The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Deletion of the Laminin α4 Chain Leads to Impaired Microvessel Maturation
Open accessAbstract
The laminin alpha4 chain, a component of laminin-8 and -9, is expressed in basement membranes, such as those beneath endothelia, the perineurium of peripheral nerves, and around developing muscle fibers. Laminin alpha4-null mice presented with hemorrhages during the embryonic and neonatal period and had extensive bleeding and deterioration of microvessel growth in experimental angiogenesis, as well as mild locomotion defects. Histological examination of newborn mice revealed delayed deposition of type IV collagen and nidogen into capillary basement membranes, and electron microscopy showed discontinuities in the lamina densa. The results demonstrate a central role for the laminin alpha4 chain in microvessel growth and, in the absence of other laminin alpha chains, in the composition of endothelial basement membranes.
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Citations
Cites
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
Cited by
Basement membranes: structure, assembly and role in tumour angiogenesis
Kalluri, R. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1094 · Cited by 1,748
The extracellular matrix in development and morphogenesis: A dynamic view
Rozario, T., & DeSimone, D. W. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.026 · Cited by 1,451
Basement Membranes: Cell Scaffoldings and Signaling Platforms
Yurchenco, P. D. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004911 · Cited by 959
The impact of the extracellular matrix on inflammation
Sorokin, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2852 · Cited by 912
Self-citationHamano, Y., Zeisberg, M., Sugimoto, H., Lively, J. C., Maeshima, Y., Yang, C., Hynes, R. O., Werb, Z., Sudhakar, A., & Kalluri, R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00133-8 · Cited by 559
Metadata
- Authors
- Thyboll, J., Kortesmaa, J., Cao, R., Soininen, R., Wang, L., Iivanainen, A., Sorokin, L., Risling, M., Cao, Y., & Tryggvason, K.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2002-02-01
- Volume
- 22
- Issue
- 4
- Pages
- 1194-1202
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2128754233
- Cited by
- 348
- References
- 1
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Deletion of the Laminin α4 Chain Leads to Impaired Microvessel Maturation. https://app.cochat.ai/papers/10.1128/mcb.22.4.1194-1202.2002
- The paper
- Thyboll, J., Kortesmaa, J., Cao, R., Soininen, R., Wang, L., Iivanainen, A., Sorokin, L., Risling, M., Cao, Y., & Tryggvason, K. (2002). Deletion of the Laminin α4 Chain Leads to Impaired Microvessel Maturation. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.22.4.1194-1202.2002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
