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p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene
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It is well established that catecholamine-stimulated thermogenesis in brown fat requires beta-adrenergic elevations in cyclic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene. However, little is known about the downstream components of the signaling cascade or the relevant transcription factor targets thereof. Here we demonstrate that cAMP- and protein kinase A-dependent activation of p38 mitogen-activated protein kinase (MAPK) in brown adipocytes is an indispensable step in the transcription of the UCP1 gene in mice. By phosphorylating activating transcription factor 2 (ATF-2) and peroxisome proliferator-activated receptor gamma (PPARgamma) coativator 1alpha (PGC-1alpha), members of two distinct nuclear factor families, p38 MAPK controls the expression of the UCP1 gene through their respective interactions with a cAMP response element and a PPAR response element that both reside within a critical enhancer motif of the UCP1 gene. Activation of ATF-2 by p38 MAPK additionally serves as the cAMP sensor that increases expression of the PGC-1alpha gene itself in brown adipose tissue. In conclusion, our findings illustrate that by orchestrating the activity of multiple transcription factors, p38 MAPK is a central mediator of the cAMP signaling mechanism of brown fat that promotes thermogenesis.
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“The most well-known condition to induce Ucp1 expression in both humans and rodents is cold, essentially by activating β-adrenergic receptors and the cAMP-dependent protein kinase (PKA)-dependent signaling pathway [38,39].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [39]
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Cites
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
Thomas, P. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.9.5201 · Cited by 7,937
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Johnson, G. L., & Lapadat, R. (2002) · Science · doi:10.1126/science.1072682 · Cited by 4,295
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
Self-citationA Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Self-citationLehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645
Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076
Self-citationEpac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
de Rooij, J., Zwartkruis, F. J. T., Verheijen, M. H. G., Cool, R. H., Nijman, S. M. B., Wittinghofer, A., & Bos, J. L. (1998) · Nature · doi:10.1038/24884 · Cited by 1,970
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., et al. (2001) · Nature · doi:10.1038/35093050 · Cited by 1,821
Self-citationTowards a molecular understanding of adaptive thermogenesis
Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630
Self-citationThe p38 signal transduction pathway Activation and function
Ono, K., & Han, J. (2000) · Cellular Signalling · doi:10.1016/s0898-6568(99)00071-6 · Cited by 1,571
Flagged first, then by citations
Research works printed but not linked: 6
- Badger A. M., 1996, J. Pharmacol. Exp. Ther., 279, 1453
- Cassard-Doulcier A.-M., 1993, Mol. Endocrinol., 7, 497
- Collins S., 1994, Mol. Endocrinol., 8, 518
- Kozak U. C., 1994, Mol. Cell. Biol., 14, 59
- Underwood D. C., 2000, Physiol., 279, L895
- Underwood D. C., 2000, J. Pharmacol. Exp. Ther., 293, 281
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Hancock, C. R., Han, D., Higashida, K., Kim, S. H., & Holloszy, J. O. (2011) · The FASEB Journal · doi:10.1096/fj.10-170415 · Cited by 131
Dermal white adipose tissue: a new component of the thermogenic response
Alexander, C. M., Kasza, I., Yen, C.-L., Reeder, S. B., Hernando, D., Gallo, R. L., Jahoda, C. A. B., Horsley, V., & MacDougald, O. A. (2015) · Journal of Lipid Research · doi:10.1194/jlr.r062893 · Cited by 140
Sakamoto, T., Takahashi, N., Sawaragi, Y., Naknukool, S., Yu, R., Goto, T., & Kawada, T. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00312.2012 · Cited by 133
