Roles of Chk1 in cell biology and cancer therapy

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Bao, S., Wu, Q., McLendon, R. E., Hao, Y., Shi, Q., Hjelmeland, A. B., Dewhirst, M. W., Bigner, D. D., & Rich, J. N. (2006) · Nature · doi:10.1038/nature05236 · Cited by 6,363 · see citing works

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works

Chk1 is an essential kinase that is regulated by Atr and required for the G ₂ /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625 · see citing works

Mitotic and G ₂ Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., & Piwnica-Worms, H. (1997) · Science · doi:10.1126/science.277.5331.1501 · Cited by 1,341 · see citing works

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320 · see citing works

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

Zhao, H., & Piwnica-Worms, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4129-4139.2001 · Cited by 1,091 · see citing works

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Falck, J., Mailand, N., Syljuåsen, R. G., Bartek, J., & Lukas, J. (2001) · Nature · doi:10.1038/35071124 · Cited by 1,085 · see citing works

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology · doi:10.1038/ncb1337 · Cited by 1,064 · see citing works

Untitled work

(1999) · PubMed · Cited by 1,030 · see citing works

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., & Prives, C. (2000) · Genes & Development · doi:10.1101/gad.14.3.289 · Cited by 972 · see citing works

Rapid Destruction of Human Cdc25A in Response to DNA Damage

Mailand, N., Falck, J., Lukas, C., Syljuåsen, R. G., Welcker, M., Bartek, J., & Lukas, J. (2000) · Science · doi:10.1126/science.288.5470.1425 · Cited by 787 · see citing works

Checking on DNA damage in S phase

Bartek, J., Lukas, C., & Lukas, J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1493 · Cited by 758 · see citing works

The DNA replication checkpoint response stabilizes stalled replication forks

Lopes, M., Cotta‐Ramusino, C., Pellicioli, A., Liberi, G., Plevani, P., Muzi-Falconi, M., Newlon, C. S., & Foiani, M. (2001) · Nature · doi:10.1038/35087613 · Cited by 749 · see citing works

Structure and regulation of Src family kinases

Boggon, T. J., & Eck, M. J. (2004) · Oncogene · doi:10.1038/sj.onc.1208081 · Cited by 712 · see citing works

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

Tercero, J. A., & Diffley, J. F. X. (2001) · Nature · doi:10.1038/35087607 · Cited by 667 · see citing works

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Sørensen, C. S., Hansen, L. T., Dziegielewski, J., Syljuåsen, R. G., Lundin, C., Bartek, J., & Helleday, T. (2005) · Nature Cell Biology · doi:10.1038/ncb1212 · Cited by 666 · see citing works

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systemsPreprint

Liu, M., Pereira, F. A., Price, S. D., Chu, M.-J., Shope, C. D., Himes, D., Eatock, R. A., Brownell, W. E., Lysakowski, A., & Tsai, M. (2000) · Genes & Development · doi:10.1101/gad.840500 · Cited by 625 · see citing works

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

Bekker‐Jensen, S., Lukas, C., Kitagawa, R., Melander, F., Kastan, M. B., Bártek, J., & Lukas, J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510130 · Cited by 621 · see citing works

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

Lopez‐Girona, A., Furnari, B. A., Mondésert, O., & Russell, P. R. (1999) · Nature · doi:10.1038/16488 · Cited by 574 · see citing works

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

Sørensen, C. S., Syljuåsen, R. G., Falck, J., Schroeder, T., Rönnstrand, L., Khanna, K. K., Zhou, B.-B., Bártek, J., & Lukas, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00048-5 · Cited by 560 · see citing works

ATR Regulates Fragile Site Stability

Casper, A. M., Nghiem, P., Arlt, M. F., & Glover, T. W. (2002) · Cell · doi:10.1016/s0092-8674(02)01113-3 · Cited by 559 · see citing works

Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Syljuåsen, R. G., Sørensen, C. S., Hansen, L. T., Fugger, K., Lundin, C., Johansson, F., Helleday, T., Sehested, M., Lukas, J., & Bártek, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3553-3562.2005 · Cited by 550 · see citing works

