Neutrophils and immunity: challenges and opportunities

Inflammation and cancer

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Superoxide Dismutase

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The Danger Model: A Renewed Sense of Self

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Tissue Destruction by Neutrophils

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Tissue Destruction by Neutrophils

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NOX enzymes and the biology of reactive oxygen

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Points of control in inflammation

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Myeloperoxidase: friend and foe

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Decoding the Patterns of Self and Nonself by the Innate Immune System

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Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

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Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

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Mammalian defensins in the antimicrobial immune response

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Neutrophil granules and secretory vesicles in inflammation

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Killing activity of neutrophils is mediated through activation of proteases by K+ flux

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Neutrophils: Molecules, Functions and Pathophysiological Aspects

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Progressive Multifocal Leukoencephalopathy Complicating Treatment with Natalizumab and Interferon Beta-1a for Multiple Sclerosis

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Progressive Multifocal Leukoencephalopathy in a Patient Treated with Natalizumab

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Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17

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Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

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Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.

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Cytokines in context.

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Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

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Murine interleukin-4 displays potent anti-tumor activity in vivo

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<i>Staphylococcus aureus</i> golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity

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Redox Redux: Revisiting PTPs and the Control of Cell Signaling

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HIF-1α expression regulates the bactericidal capacity of phagocytes

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Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins.

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Treatment of Ulcerative Colitis with a Humanized Antibody to the α 4 β 7 Integrin

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The neutrophil: Function and clinical disorders

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Conversion of Proepithelin to Epithelins

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Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

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Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties.

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Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.

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Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase

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Progranulin is a mediator of the wound response

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Wound Healing in the PU.1 Null Mouse—Tissue Repair Is Not Dependent on Inflammatory Cells

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Calprotectin – a pleiotropic molecule in acute and chronic inflammation.

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Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling

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Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes.

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G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood

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Three Different Neutrophil Subsets Exhibited in Mice with Different Susceptibilities to Infection by Methicillin-Resistant Staphylococcus aureus

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Syk is required for integrin signaling in neutrophils

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Secretory Leukocyte Protease Inhibitor: A Macrophage Product Induced by and Antagonistic to Bacterial Lipopolysaccharide

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Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN

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Immunodeficiency Diseases Caused by Defects in Phagocytes

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Type 1 Interferon (IFNα/β) and Type 2 Nitric Oxide Synthase Regulate the Innate Immune Response to a Protozoan Parasite

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Oxidative killing of microbes by neutrophils

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Cross-Talk in the Innate Immune System: Neutrophils Instruct Recruitment and Activation of Dendritic Cells during Microbial Infection

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Progressive Multifocal Leukoencephalopathy and Natalizumab — Unforeseen Consequences

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Respiratory burst in adherent human neutrophils: triggering by colony- stimulating factors CSF-GM and CSF-G

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Identification of Human Neutrophil-derived Cathepsin G and Azurocidin/CAP37 as Chemoattractants for Mononuclear Cells and Neutrophils

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Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice.

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Neutrophil-Mediated Maturation of Chemerin: A Link between Innate and Adaptive Immunity

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Adhesion-Dependent Degranulation of Neutrophils Requires the Src Family Kinases Fgr and Hck

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Vav GEFs are required for β2 integrin-dependent functions of neutrophils

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Neutrophil function in the healing wound: adding insult to injury?

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Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties.

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Inflammatory arthritis requires Foxo3a to prevent Fas ligand–induced neutrophil apoptosis

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Inflammation-associated Cell Cycle–independent Block of Apoptosis by Survivin in Terminally Differentiated Neutrophils

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Respiratory burst in adherent human neutrophils: triggering by colony- stimulating factors CSF-GM and CSF-G

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Inborn errors of immunity to infection

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Novel ? ? 3-derived local mediators in anti-inflammation and resolution

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Granulocyte clearance by apoptosis in the resolution ofinflammation

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Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosolic free Ca2+.

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Regression of an established tumor genetically modified to release granulocyte colony-stimulating factor requires granulocyte-T cell cooperation and T cell-produced interferon gamma.

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Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: implications for inflammatory diseases

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CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity.

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Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor.

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Human neutrophils produce interferon gamma upon stimulation by interleukin-12

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Albumin inhibits neutrophil spreading and hydrogen peroxide release by blocking the shedding of CD43 (sialophorin, leukosialin)

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Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen

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Purification of a cellular (granulocyte) and an extracellular (serum) phospholipase A2 that participate in the destruction of Escherichia coli in a rabbit inflammatory exudate.

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Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF

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A critical concentration of neutrophils is required for effective bacterial killing in suspension

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The Acquired Immune System

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Fatal (chronic) granulomatous disease of childhood: a hereditary defect of leukocyte function.

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Beta 2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor.

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LAD-III, a novel group of leukocyte integrin activation deficiencies

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MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial

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A Novel, Potent Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase

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Actin dynamics in human neutrophils during adhesion and phagocytosis is controlled by changes in intracellular free calcium.

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Hematologically Important Mutations: Leukocyte Adhesion Deficiency

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The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophils

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Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia

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Serine Protease Cathepsin G Regulates Adhesion-Dependent Neutrophil Effector Functions by Modulating Integrin Clustering

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mRNA expression profiles for Escherichia coli ingested by normal and phagocyte oxidase-deficient human neutrophils

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Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils

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Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma

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