Post-Translational Regulation of Oct4 Transcriptional Activity
Saxe, J. P., Tomilin, A. N., Schöler, H. R., Plath, K., & Huang, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004467 · Cited by 127
Robidoux, J., Cao, W., Quan, H. Y., Daniel, K. W., Moukdar, F., Bai, X., Floering, L. M., & Collins, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5466-5479.2005 · Cited by 122
Self-citationCollins, S., Yehuda‐Shnaidman, E., & Wang, H. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.180 · Cited by 129
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Müller, T. D., Lee, S. J., Jastroch, M., Kabra, D. G., Stemmer, K., Aichler, M., Abplanalp, B., Ananthakrishnan, G., Bhardwaj, N. J., Collins, S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64209 · Cited by 127
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Yu, H., Dilbaz, S., Coßmann, J., Hoang, A. C., Diedrich, V., Herwig, A., Harauma, A., Hoshi, Y., Moriguchi, T., Landgraf, K., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125646 · Cited by 128
p38 Mitogen-activated Protein Kinase Mediates Free Fatty Acid-induced Gluconeogenesis in Hepatocytes
Collins, Q. F., Xiong, Y., Lupo, E. G., Liu, H., & Cao, W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602177200 · Cited by 126
Self-citationLi, F., Wu, R., Cui, X., Zha, L., Yu, L., Shi, H., & Xue, B. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.677930 · Cited by 119
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Kuang, J., Chen, L., Tang, Q., Zhang, J., Li, Y., & He, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00135 · Cited by 122
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Chen, K. Y., Brychta, R. J., Sater, Z. A., Cassimatis, T. M., Cero, C., Fletcher, L. A., Israni, N. S., Johnson, J. W., Lea, H. J., Linderman, J. D., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007363 · Cited by 121
Lasar, D., Rosenwald, M., Kiehlmann, E., Baláž, M., Tall, B., Opitz, L., Lidell, M. E., Zamboni, N., Krznar, P., Sun, W., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.067 · Cited by 117
Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress
Kasza, I., Suh, Y. K., Wollny, D., Clark, R. J., Roopra, A., Colman, R. J., MacDougald, O. A., Shedd, T. A., Nelson, D. W., Yen, M., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004514 · Cited by 119
Exercise: it's the real thing!
Hawley, J. A., & Holloszy, J. O. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00185.x · Cited by 112
Transcriptional regulation of the uncoupling protein-1 gene
Villarroya, F., Peyrou, M., & Giralt, M. (2017) · Biochimie · doi:10.1016/j.biochi.2016.09.017 · Cited by 108
Anunciado‐Koza, R. P., Ukropec, J., Koza, R. A., & Kozak, L. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804268200 · Cited by 108
Vila‐Bedmar, R., Lorenzo, M., & Fernández‐Veledo, S. (2010) · Endocrinology · doi:10.1210/en.2009-0810 · Cited by 108
Liu, Z., Gan, L., Wu, T., Feng, F., Luo, D., Gu, H., Liu, S., & Sun, C. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.388 · Cited by 106
Pahlavani, M., Razafimanjato, F., Ramalingam, L., Kalupahana, N. S., Moussa, H. M., Scoggin, S. O., & Moustaïd‐Moussa, N. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.08.012 · Cited by 102
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Jeong, H.-J., Lee, H.-J., Vuong, T. A., Choi, K.-S., Choi, D., Koo, S.-H., Cho, S. C., Cho, H., & Kang, J.-S. (2016) · Diabetes · doi:10.2337/db15-1500 · Cited by 101
Exercise-Mediated Browning of White Adipose Tissue: Its Significance, Mechanism and Effectiveness
Mu, W.-J., Zhu, J.-Y., Chen, M., & Guo, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111512 · Cited by 99
Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
Snieckute, G., Genzor, A. V., Vind, A., Ryder, L., Stoneley, M., Chamois, S., Dreos, R., Nordgaard, C., Sass, F., Blasius, M., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.10.011 · Cited by 99
Xiao, X., Williams, S., Grayson, B. E., Glavas, M. M., Cowley, M. A., Smith, M. S., & Grove, K. L. (2007) · Endocrinology · doi:10.1210/en.2007-0373 · Cited by 99