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

Furnari, B. A., Rhind, N., & Russell, P. R. (1997) · Science · doi:10.1126/science.277.5331.1495 · Cited by 542 · see citing works

Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms

Sanchez, Y., Bachant, J., Wang, H., Hu, F., Liu, D., Tetzlaff, M., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1166 · Cited by 536 · see citing works

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

Yarden, R. I., Pardo-Reoyo, S., Sgagias, M. K., Cowan, K. H., & Brody, L. C. (2002) · Nature Genetics · doi:10.1038/ng837 · Cited by 483 · see citing works

Aberrant cell cycle checkpoint function and early embryonic death in Chk1−/− micePreprint

Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y. A., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M., & Nakayama, K. (2000) · Genes & Development · doi:10.1101/gad.14.12.1439 · Cited by 478 · see citing works

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints

Zhao, H., Watkins, J. L., & Piwnica-Worms, H. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182557299 · Cited by 459 · see citing works

Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2

Walworth, N. C., Davey, S. K., & Beach, D. (1993) · Nature · doi:10.1038/363368a0 · Cited by 452 · see citing works

New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network

Dai, Y., & Grant, S. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1029 · Cited by 438 · see citing works

Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

Kumagai, A., & Dunphy, W. G. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00092-4 · Cited by 430 · see citing works

ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones

Rita, S., & Kleckner, N. E. (2002) · Science · doi:10.1126/science.1071398 · Cited by 429 · see citing works

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in <i>Xenopus</i> egg extracts

Guo, Z., Kumagai, A., Wang, S. X., & Dunphy, W. G. (2000) · Genes &amp; Development · doi:10.1101/gad.842500 · Cited by 417 · see citing works

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation

O’Connell, M. J., Raleigh, J., Verkade, H. M., & Nurse, P. (1997) · The EMBO Journal · doi:10.1093/emboj/16.3.545 · Cited by 398 · see citing works

rad -Dependent Response of the chk1 -Encoded Protein Kinase at the DNA Damage Checkpoint

Walworth, N. C., & Bernards, R. (1996) · Science · doi:10.1126/science.271.5247.353 · Cited by 397 · see citing works

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

Lu, X., Nannenga, B., & Donehower, L. A. (2005) · Genes &amp; Development · doi:10.1101/gad.1291305 · Cited by 389 · see citing works

DNA Methylation Inhibitor 5-Aza-2′-Deoxycytidine Induces Reversible Genome-Wide DNA Damage That Is Distinctly Influenced by DNA Methyltransferases 1 and 3B

Palii, S. S., Emburgh, B. O. V., Sankpal, U. T., Brown, K. D., & Robertson, K. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01799-07 · Cited by 382 · see citing works

Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.

Al-Khodairy, F. M., Fotou, E., Sheldrick, K. S., Griffiths, D. J. F., Lehmann, A. R., & Carr, A. M. (1994) · Molecular Biology of the Cell · doi:10.1091/mbc.5.2.147 · Cited by 341 · see citing works

Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase

Krämer, A., Mailand, N., Lukas, C., Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bártek, J., & Lukas, J. (2004) · Nature Cell Biology · doi:10.1038/ncb1165 · Cited by 338 · see citing works

Hypoxia Links ATR and p53 through Replication Arrest

Hammond, E. M., Denko, N. C., Dorie, M. J., Abraham, R. T., & Giaccia, A. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1834-1843.2002 · Cited by 321 · see citing works

Activation of mammalian Chk1 during DNA replication arrest

Feijóo, C. G., Hall-Jackson, C. A., Wu, R., Jenkins, D., Leitch, J., Gilbert, D. M., & Smythe, C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200104099 · Cited by 318 · see citing works

Coupling of Human Circadian and Cell Cycles by the Timeless Protein

Ünsal-Kaçmaz, K., Mullen, T. E., Kaufmann, W. K., & Sancar, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.3109-3116.2005 · Cited by 310 · see citing works

