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Estrogen and Progesterone Control of Gene Expression in the Mouse Meibomian Gland

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MicroRNA-21 (miR-21) Post-Transcriptionally Downregulates Tumor Suppressor PDCD4 and Promotes Cell Transformation, Proliferation, and Metastasis in Renal Cell Carcinoma

Li, X., Xin, S., He, Z., Che, X., Wang, J., Xiao, X., Chen, J., & Song, X. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000362946 · Cited by 94 · see citing works

Programmed Cell Death-4 Tumor Suppressor Protein Contributes to Retinoic Acid–Induced Terminal Granulocytic Differentiation of Human Myeloid Leukemia Cells

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Downregulation of E-cadherin is an essential event in activating β-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells

Wang, Q., Sun, Z. X., Allgayer, H., & Yang, H. S. (2010) · Oncogene · doi:10.1038/onc.2009.302 · Cited by 89 · see citing works

Targeting mTOR for the treatment of AML. New agents and new directions

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Programmed Cell Death 4 inhibits breast cancer cell invasion by increasing Tissue Inhibitor of Metalloproteinases-2 expression

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Sensing the scent of death: Modulation of microRNAs by curcumin in gastrointestinal cancers.

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Alterations in the expression of PDCD4 in ductal carcinoma of the breast

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Targeting the eIF4A RNA helicase as an anti-neoplastic approach

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FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells

Dikshit, B., Irshad, K., Madan, E., Aggarwal, N., Sarkar, C., Chandra, P. S., Gupta, D. K., Chattopadhyay, P., Sinha, S., & Chosdol, K. (2012) · Oncogene · doi:10.1038/onc.2012.393 · Cited by 79 · see citing works

Loss of Programmed cell death 4 (Pdcd4) associates with the progression of ovarian cancer

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Helicobacter pylori Promotes Epithelial–Mesenchymal Transition in Gastric Cancer by Downregulating Programmed Cell Death Protein 4 (PDCD4)

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Structural Basis for Inhibition of Translation by the Tumor Suppressor Pdcd4

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siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression

Bitomsky, N., Wethkamp, N., Marikkannu, R., & Klempnauer, K.-H. (2008) · Oncogene · doi:10.1038/onc.2008.115 · Cited by 75 · see citing works

On the statistical assessment of classifiers using DNA microarray data

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The development of small-molecule inhibitors targeting HPK1

Zhou, L., Wang, T., Zhang, K., Zhang, X., & Jiang, S. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114819 · Cited by 72 · see citing works

Overexpression of microRNA-21 regulating PDCD4 during tumorigenesis of liver fluke-associated cholangiocarcinoma contributes to tumor growth and metastasis

Chusorn, P., Namwat, N., Loilome, W., Techasen, A., Pairojkul, C., Khuntikeo, N., Dechakhamphu, A., Talabnin, C., Chan-on, W., Ong, C. K., et al. (2013) · Tumor Biology · doi:10.1007/s13277-013-0688-0 · Cited by 71 · see citing works

Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective

Zhu, Q., Chen, N., Tian, X., Zhou, Y.-L., You, Q., & Xu, X. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00172 · Cited by 70 · see citing works

A Comprehensive Review of Dysregulated miRNAs Involved in Cervical Cancer

Sharma, G., Dua, P. K., & Agarwal, S. M. (2014) · Current Genomics · doi:10.2174/1389202915666140528003249 · Cited by 70 · see citing works

Suppression of Programmed Cell Death 4 (PDCD4) Protein Expression by BCR-ABL-regulated Engagement of the mTOR/p70 S6 Kinase Pathway

Carayol, N., Katsoulidis, E., Sassano, A., Altman, J. K., Druker, B. J., & Platanias, L. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707934200 · Cited by 69 · see citing works

Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma

Wang, Q., Zhu, J., Wang, Y.-W., Dai, Y., Wang, Y.-L., Wang, C., Liu, J., Baker, A., Colburn, N. H., & Yang, H.-S. (2017) · Oncogene · doi:10.1038/onc.2017.228 · Cited by 67 · see citing works

Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

Santhanam, A. N., Baker, A. R., Hegamyer, G., Kirschmann, D. A., & Colburn, N. H. (2010) · Oncogene · doi:10.1038/onc.2010.158 · Cited by 67 · see citing works

<i>PDCD4</i> gene silencing in gliomas is associated with 5′CpG island methylation and unfavourable prognosis