Wang, H., Zhang, Y., Yehuda‐Shnaidman, E., Medvedev, A. V., Kumar, N., Daniel, K. W., Robidoux, J., Czech, M., Mangelsdorf, D. J., & Collins, S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01479-07 · Cited by 101
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Vankoningsloo, S., Pauw, A. D., Houbion, A., Tejerina, S., Demazy, C., de Longueville, F., Bertholet, V., Renard, P., Remacle, J., Holvoet, P., et al. (2006) · Journal of Cell Science · doi:10.1242/jcs.02848 · Cited by 96
IL-33-driven ILC2/eosinophil axis in fat is induced by sympathetic tone and suppressed by obesity
Ding, X., Luo, Y., Zhang, X., Zheng, H., Yang, X., Yang, X. O., & Liu, M. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0229 · Cited by 103
Vargas‐Castillo, A., Fuentes‐Romero, R., Rodríguez-López, L. A., Torres, N., & Tovar, A. R. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.10.002 · Cited by 101
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Self-citationQiao, L., Kinney, B., Yoo, H. S., Lee, B., Schaack, J. B., & Shao, J. (2012) · Diabetes · doi:10.2337/db11-1475 · Cited by 97
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Iida, S., Chen, W., Nakadai, T., Ohkuma, Y., & Roeder, R. G. (2015) · Genes & Development · doi:10.1101/gad.252809.114 · Cited by 96
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Xiong, Y., Collins, Q. F., An, J., Lupo, E. G., Liu, H. Y., Liu, D., Robidoux, J., Liu, Z., & Cao, W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606742200 · Cited by 93
Self-citationMottillo, E. P., Shen, X., & Granneman, J. G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.04.012 · Cited by 92
Debevec, D., Christian, M., Morganstein, D. L., Seth, A., Herzog, B., Parker, M. G., & White, R. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0103 · Cited by 96
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Ro, S., Nam, M., Jang, I., Park, H., Park, H., Semple, I. A., Kim, M., Kim, J. S., Park, H., Einat, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401787111 · Cited by 88
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Tong, T., Shen, Y., Lee, H.-W., Yu, R., & Park, T. (2016) · Scientific Reports · doi:10.1038/srep34179 · Cited by 82
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Zha, L., Li, F., Wu, R., Artinian, L. R., Rehder, V., Yu, L., Liang, H., Xue, B., & Shi, H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.662650 · Cited by 80
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Sato, M., Horinouchi, T., Hutchinson, D. S., Evans, B. A., & Summers, R. J. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.035337 · Cited by 78
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Frantz, E. D. C., Prodel, E., Bráz, I. D., Giori, I. G., Bargut, T. C. L., Magliano, D. C., & da Nóbrega, A. C. L. (2018) · Clinical Science · doi:10.1042/cs20180276 · Cited by 75
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Self-citationChang, J. S., Fernand, V. E., Zhang, Y., Shin, J., Jun, H., Joshi, Y., & Gettys, T. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.320200 · Cited by 75
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Safi, R., Kovacic, A., Gaillard, S. L., Murata, Y., Simpson, E. R., McDonnell, D. P., & Clyne, C. D. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2792 · Cited by 70
Angueira, A. R., Shapira, S. N., Ishibashi, J., Sampat, S., Sostre‐Colón, J., Emmett, M. J., Titchenell, P. M., Lazar, M. A., Lim, H., & Seale, P. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.023 · Cited by 69
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Zhang, G., Sun, Q., & Liu, C. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00029 · Cited by 68
Ellis, C. N., LaRocque, R. C., Uddin, T., Krastins, B., Mayo-Smith, L. M., Sarracino, D. A., Karlsson, E. K., Rahman, A., Shirin, T., Bhuiyan, T. R., et al. (2015) · Infection and Immunity · doi:10.1128/iai.02765-14 · Cited by 64
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Palmer, B. F., & Clegg, D. J. (2017) · Obesity Reviews · doi:10.1111/obr.12563 · Cited by 67
Mottillo, E. P., & Granneman, J. G. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00039.2011 · Cited by 61
