The role and function of Fcγ receptors on myeloid cells

Exploring the full spectrum of macrophage activation

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Neutrophils and immunity: challenges and opportunities

Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971 · see citing works

Fcγ receptors as regulators of immune responses

Nimmerjahn, F., & Ravetch, J. V. (2008) · Nature Reviews Immunology · doi:10.1038/nri2206 · Cited by 2,947 · see citing works

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

Clynes, R. A., Towers, T. L., Presta, L. G., & Ravetch, J. V. (2000) · Nature Medicine · doi:10.1038/74704 · Cited by 2,768 · see citing works

The immune system in atherosclerosis

Hansson, G. K., & Hermansson, A. (2011) · Nature Immunology · doi:10.1038/ni.2001 · Cited by 2,331 · see citing works

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene

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Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity

Shields, R. L., Lai, J., Keck, R., O'Connell, L. Y., Hong, K., Meng, Y. G., Weikert, S. H. A., & Presta, L. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202069200 · Cited by 1,835 · see citing works

Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

Kaneko, Y., Nimmerjahn, F., & Ravetch, J. V. (2006) · Science · doi:10.1126/science.1129594 · Cited by 1,754 · see citing works

IgG Fc Receptors

Ravetch, J. V., & Bolland, S. M. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.275 · Cited by 1,653 · see citing works

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing

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Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease Severity

Vaughn, D. W., Green, S., Kalayanarooj, S., Innis, B. L., Nimmannitya, S., Suntayakorn, S., Endy, T. P., Raengsakulrach, B., Rothman, A. L., Ennis, F. A., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315215 · Cited by 1,633 · see citing works

Beyond oxidative stress: an immunologist's guide to reactive oxygen species

Nathan, C., & Cunningham-Bussel, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3423 · Cited by 1,619 · see citing works

Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions

Goede, V., Fischer, K., Busch, R. M., Engelke, A., Eichhorst, B. F., Wendtner, C., Chagorova, T., de la Serna, J., Dilhuydy, M., Illmer, T., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1313984 · Cited by 1,522 · see citing works

The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity

Shinkawa, T., Nakamura, K., Yamane, N., Shoji-Hosaka, E., Kanda, Y., Sakurada, M., Uchida, K., Anazawa, H., Satoh, M., Yamasaki, M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210665200 · Cited by 1,413 · see citing works

Two Immunoglobulin G Fragment C Receptor Polymorphisms Independently Predict Response to Rituximab in Patients With Follicular Lymphoma

Weng, W., & Levy, R. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.05.013 · Cited by 1,300 · see citing works

High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

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Fcγ Receptors: Old Friends and New Family Members

Nimmerjahn, F., & Ravetch, J. V. (2006) · Immunity · doi:10.1016/j.immuni.2005.11.010 · Cited by 1,072 · see citing works

Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding

Nimmerjahn, F., & Ravetch, J. V. (2005) · Science · doi:10.1126/science.1118948 · Cited by 1,040 · see citing works

Identification and characterization of a novel monocyte subpopulation in human peripheral blood

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FcR γ chain deletion results in pleiotrophic effector cell defects

Takai, T., Li, M., Sylvestre, D. L., Clynes, R., & Ravetch, J. V. (1994) · Cell · doi:10.1016/0092-8674(94)90115-5 · Cited by 951 · see citing works

Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

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Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc

Anthony, R. M., Nimmerjahn, F., Ashline, D. J., Reinhold, V. N., Paulson, J. C., & Ravetch, J. V. (2008) · Science · doi:10.1126/science.1154315 · Cited by 849 · see citing works

Augmented humoral and anaphylactic responses in FcγRII-deficient mice

Takai, T., Ono, M., Hikida, M., Ohmori, H., & Ravetch, J. V. (1996) · Nature · doi:10.1038/379346a0 · Cited by 826 · see citing works

Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody

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Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

Ono, M., Bolland, S. M., Tempst, P., & Ravetch, J. V. (1996) · Nature · doi:10.1038/383263a0 · Cited by 781 · see citing works

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose

Ferrara, C., Grau, S., Jäger, C., Sondermann, P., Brünker, P., Waldhauer, I., Hennig, M., Ruf, A., Rufer, A. C., Stihle, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108455108 · Cited by 770 · see citing works

Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis

Bolland, S. M., & Ravetch, J. V. (2000) · Immunity · doi:10.1016/s1074-7613(00)00027-3 · Cited by 753 · see citing works

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

DiLillo, D. J., Tan, G. S., Palese, P., & Ravetch, J. V. (2014) · Nature Medicine · doi:10.1038/nm.3443 · Cited by 749 · see citing works

The phagocytes: neutrophils and monocytes

Dale, D. C., Boxer, L. A., & Liles, W. C. (2008) · Blood · doi:10.1182/blood-2007-12-077917 · Cited by 740 · see citing works

The 3.2-Å crystal structure of the human IgG1 Fc fragment–FcγRIII complex

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Macrophage heterogeneity in tissues: phenotypic diversity and functions

Gordon, S., Plüddemann, A., & Martínez, F. O. (2014) · Immunological Reviews · doi:10.1111/imr.12223 · Cited by 713 · see citing works

Origins of Dengue Type 2 Viruses Associated with Increased Pathogenicity in the Americas

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Structural Analysis of Human IgG-Fc Glycoforms Reveals a Correlation Between Glycosylation and Structural Integrity

Krapp, S., Mimura, Y., Jefferis, R., Huber, R., & Sondermann, P. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)01250-0 · Cited by 674 · see citing works

The function of Fcγ receptors in dendritic cells and macrophages

Guilliams, M., Bruhns, P., Saeys, Y., Hammad, H., & Lambrecht, B. N. (2014) · Nature reviews. Immunology · doi:10.1038/nri3582 · Cited by 636 · see citing works

The Innate Mononuclear Phagocyte Network Depletes B Lymphocytes through Fc Receptor–dependent Mechanisms during Anti-CD20 Antibody Immunotherapy

Uchida, J., Hamaguchi, Y., Oliver, J. A., Ravetch, J. V., Poe, J. C., Haas, K. M., & Tedder, T. F. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040119 · Cited by 636 · see citing works

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

Anthony, R. M., Kobayashi, T., Wermeling, F., & Ravetch, J. (2011) · Nature · doi:10.1038/nature10134 · Cited by 625 · see citing works

Dengue Virus Structural Differences That Correlate with Pathogenesis

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The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity

Beltramello, M., Williams, K. L., Simmons, C. P., Macagno, A., Simonelli, L., Quyen, N. T. H., Sukupolvi-Petty, S., Navarro-Sánchez, E., Young, P. R., de Silva, A. M., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.08.007 · Cited by 583 · see citing works

A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling

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Evidence That Maternal Dengue Antibodies Are Important in the Development of Dengue Hemorrhagic Fever in Infants

Kliks, S. C., Nimmanitya, S., Nisalak, A., & Burke, D. S. (1988) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1988.38.411 · Cited by 577 · see citing works

Identification of a receptor required for the anti-inflammatory activity of IVIG

Anthony, R. M., Wermeling, F., Karlsson, M. C. I., & Ravetch, J. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810163105 · Cited by 544 · see citing works

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

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Type I and type II Fc receptors regulate innate and adaptive immunity

Pincetic, A., Bournazos, S., DiLillo, D. J., Maamary, J., Wang, T. T., Dahan, R., Fiebiger, B. M., & Ravetch, J. V. (2014) · Nature Immunology · doi:10.1038/ni.2939 · Cited by 504 · see citing works

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

Eiseman, & Bolen, J. B. (1992) · Nature · doi:10.1038/355078a0 · Cited by 493 · see citing works

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

Bournazos, S., Klein, F., Pietzsch, J., Seaman, M. S., Nussenzweig, M. C., & Ravetch, J. V. (2014) · Cell · doi:10.1016/j.cell.2014.08.023 · Cited by 493 · see citing works

Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling

Ono, M., Okada, H., Bolland, S. M., Yanagi, S., Kurosaki, T., & Ravetch, J. V. (1997) · Cell · doi:10.1016/s0092-8674(00)80337-2 · Cited by 488 · see citing works

Cytoplasmic Domain Heterogeneity and Functions of IgG Fc Receptors in B Lymphocytes

Amigorena, S., Bonnerot, C., Drake, J. R., Choquet, D., Hunziker, W., Guillet, J., Webster, P. C., Sautès‐Fridman, C., Mellman, I., & Fridman, W. H. (1992) · Science · doi:10.1126/science.1535455 · Cited by 455 · see citing works

The Fc receptor γ‐chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

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Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide.

