The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA
Abstract
Cyclic AMP (cAMP) is an intracellular second messenger that activates transcription of many cellular genes. A palindromic consensus DNA sequence, TGACGTCA, functions as a cAMP-responsive transcriptional enhancer (CRE). The CRE binds a cellular protein of 38 kD in placental JEG-3 cells. A placental λgt11 library was screened for expression of specific CRE-binding proteins with the CRE sequence as a radioactive probe. A cDNA encoding a protein of 326 amino acids with the binding properties of a specific CRE-binding protein (CREB) was isolated. The protein contains a COOH-terminal basic region adjacent to a sequence similar to the "leucine zipper" sequence believed to be involved in DNA binding and in protein-protein contacts in several other DNA-associated transcriptional proteins including the products of the c- myc , c- fos , and c- jun oncogenes and GCN4. The CREB protein also contains an NH2-terminal acidic region proposed to be a potential transcriptional activation domain. The putative DNA-binding domain of CREB is structurally similar to the corresponding domains in the phorbol ester-responsive c- jun protein and the yeast transcription factor GCN4.
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Metadata
- Authors
- Hoeffler, J. P., Meyer, T. E., Yun, Y., Jameson, J. L., & Habener, J. F.
- Venue
- Science
- Published
- 1988-12-09
- Volume
- 242
- Issue
- 4884
- Pages
- 1430-1433
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000024512
- Cited by
- 731
- References
- 34
- FWCI
- 25.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hoeffler, J. P., Meyer, T. E., Yun, Y., Jameson, J. L., & Habener, J. F. (1988). Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA. Science. https://doi.org/10.1126/science.2974179
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