Chk1 promotes replication fork progression by controlling replication initiation

Petermann, E., Woodcock, M., & Helleday, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005031107 · Cited by 308 · see citing works

Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11

Myers, J. S., & Cortez, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513265200 · Cited by 294 · see citing works

SCFβTrCP-Mediated Degradation of Claspin Regulates Recovery from the DNA Replication Checkpoint Response

Peschiaroli, A., Dorrello, N. V., Guardavaccaro, D., Venere, M., Halazonetis, T., Sherman, N. E., & Pagano, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.013 · Cited by 289 · see citing works

Positive Regulation of Wee1 by Chk1 and 14-3-3 Proteins

Lee, J., Kumagai, A., & Dunphy, W. G. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.3.551 · Cited by 287 · see citing works

Genotoxic Stress Targets Human Chk1 for Degradation by the Ubiquitin-Proteasome Pathway

Zhang, Y.-W., Otterness, D. M., Chiang, G. G., Xie, W., Liu, Y., Mercurio, F., & Abraham, R. T. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.019 · Cited by 283 · see citing works

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

Ma, C. X., Janetka, J. W., & Piwnica-Worms, H. M. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.10.009 · Cited by 271 · see citing works

Destruction of Claspin by SCFβTrCP Restrains Chk1 Activation and Facilitates Recovery from Genotoxic Stress

Mailand, N., Bekker-Jensen, S., Bartek, J., & Lukas, J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.016 · Cited by 258 · see citing works

Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast.Preprint

Rhind, N., Furnari, B. A., & Russell, P. R. (1997) · Genes & Development · doi:10.1101/gad.11.4.504 · Cited by 256 · see citing works

Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression

Shimada, M., Niida, H., Zineldeen, D. H., Tagami, H., Tanaka, M., Saito, H., & Nakanishi, M. (2008) · Cell · doi:10.1016/j.cell.2007.12.013 · Cited by 255 · see citing works

An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage

Heffernan, T. P., Simpson, D. A., Frank, A. R., Heinloth, A. N., Paules, R. S., Cordeiro-Stone, M., & Kaufmann, W. K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8552-8561.2002 · Cited by 251 · see citing works

RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

Cole, K. A., Huggins, J., Laquaglia, M., Hulderman, C. E., Russell, M. R., Bosse, K., Diskin, S. J., Attiyeh, E. F., Sennett, R., Norris, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012351108 · Cited by 249 · see citing works

Chk1‐deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

Zachos, G., Rainey, M. D., & Gillespie, D. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg060 · Cited by 247 · see citing works

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

Lam, M. H., Liu, Q., Elledge, S. J., & Rosen, J. M. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.015 · Cited by 246 · see citing works

Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response

Stracker, T. H., Usui, T., & Petrini, J. H. J. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.012 · Cited by 245 · see citing works

The Xenopus Chk1 Protein Kinase Mediates a Caffeine-sensitive Pathway of Checkpoint Control in Cell-free Extracts

Kumagai, A., Guo, Z., Emami, K. H., Wang, S. X., & Dunphy, W. G. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.6.1559 · Cited by 238 · see citing works

Chk1 Is Required for Spindle Checkpoint Function

Zachos, G., Black, E. J., Walker, M., Scott, M. T., Vagnarelli, P., Earnshaw, W. C., & Gillespie, D. A. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.01.003 · Cited by 234 · see citing works

Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

Chen, M.-S., Ryan, C. E., & Piwnica-Worms, H. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7488-7497.2003 · Cited by 234 · see citing works

ATM regulates ATR chromatin loading in response to DNA double-strand breaks

Cuadrado, M., Martinez-Pastor, B., Murga, M., Toledo, L. I., Gutierrez-Martinez, P., Lopez, E., & Fernandez-Capetillo, O. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051923 · Cited by 232 · see citing works

Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer

Xu, J., Li, Y., Wang, F., Wang, X., Cheng, B., Ye, F., Xie, X., Zhou, C., & Lü, W. (2012) · Oncogene · doi:10.1038/onc.2012.121 · Cited by 227 · see citing works

Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models

Ma, C. X., Cai, S., Li, S., Ryan, C. E., Guo, Z., Schaiff, W. T., Li, L., Hoog, J., Goiffon, R., Prat, A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58765 · Cited by 224 · see citing works

The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity

Fogarty, P. F., Campbell, S. D., Abu-Shumays, R. L., Phalle, B. D. S., Yu, K. R., Uy, G. L., Goldberg, M. L., & Sullivan, W. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00189-8 · Cited by 208 · see citing works

Activation of the ATR-mediated DNA Damage Response by the HIV-1 Viral Protein R

Roshal, M., Kim, B., Zhu, Y., Nghiem, P., & Planelles, V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303948200 · Cited by 200 · see citing works

Implications for Chk1 Regulation: The 1.7 Å Crystal Structure of Human Cell Cycle Checkpoint Kinase Chk1

Chen, P., Luo, C., Deng, Y., Ryan, K., Register, J., Margosiak, S. A., Tempczyk-Russell, A., Nguyen, B., Myers, P., Lundgren, K., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80704-7 · Cited by 199 · see citing works

Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response

Smits, V. A. J., Reaper, P. M., & Jackson, S. P. (2005) · Current Biology · doi:10.1016/j.cub.2005.11.066 · Cited by 199 · see citing works

p53 C-Terminal Phosphorylation by CHK1 and CHK2 Participates in the Regulation of DNA-Damage-induced C-Terminal Acetylation

Ou, Y.-H., Chung, P.-H., Sun, T.-P., & Shieh, S.-Y. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0689 · Cited by 198 · see citing works

The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress

Zhang, Y.-W., Brognard, J., Coughlin, C., You, Z., Dolled-Filhart, M. P., Aslanian, A., Manning, G., Abraham, R. T., & Hunter, T. R. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.030 · Cited by 186 · see citing works

Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation

Liu, S., Bekker‐Jensen, S., Mailand, N., Lukas, C., Bártek, J., & Lukas, J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00492-06 · Cited by 184 · see citing works

Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy

Bartucci, M., Svensson, S., Romania, P., Dattilo, R., Patrizii, M., Signore, M., Navarra, S., Lotti, F., Biffoni, M., Pilozzi, E., et al. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.170 · Cited by 181 · see citing works

Chk1 Requirement for High Global Rates of Replication Fork Progression during Normal Vertebrate S Phase

Petermann, E., Maya‐Mendoza, A., Zachos, G., Gillespie, D. A., Jackson, D. A., & Caldecott, K. W. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.3319-3326.2006 · Cited by 181 · see citing works

Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells

Koniaras, K., Cuddihy, A. R., Christopoulos, H., Hogg, A., & O’Connell, M. J. (2001) · Oncogene · doi:10.1038/sj.onc.1204942 · Cited by 178 · see citing works

A Role for PI 3-Kinase and PKB Activity in the G2/M Phase of the Cell Cycle

Shtivelman, E., Sussman, J., & Stokoe, D. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00843-6 · Cited by 175 · see citing works

p53 Down-Regulates CHK1 through p21 and the Retinoblastoma Protein

Gottifredi, V., Karni-Schmidt, O., Shieh, S.-Y., & Prives, C. L. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1066-1076.2001 · Cited by 174 · see citing works

BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly

Lin, S., Rai, R., Li, K., Xu, Z.-X., & Elledge, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507722102 · Cited by 173 · see citing works

Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

Xu, X., Lee, J., & Stern, D. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400139200 · Cited by 171 · see citing works

Regulation of mitotic entry by microcephalin and its overlap with ATR signalling

Alderton, G. K., Galbiati, L., Griffith, E., Surinya, K. H., Neitzel, H., Jackson, A. P., Jeggo, P. A., & O’Driscoll, M. (2006) · Nature Cell Biology · doi:10.1038/ncb1431 · Cited by 168 · see citing works

