Cited by 91Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismRedox biology and oxidative stress

Redox implications in adipose tissue (dys)function-A new look at old acquaintances

Open access
Jankovic, Aleksandra, Korac, Aleksandra, Buzadzic, Biljana, Otasevic, Vesna, Stancic, Ana, Daiber, Andreas, Korac, Bato·2015·Redox Biology

Abstract

Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and diabetes type 2, also summarized with the term metabolic syndrome or syndrome X. Increasing evidence points to "adipocyte dysfunction", rather than fat mass accretion per se, as the key pathophysiological factor for metabolic complications in obesity. The dysfunctional fat tissue in obesity characterizes a failure to safely store metabolic substrates into existing hypertrophied adipocytes and/or into new preadipocytes recruited for differentiation. In this review we briefly summarize the potential of redox imbalance in fat tissue as an instigator of adipocyte dysfunction in obesity. We reveal the challenge of the adipose redox changes, insights in the regulation of healthy expansion of adipose tissue and its reduction, leading to glucose and lipids overflow.

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Crossref · 10.1016/j.redox.2015.06.018

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  • Phycocyanin in Arthrospira platensis suppresses oxidative stress and leads to anti-inflammatory and insulin-sensitizing effects.

    “Phycocyanin in Arthrospira platensis suppresses oxidative stress and leads to anti-inflammatory and insulin-sensitizing effects [106,107,108].”

    From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [106]

    The section ‘Instigating role of mitochondrial ROS in insulin resistant adipocyte response’ discusses reduced oxidative stress and restored insulin sensitivity in adipocytes, but attributes this to uncoupling agents and MnSOD mimetics. The ‘Conclusion and clinical implication’ discusses other antioxidants. Searches for phycocyanin, Arthrospira platensis, and Spirulina found no passage connecting this compound to the claimed effects; page numbers were not available in our copy. (LLM, conf=0.76)

    Experimental — accuracy not yet measured
  • By suppressing adipocyte oxidative stress, spirulina may lead to systemic anti-inflammatory and insulin-sensitising effects.

    “Thus, by suppressing adipocyte oxidative stress, spirulina may lead to systemic anti-inflammatory and insulin-sensitising effects.12–20”

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Authors
Jankovic, A., Korac, A., Buzadzic, B., Otasevic, V., Stancic, A., Daiber, A., & Korac, B.
Affiliations
University Medical Center of the Johannes Gutenberg University Mainz (DE)
Venue
Redox Biology
Publisher
Elsevier BV
Published
2015-12
Volume
6
Pages
19-32
ISSN
2213-2317 (ISSN-L)
OpenAlex
W831177683
Cited by
91
References
201
Citations by year
2026: 5 · 2025: 8 · 2024: 3 · 2023: 10 · 2022: 5 · 2021: 14 · 2020: 7 · 2019: 11 · 2018: 6 · 2017: 9 · 2016: 12 · 2015: 1
FWCI
1.21
Type
journal article
Language
en
Open access
Locations
  • Redox Biology (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Digital Repository of Archived Publications (University of Belgrade, Institute for Biological Research Sinisa Stankovic) (submittedVersion, cc-by-nc-nd)
Funders
  • Ministry of Science and Technological Development of the Republic of Serbia (173055)
  • European Cooperation in Science and Technology
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
adipose tissue dysfunction, obesity, redox imbalance, adipocyte dysfunction, metabolic syndrome, insulin resistance, type 2 diabetes, dyslipidemia, adipose tissue expansion, adipocyte hypertrophy, preadipocyte differentiation
MeSH terms
Adipose Tissue, Diabetes Mellitus, Type 2, Energy Metabolism, Humans, Hydrogen Peroxide, Insulin Resistance, Mitochondria, NAD, Obesity, Oxidation-Reduction, Adipocytes, NADPH Oxidases, Metabolic Syndrome, Adipogenesis

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