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Little, J. P., Safdar, A., Benton, C. R., & Wright, D. C. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-076 · Cited by 62
Iwen, K. A., Senyaman, O., Schwartz, A., Drenckhan, M., Meier, B., Hadaschik, D., & Klein, J. C. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0299 · Cited by 61
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Duarte-Silva, L., Gasaly, N., Poblete-Aro, C., Uribe, D., Echeverría, F., Gotteland, M., & García‐Díaz, D. F. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09622-0 · Cited by 67
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Lin, S., & Li, P. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.07.005 · Cited by 61
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Kim, W. K., Choi, H.-R., Park, S. G., Ko, Y., Bae, K., & Lee, S. C. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.11.004 · Cited by 59
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Bartelt, A., Weigelt, C., Cherradi, M. L., Niemeier, A., Tödter, K., Heeren, J., & Scheja, L. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.11.011 · Cited by 59
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Leiva, M., Matesanz, N., Pulgarín-Alfaro, M., Nikolić, I., & Sabio, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.572089 · Cited by 62
Chen, W., Yang, Q.-H., & Roeder, R. G. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.015 · Cited by 59
Brown and Beige Adipose Tissue
Mulya, A., & Kirwan, J. P. (2016) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2016.04.010 · Cited by 68
McQueen, A. E., Kanamaluru, D., Yan, K., Gray, N. E., Wu, L., Li, M.-L., Chang, A., Hasan, A., Stifler, D., Koliwad, S. K., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.803973 · Cited by 56
Qiao, L., MacDougald, O. A., & Shao, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603038200 · Cited by 56
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Cooper, M. P., Uldry, M., Kajimura, S., Arany, Z. P., & Spiegelman, B. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805431200 · Cited by 57
Self-citationMetabolic roles of G protein‐coupled receptor signaling in obesity and type 2 diabetes
Barella, L. F., Jain, S., Kimura, T., & Pydi, S. P. (2021) · FEBS Journal · doi:10.1111/febs.15800 · Cited by 61
Fernández‐Veledo, S., Vázquez‐Carballo, A., Vila‐Bedmar, R., Ceperuelo‐Mallafré, V., & Vendrell, J. J. (2013) · IUBMB Life · doi:10.1002/iub.1170 · Cited by 57
Metadata
- Authors
- Cao, W., Daniel, K. W., Robidoux, J., Puigserver, P., Medvedev, A. V., Bai, X., Floering, L. M., Spiegelman, B. M., & Collins, S.
- Affiliations
- Duke University (US)
- Harvard University (US)
- Corresponding author
- Collins, Sheila
- ORCID
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2004-04-01
- Volume
- 24
- Issue
- 7
- Pages
- 3057-3067
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC371122
- OpenAlex
- W2162186867
- Cited by
- 605
- References
- 46
- Citations by year
- 2026: 17 · 2025: 33 · 2024: 36 · 2023: 29 · 2022: 28 · 2021: 46 · 2020: 51 · 2019: 28 · 2018: 29 · 2017: 29 · 2016: 37 · 2015: 27 · 2014: 26 · 2013: 34 · 2012: 26
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DK54477)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-54024, R01 DK54477, R01DK054024, R01DK053092, R01DK054477)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- p38 MAPK, UCP1, brown adipocytes, thermogenesis, cAMP signaling, protein kinase A, ATF2, PGC-1α, PPAR response element, cAMP response element, enhancers, catecholamine signaling, beta-adrenergic signaling
- MeSH terms
- Uncoupling Protein 1, Cyclic AMP, Animals, Adipose Tissue, Brown, Carrier Proteins, Cells, Cultured, Cold Temperature, Enhancer Elements, Genetic, Enzyme Activation, Enzyme Inhibitors, Gene Expression Regulation, Humans, Ion Channels, Membrane Proteins, Mice, Inbred C57BL, Random Allocation, Transcription Factors, Transcription, Genetic, Uncoupling Agents, Signal Transduction, Adipocytes, Mitogen-Activated Protein Kinases, Thermogenesis, Mitochondrial Proteins, p38 Mitogen-Activated Protein Kinases, Mice
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