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Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts.
Open accessAbstract
We used nucleic acid hybridization and cDNA cloning techniques to isolate human sequences that respond to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). These clones were used as probes to examine changes of gene expression that occurred after the proliferation of exponentially growing primary human fibroblasts was arrested. Transcript levels detected by these probes were increased coordinately by treatment of the cells with UV light, mitomycin C, TPA, or the UV light-induced extracellular protein synthesis-inducing factor EPIF (M. Schorpp, U. Mallick, H. J. Rahmsdorf, and P. Herrlich, Cell 37:861-868, 1984). Proteins coded for by these transcripts were characterized by hybrid-promoted translation and by cDNA sequencing. One of the cDNA clones was homologous to the metallothionein IIa gene, and one set of related clones selected RNA for the secreted TPA-inducible protein XHF1 (U. Mallick, H. J. Rahmsdorf, N. Yamamoto, H. Ponta, R.-D. Wegner, and P. Herrlich, Proc. Natl. Acad. Sci. USA 79:7886-7890, 1982).
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Citations
Cited by
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
Angel, P., Hattori, K., Smeal, T., & Karin, M. (1988) · Cell · doi:10.1016/0092-8674(88)90143-2 · Cited by 1,239
Self-citationCyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA
Hoeffler, J. P., Meyer, T. E., Yun, Y., Jameson, J. L., & Habener, J. F. (1988) · Science · doi:10.1126/science.2974179 · Cited by 731
DNA damage-inducible transcripts in mammalian cells.
Fornace, A. J., Alamo, I., & Hollander, M. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.8800 · Cited by 624
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation
Angel, P., & Karin, M. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(91)90011-9 · Cited by 450
Self-citationRapid and Preferential Activation of the c- jun Gene during the Mammalian UV Response
Devary, Y., Gottlieb, R. A., Lau, L. F., & Karin, M. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.5.2804 · Cited by 344
Metadata
- Authors
- Angel, P., Pöting, A., Mallick, U., Rahmsdorf, H. J., Schorpp, M., & Herrlich, P.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1986-05
- Volume
- 6
- Issue
- 5
- Pages
- 1760-1766
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1867843855
- Cited by
- 219
- References
- 0
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Angel, P., Pöting, A., Mallick, U., Rahmsdorf, H. J., Schorpp, M., & Herrlich, P. (1986). Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.6.5.1760
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