RETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex

Zhang, Qinghong; Wang, Su-Yan; Fleuriel, Capucine; Leprince, Dominique; Rocheleau, Jonathan V.; Piston, David W.; Goodman, Richard H.

doi:10.1073/pnas.0610590104

RETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex

The Sir2 histone deacetylases are important for gene regulation, metabolism, and longevity. A unique feature of these enzymes is their utilization of NAD + as a cosubstrate, which has led to the suggestion that Sir2 activity reflects the cellular energy state. We show that SIRT1, a mammalian Sir2…