The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Kaiso-Deficient Mice Show Resistance to Intestinal Cancer
Open accessAbstract
Kaiso is a BTB domain protein that associates with the signaling molecule p120-catenin and binds to the methylated sequence mCGmCG or the nonmethylated sequence CTGCNA to modulate transcription. In Xenopus laevis, xKaiso deficiency leads to embryonic death accompanied by premature gene activation in blastulae and upregulation of the xWnt11 gene. Kaiso has also been proposed to play an essential role in mammalian synapse-specific transcription. We disrupted the Kaiso gene in mice to assess its role in mammalian development. Kaiso-null mice were viable and fertile, with no detectable abnormalities of development or gene expression. However, when crossed with tumor-susceptible Apc(Min/+) mice, Kaiso-null mice showed a delayed onset of intestinal tumorigenesis. Kaiso was found to be upregulated in murine intestinal tumors and is expressed in human colon cancers. Our data suggest that Kaiso plays a role in intestinal cancer and may therefore represent a potential target for therapeutic intervention.
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Cites
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
Ying, Q.-L., Stavridis, M., Griffiths, D., Li, M., & Smith, A. (2003) · Nature Biotechnology · doi:10.1038/nbt780 · Cited by 1,504
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
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Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
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Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
Walsh, C. P., Chaillet, J. R., & Bestor, T. H. (1998) · Nature Genetics · doi:10.1038/2413 · Cited by 1,105
Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. (2002) · Science · doi:10.1126/science.1069094 · Cited by 936
Self-citationThe p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor
Prokhortchouk, A., Hendrich, B., Jørgensen, H., Ruzov, A., Wilm, M., Georgiev, G., Bird, A., & Prokhortchouk, E. (2001) · Genes & Development · doi:10.1101/gad.198501 · Cited by 533
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Cited by
Genomic DNA methylation: the mark and its mediators.
Klose, R. J., & Bird, A. P. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.12.008 · Cited by 2,501
Self-citationTETonic shift: biological roles of TET proteins in DNA demethylation and transcription
Pastor, W. A., Aravind, L., & Rao, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3589 · Cited by 897
Deconstructing repression: evolving models of co-repressor action
Perissi, V., Jepsen, K., Glass, C. K., & Rosenfeld, M. G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2736 · Cited by 532
Catenins: Keeping Cells from Getting Their Signals Crossed
Perez-Moreno, M., & Fuchs, E. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.010 · Cited by 295
POZ for effect – POZ-ZF transcription factors in cancer and development
Kelly, K. F., & Daniel, J. M. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.09.003 · Cited by 254
Metadata
- Authors
- Prokhortchouk, A., Sansom, O., Selfridge, J., Caballero, I. M., Salozhin, S., Aithozhina, D., Cerchietti, L., Meng, F. G., Augenlicht, L. H., Mariadason, J. M., Hendrich, B., Melnick, A., Prokhortchouk, E., Clarke, A., & Bird, A.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2006-01-01
- Volume
- 26
- Issue
- 1
- Pages
- 199-208
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2152326032
- Cited by
- 169
- References
- 6
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Prokhortchouk, A., Sansom, O., Selfridge, J., Caballero, I. M., Salozhin, S., Aithozhina, D., Cerchietti, L., Meng, F. G., Augenlicht, L. H., Mariadason, J. M., Hendrich, B., Melnick, A., Prokhortchouk, E., Clarke, A., & Bird, A. (2006). Kaiso-Deficient Mice Show Resistance to Intestinal Cancer. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.26.1.199-208.2006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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