Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress Colon Carcinoma Cell Invasion

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1. An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4
   Fehler, Olesja, Singh, Priyanka, Haas, Astrid, Ulrich, Diana, Müller, Jan P., Ohnheiser, Johanna, Klempnauer, Karl-Heinz · 2014 · Nucleic Acids Research
2. Downregulation of programmed cell death 4 (PDCD4) in tumorigenesis and progression of human digestive tract cancers
   Gang Ma, Hao Zhang, Ming Dong, Xinyu Zheng, Iwata Ozaki, Sachiko Matsuhashi, Kejian Guo · 2013 · Tumor Biology
3. Feedback Regulations of miR-21 and MAPKs via Pdcd4 and Spry1 Are Involved in Arsenite-Induced Cell Malignant Transformation
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4. Pdcd4 protein and mRNA level alterations do not correlate in human lung tumors
   С. В. Калиниченко, E. P. Kopantzev, Elena V. Korobko, Irina V. Palgova, Завалишина Лариса Эдуардовна, Bateva Mv, Andrey N. Petrov, Georgii A. Frank, Eugene D. Sverdlov, Igor V. Korobko · 2008 · Lung Cancer
5. Programmed Cell Death 4 (PDCD4) Enhances the Sensitivity of Gastric Cancer Cells to TRAIL-Induced Apoptosis by Inhibiting the PI3K/Akt Signaling Pathway
   Weiqiang Wang, Hao Zhang, Hongbin Wang, Yong-Gang Sun, Zhi-Hong Peng, Gang Zhou, Shiming Yang, Rongquan Wang, Dian-Chun Fang · 2010 · Molecular Diagnosis & Therapy
6. Association of Tumor Suppressor Protein Pdcd4 With Ribosomes Is Mediated by Protein-Protein and Protein-RNA Interactions
   Lena Wedeken, Johanna Ohnheiser, Benjamin Hirschi, Nils Wethkamp, Karl‐Heinz Klempnauer · 2010 · Genes & Cancer
7. Current Status and Perspectives Regarding LNA‐Anti‐miR Oligonucleotides and microRNA miR‐21 Inhibitors as a Potential Therapeutic Option in Treatment of Colorectal Cancer
   Reza Nedaeinia, Amir Avan, Mehdi Ahmadian, Sasan Nedaee Nia, Maryam Ranjbar, Mohammadreza Sharifi, Mohammad Goli, Ahmad Piroozmand, Esmail Nourmohammadi, Mostafa Manian et al. · 2017 · Journal of Cellular Biochemistry
8. Proteasome-Mediated Degradation and Functions of Hematopoietic Progenitor Kinase 1 in Pancreatic Cancer
   Hua Wang, Xianzhou Song, Craig D. Logsdon, Guisheng Zhou, Douglas B. Evans, James L. Abbruzzese, Stanley R. Hamilton, Tse‐Hua Tan, Huamin Wang · 2009 · Cancer Research
9. Interactions between hematopoietic progenitor kinase 1 and its adaptor proteins
   Qing Hua Zhang, Shu Ding, Huilin Zhang · 2017 · Molecular Medicine Reports
10. Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46
    Kumar, N, Wethkamp, N, Waters, L C, Carr, M D, Klempnauer, K-H · 2013 · Oncogenesis
11. Effect of microRNA-21 on the proliferation of human degenerated nucleus pulposus by targeting programmed cell death 4
    Bo Chen, S.G. Huang, Li Ju, M. Li, F.F. Nie, Y. Zhang, Y.H. Zhang, Xinlei Chen, F. Gao · 2016 · Brazilian Journal of Medical and Biological Research
12. Prognostic significance of PDCD4 expression and association with microRNA-21 in each Dukes' stage of colorectal cancer patients
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13. Enhanced Arginine Methylation of Programmed Cell Death 4 Protein during Nutrient Deprivation Promotes Tumor Cell Viability
    Fay, Marta M., Clegg, James M., Uchida, Kimberly A., Powers, Matthew A., Ullman, Katharine S. · 2014 · Journal of Biological Chemistry
14. Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair
    Tao Wang, Shuang Long, Na Zhao, Yu Wang, Huiqin Sun, Zhongmin Zou, Junping Wang, Xinze Ran, Yongping Su · 2015 · International Journal of Molecular Sciences
15. PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression
    Guo, Jing, Ozaki, Iwata, Xia, Jinghe, Kuwashiro, Takuya, Kojima, Motoyasu, Takahashi, Hirokazu, Ashida, Kenji, Anzai, Keizo, Matsuhashi, Sachiko · 2019 · Frontiers in Oncology
16. GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer
    Chung‐Ping Hsu, Huai‐Chia Chuang, Ming-Ching Lee, Hsiao‐Hui Tsou, Li‐Wen Lee, Ju‐Pi Li, Tse‐Hua Tan · 2016 · Oncotarget
17. Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells
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18. PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses
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19. Programmed cell death 4 (PDCD4) mediates the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by down-regulation of FLIP expression