Nathan, C., Brukner, L. H., Silverstein, S. C., & Cohn, Z. A. (1979) · The Journal of Experimental Medicine · doi:10.1084/jem.149.1.84 · Cited by 421 · see citing works

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

DiLillo, D. J., Palese, P., Wilson, P. C., & Ravetch, J. V. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84428 · Cited by 409 · see citing works

Cell Surface Recycling of Internalized Antigen Permits Dendritic Cell Priming of B Cells

Bergtold, A., Desai, D. D., Gavhane, A., & Clynes, R. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.013 · Cited by 401 · see citing works

Modulation of Immune Complex–induced Inflammation In Vivo by the Coordinate Expression of Activation and Inhibitory Fc Receptors

Clynes, R., Maizes, J. S., Guinamard, R., Ono, M., Takai, T., & Ravetch, J. V. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.179 · Cited by 387 · see citing works

Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions

Boruchov, A. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24772 · Cited by 378 · see citing works

Genetic variation in Toll-like receptors and disease susceptibility

Netea, M. G., Wijmenga, C., & O'Neill, L. A. J. (2012) · Nature Immunology · doi:10.1038/ni.2284 · Cited by 375 · see citing works

Inducing Tumor Immunity through the Selective Engagement of Activating Fcγ Receptors on Dendritic Cells

Kalergis, A. M., & Ravetch, J. V. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020338 · Cited by 370 · see citing works

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

Mócsai, A., Abram, C. L., Jakus, Z., Hu, Y., Lanier, L. L., & Lowell, C. A. (2006) · Nature Immunology · doi:10.1038/ni1407 · Cited by 369 · see citing works

Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation.

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The Human Antibacterial Cathelicidin, hCAP-18, Is Synthesized in Myelocytes and Metamyelocytes and Localized to Specific Granules in Neutrophils

Sørensen, O. E., Arnljots, K., Cowland, J. B., Bainton, D. F., & Borregaard, N. (1997) · Blood · doi:10.1182/blood.v90.7.2796 · Cited by 364 · see citing works

The Structure of a Human Type III Fcγ Receptor in Complex with Fc*

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Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor.

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Selective Suppression of Interleukin-12 Induction after Macrophage Receptor Ligation

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Enhanced clearance of HIV-1–infected cells by broadly neutralizing antibodies against HIV-1 in vivo

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hCAP‐18, a cathelin/pro‐bactenecin‐like protein of human neutrophil specific granules

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Two species of human Fcε receptor II ( ): Tissue-specific and IL-4-specific regulation of gene expression

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Dynamics of Dengue Disease Severity Determined by the Interplay Between Viral Genetics and Serotype-Specific Immunity

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The coordination of signaling during Fc receptor-mediated phagocytosis

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Deletion of Fcγ Receptor IIB Renders H-2b Mice Susceptible to Collagen-induced Arthritis

Yuasa, T., Kubo, S., Yoshino, T., Ujike, A., Matsumura, K., Ono, M., Ravetch, J. V., & Takai, T. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.1.187 · Cited by 325 · see citing works

CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation.

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Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

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THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS

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SEROTYPE-SPECIFIC DIFFERENCES IN CLINICAL MANIFESTATIONS OF DENGUE

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Mouse model recapitulating human Fcγ receptor structural and functional diversity

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Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.

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Organization of the Human and Mouse Low-affinity FcγR Genes: Duplication and Recombination

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Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ‐chain

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Fc Optimization of Therapeutic Antibodies Enhances Their Ability to Kill Tumor Cells In vitro and Controls Tumor Expansion In vivo via Low-Affinity Activating Fcγ Receptors

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Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function.

