The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1
Open accessAbstract
Notch-1 belongs to a family of transmembrane receptor proteins that direct the decisions as to various cell fates. After ligand binding, a proteolytic cleavage step occurs and the intracellular part of Notch-1, Notch-1-IC, translocates into the nucleus, where it targets the DNA binding protein RBP-J kappa/CBF1. RBP-J kappa mediates repression through recruitment of a histone deacetylase-containing complex. The Notch-1-IC/RBP-J kappa complex overcomes repression and activates the transcription of Notch target genes. We have identified a novel domain in Notch-1-IC, the EP domain, which is indispensable for full transcriptional activation. This transactivation domain is localized adjacent to the ankyrin repeats of Notch-1-IC. In cotransfection experiments, Notch-1-IC-mediated transcriptional activation was inhibited by E1A12S and p53, two proteins, which interfere with the function of the common coactivator p300. Protein-protein interaction assays demonstrated the association of Notch-1-IC and the CH3 region of p300. In addition, the interaction of mammalian Notch-1-IC with p300 was destabilized after deletion of the EP domain of Notch-1-IC. Based on physical interaction with Notch-1-IC and coactivator functions of p300, we propose a model for Notch-1-mediated gene regulation via p300.
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Cites
Transcriptional Cross Talk between NF-κB and p53
Webster, G. A., & Perkins, N. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3485 · Cited by 598
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Aster, J. C., Pear, W. S., & Blacklow, S. C. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100127 · Cited by 710
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Wiedenmann, J., Ivanchenko, S., Oswald, F., Schmitt, F., Röcker, C., Salih, A., Spindler, K.-D., & Nienhaus, G. U. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403668101 · Cited by 678
Self-citationNotch Directly Regulates Gata3 Expression during T Helper 2 Cell Differentiation
Fang, T. C., Yashiro-Ohtani, Y., Del Bianco, C., Knoblock, D. M., Blacklow, S. C., & Pear, W. S. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.018 · Cited by 363
Metadata
- Authors
- Oswald, F., Täuber, B., Dobner, T., Bourteele, S., Kostezka, U., Adler, G., Liptay, S., & Schmid, R. M.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2001-11-01
- Volume
- 21
- Issue
- 22
- Pages
- 7761-7774
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2102645961
- Cited by
- 318
- References
- 1
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Oswald, F., Täuber, B., Dobner, T., Bourteele, S., Kostezka, U., Adler, G., Liptay, S., & Schmid, R. M. (2001). p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.21.22.7761-7774.2001
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