The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding
Open accessAbstract
The order and fidelity of cell cycle events in mammals is intimately linked to the integrity of the Chk1 kinase-Cdc25A phosphatase pathway. Chk1 phosphorylation targets Cdc25A for destruction and, as shown here, inhibits interactions between Cdc25A and its mitotic substrate cyclin B1-Cdk1. Phosphorylation of Cdc25A on serine 178 and threonine 507 facilitates 14-3-3 binding, and Chk1 phosphorylates both residues in vitro. Mutation of T507 to alanine (T507A) enhanced the biological activity of Cdc25A. Cdc25A(T507A) was more efficient in binding to cyclin B1, activating cyclin B1-Cdk1, and promoting premature entry into mitosis. We propose that the Chk1/Cdc25A/14-3-3 pathway functions to prevent cells from entering into mitosis prior to replicating their genomes to ensure the fidelity of the cell division process.
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Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943 · cited 1×
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MethodThe ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
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14-3-3σ is required to prevent mitotic catastrophe after DNA damage
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Rapid Destruction of Human Cdc25A in Response to DNA Damage
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Regulation of DNA repair throughout the cell cycle
Branzei, D., & Foiani, M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2351 · Cited by 1,228
The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector
Screaton, R. A., Conkright, M. D., Katoh, Y., Best, J. L., Canettieri, G., Jeffries, S., Guzman, E., Niessen, S., Yates, J. R., Takemori, H., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.015 · Cited by 648
Roles of Chk1 in cell biology and cancer therapy
Zhang, Y., & Hunter, T. (2014) · International Journal of Cancer · doi:10.1002/ijc.28226 · Cited by 462
The when and wheres of CDC25 phosphatases
Boutros, R., Dozier, C., & Ducommun, B. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.02.003 · Cited by 414
p38 MAP Kinase's Emerging Role as a Tumor Suppressor
(2004) · Advances in Cancer Research · doi:10.1016/s0065-230x(04)92005-2 · Cited by 290
Metadata
- Authors
- Chen, M.-S., Ryan, C. E., & Piwnica-Worms, H.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2003-11-01
- Volume
- 23
- Issue
- 21
- Pages
- 7488-7497
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2102233623
- Cited by
- 238
- References
- 4
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, M.-S., Ryan, C. E., & Piwnica-Worms, H. (2003). Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.23.21.7488-7497.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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