The DOI matches its OpenAlex record; 213 of the 213 references it cites were found in a registry or an index.
Mechanism of action of regulatory proteins encoded by complex retroviruses
Open accessAbstract
Complex retroviruses are distinguished by their ability to control the expression of their gene products through the action of virally encoded regulatory proteins. These viral gene products modulate both the quantity and the quality of viral gene expression through regulation at both the transcriptional and posttranscriptional levels. The most intensely studied retroviral regulatory proteins, termed Tat and Rev, are encoded by the prototypic complex retrovirus human immunodeficiency virus type 1. However, considerable information also exists on regulatory proteins encoded by human T-cell leukemia virus type I, as well as several other human and animal complex retroviruses. In general, these data demonstrate that retrovirally encoded transcriptional trans-activators can exert a similar effect by several very different mechanisms. In contrast, posttranscriptional regulation of retroviral gene expression appears to occur via a single pathway that is probably dependent on the recruitment of a highly conserved cellular cofactor. These two shared regulatory pathways are proposed to be critical to the ability of complex retroviruses to establish chronic infections in the face of an ongoing host immune response.
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Barré-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Chamaret, S., Gruest, J., Dauguet, C., Axler-Blin, C., Vézinet-Brun, F., Rouzioux, C., et al. (1983) · Science · doi:10.1126/science.6189183 · Cited by 7,038
Popovic, M., Sarngadharan, M. G., Read, E., & Gallo, R. C. (1984) · Science · doi:10.1126/science.6200935 · Cited by 3,535
An inducible transcription factor activates expression of human immunodeficiency virus in T cells
Nabel, G., & Baltimore, D. (1987) · Nature · doi:10.1038/326711a0 · Cited by 2,041
Importance of the nef gene for maintenance of high virus loads and for development of AIDS
Kestier, H. W., Ringler, D. J., Mori, K., Panicali, D. L., Sehgal, P. K., Daniel, M. D., & Desrosiers, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90097-i · Cited by 1,596
NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control
Lenardo, M. J., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90833-7 · Cited by 1,585
The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis
Fauci, A. S. (1988) · Science · doi:10.1126/science.3277274 · Cited by 1,486
Malim, M. H., Hauber, J., Le, S.-Y., Maizel, J. V., & Cullen, B. R. (1989) · Nature · doi:10.1038/338254a0 · Cited by 1,280
Self-citationAnti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product
Kao, S.-Y., Calman, A. F., Luciw, P. A., & Peterlin, B. M. (1987) · Nature · doi:10.1038/330489a0 · Cited by 909
Trans -Activator Gene of Human T-Lymphotropic Virus Type III (HTLV-III)
Arya, S. K., Guo, C., Josephs, S. F., & Wong-Staal, F. (1985) · Science · doi:10.1126/science.2990040 · Cited by 858
Rosen, C. A., Sodroski, J. G., & Haseltine, W. A. (1985) · Cell · doi:10.1016/s0092-8674(85)80062-3 · Cited by 807
Cited by
Studies of endogenous retroviruses reveal a continuing evolutionary saga
Stoye, J. P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2783 · Cited by 350
Control of rRNA transcription in Escherichia coli
Condon, C., Squires, C., & Squires, C. L. (1995) · Microbiological Reviews · doi:10.1128/mr.59.4.623-645.1995 · Cited by 349
Sandri-Goldin, R. M. (1998) · Genes & Development · doi:10.1101/gad.12.6.868 · Cited by 264
Lever, A. M. L. (2007) · Advances in Pharmacology · doi:10.1016/s1054-3589(07)55001-5 · Cited by 103
Human T cell leukemia virus type I-induced disease: pathways to cancer and neurodegeneration
Barmak, K., Harhaj, E., Grant, C., Alefantis, T., & Wigdahl, B. (2003) · Virology · doi:10.1016/s0042-6822(02)00091-0 · Cited by 101
Metadata
- Authors
- Cullen, B. R.
- Venue
- Microbiological Reviews
- Publisher
- American Society for Microbiology
- Published
- 1992-01-01
- Volume
- 56
- Issue
- 3
- Pages
- 375-394
- ISSN
- 0146-0749 (ISSN-L)
- OpenAlex
- W1955991880
- Cited by
- 324
- References
- 213
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
