The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Overlapping and Unique Roles for C-Terminal Binding Protein 1 (CtBP1) and CtBP2 during Mouse Development
Open accessAbstract
The C-terminal binding protein (CtBP) family of proteins has been linked to multiple biological processes through their association with numerous transcription factors. We generated mice harboring mutations in both Ctbp1 and Ctbp2 to address the in vivo function of CtBPs during vertebrate development. Ctbp1 mutant mice are small but viable and fertile, whereas Ctbp2-null mice show defects in axial patterning and die by E10.5 due to aberrant extraembryonic development. Mice harboring various combinations of Ctbp1 and Ctbp2 mutant alleles exhibit dosage-sensitive defects in a wide range of developmental processes. The strong genetic interaction, as well as transcription assays with CtBP-deficient cells, indicates that CtBPs have overlapping roles in regulating gene expression. We suggest that the observed phenotypes reflect the large number of transcription factors whose activities are compromised in the absence of CtBP.
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Self-citationAutophosphorylation of the Focal Adhesion Kinase, ppl25FAK, Directs SH2-Dependent Binding of pp60src
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Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex
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Glessner, J. T., Bick, A. G., Ito, K., Homsy, J. G., Rodriguez-Murillo, L., Fromer, M., Mazaika, E., Vardarajan, B., Italia, M., Leipzig, J., et al. (2014) · Circulation Research · doi:10.1161/circresaha.115.304458 · Cited by 268
RETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
Zhang, Q., Wang, S.-Y., Fleuriel, C., Leprince, D., Rocheleau, J. V., Piston, D. W., & Goodman, R. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610590104 · Cited by 171
RetractedHIC1 attenuates Wnt signaling by recruitment of TCF‐4 and β‐catenin to the nuclear bodies
Valenta, T., Lukas, J., Doubravska, L., Fafilek, B., & Korinek, V. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601147 · Cited by 91
Metadata
- Authors
- Hildebrand, J. D., & Soriano, P.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2002-08-01
- Volume
- 22
- Issue
- 15
- Pages
- 5296-5307
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2149290739
- Cited by
- 301
- References
- 52
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Hildebrand, J. D., & Soriano, P. (2002). Overlapping and Unique Roles for C-Terminal Binding Protein 1 (CtBP1) and CtBP2 during Mouse Development. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.22.15.5296-5307.2002
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