Cited by 1,009Evolution and Genetic DynamicsMathematical and Theoretical Epidemiology and Ecology ModelsRNA and protein synthesis mechanisms

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Viral Quasispecies Evolution

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Domingo, Esteban, Sheldon, Julie, Perales, Celia·2012·Microbiology and Molecular Biology Reviews

DOI 10.1128/mmbr.05023-11PMC PMC3372249

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Abstract

SUMMARY: Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant spectra or mutant clouds termed viral quasispecies. Here we review the origin of the quasispecies concept and some biological implications of quasispecies dynamics. Two main aspects are addressed: (i) mutant clouds as reservoirs of phenotypic variants for virus adaptability and (ii) the internal interactions that are established within mutant spectra that render a virus ensemble the unit of selection. The understanding of viruses as quasispecies has led to new antiviral designs, such as lethal mutagenesis, whose aim is to drive viruses toward low fitness values with limited chances of fitness recovery. The impact of quasispecies for three salient human pathogens, human immunodeficiency virus and the hepatitis B and C viruses, is reviewed, with emphasis on antiviral treatment strategies. Finally, extensions of quasispecies to nonviral systems are briefly mentioned to emphasize the broad applicability of quasispecies theory.

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Mutagenesis-Induced, Large Fitness Variations with an Invariant Arenavirus Consensus Genomic Nucleotide Sequence
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Self-citation
Tracking the Evolution of MultipleIn VitroHepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing
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Competition-colonization dynamics in an RNA virus
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Self-citation
Error-threshold exists in fitness landscapes with lethal mutants.
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Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase
Ferrer‐Orta, C., Agudo, R., Domingo, E., & Verdaguer, N. (2009) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2009.10.016 · Cited by 66
Self-citation
Reproducible Nonlinear Population Dynamics and Critical Points During Replicative Competitions of RNA Virus Quasispecies
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Self-citation
Many-trillionfold amplification of single RNA virus particles fails to overcome the Muller's ratchet effect
Duarte, E. A., Clarke, D. K., Moyá, A., Elena, S. F., Domingo, E., & Holland, J. J. (1993) · Journal of Virology · doi:10.1128/jvi.67.6.3620-3623.1993 · Cited by 65
Self-citation

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3 of the 888 references couldn’t be matched to a known paper.

Research works printed but not linked: 29

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“We did not directly address the fitness of the mutants generated in this study, and any studies of the fitness of the VSVSARS-CoV-2 variants would pertain to their relative replicative fitness measured in cell culture (Domingo et al., 2012).”
Background
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See all 1,009

Authors: Domingo, E., Sheldon, J., & Perales, C.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
ORCID: Domingo, Esteban
Sheldon, Julie
Perales, Celia
Venue: Microbiology and Molecular Biology Reviews
Publisher: American Society for Microbiology
Published: 2012-06
Volume: 76
Issue: 2
Pages: 159-216
ISSN: 1092-2172 (ISSN-L)
1098-5557
DOI: 10.1128/mmbr.05023-11
PMC: PMC3372249
OpenAlex: W2073918065
Cited by: 1,009
References: 888
Citations by year: 2026: 51 · 2025: 38 · 2024: 56 · 2023: 55 · 2022: 58 · 2021: 130 · 2020: 104 · 2019: 96 · 2018: 76 · 2017: 76 · 2016: 77 · 2015: 75 · 2014: 63 · 2013: 38 · 2012: 15
FWCI: 7.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Microbiology and Molecular Biology Reviews (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Physical Sciences › Mathematics › Applied Mathematics › Mathematical and Theoretical Epidemiology and Ecology Models
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: viral quasispecies, RNA viruses, units of selection, lethal mutagenesis, antiviral strategies, HIV, hepatitis B virus, hepatitis C virus
MeSH terms: Hepatitis B virus, HIV, Humans, RNA Viruses, Selection, Genetic, Virus Diseases, Genome, Viral, Evolution, Molecular

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Viral Quasispecies Evolution

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