Gao, F., Wang, X., Zhu, F., Wang, Q., Zhang, X., Guo, C., Zhou, C., Ma, C., Sun, W., Zhang, Y., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00497.x · Cited by 66 · see citing works

Pdcd4 deficiency enhances macrophage lipoautophagy and attenuates foam cell formation and atherosclerosis in mice

Wang, L., Jiang, Y., Song, X., Guo, C. H., Zhu, F., Wang, X., Wang, Q., Shi, Y., Wang, J., Gao, F., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2015.416 · Cited by 66 · see citing works

miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4

Liu, Y., Ur-Rehman, U., Guo, Y., Liang, H., Cheng, R., Yang, F., Hong, Y., Zhao, C., Liu, M., Yu, M., et al. (2016) · Protein & Cell · doi:10.1007/s13238-016-0313-2 · Cited by 65 · see citing works

MicroRNA-21 suppression impedes medulloblastoma cell migration

Grunder, E., D’Ambrosio, R., Fiaschetti, G., Abela, L., Arcaro, A., Zuzak, T. J., Ohgaki, H., Lv, S., Shalaby, T., & Grotzer, M. A. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.06.041 · Cited by 65 · see citing works

Loss of programmed cell death 4 induces apoptosis by promoting the translation of procaspase-3 mRNA

Eto, K., Goto, S., Nakashima, W., Ura, Y., & Abe, S.-I. (2012) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2011.126 · Cited by 64 · see citing works

Targeting strategies on miRNA-21 and PDCD4 for glioblastoma

Wang, G., Wang, J. J., Tang, H., & To, S. S. T. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.07.001 · Cited by 63 · see citing works

Erioflorin Stabilizes the Tumor Suppressor Pdcd4 by Inhibiting Its Interaction with the E3-ligase β-TrCP1

Blees, J. S., Bokesch, H. R., Rübsamen, D., Schulz, K. L., Milke, L., Bajer, M. M., Gustafson, K. R., Henrich, C. J., McMahon, J. B., Colburn, N. H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046567 · Cited by 63 · see citing works

miRNAs in breast cancer tumorigenesis (Review)

ZHANG, Z. J., & Shi, L. (2011) · Oncology Reports · doi:10.3892/or.2011.1611 · Cited by 60 · see citing works

Biosignatures for Parkinson’s Disease and Atypical Parkinsonian Disorders Patients

Potashkin, J. A., Santiago, J. A., Ravina, B. M., Watts, A., & Leontovich, A. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043595 · Cited by 59 · see citing works

MicroRNA-330-3p functions as an oncogene in human esophageal cancer by targeting programmed cell death 4.

Meng, H., Wang, K., Chen, X., Guan, X., Hu, L., Xiong, G., Li, J., & Bai, Y. (2015) · PubMed Central · Cited by 59 · see citing works

Tumour Suppressive Function and Modulation of Programmed Cell Death 4 (PDCD4) in Ovarian Cancer

Wei, N., Liu, S. S., Chan, K. K. L., & Ngan, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030311 · Cited by 58 · see citing works

MicroRNA-21, up-regulated by arsenite, directs the epithelial–mesenchymal transition and enhances the invasive potential of transformed human bronchial epithelial cells by targeting PDCD4

Luo, F., Ji, J., Liu, Y., Xu, Y., Zheng, G., Jing, J., Wang, B., Xu, W., Shi, L., Lü, X., et al. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.11.001 · Cited by 56 · see citing works

The role of IRES trans-acting factors in carcinogenesis

Faye, M. D., & Holčı́k, M. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.09.012 · Cited by 55 · see citing works

Programmed cell death factor 4 (PDCD4), a novel therapy target for metabolic diseases besides cancer

Lu, K., Chen, Q., Li, M., He, L., Riaz, F., Zhang, T., & Li, D. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.06.016 · Cited by 53 · see citing works

PDCD4 inhibits the malignant phenotype of ovarian cancer cells

Wei, Z., Zhang, X., Wang, X., Gao, F., Zhou, C., Zhu, F., Wang, Q., Gao, Q., Ma, C., Sun, W., et al. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01210.x · Cited by 54 · see citing works

Actinopolysporins A–C and Tubercidin as a Pdcd4 Stabilizer from the Halophilic Actinomycete Actinopolyspora erythraea YIM 90600

