Décaillet, C., Stasiak, A. Z., Stasiak, A., & Constantinou, A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.11.032 · Cited by 257 · see citing works

SUMOylation regulates Rad18-mediated template switch

Branzei, D., Vanoli, F., & Foiani, M. (2008) · Nature · doi:10.1038/nature07587 · Cited by 256 · see citing works

Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs.

Worth, L., Clark, S., Radman, M., & Modrich, P. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3238 · Cited by 256 · see citing works

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombinationPreprint

Prakash, R., Satory, D., Dray, E. V., Papusha, A., Scheller, J., Kramer, W., Krejčí, L., Klein, H. L., Haber, J. E., Sung, P., et al. (2009) · Genes & Development · doi:10.1101/gad.1737809 · Cited by 254 · see citing works

Rad54: the Swiss Army knife of homologous recombination?

Heyer, W., Li, X., Rolfsmeier, M. L., & Zhang, X. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl481 · Cited by 254 · see citing works

Drosophila BLM in Double-Strand Break Repair by Synthesis-Dependent Strand Annealing

Adams, M. D., McVey, M., & Sekelsky, J. J. (2003) · Science · doi:10.1126/science.1077198 · Cited by 246 · see citing works

Ca 2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity

Bugreev, D. V., & Mazin, A. V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402105101 · Cited by 245 · see citing works

Double Holliday junctions are intermediates of DNA break repair

Bzymek, M., Thayer, N. H., Oh, S. D., Kleckner, N. E., & Hunter, N. (2010) · Nature · doi:10.1038/nature08868 · Cited by 243 · see citing works

Remodeling of DNA replication structures by the branch point translocase FANCM

Gari, K., Décaillet, C., Delannoy, M., Wu, L., & Constantinou, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804777105 · Cited by 234 · see citing works

Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast

Datta, A., Hendrix, M. M., Lipsitch, M., & Jinks-Robertson, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9757 · Cited by 229 · see citing works

Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase

Bachrati, C. Z. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl258 · Cited by 226 · see citing works

Nucleases and helicases take center stage in homologous recombination

Mimitou, E. P., & Symington, L. S. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.01.010 · Cited by 224 · see citing works

Parameter Sensitivity as a Criterion for Evaluating and Comparing the Performance of Biochemical Systems

Savageau, M. A. (1971) · Nature · doi:10.1038/229542a0 · Cited by 222 · see citing works

Mitotic Crossovers between Diverged Sequences Are Regulated by Mismatch Repair Proteins in Saccharomyces cerevisiae

Datta, A., Adjiri, A., New, L., Crouse, G. F., & Jinks-Robertson, S. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1085 · Cited by 213 · see citing works

Heteroduplex rejection during single-strand annealing requires Sgs1 helicase and mismatch repair proteins Msh2 and Msh6 but not Pms1

Sugawara, N., Goldfarb, T., Studamire, B., Alani, E., & Haber, J. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305749101 · Cited by 200 · see citing works

Radiobiological and Genetic Studies on a Polyploid Series (Haploid to Hexaploid) of Saccharomyces cerevisiae

Mortimer, R. (1958) · Radiation Research · doi:10.2307/3570795 · Cited by 198 · see citing works

Telomeric Strategies: Means to an End

Jain, D., & Cooper, J. P. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134841 · Cited by 196 · see citing works

RADH, a gene ofSaccharomyces cerevisiaeencoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene

Aboussekhra, A., Chanet, R., Zgaga, Z., Cassier‐Chauvat, C., Heude, M., & Fabre, F. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.18.7211 · Cited by 195 · see citing works

Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths

Lee, S. E., Pâques, F., Sylvan, J. B., & Haber, J. E. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80339-x · Cited by 195 · see citing works

Transient Stability of DNA Ends Allows Nonhomologous End Joining to Precede Homologous Recombination

Frank-Vaillant, M., & Marcand, S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00705-0 · Cited by 194 · see citing works

Control of Rad52 recombination activity by double-strand break-induced SUMO modification

Sacher, M., Pfander, B., Hoege, C., & Jentsch, S. (2006) · Nature Cell Biology · doi:10.1038/ncb1488 · Cited by 188 · see citing works

RTEL-1 Enforces Meiotic Crossover Interference and Homeostasis

Youds, J. L., Mets, D. G., Mcilwraith, M., Martin, J., Ward, J. D., ONeil, N. J., Rose, A., West, S., Meyer, B. J., & Boulton, S. (2010) · Science · doi:10.1126/science.1183112 · Cited by 181 · see citing works

The SRS2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway.

Schiestl, R. H., Prakash, S., & Prakash, L. (1990) · Genetics · doi:10.1093/genetics/124.4.817 · Cited by 179 · see citing works

RAD51 -Dependent Break-Induced Replication Differs in Kinetics and Checkpoint Responses from RAD51 -Mediated Gene Conversion

Malkova, A., Naylor, M. L., Yamaguchi, M., Ira, G., & Haber, J. E. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.933-944.2005 · Cited by 173 · see citing works

Regulation of Meiotic Recombination via Mek1-Mediated Rad54 Phosphorylation

Niu, H., Wan, L., Busygina, V., Kwon, Y., Allen, J. J., Li, X., Kunz, R. C., Kubota, K., Wang, B., Sung, P., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.029 · Cited by 171 · see citing works

NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the Ligase IV pathwayPreprint

Frank-Vaillant, M., & Marcand, S. (2001) · Genes & Development · doi:10.1101/gad.206801 · Cited by 166 · see citing works

