Redox implications in adipose tissue (dys)function-A new look at old acquaintances
Open accessAbstract
Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and diabetes type 2, also summarized with the term metabolic syndrome or syndrome X. Increasing evidence points to "adipocyte dysfunction", rather than fat mass accretion per se, as the key pathophysiological factor for metabolic complications in obesity. The dysfunctional fat tissue in obesity characterizes a failure to safely store metabolic substrates into existing hypertrophied adipocytes and/or into new preadipocytes recruited for differentiation. In this review we briefly summarize the potential of redox imbalance in fat tissue as an instigator of adipocyte dysfunction in obesity. We reveal the challenge of the adipose redox changes, insights in the regulation of healthy expansion of adipose tissue and its reduction, leading to glucose and lipids overflow.
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Phycocyanin in Arthrospira platensis suppresses oxidative stress and leads to anti-inflammatory and insulin-sensitizing effects.
“Phycocyanin in Arthrospira platensis suppresses oxidative stress and leads to anti-inflammatory and insulin-sensitizing effects [106,107,108].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [106]
The section ‘Instigating role of mitochondrial ROS in insulin resistant adipocyte response’ discusses reduced oxidative stress and restored insulin sensitivity in adipocytes, but attributes this to uncoupling agents and MnSOD mimetics. The ‘Conclusion and clinical implication’ discusses other antioxidants. Searches for phycocyanin, Arthrospira platensis, and Spirulina found no passage connecting this compound to the claimed effects; page numbers were not available in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredBy suppressing adipocyte oxidative stress, spirulina may lead to systemic anti-inflammatory and insulin-sensitising effects.
“Thus, by suppressing adipocyte oxidative stress, spirulina may lead to systemic anti-inflammatory and insulin-sensitising effects.12–20”
From Effects of spirulina on weight loss and blood lipids: A review (2020) · cites this paper as [19]
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Targeting vascular (endothelial) dysfunction
Daiber, A., Steven, S., Weber, A., Shuvaev, V. V., Muzykantov, V. R., Laher, I., Li, H., Lamas, S., & Münzel, T. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13517 · Cited by 501 · see citing works
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Gentscheva, G., Nikolova, K., Panayotova, V., Peycheva, K., Makedonski, L., Slavov, P., Radusheva, P., Petrova, P., & Yotkovska, I. (2023) · Life · doi:10.3390/life13030845 · Cited by 106 · see citing works
Effects of spirulina on weight loss and blood lipids: A review
DiNicolantonio, J. J., Bhat, A. G., & OKeefe, J. (2020) · Open Heart · doi:10.1136/openhrt-2018-001003 · Cited by 98 · see citing works
- Authors
- Jankovic, A., Korac, A., Buzadzic, B., Otasevic, V., Stancic, A., Daiber, A., & Korac, B.
- Affiliations
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- ORCID
- Daiber, Andreas
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 6
- Pages
- 19-32
- ISSN
- 2213-2317 (ISSN-L)
- PMC
- PMC4511633
- OpenAlex
- W831177683
- Cited by
- 91
- References
- 201
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 3 · 2023: 10 · 2022: 5 · 2021: 14 · 2020: 7 · 2019: 11 · 2018: 6 · 2017: 9 · 2016: 12 · 2015: 1
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Redox Biology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Digital Repository of Archived Publications (University of Belgrade, Institute for Biological Research Sinisa Stankovic) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Science and Technological Development of the Republic of Serbia (173055)
- European Cooperation in Science and Technology
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- adipose tissue dysfunction, obesity, redox imbalance, adipocyte dysfunction, metabolic syndrome, insulin resistance, type 2 diabetes, dyslipidemia, adipose tissue expansion, adipocyte hypertrophy, preadipocyte differentiation
- MeSH terms
- Adipose Tissue, Diabetes Mellitus, Type 2, Energy Metabolism, Humans, Hydrogen Peroxide, Insulin Resistance, Mitochondria, NAD, Obesity, Oxidation-Reduction, Adipocytes, NADPH Oxidases, Metabolic Syndrome, Adipogenesis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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