    Weiqiang Wang, Jingjing Zhao, Hongbin Wang, Sun Yonggang, Zhihong Peng, Gang Zhou, Lilin Fan, Xingwei Wang, Shiming Yang, Rongquan Wang et al. · 2010 · Experimental Cell Research
20. The action of Pdcd4 may be cell type specific: evidence that reduction of dUTPase levels might contribute to its tumor suppressor activity in Bon-1 cells
    Brigitte Lankat–Buttgereit, Barbara Lenschen, Harald Schmidt, Rüdiger Göke · 2007 · APOPTOSIS
21. RNA-binding proteins La and HuR cooperatively modulate translation repression of PDCD4 mRNA
    Ravi Kumar, Dipak Kumar Poria, Partho Sarothi Ray · 2020 · Journal of Biological Chemistry
22. Down-regulation of programmed cell death 4 leads to epithelial to mesenchymal transition and promotes metastasis in mice
    Qing Wang, Jiang Zhu, Yong Zhang, Zhenxiao Sun, Xiaoling Guo, Xin Wang, Eun Young Lee, Vasudevan Bakthavatchalu, Qifeng Yang, Hsin‐Sheng Yang · 2013 · European Journal of Cancer
23. c-Jun NH2 Terminal Kinase Activation and Decreased Expression of Mitogen-Activated Protein Kinase Phosphatase-1 Play Important Roles in Invasion and Angiogenesis of Urothelial Carcinomas
    Keiji Shimada, Mitsutoshi Nakamura, Eiwa Ishida, Tomonori Higuchi, Motoyoshi Tanaka, Ichiro Ota, Noboru Konishi · 2007 · American Journal Of Pathology
24. Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line
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25. Disruption of the Pdcd4 tumor suppressor gene in chicken DT40 cells reveals its role in the DNA-damage response
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26. Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction
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27. Suppression of PDCD4 mediated by the long non-coding RNA HOTAIR inhibits the proliferation and invasion of glioma cells
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28. Characterization of the Phosphoproteome in LNCaP Prostate Cancer Cells by In-Gel Isoelectric Focusing and Tandem Mass Spectrometry
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29. MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway
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30. Optimizing component formula suppresses lung cancer by blocking DTL-mediated PDCD4 ubiquitination to regulate the MAPK/JNK pathway
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34. Stat‐3 signaling promotes cell proliferation and metastasis of gastric cancer through PDCD4 downregulation
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35. Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy
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36. Programmed Cell Death 4 ( PDCD 4): A Novel Player in Ethanol‐Mediated Suppression of Protein Translation in Primary Cortical Neurons and Developing Cerebral Cortex
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37. Proteomics perturbations promoted by the protein kinase CK2 inhibitor quinalizarin
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38. Repressing PDCD4 activates JNK/ABCG2 pathway to induce chemoresistance to fluorouracil in colorectal cancer cells
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39. Activation and up‐regulation of translation initiation factor 4B contribute to arsenic‐induced transformation
    Yong Zhang, Qing Wang, Xiaoling Guo, Robert Miller, Yinglu Guo, Hsin‐Sheng Yang · 2011 · Molecular Carcinogenesis
40. Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation
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42. Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers
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43. Interaction of Pdcd4 with eIF4E inhibits the metastatic potential of hepatocellular carcinoma
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44. PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs
    Astrid Haas, Benedikt S. Nilges, Sebastian A. Leidel, Karl‐Heinz Klempnauer · 2020 · Scientific Reports
45. PDCD4 regulates apoptosis in human peritoneal mesothelial cells and promotes gastric cancer peritoneal metastasis.
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57. Programmed cell death 4 protein (Pdcd4) and homeodomain-interacting protein kinase 2 (Hipk2) antagonistically control translation of Hipk2 mRNA
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