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response

Morin, I., Ngo, H., Greenall, A., Zubko, M. K., Morrice, N., & Lydall, D. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.171 · Cited by 164 · see citing works

DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints

Bashkirov, V. I., King, J. S., Bashkirova, E. V., Schmuckli-Maurer, J., & Heyer, W.-D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4393-4404.2000 · Cited by 164 · see citing works

Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification

Eladad, S., Ye, T.-Z., Hu, P., Leversha, M. A., Beresten, S. F., Matunis, M. J., & Ellis, N. A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi145 · Cited by 158 · see citing works

Cdc2–cyclin B kinase activity links Crb2 and Rqh1–topoisomerase IIIPreprint

Caspari, T., Murray, J. M., & Carr, A. M. (2002) · Genes & Development · doi:10.1101/gad.221402 · Cited by 156 · see citing works

Human and mouse homologs of the Saccharomyces cerevisiaeRAD54 DNA repair gene: evidence for functional conservation

Kanaar, R., Troelstra, C., Swagemakers, S. M. A., Essers, J., Smit, B., Franssen, J. H., Pastink, A., Bezzubova, O. Y., Buerstedde, J.-M., Clever, B., et al. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00606-1 · Cited by 152 · see citing works

Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis

Jessop, L., & Lichten, M. (2008) · Molecules and Cells · doi:10.1016/j.molcel.2008.05.021 · Cited by 148 · see citing works

Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M

Bakker, S. T., van de Vrugt, H. J., Rooimans, M. A., Oostra, A. B., Steltenpool, J., Delzenne‐Goette, E., van der Wal, A., van der Valk, M., Joenje, H., Riele, H. T., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp297 · Cited by 148 · see citing works

The FANCM Ortholog Fml1 Promotes Recombination at Stalled Replication Forks and Limits Crossing Over during DNA Double-Strand Break Repair

Sun, W., Nandi, S., Osman, F., Ahn, J. S., Jakovleska, J., Lorenz, A., & Whitby, M. C. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.024 · Cited by 147 · see citing works

Competition between the Rad50 Complex and the Ku Heterodimer Reveals a Role for Exo1 in Processing Double-Strand Breaks but Not Telomeres

Tomita, K., Matsuura, A., Caspari, T., Carr, A. M., Akamatsu, Y., Iwasaki, H., Mizuno, K., Ohta, K., Uritani, M., Ushimaru, T., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5186-5197.2003 · Cited by 147 · see citing works

Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stressPreprint

Kai, M., Boddy, M. N., Russell, P. R., & Wang, T. S. ‐. (2005) · Genes & Development · doi:10.1101/gad.1304305 · Cited by 145 · see citing works

Budding yeast Hed1 down-regulates the mitotic recombination machinery when meiotic recombination is impairedPreprint

Tsubouchi, H., & Roeder, G. S. (2006) · Genes & Development · doi:10.1101/gad.1422506 · Cited by 145 · see citing works

ATP-dependent chromatin remodeling factors and DNA damage repair

Osley, M. A., Tsukuda, T., & Nickoloff, J. A. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.07.011 · Cited by 141 · see citing works

A recombination execution checkpoint regulates the choice of homologous recombination pathway during DNA double-strand break repairPreprint

Jain, S., Sugawara, N., Lydeard, J. R., Vaze, M. B., Gac, N. T. L., & Haber, J. E. (2009) · Genes & Development · doi:10.1101/gad.1751209 · Cited by 140 · see citing works

Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52

Chen, F., Nastasi, A. J., Shen, Z., Brenneman, M. A., Crissman, H. A., & Chen, D. J. (1997) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(97)00020-7 · Cited by 131 · see citing works

SUMO Modification Regulates BLM and RAD51 Interaction at Damaged Replication Forks

Ouyang, K. J., Woo, L. L., Zhu, J., Huo, D., Matunis, M. J., & Ellis, N. A. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000252 · Cited by 128 · see citing works

The Srs2 Helicase Activity Is Stimulated by Rad51 Filaments on dsDNA: Implications for Crossover Incidence during Mitotic Recombination

Pauline, D., Breton, C. L., Fabre, F., Gangloff, S., Cam, É. L., & Veaute, X. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.11.033 · Cited by 127 · see citing works

Molecular Genetics of Recombination

Heyer, W.-D. (2007) · Topics in current genetics · doi:10.1007/978-3-540-71021-9 · Cited by 126 · see citing works

The F-Box DNA Helicase Fbh1 Prevents Rhp51-Dependent Recombination without Mediator Proteins

Osman, F., Dixon, J. E., Barr, A. R., & Whitby, M. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8084-8096.2005 · Cited by 121 · see citing works

Yeast cell-type regulation of DNA repair

Åström, S. U., Okamura, S. M., & Rine, J. (1999) · Nature · doi:10.1038/16833 · Cited by 119 · see citing works

Molecular Dissection of Mitotic Recombination in the Yeast Saccharomyces cerevisiae

Aylon, Y., Liefshitz, B., Bitan-Banin, G., & Kupiec, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1403-1417.2003 · Cited by 117 · see citing works

The Functions of Budding Yeast Sae2 in the DNA Damage Response Require Mec1- and Tel1-Dependent Phosphorylation

Baroni, E., Viscardi, V., Cartagena‐Lirola, H., Lucchini, G., & Longhese, M. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4151-4165.2004 · Cited by 116 · see citing works

FANCJ Uses Its Motor ATPase to Destabilize Protein-DNA Complexes, Unwind Triplexes, and Inhibit RAD51 Strand Exchange

