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Viral Quasispecies Evolution
Open accessAbstract
SUMMARY: Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant spectra or mutant clouds termed viral quasispecies. Here we review the origin of the quasispecies concept and some biological implications of quasispecies dynamics. Two main aspects are addressed: (i) mutant clouds as reservoirs of phenotypic variants for virus adaptability and (ii) the internal interactions that are established within mutant spectra that render a virus ensemble the unit of selection. The understanding of viruses as quasispecies has led to new antiviral designs, such as lethal mutagenesis, whose aim is to drive viruses toward low fitness values with limited chances of fitness recovery. The impact of quasispecies for three salient human pathogens, human immunodeficiency virus and the hepatitis B and C viruses, is reviewed, with emphasis on antiviral treatment strategies. Finally, extensions of quasispecies to nonviral systems are briefly mentioned to emphasize the broad applicability of quasispecies theory.
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“although most will be detrimental or confer no advantage to the virus, some will be advantageous and be the subject of rapid natural selection (Domingo et al., 2012; Rambaut et al., 2020).”
From Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum (2021) · cites this paper as Domingo et al., 2012
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“We did not directly address the fitness of the mutants generated in this study, and any studies of the fitness of the VSVSARS-CoV-2 variants would pertain to their relative replicative fitness measured in cell culture (Domingo et al., 2012).”
BackgroundReduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum
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Metadata
- Authors
- Domingo, E., Sheldon, J., & Perales, C.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2012-06
- Volume
- 76
- Issue
- 2
- Pages
- 159-216
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- PMC
- PMC3372249
- OpenAlex
- W2073918065
- Cited by
- 1,009
- References
- 888
- Citations by year
- 2026: 51 · 2025: 38 · 2024: 56 · 2023: 55 · 2022: 58 · 2021: 130 · 2020: 104 · 2019: 96 · 2018: 76 · 2017: 76 · 2016: 77 · 2015: 75 · 2014: 63 · 2013: 38 · 2012: 15
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microbiology and Molecular Biology Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Mathematics › Applied Mathematics › Mathematical and Theoretical Epidemiology and Ecology Models
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- viral quasispecies, RNA viruses, units of selection, lethal mutagenesis, antiviral strategies, HIV, hepatitis B virus, hepatitis C virus
- MeSH terms
- Hepatitis B virus, HIV, Humans, RNA Viruses, Selection, Genetic, Virus Diseases, Genome, Viral, Evolution, Molecular
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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