The expanding universe of p53 targets

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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WebLogo: A Sequence Logo Generator: Figure 1Preprint

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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

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Mdm2 promotes the rapid degradation of p53

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Live or let die: the cell's response to p53

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Blinded by the Light: The Growing Complexity of p53

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

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Definition of a consensus binding site for p53

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Transcriptional control of human p53-regulated genes

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p53 function and dysfunction

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p53 Regulates Mitochondrial Respiration

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Impact of mutant p53 functional properties on <i>TP53</i> mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

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miR-34a repression of SIRT1 regulates apoptosis

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Post-translational modification of p53 in tumorigenesis

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A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

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Histone modifications in transcriptional regulation

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A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome

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When mutants gain new powers: News from the mutant p53 field

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Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

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p53 ubiquitination: Mdm2 and beyond

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TP53 mutations in human cancers: Functional selection and impact on cancer prognosis and outcomes

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p53 represses c-Myc through induction of the tumor suppressor miR-145

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p53 isoforms can regulate p53 transcriptional activity

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

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Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53

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A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

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Proceedings of the American Association for Cancer Research.

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Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

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Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors

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Role of NF-κB in p53-mediated programmed cell death

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A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

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Regulation and function of the p53 tumor suppressor protein

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Structural Biology of the Tumor Suppressor p53

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Binding and modulation of p53 by p300/CBP coactivators

Lill, N. L., Grossman, S. R., Ginsberg, D., DeCaprio, J. A., & Livingston, D. M. (1997) · Nature · doi:10.1038/42981 · Cited by 693 · see citing works

The Regulation of Exosome Secretion: a Novel Function of the p53 Protein

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Recruitment of p300/CBP in p53-Dependent Signal Pathways

Avantaggiati, M. L., Ogryzko, V. V., Gardner, K., Giordano, A., Levine, A. S., & Kelly, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80304-9 · Cited by 668 · see citing works

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcriptionPreprint

Zhao, J., Kennedy, B. K., Lawrence, B. D., Barbie, D. A., Matera, A. G., Fletcher, J. A., & Harlow, E. (2000) · Genes & Development · doi:10.1101/gad.827700 · Cited by 665 · see citing works

ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

Samuels-Lev, Y., O'Connor, D. J., Bergamaschi, D., Trigiante, G., Hsieh, J.-K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., & Lu, X. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00367-7 · Cited by 664 · see citing works

MicroRNA-125b is a novel negative regulator of p53Preprint

Le, M. T. N., Teh, C., Shyh‐Chang, N., Xie, H., Zhou, B., Korzh, V. P., Lodish, H. F., & Lim, B. (2009) · Genes & Development · doi:10.1101/gad.1767609 · Cited by 655 · see citing works

Analysis of p53-regulated gene expression patterns using oligonucleotide arraysPreprint

Zhao, R., Gish, K., Murphy, M. E., Yin, Y., Notterman, D. A., Hoffman, W. H., Tom, E., Mack, D. H., & Levine, A. J. (2000) · Genes & Development · doi:10.1101/gad.14.8.981 · Cited by 631 · see citing works

Modeling the Therapeutic Efficacy of p53 Restoration in Tumors

Martins, C. P., Brown-Swigart, L., & Evan, G. I. (2006) · Cell · doi:10.1016/j.cell.2006.12.007 · Cited by 600 · cited 1× · see citing works

Transcriptional Cross Talk between NF-κB and p53

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The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

Olivier, M., Langer√∏d, A., Carrieri, P., Bergh, J. C. S., Klaar, S., Eyfjord, J. E., Theillet, C. G., Rodríguez, C., Lidereau, R., Bièche, I., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1029 · Cited by 590 · see citing works

microRNAs join the p53 network — another piece in the tumour-suppression puzzle

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An inherited <i>p53</i> mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma

Ribeiro, R. C., Sandrini, F., Figueiredo, B., Zambetti, G. P., Michalkiewicz, E., Lafferty, A. R., DeLacerda, L., Rabin, M., Cadwell, C., Sampaio, G., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161479898 · Cited by 541 · see citing works

p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress

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Ordered Cooperative Functions of PRMT1, p300, and CARM1 in Transcriptional Activation by p53

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p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest

Braun, C. J., Zhang, X., Savelyeva, I., Wolff, S., Moll, U. M., Schepeler, T., Orntoft, T. F., Andersen, C. L., & Dobbelstein, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1569 · Cited by 467 · see citing works

Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3aPreprint

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p53 regulates maternal reproduction through LIF

Hu, W., Feng, Z., Teresky, A. K., & Levine, A. J. (2007) · Nature · doi:10.1038/nature05993 · Cited by 446 · see citing works

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

Espinosa, J. M., & Emerson, B. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00283-0 · Cited by 440 · see citing works

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

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Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

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Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