Hsp90 Inhibition Depletes Chk1 and Sensitizes Tumor Cells to Replication Stress

Arlander, S. J. H., Eapen, A. K., Vroman, B. T., McDonald, R. J., Toft, D. O., & Karnitz, L. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309054200 · Cited by 166 · see citing works

Human Tousled like kinases are targeted by an ATM‐ and Chk1‐dependent DNA damage checkpoint

Groth, A., Lukáš, J., Nigg, E. A., Silljé, H. H. W., Wernstedt, C., Bartek, J. J., & Hansen, K. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg151 · Cited by 166 · see citing works

Specific Role of Chk1 Phosphorylations in Cell Survival and Checkpoint Activation

Niida, H., Katsuno, Y., Banerjee, B., Hande, M. P., & Nakanishi, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01611-06 · Cited by 166 · see citing works

Cyclin A–Cdk1 regulates the origin firing program in mammalian cells

Katsuno, Y., Suzuki, A., Sugimura, K., Okumura, K., Zineldeen, D. H., Shimada, M., Niida, H., Mizuno, T., Hanaoka, F., & Nakanishi, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809350106 · Cited by 161 · see citing works

Regulation of NF‐κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

Rocha, S., Garrett, M. D., Campbell, K. J., Schumm, K., & Perkins, N. D. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600608 · Cited by 161 · see citing works

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

Blasius, M., Forment, J. V., Thakkar, N., Wagner, S., Choudhary, C., & Jackson, S. P. (2011) · Genome biology · doi:10.1186/gb-2011-12-8-r78 · Cited by 155 · see citing works

Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.

Menoyo, A., Alazzouzi, H., Espín, E., Armengol, M., Yamamoto, H., & Schwartz, S. (2001) · PubMed · Cited by 151 · see citing works

Cell cycle-dependent and ATM-independent expression of human Chk1 kinase

Kaneko, Y., Watanabe, N., Morisaki, H., Akita, H., Fujimoto, A., Tominaga, K., Terasawa, M., Tachibana, A., Ikeda, K., & Nakanishi, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202706 · Cited by 150 · see citing works

The E2F-Regulated Gene Chk1 Is Highly Expressed in Triple-Negative Estrogen Receptor−/Progesterone Receptor−/HER-2− Breast Carcinomas

Verlinden, L., Bempt, I. V., Eelen, G., Drijkoningen, M., Verlinden, I., Marchal, K., Wolf‐Peeters, C. D., Christiaens, M.-R., Michiels, L., Bouillon, R., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3545 · Cited by 149 · see citing works

Regulation of Chk1 Includes Chromatin Association and 14-3-3 Binding following Phosphorylation on Ser-345

Jiang, K., Pereira, E., Maxfield, M. D., Russell, B., Goudelock, D. M., & Sánchez, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300070200 · Cited by 147 · see citing works

Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest

Capasso, H., Palermo, C., Wan, S., Rao, H., John, U. P., O’Connell, M. J., & Walworth, N. C. (2002) · Journal of Cell Science · doi:10.1242/jcs.00133 · Cited by 147 · see citing works

Chk1-Mediated Phosphorylation of FANCE Is Required for the Fanconi Anemia/BRCA Pathway

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Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint functionPreprint

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Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

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Determination of Substrate Motifs for Human Chk1 and hCds1/Chk2 by the Oriented Peptide Library Approach

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Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

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CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers

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NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint

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Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

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Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1)

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Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast

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Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation

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Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

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CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma

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Chk1 is Essential for Tumor Cell Viability Following Activation of the Replication Checkpoint

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DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress

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Association of Chk1 with 14-3-3 proteins is stimulated by DNA damagePreprint

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An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

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14‐3‐3γ binds to MDMX that is phosphorylated by UV‐activated Chk1, resulting in p53 activation

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HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability

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The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis

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DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system

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Atm-dependent interactions of a mammalian Chk1 homolog with meiotic chromosomes

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Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress InVitro and In Vivo

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Checkpoint Signaling from a Single DNA Interstrand Crosslink

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CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage

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The Chk1-mediated S-phase Checkpoint Targets Initiation Factor Cdc45 via a Cdc25A/Cdk2-independent Mechanism

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A Proteomics Analysis of Cell Signaling Alterations in Colorectal Cancer

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Inhibition of Aurora A in response to DNA damage

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Phosphorylation at serine 331 is required for Aurora B activation

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Global Gene Expression Profile of Nasopharyngeal Carcinoma by Laser Capture Microdissection and Complementary DNA Microarrays

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14‐3‐3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage

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Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response

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FANCM regulates DNA chain elongation and is stabilized by S‐phase checkpoint signalling

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Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity

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Unleashing Chk1 in cancer therapy

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Mechanism of Caffeine-Induced Checkpoint Override in Fission Yeast

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Constitutive Activation of the DNA Damage Signaling Pathway in Acute Myeloid Leukemia with Complex Karyotype: Potential Importance for Checkpoint Targeting Therapy

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Targeting the checkpoint kinase Chk1 in cancer therapy

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Histological type-selective, tumor-predominant expression of a novel CHK1 isoform and infrequent in vivo somatic CHK2 mutation in small cell lung cancer.

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Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2

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Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway

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Regulation of Chk1 Kinase by Autoinhibition and ATR-mediated Phosphorylation

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Novel Positive Feedback Loop between Cdk1 and Chk1 in the Nucleus during G2/M Transition

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Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast

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The Mammalian DNA Replication Elongation Checkpoint: Implication of Chk1 and Relationship with Origin Firing as Determined by Single DNA Molecule and Single Cell Analyses

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Gene products of chromosome 11q and their association with CCND1gene amplification and tamoxifen resistance in premenopausal breast cancer

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USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation

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Histone Deacetylase Inhibitors Downregulate Checkpoint Kinase 1 Expression to Induce Cell Death in Non-Small Cell Lung Cancer Cells

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CRL4CDT2 Targets CHK1 for PCNA-Independent Destruction

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Fission Yeast Rnf4 Homologs Are Required for DNA Repair

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A molecular mechanism for autoinhibition of myosin light chain kinases.

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Chk1 knockdown confers radiosensitization in prostate cancer stem cells

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A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair

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Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress

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Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints

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The Drosophila Grp/Chk1 DNA Damage Checkpoint Controls Entry into Anaphase

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The Grapes checkpoint coordinates nuclear envelope breakdown and chromosome condensation

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Cross-talk between Chk1 and Chk2 in double-mutant thymocytes

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Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif

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Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy

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RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells

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Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase

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Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction

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Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structuresPreprint

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The Ded1 DEAD Box Helicase Interacts with Chk1 and Cdc2

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Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites

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Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors

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Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation

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Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin‐dependent kinase 1 (Cdk1)

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Characterization of the 5’flanking Region of the Human chk1 Gene: Identification of E2F1 Functional Sites

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p50 (NF-κB1) Is an Effector Protein in the Cytotoxic Response to DNA Methylation Damage

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The MDM2 Ubiquitination Signal in the DNA-Binding Domain of p53 Forms a Docking Site for Calcium Calmodulin Kinase Superfamily Members

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P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation

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Interaction of 14-3-3 protein with Chk1 affects localization and checkpoint function

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p300/CREB-binding Protein Interacts with ATR and Is Required for the DNA Replication Checkpoint

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Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms

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Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53

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Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis

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Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells

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Phosphorylation of the tumor suppressor p33 ING1b at Ser‐126 influences its protein stability and proliferation of melanoma cells

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Checkpoint Kinase 1 Prevents Cell Cycle Exit Linked to Terminal Cell Differentiation

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Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response

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Requirement of MTA1 in ATR-mediated DNA Damage Checkpoint Function

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Cleavage-mediated Activation of Chk1 during Apoptosis

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Coupling Cellular Localization and Function of Checkpoint Kinase 1 (Chk1) in Checkpoints and Cell Viability

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Replication stress activates DNA polymerase alpha-associated Chk1

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Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1

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Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart

