Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46
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The tumor suppressor protein Pdcd4 is a nuclear/cytoplasmic shuttling protein that has been implicated in the development of several types of human cancer. In the nucleus, Pdcd4 affects the transcription of specific genes by modulating the activity of several transcription factors. We have identified the Daxx protein as a novel interaction partner of Pdcd4. Daxx is a scaffold protein with roles in diverse processes, including transcriptional regulation, DNA-damage signaling, apoptosis and chromatin remodeling. We show that the interaction of both proteins is mediated by the N-terminal domain of Pdcd4 and the central part of Daxx, and that binding to Pdcd4 stimulates the degradation of Daxx, presumably by disrupting the interaction of Daxx with the de-ubiquitinylating enzyme Hausp. Daxx has previously been shown to serve as a scaffold for protein kinase Hipk2 and tumor suppressor protein p53 and to stimulate the phosphorylation of p53 at serine 46 (Ser-46) in response to genotoxic stress. We show that Pdcd4 also disrupts the Daxx-Hipk2 interaction and inhibits the phosphorylation of p53. We also show that ultraviolet irradiation decreases the expression of Pdcd4. Taken together, our results support a model in which Pdcd4 serves to suppress the phosphorylation of p53 in the absence of DNA damage, while the suppressive effect of Pdcd4 is abrogated after DNA damage owing to the decrease of Pdcd4. Overall, our data demonstrate that Pdcd4 is a novel modulator of Daxx function and provide evidence for a role of Pdcd4 in restraining p53 activity in unstressed cells.
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DNA damages decrease PDCD4 expression and increase phosphorylation of TP53 protein.
“PDCD4 inhibits the phosphorylation of TP53 in the absence of DNA damage disrupting the DAXX and HIPK2 association, while DNA damages decrease the PDCD4 expression and increase the phosphorylation of TP53 protein.”
From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [42]
PDCD4 inhibits phosphorylation of TP53 in the absence of DNA damage by disrupting the DAXX and HIPK2 association.
“PDCD4 inhibits the phosphorylation of TP53 in the absence of DNA damage disrupting the DAXX and HIPK2 association, while DNA damages decrease the PDCD4 expression and increase the phosphorylation of TP53 protein.”
From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [42]
PDCD4 may function to restrain TP53 activity in unstressed conditions.
“Thus, PDCD4 may function to restrain TP53 activity in unstressed conditions [42].”
From Control Mechanisms of the Tumor Suppressor PDCD4: Expression and Functions (2019) · cites this paper as [42]
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- Authors
- Kumar, N., Wethkamp, N., Waters, L. C., Carr, M. D., & Klempnauer, K.-H.
- Affiliations
- University of Münster (DE)
- University of Leicester (GB)
- Corresponding author
- Klempnauer, K-H
- ORCID
- Carr, M D
- Venue
- Oncogenesis
- Published
- 2013-01-14
- Volume
- 2
- Issue
- 1
- Pages
- e37-e37
- ISSN
- 2157-9024 (ISSN-L)
- PMC
- PMC3564021
- OpenAlex
- W2133221120
- Cited by
- 30
- References
- 74
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 6
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Oncogenesis (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Leicester Research Archive (University of Leicester) (submittedVersion, cc-by-nc-nd)
- Funders
- Wellcome Trust
- Deutsche Krebshilfe
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- PDCD4, DAXX, HIPK2, protein-protein interaction, protein stability, protein degradation, DNA damage response, UV irradiation, tumor suppressor, transcriptional regulation
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