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Identity between TRAP and SMCC Complexes Indicates Novel Pathways for the Function of Nuclear Receptors and Diverse Mammalian Activators

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Structural Basis of DNA Recognition by p53 Tetramers

Kitayner, M., Rozenberg, H., Kessler, N., Rabinovich, D., Shaulov, L., Haran, T. E., & Shakked, Z. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.015 · Cited by 408 · see citing works

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

Boeckler, F. M., Joerger, A. C., Jaggi, G., Rutherford, T. J., Veprintsev, D. B., & Fersht, A. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805326105 · Cited by 389 · see citing works

Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53

Wang, T., Zeng, J., Lowe, C. B., Sellers, R. G., Salama, S. R., Yang, M., Burgess, S. M., Brachmann, R. K., & Haussler, D. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703637104 · Cited by 389 · see citing works

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

Christophorou, M. A., Ringshausen, I., Finch, A. J., Swigart, L. B., & Evan, G. I. (2006) · Nature · doi:10.1038/nature05077 · Cited by 382 · see citing works

Links between Tumor Suppressors

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Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis

Xu, X., Qiao, W., Linke, S. P., Cao, L., Li, W., Furth, P. A., Harris, C. C., & Deng, C. (2001) · Nature Genetics · doi:10.1038/90108 · Cited by 372 · see citing works

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human

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Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

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p53-Dependent Transcriptional Repression of c-myc Is Required for G1 Cell Cycle Arrest

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p53 modulation of the DNA damage response

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Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53

Zhai, W., & Comai, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5930-5938.2000 · Cited by 289 · see citing works

Negative feedback regulation of wild‐type p53 biosynthesis.

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A Novel Human SRB/MED-Containing Cofactor Complex, SMCC, Involved in Transcription Regulation

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A polymorphic microsatellite that mediates induction of PIG3 by p53

Contente, A., Dittmer, A., Koch, M. C., Roth, J., & Dobbelstein, M. (2002) · Nature Genetics · doi:10.1038/ng836 · Cited by 274 · see citing works

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors

Gurova, K. V., Hill, J. E., Guo, C., Prokvolit, A., Burdelya, L. G., Samoylova, E. M., Khodyakova, A. V., Ganapathi, R. N., Ganapathi, M. K., Tararova, N. D., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508888102 · Cited by 266 · see citing works

p300/CBP/p53 interaction and regulation of the p53 response

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MDM2 and MDM4: p53 regulators as targets in anticancer therapy

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How p53 binds DNA as a tetramer

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iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53

Bergamaschi, D., Samuels, Y., Sullivan, A., Zvelebil, M., Breyssens, H., Bisso, A., Sal, G. D., Syed, N., Smith, P. D., Gasco, M., et al. (2006) · Nature Genetics · doi:10.1038/ng1879 · Cited by 260 · see citing works

p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

Espinosa, J. M., Verdun, R. E., & Emerson, B. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00359-9 · Cited by 256 · see citing works

CDK8 Is a Stimulus-Specific Positive Coregulator of p53 Target Genes

Donner, A. J., Szostek, S. A., Hoover, J. M., & Espinosa, J. M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.026 · Cited by 253 · see citing works

Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor

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Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

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Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

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Screening patients for heterozygous p53 mutations using a functional assay in yeast

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p53 mRNA controls p53 activity by managing Mdm2 functions

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E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation

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Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

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p53 domains: identification and characterization of two autonomous DNA-binding regions.Preprint

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p53 and Metabolism: Inside the TIGAR

Green, D. R., & Chipuk, J. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.032 · Cited by 239 · see citing works

Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response

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Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression.

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SWI/SNF Complex Interacts with Tumor Suppressor p53 and Is Necessary for the Activation of p53-mediated Transcription

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Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice

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Dynamics of p53: A Master Decider of Cell Fate

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Whole-genome cartography of p53 response elements ranked on transactivation potential

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Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

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Growth hormone is a cellular senescence target in pituitary and nonpituitary cells

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Mutant TP53 Posttranslational Modifications: Challenges and Opportunities

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Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2

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Analysis of p53 Transactivation Domain Mutants Reveals Acad11 as a Metabolic Target Important for p53 Pro-Survival Function

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Involvement of S100A14 Protein in Cell Invasion by Affecting Expression and Function of Matrix Metalloproteinase (MMP)-2 via p53-dependent Transcriptional Regulation

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USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2

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A Comprehensive and High-Resolution Genome-wide Response of p53 to Stress

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Silver-Promoted Desilylation Catalyzed by Ortho- and Allosteric Cucurbiturils

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Degradation of p53 by Human Alphapapillomavirus E6 Proteins Shows a Stronger Correlation with Phylogeny than Oncogenicity

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The magic bullet: Niclosamide

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Functional evolution of the p53 regulatory network through its target response elements

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