The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites.
Open accessAbstract
Different 3' coding exons in the rat calcitonin gene are used to generate distinct mRNAs encoding either the hormone calcitonin in thyroidal C-cells or a new neuropeptide referred to as calcitonin gene-related peptide in neuronal tissue, indicating the RNA processing regulation is one strategy used in tissue-specific regulation of gene expression in the brain. Although the two mRNAs use the same transcriptional initiation site and have identical 5' terminal sequences, their 3' termini are distinct. The polyadenylation sites for calcitonin and calcitonin gene-related peptide mRNAs are located at the end of the exons 4 and 6, respectively. Termination of transcription after the calcitonin exon does not dictate the production of calcitonin mRNA, because transcription proceeds through both calcitonin and calcitonin gene-related peptide exons irrespective of which mRNA is ultimately produced. In isolated nuclei, both polyadenylation sites appear to be utilized; however, the proximal (calcitonin) site is preferentially used in nuclei from tissues producing calcitonin mRNA. These data suggest that the mechanism dictating production of each mRNA involves the selective use of alternative polyadenylation sites.
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Citations
Cites
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Rosenfeld, M. G., Mermod, J.-J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W., & Evans, R. M. (1983) · Nature · doi:10.1038/304129a0 · Cited by 2,302
Self-citation
Cited by
Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740
Amara, S. G., Arriza, J. L., Leff, S. E., Swanson, L. W., Evans, R. M., & Rosenfeld, M. G. (1985) · Science · doi:10.1126/science.2994212 · Cited by 610
Self-citationNeuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems
Scholzen, T., Armstrong, C. A., Bunnett, N. W., Luger, T. A., Olerud, J. E., & Ansel, J. C. (1998) · Experimental Dermatology · doi:10.1111/j.1600-0625.1998.tb00307.x · Cited by 391
Connelly, S., & Manley, J. L. (1988) · Genes & Development · doi:10.1101/gad.2.4.440 · Cited by 384
A second human calcitonin/CGRP gene
Steenbergh, P. H., Höppener, J. W. M., Zandberg, J., Lips, C. J. M., & Jansz, H. S. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80820-6 · Cited by 364
Metadata
- Authors
- Amara, S. G., Evans, R. M., & Rosenfeld, M. G.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1984-10
- Volume
- 4
- Issue
- 10
- Pages
- 2151-2160
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1799462851
- Cited by
- 194
- References
- 1
- FWCI
- 10.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Amara, S. G., Evans, R. M., & Rosenfeld, M. G. (1984). Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.4.10.2151
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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