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Ubiquitin is a heat shock protein in chicken embryo fibroblasts.
Open accessAbstract
Clones containing heat-inducible mRNA sequences were selected from a cDNA library prepared from polyadenylated RNA isolated from heat-shocked chicken embryo fibroblasts. One recombinant DNA clone, designated clone 7, hybridized to a 1.2-kilobase RNA that was present in normal cells and increased fivefold during heat shock. Clone 7 also hybridized to an RNA species of 1.7 kilobases that was present exclusively in heat-shocked cells. In vitro translation of mRNA hybrid selected from clone 7 produced a protein product with a molecular weight of approximately 8,000. Increased synthesis of a protein of similar size was detected in chicken embryo fibroblasts after heat shock. DNA sequence analysis of clone 7 indicated its protein product has amino acid sequences identical to bovine ubiquitin. In addition, clone 7 contains tandem copies of the ubiquitin sequences contiguous to each other with no untranslated sequences between them. We discuss some possible roles for ubiquitin in the heat shock response.
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Cited by
Structure of ubiquitin refined at 1.8 Å resolution
Vijay-kumar, S., Bugg, C. E., & Cook, W. J. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90679-6 · Cited by 1,742
Finley, D., Özkaynak, E., & Varshavsky, A. (1987) · Cell · doi:10.1016/0092-8674(87)90711-2 · Cited by 851
James, T. C., & Elgin, S. C. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.11.3862 · Cited by 643
Lowe, J., Blanchard, A., Morrell, K., Lennox, G., Reynolds, L., Billett, M., Landon, M., & Mayer, R. J. (1988) · The Journal of Pathology · doi:10.1002/path.1711550105 · Cited by 539
Ubiquitin-mediated protein degradation.
Hershko, A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37575-1 · Cited by 450
Metadata
- Authors
- Bond, U., & Schlesinger, M. J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1985-05
- Volume
- 5
- Issue
- 5
- Pages
- 949-956
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1869169988
- Cited by
- 399
- References
- 0
- FWCI
- 16.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Bond, U., & Schlesinger, M. J. (1985). Ubiquitin is a heat shock protein in chicken embryo fibroblasts. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.5.5.949
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