Sommers, J. A., Rawtani, N., Gupta, R., Bugreev, D. V., Mazin, A. V., Cantor, S. B., & Brosh, R. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809019200 · Cited by 112 · see citing works

Regulation of Mitotic Homeologous Recombination in Yeast: Functions of Mismatch Repair and Nucleotide Excision Repair Genes

Nicholson, A. C., Hendrix, M. M., Jinks-Robertson, S., & Crouse, G. F. (2000) · Genetics · doi:10.1093/genetics/154.1.133 · Cited by 112 · see citing works

Rad54 dissociates homologous recombination intermediates by branch migration

Bugreev, D. V., Hanaoka, F., & Mazin, A. V. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1268 · Cited by 111 · see citing works

RECQL, a Member of the RecQ Family of DNA Helicases, Suppresses Chromosomal Instability

Sharma, S., Stumpo, D. J., Balajee, A. S., Bock, C. B., Lansdorp, P. M., Brosh, R. M., & Blackshear, P. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01620-06 · Cited by 111 · see citing works

Hed1 regulates Rad51-mediated recombination via a novel mechanismPreprint

Busygina, V., Sehorn, M. G., Shi, I. Y., Tsubouchi, H., Roeder, G. S., & Sung, P. (2008) · Genes & Development · doi:10.1101/gad.1638708 · Cited by 111 · see citing works

Mismatch Repair Proteins Regulate Heteroduplex Formation during Mitotic Recombination in Yeast

Chen, W., & Jinks-Robertson, S. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6525 · Cited by 110 · see citing works

The FANCM family of DNA helicases/translocases

Whitby, M. C. (2010) · DNA repair · doi:10.1016/j.dnarep.2009.12.012 · Cited by 109 · see citing works

Chromosomal Instability in Microsatellite-Unstable and Stable Colon Cancer

Trautmann, K., Terdiman, J. P., French, A. J., Roydasgupta, R., Sein, N., Kakar, S., Fridlyand, J., Snijders, A. M., Albertson, D. G., Thibodeau, S. N., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1248 · Cited by 107 · see citing works

Human RECQ1 Is a DNA Damage Responsive Protein Required for Genotoxic Stress Resistance and Suppression of Sister Chromatid Exchanges

Sharma, S., & Brosh, R. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001297 · Cited by 106 · see citing works

Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

Fugger, K., Mistrík, M., Danielsen, J. M. R., Dinant, C., Falck, J., Bártek, J., Lukas, J., & Mailand, N. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200812138 · Cited by 103 · see citing works

DOG-1 Is the Caenorhabditis elegans BRIP1/FANCJ Homologue and Functions in Interstrand Cross-Link Repair

Youds, J. L., Barber, L. J., Ward, J. D., Collis, S. J., O’Neil, N. J., Boulton, S. J., & Rose, A. M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01641-07 · Cited by 102 · see citing works

Yeast MPH1 Gene Functions in an Error-Free DNA Damage Bypass Pathway That Requires Genes From Homologous Recombination, but Not From Postreplicative Repair

Schürer, K. A., Rudolph, C. J., Ulrich, H. D., & Kramer, W. (2004) · Genetics · doi:10.1534/genetics.166.4.1673 · Cited by 99 · see citing works

Overlapping Mechanisms Promote Postsynaptic RAD-51 Filament Disassembly during Meiotic Double-Strand Break Repair

Ward, J. D., Muzzini, D. M., Petalcorin, M. I. R., Martínez-Pérez, E., Martin, J. S., Plevani, P., Cassata, G., Marini, F., & Boulton, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2009.12.026 · Cited by 97 · see citing works

Phosphorylation of Rad55 on Serines 2, 8, and 14 Is Required for Efficient Homologous Recombination in the Recovery of Stalled Replication Forks

Herzberg, K., Bashkirov, V. I., Rolfsmeier, M., Haghnazari, E., McDonald, W. H., Anderson, S., Bashkirova, E. V., Yates, J. R., & Heyer, W.-D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01317-06 · Cited by 95 · see citing works

Cellular Redistribution of Rad51 in Response to DNA Damage

Gildemeister, O. S., Sage, J. M., & Knight, K. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.024646 · Cited by 94 · see citing works

Induced intragenic recombination in yeast can occur during the G1 mitotic phase

Fabre, F. (1978) · Nature · doi:10.1038/272795a0 · Cited by 92 · see citing works

Rad51 Protein Controls Rad52-mediated DNA Annealing

Wu, Y., Kantake, N., Sugiyama, T., & Kowalczykowski, S. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801097200 · Cited by 90 · see citing works

Functional Interaction between the Bloom's Syndrome Helicase and the RAD51 Paralog, RAD51L3 (RAD51D)

Braybrooke, J. P., Li, J., Wu, L., Caple, F., Benson, F. E., & Hickson, I. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308838200 · Cited by 88 · see citing works

Cleavage of Stalled Forks by Fission Yeast Mus81/Eme1 in Absence of DNA Replication Checkpoint

Froget, B., Blaisonneau, J., Lambert, S., & Baldacci, G. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-07-0728 · Cited by 88 · see citing works

Examination of the Roles of Sgs1 and Srs2 Helicases in the Enforcement of Recombination Fidelity in Saccharomyces cerevisiae

Spell, R. M., & Jinks-Robertson, S. (2004) · Genetics · doi:10.1534/genetics.104.032771 · Cited by 86 · see citing works

Semidominant Mutations in the Yeast Rad51 Protein and Their Relationships with the Srs2 Helicase

Chanet, R., Heude, M., Adjiri, A., Maloisel, L., & Fabre, F. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4782 · Cited by 85 · see citing works

