The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Characterization of the human p53 gene.
Open accessAbstract
Cosmid and lambda clones containing the human p53 gene were isolated and characterized in detail. The gene is 20 kilobases (kb) long and has 11 exons, the first and second exons being separated by an intron of 10 kb. Restriction fragments upstream of sequences known to be within the first identified exon were tested for promoter activity by cloning them in front of the chloramphenicol acetyltransferase gene and transfecting the resulting constructs into HeLa cells. A 0.35-kb DNA fragment was identified that had promoter activity. Results of primer extension experiments indicated that the mRNA cap site falls within this fragment, as expected. Analysis of the sequence upstream of the presumptive cap site indicated that the human p53 promoter may be of an unusual type.
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Cites
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Ruley, H. E. (1983) · Nature · doi:10.1038/304602a0 · Cited by 1,248
Cited by
p53 isoforms can regulate p53 transcriptional activity
Bourdon, J.-C., Fernandes, K., Murray-Zmijewski, F., Liu, G., Diot, A., Xirodimas, D. P., Saville, M. K., & Lane, D. P. (2005) · Genes & Development · doi:10.1101/gad.1339905 · Cited by 810
Low nucleotide diversity in man.
Li, W. H., & Sadler, L. A. (1991) · Genetics · doi:10.1093/genetics/129.2.513 · Cited by 501
Cytosine methylation determines hot spots of DNA damage in the human P 53 gene
Denissenko, M. F., Chen, J. X., Tang, M.-S., & Pfeifer, G. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3893 · Cited by 339
p53 is frequently mutated in Burkitt's lymphoma cell lines
Farrell, P. J., Allan, G. J., Shanahan, F., Vousden, K. H., & Crook, T. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07837.x · Cited by 254
Structural Aspects of the p53 Protein in Relation to Gene Evolution: A Second Look
Soussi, T., & May, P. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0425 · Cited by 208
Metadata
- Authors
- Lamb, P., & Crawford, L.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1986-05
- Volume
- 6
- Issue
- 5
- Pages
- 1379-1385
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2113954582
- Cited by
- 327
- References
- 2
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Lamb, P., & Crawford, L. (1986). Characterization of the human p53 gene. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.6.5.1379
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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