The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Discoidin Domain Receptor 1 Tyrosine Kinase Has an Essential Role in Mammary Gland Development
Open accessAbstract
Various types of collagen have been identified as potential ligands for the two mammalian discoidin domain receptor tyrosine kinases, DDR1 and DDR2. Here, we used a recombinant fusion protein between the extracellular domain of DDR1 and alkaline phosphatase to detect specific receptor binding sites during mouse development. Major sites of DDR1-binding activity, indicative of ligand expression, were found in skeletal bones, the skin, and the urogenital tract. Ligand expression in the uterus during implantation and in the mammary gland during pregnancy colocalized with the expression of the DDR1 receptor. The generation of DDR1-null mice by gene targeting yielded homozygous mutant animals that were viable but smaller in size than control littermates. The majority of mutant females were unable to bear offspring due to a lack of proper blastocyst implantation into the uterine wall. When implantation did occur, the mutant females were unable to lactate. Histological analysis showed that the alveolar epithelium failed to secrete milk proteins into the lumen of the mammary gland. The lactational defect appears to be caused by hyperproliferation and abnormal branching of mammary ducts. These results suggest that DDR1 is a key mediator of the stromal-epithelial interaction during ductal morphogenesis in the mammary gland.
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Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
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Stat5a is mandatory for adult mammary gland development and lactogenesis.
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The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen
Vogel, W., Gish, G. D., Alves, F., & Pawson, T. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80003-9 · Cited by 1,002
Self-citationAn Orphan Receptor Tyrosine Kinase Family Whose Members Serve as Nonintegrin Collagen Receptors
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Discoidin domain receptors: structural relations and functional implications
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Cited by
The extracellular matrix in development and morphogenesis: A dynamic view
Rozario, T., & DeSimone, D. W. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.026 · Cited by 1,451
Role of Extracellular Matrix in Development and Cancer Progression
Walker, C., Mojares, E., & Del Río Hernández, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,084
The collagen family members as cell adhesion proteins
Heino, J. (2007) · BioEssays · doi:10.1002/bies.20636 · Cited by 439
Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion
Sun, X., Wu, B., Chiang, H.-C., Deng, H., Zhang, X., Xiong, W., Liu, J., Rozeboom, A. M., Harris, B. T., Blommaert, E., et al. (2021) · Nature · doi:10.1038/s41586-021-04057-2 · Cited by 401
Fata, J. E., Werb, Z., & Bissell, M. J. (2003) · Breast Cancer Research · doi:10.1186/bcr634 · Cited by 383
Metadata
- Authors
- Vogel, W. F., Aszódi, A., Alves, F., & Pawson, T.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2001-04-01
- Volume
- 21
- Issue
- 8
- Pages
- 2906-2917
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2168181903
- Cited by
- 309
- References
- 34
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Vogel, W. F., Aszódi, A., Alves, F., & Pawson, T. (2001). Discoidin Domain Receptor 1 Tyrosine Kinase Has an Essential Role in Mammary Gland Development. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.21.8.2906-2917.2001
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