The DOI matches its Crossref record; 110 of the 145 references it cites were found in a registry or an index.
Cellulose biosynthesis and function in bacteria
Open accessAbstract
The current model of cellulose biogenesis in plants, as well as bacteria, holds that the membranous cellulose synthase complex polymerizes glucose moieties from UDP-Glc into beta-1,4-glucan chains which give rise to rigid crystalline fibrils upon extrusion at the outer surface of the cell. The distinct arrangement and degree of association of the polymerizing enzyme units presumably govern extracellular chain assembly in addition to the pattern and width of cellulose fibril deposition. Most evident for Acetobacter xylinum, polymerization and assembly appear to be tightly coupled. To date, only bacteria have been effectively studied at the biochemical and genetic levels. In A. xylinum, the cellulose synthase, composed of at least two structurally similar but functionally distinct subunits, is subject to a multicomponent regulatory system. Regulation is based on the novel nucleotide cyclic diguanylic acid, a positive allosteric effector, and the regulatory enzymes maintaining its intracellular turnover: diguanylate cyclase and Ca2(+)-sensitive bis-(3',5')-cyclic diguanylic acid (c-di-GMP) phosphodiesterase. Four genes have been isolated from A. xylinum which constitute the operon for cellulose synthesis. The second gene encodes the catalytic subunit of cellulose synthase; the functions of the other three gene products are still unknown. Exclusively an extracellular product, bacterial cellulose appears to fulfill diverse biological roles within the natural habitat, conferring mechanical, chemical, and physiological protection in A. xylinum and Sarcina ventriculi or facilitating cell adhesion during symbiotic or infectious interactions in Rhizobium and Agrobacterium species. A. xylinum is proving to be most amenable for industrial purposes, allowing the unique features of bacterial cellulose to be exploited for novel product applications.
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“Bacterial cellulose (BC), produced by acetic acid bacteria Gluconobacter xylinum, is obtainable in a pure form which requires no intensive processing to remove undesirable impurities and contaminants such as lignin, pectin and hemicellulose.75,76”
From Sustainable hybrid photocatalysts: titania immobilized on carbon materials derived from renewable and biodegradable resources (2016) · cites this paper as [76]
Citations
Cites
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“xylinum does not engage in glycogen production (73), which in bacteria typically requires ADP-Glc (103).”
BackgroundInfluentialRegulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid
Ross, P., Weinhouse, H., Aloni, Y., Michaeli, D., Weinberger-Ohana, P., Mayer, R., Braun, S., de VROOM, E., van der Marel, G. A., BOOM, J. H. V., et al. (1987) · Nature · doi:10.1038/325279a0 · Cited by 1,018 · cited 6×
“1, Cellulose synthase (2, 115); 2, glucose oxidase (60); 3, glucose permease; 4, gluconate permease (19); 5, UDPG-pyrophosphorylase (UTP) (143); 6, glucokinase (ATP) (19); 7, gluconokinase (ATP); 8, phosphogluco-”
BackgroundInfluentialSelf-citationDetermination of the Pore Size of Cell Walls of Living Plant Cells
Carpita, N. C., Sabularse, D. C., Montezinos, D., & Delmer, D. P. (1979) · Science · doi:10.1126/science.205.4411.1144 · Cited by 847 · cited 1×
“The plant cell wall is a semipermeable composite tissue of high species variability (34) and is compounded from layered deposits of cellulose fibrils in which are embedded more amorphous polymers, including neutral and acidic polysaccharides, glycoproteins, and waxy aromatic substances (40).”
BackgroundThe physical biology of plant cell walls
Green, P. B., & Preston, R. (1975) · Kew Bulletin · doi:10.2307/4109018 · Cited by 521 · cited 1×
“Both the width of microfibrils and the parallel glucan chain arrangement within them may be accounted for by current models of cellulose biogenesis (101, 105, 112, 130) in which the sites of glucose polymerization are situated in clusters according to two basic degrees of organization.”
BackgroundThe role of polyprenol-linked sugars in glycoprotein synthesis.
Waechter, C. J., & Lennarz, W. (1976) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.45.070176.000523 · Cited by 496
Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography.
Bochner, B., & Ames, B. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34138-3 · Cited by 476 · cited 1×
“On the basis of PDE-A and cellulose synthase reaction data (Table 1), these molecules would not be expected to be functionally distinct from c-di-GMP, and it is not clear whether they would be formed within the cell, considering the much higher concentration of GTP than dGTP (25).”
BackgroundBrown, R. H., Willison, J., & Richardson, C. (1976) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.73.12.4565 · Cited by 456 · cited 4×
“This is in contradiction to previously proposed models in which intramembranous particles that were revealed by freeze-etching of the cell envelope were taken to indicate that cellulose synthase is located in the outer membrane (28, 38).”
BackgroundResultInfluentialMueller, S., & Brown, R. M. (1980) · Journal of Cell Biology · doi:10.1083/jcb.84.2.315 · Cited by 399 · cited 1×
“Both the width of microfibrils and the parallel glucan chain arrangement within them may be accounted for by current models of cellulose biogenesis (101, 105, 112, 130) in which the sites of glucose polymerization are situated in clusters according to two basic degrees of organization.”
BackgroundBacterial glycogen synthesis and its regulation.
Preiss, J. (1984) · Annual Review of Microbiology · doi:10.1146/annurev.mi.38.100184.002223 · Cited by 397 · cited 1×
“xylinum does not engage in glycogen production (73), which in bacteria typically requires ADP-Glc (103).”
BackgroundSchramm, M., & Hestrin, S. (1954) · Journal of General Microbiology · doi:10.1099/00221287-11-1-123 · Cited by 386 · cited 4×
“Such Celmutants may be isolated and may prove to be stable and nonreverting over the course of years of cultivation (123).”
BackgroundInfluential
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Svensson, A., Nicklasson, E., Harrah, T., Panilaitis, B., Kaplan, D. L., Brittberg, M., & Gatenholm, P. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.02.049 · Cited by 1,027
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Novel domains of the prokaryotic two-component signal transduction systems
Galperin, M. Y., Nikolskaya, A. N., & Koonin, E. V. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10814.x · Cited by 652
“An extensive study of this process by Benziman and colleagues showed that it is regulated by cyclic diguanylate (c-diGMP, bis(3P,5P)-cyclic diguanylic acid), a novel e¡ector molecule that consists of two cGMP moieties bound head-to-tail [31].”
Background
Metadata
- Authors
- Ross, P., Mayer, R., & Benziman, M.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Venue
- Microbiological Reviews
- Publisher
- American Society for Microbiology
- Published
- 1991-03
- Volume
- 55
- Issue
- 1
- Pages
- 35-58
- ISSN
- 0146-0749 (ISSN-L)
- PMC
- PMC372800
- OpenAlex
- W1911657064
- Cited by
- 1,231
- References
- 145
- Citations by year
- 2026: 18 · 2025: 43 · 2024: 45 · 2023: 64 · 2022: 67 · 2021: 74 · 2020: 56 · 2019: 59 · 2018: 60 · 2017: 56 · 2016: 48 · 2015: 70 · 2014: 67 · 2013: 53 · 2012: 47
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Microbiological Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Advanced Cellulose Research Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- bacterial cellulose, cellulose biosynthesis, cellulose synthase, Acetobacter xylinum, c-di-GMP, diguanylate cyclase, c-di-GMP phosphodiesterase, allosteric regulation, Sarcina ventriculi, Rhizobium, Agrobacterium, cell adhesion
- MeSH terms
- Bacteria, Cellulose
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