ATR-dependent pathways control hEXO1 stability in response to stalled forks

El‐Shemerly, M., Heß, D., Pyakurel, A., Moselhy, S. S., & Ferrari, S. M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1052 · Cited by 82 · see citing works

Budding Yeast Sae2 is an In Vivo Target of the Mec1 and Tel1 Checkpoint Kinases During Meiosis

Cartagena‐Lirola, H., Guerini, I., Viscardi, V., Lucchini, G., & Longhese, M. P. (2006) · Cell Cycle · doi:10.4161/cc.5.14.2916 · Cited by 80 · see citing works

Regulation of yeast sirtuins by NAD+ metabolism and calorie restriction

Lu, S.-P., & Lin, S.-J. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.09.030 · Cited by 77 · see citing works

Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatinPreprint

Holzen, T. M., Shah, P. P., Olivares, H. A., & Bishop, D. K. (2006) · Genes & Development · doi:10.1101/gad.1447106 · Cited by 77 · see citing works

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

Rosado, I. V., Niedźwiedź, W., Alpi, A. F., & Patel, K. J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp365 · Cited by 77 · see citing works

RECQ1 Possesses DNA Branch Migration Activity

Bugreev, D. V., Brosh, R. M., & Mazin, A. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801582200 · Cited by 74 · see citing works

Regulated degradation of FANCM in the Fanconi anemia pathway during mitosisPreprint

Kee, Y., Kim, J. M., & D’Andrea, A. D. (2009) · Genes & Development · doi:10.1101/gad.1761309 · Cited by 74 · see citing works

Behind the wheel and under the hood: Functions of cyclin-dependent kinases in response to DNA damage

Wohlbold, L., & Fisher, R. P. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.009 · Cited by 64 · see citing works

Quality control of DNA break metabolism: in the ‘end’, it's a good thing

Kanaar, R., Wyman, C., & Rothstein, R. J. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.11 · Cited by 63 · see citing works

Failure to induce a DNA repair gene, RAD54, in Saccharomyces cerevisiae does not affect DNA repair or recombination phenotypes.

Cole, G. M., & Mortimer, R. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.8.3314 · Cited by 62 · see citing works

The Human F-Box DNA Helicase FBH1 Faces Saccharomyces cerevisiae Srs2 and Postreplication Repair Pathway Roles

Chiolo, I., Saponaro, M., Baryshnikova, A., Kim, J., Seo, Y., & Liberi, G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00963-07 · Cited by 60 · see citing works

Esc2 and Sgs1 Act in Functionally Distinct Branches of the Homologous Recombination Repair Pathway in Saccharomyces cerevisiae

Mankouri, H. W., Ngo, H.-P., & Hickson, I. D. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-08-0877 · Cited by 59 · see citing works

Some disassembly required: role of DNA translocases in the disruption of recombination intermediates and dead-end complexesPreprint

Symington, L. S., & Heyer, W. (2006) · Genes & Development · doi:10.1101/gad.1477106 · Cited by 58 · see citing works

Influence of DNA Sequence Identity on Efficiency of Targeted Gene Replacement

Negritto, M. T., Wu, X., Kuo, T., Chu, S., & Bailis, A. M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.278 · Cited by 57 · see citing works

Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination

Banerjee, S., Smith, S. N., Oum, J., Liaw, H., Hwang, J., Sikdar, N., Motegi, A., Lee, S. E., & Myung, K. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200711146 · Cited by 48 · see citing works

Multiple start codons and phosphorylation result in discrete Rad52 protein species

de Mayolo, A. A., Lisby, M., Erdeniz, N., Thybo, T., Mortensen, U. H., & Rothstein, R. J. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl280 · Cited by 41 · see citing works

Different Mating-Type-Regulated Genes Affect the DNA Repair Defects of SaccharomycesRAD51,RAD52andRAD55Mutants

Valencia‐Burton, M., Oki, M., Johnson, J., Seier, T., Kamakaka, R. T., & Haber, J. E. (2006) · Genetics · doi:10.1534/genetics.106.058685 · Cited by 38 · see citing works

Sequence Divergence Impedes Crossover More Than Noncrossover Events During Mitotic Gap Repair in Yeast

Welz-Voegele, C., & Jinks-Robertson, S. (2008) · Genetics · doi:10.1534/genetics.108.090233 · Cited by 38 · see citing works

Biochemistry of Eukaryotic Homologous Recombination

Heyer, W. (2006) · Springer eBooks · doi:10.1007/978-3-540-71021-9_4 · Cited by 38 · see citing works

Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates

Ehmsen, K. T., & Heyer, W. (2008) · Genome dynamics and stability · doi:10.1007/7050_2008_039 · Cited by 34 · see citing works

Nej1 recruits the Srs2 helicase to DNA double-strand breaks and supports repair by a single-strand annealing-like mechanism

Carter, S. D., Vigašová, D., Chen, J., Chovanec, M., & Åström, S. U. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903869106 · Cited by 27 · see citing works

A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae

Janke, R., Herzberg, K., Rolfsmeier, M. L., Mar, J. S., Bashkirov, V. I., Haghnazari, E., Cantin, G. T., Yates, J. R., & Heyer, W. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1222 · Cited by 27 · see citing works

Meiotic recombination

Hunter, N. M. (2006) · Springer eBooks · doi:10.1007/4735_2006_0215 · Cited by 27 · see citing works

Genetic evidence for a role of Saccharomyces cerevisiae Mph1 in recombinational DNA repair under replicative stress

