Cited by 461Adipose Tissue and MetabolismMitochondrial Function and PathologyPeroxisome Proliferator-Activated Receptors

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Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.

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Wilson-Fritch, Leanne, Burkart, Alison, Bell, Gregory, Mendelson, Karen, Leszyk, John, Nicoloro, Sarah, Czech, Michael, Corvera, Silvia·2003·Molecular and Cellular Biology

DOI 10.1128/mcb.23.3.1085-1094.2003PMC PMC140688

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Abstract

White adipose tissue is an important endocrine organ involved in the control of whole-body metabolism, insulin sensitivity, and food intake. To better understand these functions, 3T3-L1 cell differentiation was studied by using combined proteomic and genomic strategies. The proteomics approach developed here exploits velocity gradient centrifugation as an alternative to isoelectric focusing for protein separation in the first dimension. A 20- to 30-fold increase in the concentration of numerous mitochondrial proteins was observed during adipogenesis, as determined by mass spectrometry and database correlation analysis. Light and electron microscopy confirmed a large increase in the number of mitochondrion profiles with differentiation. Furthermore, mRNA profiles obtained by using Affymetrix GeneChips revealed statistically significant increases in the expression of many nucleus-encoded mitochondrial genes during adipogenesis. Qualitative changes in mitochondrial composition also occur during adipose differentiation, as exemplified by increases in expression of proteins involved in fatty acid metabolism and of mitochondrial chaperones. Furthermore, the insulin sensitizer rosiglitazone caused striking changes in mitochondrial shape and expression of selective mitochondrial proteins. Thus, although mitochondrial biogenesis has classically been associated with brown adipocyte differentiation and thermogenesis, our results reveal that mitochondrial biogenesis and remodeling are inherent to adipose differentiation per se and are influenced by the actions of insulin sensitizers.

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Authors: Wilson-Fritch, L., Burkart, A., Bell, G., Mendelson, K., Leszyk, J., Nicoloro, S., Czech, M., & Corvera, S.
Affiliations: Program in Molecular Medicine
University of Massachusetts Chan Medical School (US)
Corresponding author: Corvera, Silvia
ORCID: Nicoloro, Sarah
Czech, Michael
Corvera, Silvia
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2003-02-01
Volume: 23
Issue: 3
Pages: 1085-1094
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.23.3.1085-1094.2003
PMC: PMC140688
OpenAlex: W2114978842
Cited by: 459
References: 28
Citations by year: 2026: 3 · 2025: 17 · 2024: 13 · 2023: 15 · 2022: 8 · 2021: 13 · 2020: 29 · 2019: 23 · 2018: 22 · 2017: 24 · 2016: 23 · 2015: 28 · 2014: 18 · 2013: 26 · 2012: 25
FWCI: 8.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK-60837, R01DK060837)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: mitochondrial biogenesis, mitochondrial remodeling, adipogenesis, 3T3-L1 cells, rosiglitazone, insulin sensitizers, white adipose tissue, mitochondrial proteins, fatty acid metabolism, mitochondrial chaperone, mitochondrial morphology, gene expression profiling
MeSH terms: Rosiglitazone, Animals, Cell Differentiation, Insulin, Microscopy, Electron, Mitochondria, Oxygen Consumption, RNA, Messenger, Thiazoles, 3T3 Cells, Adipocytes, Mitochondrial Proteins, Thiazolidinediones, Mice

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Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.

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