The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
The GLI-Kruppel family of human genes.
Open accessAbstract
Previous characterization of GLI, a gene found to be amplified and expressed in a subset of human brain tumors, revealed the presence of five tandem zinc fingers related to those of Krüppel (Kr), a Drosophila segmentation gene of the gap class. We have used the GLI cDNA as a molecular probe to isolate related sequences from the human genome. Partial characterization of six related loci, including sequence determination, expression studies, and chromosome localization, revealed that each locus could encode a separate finger protein. The predicted proteins all had similar H-C links, i.e., a conserved stretch of 9 amino acids connecting the C-terminal histidine of one finger to the N-terminal cysteine of the next. On the basis of amino acid sequence and intron-exon organization, the genes could be placed into one of two subgroups: the GLI subgroup (with the consensus finger amino acid sequence [Y/F]XCX3GCX3[F/Y]X5LX2HX3-4H[T/S]GEKP) or the Kr subgroup (with the consensus finger amino acid sequence [Y/F]XCX2CX3FX5LX2HXRXHTGEKP). Unlike GLI or Kr, most of the newly isolated genes were expressed in many adult tissues. The predicted proteins probably control the expression of other genes and, by analogy with Kr and GLI, may be important in human development, tissue-specific differentiation, or neoplasia.
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Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
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Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3
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Metadata
- Authors
- Ruppert, J. M., Kinzler, K. W., Wong, A. J., Bigner, S. H., Kao, F. T., Law, M. L., Seuanez, H. N., O'Brien, S. J., & Vogelstein, B.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1988-08
- Volume
- 8
- Issue
- 8
- Pages
- 3104-3113
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2149031125
- Cited by
- 299
- References
- 55
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Ruppert, J. M., Kinzler, K. W., Wong, A. J., Bigner, S. H., Kao, F. T., Law, M. L., Seuanez, H. N., O'Brien, S. J., & Vogelstein, B. (1988). The GLI-Kruppel family of human genes. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.8.8.3104
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