Panico, E. R., Ede, C., Schildmann, M., Schürer, K. A., & Kramer, W. (2009) · Yeast · doi:10.1002/yea.1727 · Cited by 26 · see citing works

Failure To Induce a DNA Repair Gene, RAD54 , in Saccharomyces cerevisiae Does Not Affect DNA Repair or Recombination Phenotypes

Cole, G. M., & Mortimer, R. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.8.3314-3322.1989 · Cited by 26 · see citing works

Mph1 requires mismatch repair-independent and -dependent functions of MutSα to regulate crossover formation during homologous recombination repair

Tay, Y. D., Sidebotham, J. M., & Wu, L. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1199 · Cited by 24 · see citing works

Sae2p phosphorylation is crucial for cooperation with Mre11p for resection of DNA double-strand break ends during meiotic recombination in Saccharomyces cerevisiae

Terasawa, M., Ogawa, T., Tsukamoto, Y., & Ogawa, H. (2008) · Genes & Genetic Systems · doi:10.1266/ggs.83.209 · Cited by 23 · see citing works

The Anaphase-Promoting Complex/Cyclosome Controls Repair and Recombination by Ubiquitylating Rhp54 in Fission Yeast

Trickey, M., Grimaldi, M., & Yamano, H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02116-07 · Cited by 23 · see citing works

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

Anzalone, A. V., Koblan, L. W., & Liu, D. R. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0561-9 · Cited by 2,237 · see citing works

Repair Pathway Choices and Consequences at the Double-Strand Break

Ceccaldi, R., Rondinelli, B., & D’Andrea, A. D. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.07.009 · Cited by 1,499 · see citing works

DNA double-strand break repair-pathway choice in somatic mammalian cells

Scully, R., Panday, A., Elango, R., & Willis, N. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0152-0 · Cited by 1,445 · see citing works

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

Lin, S., Staahl, B. T., Alla, R. K., & Doudna, J. A. (2014) · eLife · doi:10.7554/elife.04766 · Cited by 1,189 · see citing works

Double-strand break repair: 53BP1 comes into focus

Panier, S., & Boulton, S. J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3719 · Cited by 1,090 · see citing works

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

Komor, A. C., Badran, A. H., & Liu, D. R. (2016) · Cell · doi:10.1016/j.cell.2016.10.044 · Cited by 1,011 · see citing works

Homologous recombination and the repair of DNA double-strand breaks

Wright, W. D., Shah, S. S., & Heyer, W.-D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.000372 · Cited by 713 · see citing works

Genome-editing Technologies for Gene and Cell Therapy

Maeder, M. L., & Gersbach, C. A. (2016) · Molecular Therapy · doi:10.1038/mt.2016.10 · Cited by 722 · see citing works

DNA repair mechanisms in dividing and non-dividing cells

Iyama, T., & Wilson, D. M. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.04.015 · Cited by 697 · see citing works

Homologous recombination and its regulation

Krejčí, L., Altmannová, V., Spirek, M., & Zhao, X. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks270 · Cited by 642 · see citing works

Prime editing for precise and highly versatile genome manipulation

Chen, P. J., & Liu, D. R. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00541-1 · Cited by 621 · see citing works

Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing

Anzalone, A. V., Gao, X. D., Podracky, C. J., Nelson, A. T., Koblan, L. W., Raguram, A., Levy, J. M., Mercer, J. A. M., & Liu, D. R. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01133-w · Cited by 613 · see citing works

Delivery technologies for genome editing

Yin, H., Kauffman, K. J., & Anderson, D. G. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.280 · Cited by 597 · see citing works

Past, present, and future of CRISPR genome editing technologies

Pacesa, M., Pelea, O., & Jinek, M. (2024) · Cell · doi:10.1016/j.cell.2024.01.042 · Cited by 609 · see citing works

CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future

Uddin, F. Z., Rudin, C. M., & Sen, T. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01387 · Cited by 605 · see citing works

PARP inhibitor resistance: the underlying mechanisms and clinical implications

Li, H., Liu, Z., Wu, N., Chen, Y., Cheng, Q., & Wang, J. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01227-0 · Cited by 558 · see citing works

Germline mutations in RAD51D confer susceptibility to ovarian cancer

Loveday, C., Turnbull, C., Ramsay, E., Hughes, D., Ruark, E., Frankum, J. R., Bowden, G. R., Kalmyrzaev, B., Warren-Perry, M., Snape, K. M. G., et al. (2011) · Nature Genetics · doi:10.1038/ng.893 · Cited by 530 · see citing works

The multi-factorial nature of clinical multidrug resistance in cancer

Assaraf, Y. G., Brozović, A., Gonçalves, A. C., Jurkovičová, D., Linē, A., Machuqueiro, M., Saponara, S., Sarmento‐Ribeiro, A. B., Xavier, C. P. R., & Vasconcelos, M. H. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100645 · Cited by 535 · see citing works

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayPreprint

Kim, H., & D’Andrea, A. D. (2012) · Genes & Development · doi:10.1101/gad.195248.112 · Cited by 510 · see citing works

Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System

Alt, F. W., Zhang, Y., Meng, F., Guo, C., & Schwer, B. (2013) · Cell · doi:10.1016/j.cell.2013.01.007 · Cited by 477 · see citing works

Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage

Zhang, J., Li, X., Li, G., Chen, W., Arakaki, C., Botimer, G. D., Baylink, D. J., Zhang, L., Wen, W., Fu, Y.-W., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1164-8 · Cited by 473 · see citing works

Causes of genome instability

Aguilera, A., & García-Muse, T. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133232 · Cited by 476 · see citing works