Zhao, L., Huang, S., Tang, S., Jiang, C., Duan, Y., Beutler, J. A., Henrich, C. J., McMahon, J. B., Schmid, T., Blees, J. S., et al. (2011) · Journal of Natural Products · doi:10.1021/np200603g · Cited by 51 · see citing works

Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65

Hwang, S.-K., Baker, A. R., Young, M. R., & Colburn, N. H. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu008 · Cited by 49 · see citing works

Tumor suppressor genePDCD4negatively regulates autophagy by inhibiting the expression of autophagy-related geneATG5

Song, X., Zhang, X., Wang, X., Zhu, F., Guo, C. H., Wang, Q., Shi, Y., Wang, J., Chen, Y., & Zhang, L. (2013) · Autophagy · doi:10.4161/auto.24069 · Cited by 49 · see citing works

Oncogenic miRNAs and target therapies in colorectal cancer

Saberinia, A., Alinezhad, A., Jafari, F., Soltany, S., & Akhavan‐Sigari, R. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.05.012 · Cited by 49 · see citing works

COX-2 Promotes Migration and Invasion by the Side Population of Cancer Stem Cell-Like Hepatocellular Carcinoma Cells

Guo, Z., Jiang, J., Zhang, J., Yang, H., Yang, F., Qi, Y., Zhong, Y., Su, J. S., Yang, R., Li, L., et al. (2015) · Medicine · doi:10.1097/md.0000000000001806 · Cited by 48 · see citing works

Microarray-Based Cancer Prediction Using Soft Computing Approach

Wang, X., & Gotoh, O. (2009) · Cancer Informatics · doi:10.4137/cin.s2655 · Cited by 47 · see citing works

Programmed cell death 4 (PDCD4) suppresses metastastic potential of human hepatocellular carcinoma cells

Zhang, S., Li, J., Jiang, Y., Xu, Y., & Qin, C. (2009) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-28-71 · Cited by 47 · see citing works

MiR‐155 inhibits proliferation and invasion by directly targeting PDCD 4 in non‐small cell lung cancer

Liu, F., Song, D., Wu, Y., Liu, X., Zhu, J., & Tang, Y. (2017) · Thoracic Cancer · doi:10.1111/1759-7714.12492 · Cited by 47 · see citing works

Programmed cell death 4 protein in esophageal cancer

Rugge (2010) · Oncology Reports · doi:10.3892/or_00000838 · Cited by 45 · see citing works

STAT3 regulates the migration and invasion of a stem-like subpopulation through microRNA-21 and multiple targets in hepatocellular carcinoma

Zhang, N., DUAN, W.-D., Leng, J., Zhou, L., Wang, X., Xu, Y., WANG, X.-D., Zhang, A., & Dong, J. (2015) · Oncology Reports · doi:10.3892/or.2015.3710 · Cited by 44 · see citing works

PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice

Wang, L., Zhao, M., Guo, C. H., Wang, G., Zhu, F., Wang, J., Wang, X., Wang, Q., Zhao, W., Shi, Y., et al. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000729 · Cited by 43 · see citing works

FAT1 is a novel upstream regulator of HIF1α and invasion of high grade glioma

Madan, E., Dikshit, B., Gowda, S. H., Srivastava, C., Sarkar, C., Chattopadhyay, P., Sinha, S., & Chosdol, K. (2016) · International Journal of Cancer · doi:10.1002/ijc.30386 · Cited by 42 · see citing works

PDCD4 suppresses proliferation, migration, and invasion of endometrial cells by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway†

Li, Y., Wang, X., Wang, X., Wan, L., Liu, Y., Shi, Y., Zhang, L., Fang, Z., & Wei, Z. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy052 · Cited by 42 · see citing works

SNPs in miRNAs and Target Sequences: Role in Cancer and Diabetes

Chhichholiya, Y., Suryan, A. K., Suman, P., Munshi, A., & Singh, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.793523 · Cited by 41 · see citing works

Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells

Wang, M., Wang, Y., Zang, W., Wang, H., Chu, H., Li, P., Li, M., Zhang, G., & Zhao, G. (2013) · Tumor Biology · doi:10.1007/s13277-013-1004-8 · Cited by 41 · see citing works

Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression

Saxena, A., Shoeb, M., Ramana, K. V., & Srivastava, S. K. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.05.031 · Cited by 41 · see citing works

Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc

Wang, Q., Zhang, Y., & Yang, H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.07.004 · Cited by 41 · see citing works

Transcriptomic analysis of bottlenose dolphin (Tursiops truncatus) skin biopsies to assess the effects of emerging contaminants

Lunardi, D., Abelli, L., Panti, C., Marsili, L., Fossi, M. C., & Mancia, A. (2016) · Marine Environmental Research · doi:10.1016/j.marenvres.2016.01.002 · Cited by 41 · see citing works

Evaluation of miRNA-196a2 and apoptosis-related target genes: ANXA1, DFFA and PDCD4 expression in gastrointestinal cancer patients: A pilot study

Fawzy, M. S., Toraih, E. A., Ibrahiem, A. T., Abdeldayem, H., Mohamed, A. O., & Abdel‐Daim, M. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187310 · Cited by 41 · see citing works

4‐protein signature predicting tamoxifen treatment outcome in recurrent breast cancer

Marchi, T. D., Liu, N. Q., Stingl, C., Timmermans, M. A. M., Smid, M., Look, M. P., Tjoa, M., Braakman, R. B. H., Opdam, M., Linn, S. C., et al. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.07.004 · Cited by 39 · see citing works

MicroRNA-183 inhibits apoptosis and promotes proliferation and invasion of gastric cancer cells by targeting PDCD4.

Gu, W., Gao, T., Shen, J., Sun, Y., Zheng, X., Ji, W., Ma, J., Hu, X.-Y., Li, J., & Hu, M. (2014) · PubMed Central · Cited by 40 · see citing works

The mechanisms and clinical significance of PDCD4 in colorectal cancer

Long, J., Yin, Y., Guo, H., Li, S., Sun, Y., Zeng, C., & Zhu, W. (2018) · Gene · doi:10.1016/j.gene.2018.09.034 · Cited by 40 · see citing works

Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation

Schmid, T., Bajer, M. M., Blees, J. S., Eifler, L. K., Milke, L., Rübsamen, D., Schulz, K., Weigert, A., Baker, A. R., Colburn, N. H., et al. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr131 · Cited by 39 · see citing works

Programmed cell death 4 enhances chemosensitivity of ovarian cancer cells by activating death receptor pathway in vitro and in vivo

Zhang, X., Wang, X., Song, X., Liu, C., Shi, Y., Wang, Y., Afonja, O., Ma, C., Chen, Y. H., & Zhang, L. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01664.x · Cited by 39 · see citing works

A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: Inhibition of translation elongation

Biyanee, A., Ohnheiser, J., Singh, P., & Klempnauer, K.-H. (2015) · Oncogene · doi:10.1038/onc.2014.83 · Cited by 37 · see citing works

DLX6-AS1 promotes cell proliferation, migration and EMT of gastric cancer through FUS-regulated MAP4K1

Wu, Q., Ma, J., Meng, W., & Hui, P. (2019) · Cancer Biology & Therapy · doi:10.1080/15384047.2019.1647050 · Cited by 37 · see citing works

The inhibitory action of PDCD4 in lipopolysaccharide/D-galactosamine-induced acute liver injury

Wang, X., Zhang, L., Wei, Z., Zhang, X., Gao, Q., Ma, Y., Liu, X., Jiang, Y. Z., Liu, X., Guo, C., et al. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2012.174 · Cited by 36 · see citing works

Abstract 3096: c-Myc regulates MAP4K1 expression and AP-1 activity in Pdcd4 knock-down cells

Yang, H., & Wang, Q. (2010) · Cancer Research · doi:10.1158/1538-7445.am10-3096

Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc

Wang, Q., Zhang, Y., & Yang, H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.07.004 · Cited by 41 · see citing works

Down-regulation of Pdcd4 is sufficient to promote colon tumor cell invasion

Wang, Q., Sun, Z., & Yang, H. (2007) · Cancer Research

Abstract 2244: AKT activation by Pdcd4 knockdown upregulates cyclin D1 expression and promotes cell proliferation

Wang, Q., Guo, X., Li, W., & Yang, H. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-2244 · Cited by 1 · see citing works

Translation Inhibitor Pdcd4 Is Targeted for Degradation during Tumor Promotion

Schmid, T., Jansen, A. P., Baker, A. R., Hegamyer, G., Hagan, J. P., & Colburn, N. H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-1719 · Cited by 151 · see citing works