The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
p53 Binds and Activates the Xeroderma Pigmentosum DDB2 Gene in Humans but Not Mice
Open accessAbstract
The DDB2 gene, which is mutated in xeroderma pigmentosum group E, enhances global genomic repair of cyclobutane pyrimidine dimers and suppresses UV-induced mutagenesis. Because DDB2 transcription increases after DNA damage in a p53-dependent manner, we searched for and found a region in the human DDB2 gene that binds and responds transcriptionally to p53. The corresponding region in the mouse DDB2 gene shared significant sequence identity with the human gene but was deficient for p53 binding and transcriptional activation. Furthermore, when mouse cells were exposed to UV, DDB2 transcription remained unchanged, despite the accumulation of p53 protein. These results demonstrate direct activation of the human DDB2 gene by p53. They also explain an important difference in DNA repair between humans and mice and show how mouse models can be improved to better reflect cancer susceptibility in humans.
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“The p53 target genes DDB2165 and XPC166 encode for proteins related to nucleotide excision repair.”
From Census and evaluation of p53 target genes (2017) · cites this paper as [165]
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Metadata
- Authors
- Tan, T., & Chu, G.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Chu, Gilbert
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2002-05
- Volume
- 22
- Issue
- 10
- Pages
- 3247-3254
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC133779
- OpenAlex
- W2147640875
- Cited by
- 167
- References
- 38
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 11 · 2012: 5
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health
- National Institute of General Medical Sciences (T32GM007276, GMO7276)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- p53, transcriptional activation, p53 binding sites, cyclobutane pyrimidine dimers, UV mutagenesis, DNA damage response, mouse tumor model, DNA repair
- MeSH terms
- Animals, Base Sequence, Cell Line, DNA Repair, DNA-Binding Proteins, Gene Expression Regulation, Humans, Molecular Sequence Data, Transcription, Genetic, Ultraviolet Rays, Xeroderma Pigmentosum, Tumor Suppressor Protein p53, Genes, Reporter, Response Elements, Mice
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