An Overview of the Molecular Mechanisms of Recombinational DNA RepairPreprint

Kowalczykowski, S. C. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016410 · Cited by 475 · see citing works

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

Pfister, S. X., Ahrabi, S., Zalmas, L., Sarkar, S., Aymard, F., Bachrati, C. Z., Helleday, T., Legube, G., Thangue, N. B. L., Porter, A. C. G., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.026 · Cited by 465 · see citing works

Mating-Type Genes and MAT Switching in Saccharomyces cerevisiae

Haber, J. E. (2012) · Genetics · doi:10.1534/genetics.111.134577 · Cited by 424 · see citing works

Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways

Mladenov, E., & Iliakis, G. E. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.02.005 · Cited by 381 · see citing works

Breaking bad: R-loops and genome integrity

Sollier, J., & Cimprich, K. A. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.05.003 · Cited by 369 · see citing works

Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357 · see citing works

Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

Schwertman, P., Bekker‐Jensen, S., & Mailand, N. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.58 · Cited by 354 · see citing works

Hereditary Breast Cancer: The Era of New Susceptibility Genes

Apostolou, P., & Fostira, F. (2013) · BioMed Research International · doi:10.1155/2013/747318 · Cited by 353 · see citing works

DNA helicases involved in DNA repair and their roles in cancer

Brosh, R. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3560 · Cited by 345 · see citing works

Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair

He, X., Tan, C., Wang, F., Wang, Y., Zhou, R., Cui, D., You, W., Zhao, H., Ren, J., & Feng, B. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw064 · Cited by 338 · see citing works

Chromatin and nucleosome dynamics in DNA damage and repairPreprint

Hauer, M., & Gasser, S. M. (2017) · Genes & Development · doi:10.1101/gad.307702.117 · Cited by 320 · see citing works

Transcript-RNA-templated DNA recombination and repair

Keskin, H., Shen, Y., Huang, F., Patel, M., Yang, T., Ashley, K., Mazin, A. V., & Storici, F. (2014) · Nature · doi:10.1038/nature13682 · Cited by 310 · see citing works

Pathway choice in DNA double strand break repair: observations of a balancing act

Brandsma, I., & van Gent, D. C. (2012) · Genome Integrity · doi:10.1186/2041-9414-3-9 · Cited by 304 · see citing works

Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair

Gutschner, T., Hämmerle, M., Genovese, G., Draetta, G. F., & Chin, L. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.019 · Cited by 296 · see citing works

Functions of PARylation in DNA Damage Repair Pathways

Wei, H., & Yu, X. (2016) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.05.001 · Cited by 296 · see citing works

DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice

Schipler, A., & Iliakis, G. E. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt556 · Cited by 290 · see citing works

Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C. W., Boulton, S. J., Saghatelian, A., et al. (2017) · Nature · doi:10.1038/nature24023 · Cited by 299 · see citing works

Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches

Dietlein, F., Thelen, L., & Reinhardt, H. C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.06.003 · Cited by 280 · see citing works

Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks

Boboilă, C., Alt, F. W., & Schwer, B. (2012) · Advances in immunology · doi:10.1016/b978-0-12-394300-2.00001-6 · Cited by 273 · see citing works

RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis.

Suwaki, N., Klare, K., & Tarsounas, M. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.07.019 · Cited by 294 · see citing works

Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges

Taha, E. A., Lee, J., & Hotta, A. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.013 · Cited by 259 · see citing works

Methods Favoring Homology-Directed Repair Choice in Response to CRISPR/Cas9 Induced-Double Strand Breaks

Yang, H., Ren, S., Yu, S., Pan, H., Li, T., Ge, S., Zhang, J., & Xia, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186461 · Cited by 258 · see citing works

In vivo base editing of post-mitotic sensory cells

Yeh, W.-H., Chiang, H., Rees, H. A., Edge, A. S. B., & Liu, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-04580-3 · Cited by 225 · see citing works

Histone methylation and the DNA damage response

Gong, F., & Miller, K. M. (2017) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2017.09.003 · Cited by 247 · see citing works

Hematopoietic Stem Cell Gene Therapy: Progress and Lessons Learned

Morgan, R. A., Gray, D., Lomova, A., & Kohn, D. B. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.10.010 · Cited by 243 · see citing works

DNA Sequence Alignment by Microhomology Sampling during Homologous Recombination

Qi, Z., Redding, S., Lee, J. Y., Gibb, B., Kwon, Y., Niu, H., Gaines, W. A., Sung, P., & Greene, E. C. (2015) · Cell · doi:10.1016/j.cell.2015.01.029 · Cited by 233 · see citing works

DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells

Sturzenegger, A., Burdová, K., Kanagaraj, R., Levikova, M., Pinto, C., Ćejka, P., & Janščák, P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.578823 · Cited by 216 · see citing works

CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein

Tang, L., Zeng, Y., Du, H., Gong, M., Peng, J., Zhang, B., Lei, M., Zhao, F., Wang, W., Li, X., et al. (2017) · Molecular Genetics and Genomics · doi:10.1007/s00438-017-1299-z · Cited by 220 · see citing works

Unraveling the mechanism of BRCA2 in homologous recombination

Holloman, W. K. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2096 · Cited by 220 · see citing works

Rad51 Paralog Complexes BCDX2 and CX3 Act at Different Stages in the BRCA1-BRCA2-Dependent Homologous Recombination Pathway

Chun, J., Buechelmaier, E. S., & Powell, S. N. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00465-12 · Cited by 207 · see citing works