Hromas, R., Williamson, E. A., Fnu, S., Lee, Y.-J., Park, S.-J., Beck, B. D., You, J.-S., Laitao, A., Nickoloff, J. A., & Lee, S. H. (2012) · Oncogene · doi:10.1038/onc.2011.586 · Cited by 40 · see citing works

Autoregulatory Mechanisms of Phosphorylation of Checkpoint Kinase 1

Wang, J., Han, X., & Zhang, Y. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0523 · Cited by 40 · see citing works

Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma

Røe, O. D., Szulkin, A., Anderssen, E., Flatberg, A., Sandeck, H., Amundsen, T., Erlandsen, S. E., Dobra, K., & Sundstrøm, S. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040521 · Cited by 39 · see citing works

A Conserved Proliferating Cell Nuclear Antigen-interacting Protein Sequence in Chk1 Is Required for Checkpoint Function

Scorah, J., Dong, M., Yates, J. R., Scott, M. T., Gillespie, D. A., & McGowan, C. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800369200 · Cited by 38 · see citing works

Nuclear Chk1 prevents premature mitotic entry

Matsuyama, M., Goto, H., Kasahara, K., Kawakami, Y., Nakanishi, M., Kiyono, T., Goshima, N., & Inagaki, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.086488 · Cited by 37 · see citing works

Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer

Bennett, C. N., Tomlinson, C. C., Michalowski, A. M., et al. (2012) · Breast Cancer Research · doi:10.1186/bcr3230 · Cited by 36 · see citing works

Chk1 Haploinsufficiency Results in Anemia and Defective Erythropoiesis

Boles, N. C., Peddibhotla, S., Chen, A. J., Goodell, M. A., & Rosen, J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008581 · Cited by 35 · see citing works

Interaction of checkpoint kinase 1 and the X‐linked inhibitor of apoptosis during mitosis

Galván, V., Kurakin, A. V., & Bredesen, D. E. (2004) · FEBS Letters · doi:10.1016/s0014-5793(03)01488-1 · Cited by 33 · see citing works

Regulation of Chk1 by Its C-terminal Domain

Kosoy, A., & O’Connell, M. J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-04-0444 · Cited by 32 · see citing works

Chk1 frameshift mutation in sporadic and hereditary non-polyposis colorectal cancers with microsatellite instability

Kim, C. J., Lee, J. H., Song, J. W., Cho, Y. G., Kim, S., Nam, S. W., Yoo, N. J., Park, W. S., & Lee, J. Y. (2007) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2007.02.007 · Cited by 32 · see citing works

Chk1-Dependent Constitutive Phosphorylation of BLM Helicase at Serine 646 Decreases after DNA Damage

Kaur, S., Modi, P., Srivastava, V. K., et al. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0233 · Cited by 25 · see citing works

Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families

Sólyom, S., Pylkäs, K., & Winqvist, R. (2010) · Familial Cancer · doi:10.1007/s10689-010-9360-7 · Cited by 22 · see citing works

Phosphorylation of the regulatory β‐subunit of protein kinase CK2 by checkpoint kinase Chk1: identification of the in vitro CK2β phosphorylation site

Kristensen, L. P., Larsen, M. R., Højrup, P., et al. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.069 · Cited by 20 · see citing works

Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR‐Chk1 pathway

Liu, Y., Fang, Y., Shao, H., Lindsey‐Boltz, L. A., Sancar, A., & Modrich, P. L. (2010) · The FASEB Journal · doi:10.1096/fasebj.24.1_supplement.492.10 · Cited by 20 · see citing works

Checkpoint Kinase 1 Is Cleaved in a Caspase-Dependent Pathway during Genotoxic Stress-Induced Apoptosis

Okita, N., Kudo, Y., & Tanuma, S. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.359 · Cited by 19 · see citing works

[Expression of checkpoint kinase 1 and polo-like kinase 1 and its clinicopathological significance in benign and malignant lesions of the stomach].