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Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes

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Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect

DiLillo, D. J., & Ravetch, J. V. (2015) · Cell · doi:10.1016/j.cell.2015.04.016 · Cited by 262 · see citing works

Fc receptor isoforms exhibit distinct abilities for coated pit localization as a result of cytoplasmic domain heterogeneity

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Genetic Modifiers of Systemic Lupus Erythematosus in FcγRIIB−/− Mice

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Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity

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Cytotoxic antibodies trigger inflammation through Fc receptors

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Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells

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HLA‐A and ‐B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais

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Family of disulphide-linked dimers containing the ζ and η chains of the T-cell receptor and the γ chain of Fc receptors

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Impaired inhibitory Fcγ receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy

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Global Pattern of CD8+ T-Cell Infiltration and Exhaustion in Colorectal Cancer Predicts Cancer Immunotherapy Response

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Correlation of the Evolution of Immunity and Inflammation in Vertebrates

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Noninvasive In Vivo Imaging of T-Cells during Cancer Immunotherapy Using Rare-Earth Nanoparticles

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Immunization with Brugia malayi Calreticulin Protein Generates Robust Antiparasitic Immunity and Offers Protection during Experimental Lymphatic Filariasis

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A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machineryPreprint

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SOCS1‐KIR Peptide in PEGDA Hydrogels Reduces Pro‐Inflammatory Macrophage Activation

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The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia

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Immunoglobulin G2 Antibody as a Potential Target for COVID-19 Vaccine

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Bone Marrow Monocytes and Derived Dendritic Cells from Myelodysplastic Patients Have Functional Abnormalities Associated with Defective Response to Bacterial Infection

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A Unique Immune-Related Gene Signature Represents Advanced Liver Fibrosis and Reveals Potential Therapeutic Targets

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Comparative Analysis of In Vitro Models to Study Antibody-Dependent Enhancement of Zika Virus Infection

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Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems

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Comparison of genetic and epigenetic profiles of periodontitis according to the presence of type 2 diabetes

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A VLP-Based Vaccine Displaying HBHA and MTP Antigens of Mycobacterium tuberculosis Induces Potentially Protective Immune Responses in M. tuberculosis H37Ra Infected Mice

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Fc receptors and the diversity of antibody responses to HIV infection and vaccination

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Opsonization but not pretreatment of equine macrophages with hyperimmune plasma nonspecifically enhances phagocytosis and intracellular killing of Rhodococcus equi

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A bispecific anti-MUC16/anti-death receptor 5 antibody achieves effective and tumor-selective death receptor 5-mediated tumor regression

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An integrative network analysis framework for identifying molecular functions in complex disorders examining major depressive disorder as a test case

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A multifaceted high-throughput assay for probing antigen-specific antibody-mediated primary monocyte phagocytosis and downstream functions

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Pathogenesis of Lupus Nephritis

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Elderly individuals exhibit dysregulated monocyte responses to viral immune complexes compared to adults and children

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Decoding functional and developmental trajectories of tissue-resident uterine dendritic cells through integrative omics

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Are Changes in Serum IgG Glycosylation Related to the Severe Course of SARS-CoV-2 Infection and Recovery Process? In Search of New Diagnostic and Prognostic Biomarkers

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Functional Characterization of Largemouth Bass (Micropterus salmoides) Soluble FcγR Homolog in Response to Bacterial Infection

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NOD2 activation enhances macrophage Fcγ receptor function and may increase the efficacy of antibody therapy

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NK Cytotoxicity Mediated by NK-92 Cell Lines Expressing Combinations of Two Allelic Variants for FCGR3

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Development and validation of a potency assay matrix for optimized and consistent manufacture of clinical mesenchymal stem/stromal cells

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Beyond ADCs: harnessing bispecific antibodies to directly induce apoptosis for targeted tumor eradication

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Development and Validation of a Cell-Based Binding Neutralizing Antibody Assay for an Antibody–Drug Conjugate

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FcγRIIB (CD32B) antibodies enhance immune responses through activating FcγRs

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Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2

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Deciphering Fc-mediated Antiviral Antibody Functions in Animal Models

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Identification of M2 macrophage markers for predicting outcome and therapeutic response in osteosarcoma: Integrated analysis of single-cell and bulk RNA-sequencing

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Signaling by Antibodies: Recent Progress

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