DNA Repair and the Stability of the Plant Mitochondrial Genome

Chevigny, N., Schatz-Daas, D., Weber‐Lotfi, F., & Gualberto, J. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010328 · Cited by 207 · see citing works

Exome Sequencing Identifies Rare Deleterious Mutations in DNA Repair Genes FANCC and BLM as Potential Breast Cancer Susceptibility Alleles

Thompson, E. R., Doyle, M., Ryland, G. L., Rowley, S. M., Choong, D. Y. H., Tothill, R. W., Thorne, H., kConFab, Barnes, D. R., Li, J., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002894 · Cited by 211 · see citing works

Mechanisms and principles of homology search during recombination

Renkawitz, J., Lademann, C. A., & Jentsch, S. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3805 · Cited by 201 · see citing works

Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing

Pandey, S., Gao, X. D., Krasnow, N. A., McElroy, A. N., Tao, Y., Duby, J. E., Steinbeck, B. J., McCreary, J., Pierce, S. E., Tolar, J., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01227-1 · Cited by 207 · see citing works

Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

Liu, J., Renault, L. L. R., Veaute, X., Fabre, F., Stahlberg, H., & Heyer, W. (2011) · Nature · doi:10.1038/nature10522 · Cited by 203 · see citing works

Homology-directed repair of DNA nicks via pathways distinct from canonical double-strand break repair

Davis, L., & Maizels, N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400236111 · Cited by 199 · see citing works

Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases

Yang, D., Scavuzzo, M. A., Chmielowiec, J., Sharp, R., Bajić, A., & Borowiak, M. (2016) · Scientific Reports · doi:10.1038/srep21264 · Cited by 198 · see citing works

Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations

Iliakis, G. E., Murmann-Konda, T., & Soni, A. (2015) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2015.07.001 · Cited by 199 · see citing works

CRISPR-Cas9: a new and promising player in gene therapy

Xiao-Jie, L., Hui-Ying, X., Zun-Ping, K., Jin-Lian, C., & Li-Juan, J. (2015) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2014-102968 · Cited by 200 · see citing works

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

Domínguez-Kelly, R., Martín, Y., Koundrioukoff, S., Tanenbaum, M. E., Smits, V. A. J., Medema, R. H., Debatisse, M., & Freire, R. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201101047 · Cited by 193 · see citing works

Prime editing: advances and therapeutic applications

Zhao, Z., Shang, P., Mohanraju, P., & Geijsen, N. (2023) · Trends in biotechnology · doi:10.1016/j.tibtech.2023.03.004 · Cited by 199 · see citing works

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism

Schmid-Burgk, J. L., Höning, K., Ebert, T. S., & Hornung, V. (2016) · Nature Communications · doi:10.1038/ncomms12338 · Cited by 190 · see citing works

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors

Reisländer, T., Lombardi, E. P., Groelly, F. J., Miar, A., Porru, M., Vito, S. D., Wright, B., Lockstone, H. E., Biroccio, A., Harris, A. L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11048-5 · Cited by 192 · see citing works

The role of microhomology in genomic structural variation

Ottaviani, D., LeCain, M., & Sheer, D. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.01.001 · Cited by 187 · see citing works

FOXM1 (Forkhead box M1) in Tumorigenesis

Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407190-2.00016-2 · Cited by 183 · see citing works

CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement

Li, C., Brant, E. J., Budak, H., & Zhang, B. (2021) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2100009 · Cited by 188 · see citing works

Mismatch Repair during Homologous and Homeologous RecombinationPreprint

Spies, M., & Fishel, R. A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022657 · Cited by 178 · see citing works

The Transcription Factor FOXM1 (Forkhead box M1)

Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 174 · see citing works

Genome-Scale Sequence Disruption Following Biolistic Transformation in Rice and Maize

Liu, J., Nannas, N. J., Fu, F., Shi, J., Aspinwall, B., Parrott, W. A., & Dawe, R. K. (2019) · The Plant Cell · doi:10.1105/tpc.18.00613 · Cited by 176 · see citing works

Precision genome editing using cytosine and adenine base editors in mammalian cells

Huang, T. P., Newby, G. A., & Liu, D. R. (2021) · Nature Protocols · doi:10.1038/s41596-020-00450-9 · Cited by 175 · see citing works

Push back to respond better: regulatory inhibition of the DNA double-strand break response

Panier, S., & Durocher, D. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3659 · Cited by 168 · see citing works

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

Ameziane, N., May, P., Haitjema, A., van de Vrugt, H. J., van Rossum-Fikkert, S. E., Ristić, D., Williams, G. J., Balk, J. A., Rockx, D., Li, H., et al. (2015) · Nature Communications · doi:10.1038/ncomms9829 · Cited by 165 · see citing works

Alternative end-joining pathway(s): Bricolage at DNA breaks

Frit, P., Barboule, N., Yuan, Y., Gómez, D., & Calsou, P. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.02.007 · Cited by 166 · see citing works

RNA transcripts stimulate homologous recombination by forming DR-loops

Ouyang, J., Yadav, T., Zhang, J., Yang, H., Rheinbay, E., Guo, H., Haber, D. A., Lan, L., & Zou, L. (2021) · Nature · doi:10.1038/s41586-021-03538-8 · Cited by 167 · see citing works

A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice

Pai, C., Deegan, R. S., Subramanian, L., Gal, C., Sarkar, S., Blaikley, E., Walker, C. A., Hulme, L., Bernhard, E. J., Codlin, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms5091 · Cited by 166 · see citing works

Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells

Byrne, S. M., Ortiz, L., Mali, P., Aach, J., & Church, G. M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1246 · Cited by 164 · see citing works