Yao, H., Yang, Z., & Li, Y. (2010) · PubMed · doi:10.3969/j.issn.1672-7347.2010.10.008 · Cited by 19 · see citing works

Cloning and Characterization of Liver-specific Isoform of Chk1 Gene from Rat

Shann, Y., & Hsu, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108253200 · Cited by 18 · see citing works

Importance of a C-Terminal Conserved Region of Chk1 for Checkpoint Function

Palermo, C., Hope, J. C., Freyer, G. A., Rao, H., & Walworth, N. C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001427 · Cited by 17 · see citing works

Interferon-gamma enhances radiation-induced cell death via downregulation of Chk1

Kim, K. S., Choi, K. J., & Bae, S. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.20990 · Cited by 14 · see citing works

Glucose deprivation is associated with Chk1 degradation through the ubiquitin–proteasome pathway and effective checkpoint response to replication blocks

Kim, A. J., Kim, H., Jee, H. J., Song, N., Kim, M., Bae, Y., Chung, J. H., & Yun, J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.03.012 · Cited by 14 · see citing works

The Expression of DNA Damage Checkpoint Proteins and Prognostic Implication in Metastatic Brain Tumors

Seol, H. J., Yoo, H. Y., Jin, J., et al. (2011) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504011x13123323849654 · Cited by 12 · see citing works

Interaction with Checkpoint Kinase 1 Modulates the Recruitment of Nucleophosmin to Chromatin

Chen, S., Maya‐Mendoza, A., Zeng, K., Tang, C. W., Sims, P. F. G., Loric, J., & Jackson, D. A. (2009) · Journal of Proteome Research · doi:10.1021/pr900396d · Cited by 10 · see citing works

Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress

Sun, T.-P., & Shieh, S.-Y. (2009) · Oncogene · doi:10.1038/onc.2009.58 · Cited by 8 · see citing works

Chkl binds and phosphorylates BAD protein.

Han, E. K.-H., Butler, C., Zhang, H., et al. (2005) · PubMed · Cited by 6 · see citing works

Cellular Mechanisms of Liver Fibrosis

Acharya, P., Chouhan, K., Weiskirchen, S., & Weiskirchen, R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.671640 · Cited by 252 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

Manic, G., Signore, M., Sistigu, A., Russo, G., Corradi, F., Siteni, S., Musella, M., Vitale, S., De Angelis, M. L., Pallocca, M., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-312623 · Cited by 98 · see citing works

scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens

Yang, L., Zhu, Y., Yu, H., Cheng, X., Chen, S., Chu, Y., Huang, H., Zhang, J., & Li, W. (2020) · Genome Biology · doi:10.1186/s13059-020-1928-4 · Cited by 94 · see citing works

Resisting Arrest: Recovery from Checkpoint Arrest Through Dephosphorylation of Chk1 by PP1

den Elzen, N. R., Kosoy, A., Christopoulos, H., & O’Connell, M. J. (2004) · Cell Cycle · doi:10.4161/cc.3.5.820 · Cited by 25 · see citing works

Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation

Lee, M., Kim, H., Kim, M.-A., Jee, H. J., Kim, A. J., Bae, Y., Park, J., Chung, J. H., & Yun, J. (2008) · Cell Cycle · doi:10.4161/cc.7.17.6551 · Cited by 65 · see citing works

Establishment of and Recovery from Damage Checkpoint Requires Sequential Interactions of Crb2 with Protein Kinases Rad3, Chk1, and Cdc2Preprint

Esashi, F., Mochida, S., Matsusaka, T., OBARA, T., OGAWA, A., Tamai, K., & Yanagida, M. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.443 · Cited by 8 · see citing works

The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway

Cohen‐Fix, O., & Koshland, D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14361 · Cited by 158 · see citing works

Elevated Cyclin G2 Expression Intersects with DNA Damage Checkpoint Signaling and Is Required for a Potent G2/M Checkpoint Arrest Response to Doxorubicin

Zimmermann, M., Don, A. S. A., Donaldson, M. S., Dallapiazza, R. F., Cowan, C. E., & Horne, M. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.376855 · Cited by 58 · see citing works