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament

Ma, C. J., Gibb, B., Kwon, Y., Sung, P., & Greene, E. C. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1125 · Cited by 161 · see citing works

Drugging the Cancers Addicted to DNA Repair

Nickoloff, J. A., Jones, D. V., Lee, S., Williamson, E. A., & Hromas, R. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx059 · Cited by 159 · see citing works

Holliday junction resolution: Regulation in space and time

Matos, J., & West, S. C. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.03.013 · Cited by 158 · see citing works

Prolyl isomerase Pin1: a promoter of cancer and a target for therapy

Chen, Y., Wu, Y., Yang, H., Li, X., Jie, M., Hu, C.-J., Wu, Y., Yang, S., & Yang, Y. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0844-y · Cited by 159 · see citing works

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

Chakraborty, A., Tapryal, N., Venkova, T., Horikoshi, N., PANDITA, R. K., Sarker, A. H., Sarkar, P. S., Pandita, T. K., & Hazra, T. K. (2016) · Nature Communications · doi:10.1038/ncomms13049 · Cited by 155 · see citing works

New Insights into the Link Between DNA Damage and Apoptosis

Zio, D. D., Cianfanelli, V., & Cecconi, F. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4938 · Cited by 153 · see citing works

Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination

Ceballos, S. J., & Heyer, W. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.06.006 · Cited by 151 · see citing works

Rad54 Functions as a Heteroduplex DNA Pump Modulated by Its DNA Substrates and Rad51 during D Loop Formation

Wright, W. D., & Heyer, W. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.027 · Cited by 150 · see citing works

ATRX Promotes DNA Repair Synthesis and Sister Chromatid Exchange during Homologous Recombination

Juhász, S., Elbakry, A., Mathes, A., & Löbrich, M. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.05.014 · Cited by 150 · see citing works

HELB Is a Feedback Inhibitor of DNA End Resection

Tkáč, J., Xu, G., Adhikary, H., Young, J. T. F., Gallo, D., Escribano‐Diaz, C., Krietsch, J., Orthwein, A., Munro, M., Sol, W., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.013 · Cited by 144 · see citing works

Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases

Lampe, G. D., King, R. T., Halpin-Healy, T. S., Klompe, S. E., Hogan, M. I., Vo, P. L. H., Tang, S., Chavez, A., & Sternberg, S. H. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01748-1 · Cited by 143 · see citing works

DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin

Ciszewski, W., Tavecchio, M., Dastych, J., & Curtin, N. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2785-6 · Cited by 136 · see citing works

Autophagy Roles in the Modulation of DNA Repair Pathways

Gomes, L., Menck, C. F. M., & Leandro, G. D. S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112351 · Cited by 141 · see citing works

Noncanonical views of homology-directed DNA repairPreprint

Verma, P., & Greenberg, R. A. (2016) · Genes & Development · doi:10.1101/gad.280545.116 · Cited by 139 · see citing works

DNA–RNA hybrids: the risks of DNA breakage during transcription

Aguilera, A., & Gómez‐González, B. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3395 · Cited by 137 · see citing works

Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells

Hung, K. L., Meitlis, I., Hale, M. R., Chen, C., Singh, S., Jackson, S. W., Miao, C. H., Khan, I., Rawlings, D. J., & James, R. G. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.11.012 · Cited by 137 · see citing works

Congenital microcephaly

Alcantara, D., & O’Driscoll, M. (2014) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31397 · Cited by 136 · see citing works

Nonhomologous end joining: A good solution for bad ends

Waters, C. A., Strande, N. T., Wyatt, D. W., Pryor, J. M., & Ramsden, D. A. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.02.008 · Cited by 132 · see citing works

DNA breaks and chromosomal aberrations arise when replication meets base excision repair

Ensminger, M., Iloff, L., Ebel, C., Nikolova, T., Kaina, B., & Löbrich, M. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201312078 · Cited by 138 · see citing works

The MCM8-MCM9 Complex Promotes RAD51 Recruitment at DNA Damage Sites To Facilitate Homologous Recombination

Park, J.-H., Long, D. T., Lee, K. Y., Abbas, T., Shibata, E., Negishi, M., Luo, Y., Schimenti, J. C., Gambus, A., Walter, J. C., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01503-12 · Cited by 131 · see citing works

Chromothripsis: Chromosomes in Crisis

Jones, M. V., & Jallepalli, P. V. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.10.010 · Cited by 130 · see citing works

Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases

Shadfar, S., Parakh, S., Jamali, M. S., & Atkin, J. D. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00350-4 · Cited by 135 · see citing works

Homologous Recombination in Mammals

Barascu, A., Grabarz, A., & López, B. S. (2012) · Topics in current genetics · doi:10.1007/978-94-007-4531-5_4 · Cited by 1 · see citing works

Homologous Recombination in Eukaryotes

Amunugama, R., & Fishel, R. A. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-387665-2.00007-9 · Cited by 35 · see citing works

Mechanism and significance of chromosome damage repair by homologous recombination

Kawale, A. S., & Sung, P. (2020) · Essays in Biochemistry · doi:10.1042/ebc20190093 · Cited by 33 · see citing works

Homologous recombination in mammalian cells: From molecular mechanisms to pathology

Ragu, S., Matos-Rodrigues, G. E., THOMAS, M. L., & López, B. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85679-9.00020-9 · Cited by 1 · see citing works

SURVEY AND SUMMARY Homologous recombination and its regulation

Krejčí, L., Altmannová, V., Špı́rek, M., & Zhao, X. (2012)