HIV-1 RNA packaging

HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots

Schröder, A. R. W., Shinn, P., Chen, H., Berry, C., Ecker, J. R., & Bushman, F. (2002) · Cell · doi:10.1016/s0092-8674(02)00864-4 · Cited by 1,832 · see citing works

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells

Bukrinsky, M., Haggerty, S., Dempsey, M. P., Sharova, N., Adzhubei, A. A., Spitz, L., Lewis, P. F., Goldfarb, D. S., Emerman, M., & Stevenson, M. (1993) · Nature · doi:10.1038/365666a0 · Cited by 801 · see citing works

Structure of the HIV-1 Nucleocapsid Protein Bound to the SL3 Ψ-RNA Recognition Element

De Guzman, R. N., Wu, Z. R., Stalling, C. C., Pappalardo, L., Borer, P. N., & Summers, M. F. (1998) · Science · doi:10.1126/science.279.5349.384 · Cited by 659 · see citing works

staufen, a gene required to localize maternal RNAs in the Drosophila egg

Johnston, D. S., Beuchle, D., & Nüsslein‐Volhard, C. (1991) · Cell · doi:10.1016/0092-8674(91)90138-o · Cited by 631 · see citing works

Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus

Aldovini, A., & Young, R. A. (1990) · Journal of Virology · doi:10.1128/jvi.64.5.1920-1926.1990 · Cited by 548 · see citing works

Systematic Determination of the Packaging Limit of Lentiviral Vectors

Kumar, M., Keller, B. C., Makalou, N., & Sutton, R. E. (2001) · Human Gene Therapy · doi:10.1089/104303401753153947 · Cited by 456 · see citing works

The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export

Neville, M., Stutz, F., Lee, L., Davis, L. I., & Rosbash, M. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00335-6 · Cited by 439 · see citing works

Identification of the primary site of the human immunodeficiency virus type 1 RNA dimerization in vitro

Skripkin, E., Paillart, J. C., Marquet, R., Ehresmann, B., & Ehresmann, C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4945 · Cited by 401 · see citing works

Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA

Gorelick, R. J., Nigida, S. M., Bess, J. W., Arthur, L. O., Henderson, L. E., & Rein, A. R. (1990) · Journal of Virology · doi:10.1128/jvi.64.7.3207-3211.1990 · Cited by 386 · see citing works

Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions

Lever, A. M. L., Göttlinger, H. G., Haseltine, W. A., & Sodroski, J. (1989) · Journal of Virology · doi:10.1128/jvi.63.9.4085-4087.1989 · Cited by 375 · see citing works

Nucleic Acid Chaperone Activity of HIV‐1 Nucleocapsid Protein: Critical Role in Reverse Transcription and Molecular Mechanism

Levin, J. G., Guo, J., Rouzina, I. F., & Musier‐Forsyth, K. (2005) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(05)80006-6 · Cited by 367 · see citing works

NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition.

Amarasinghe, G., Guzman, R. D. D., Turner, R. B., Chancellor, K. J., Wu, Z.-R., & Summers, M. F. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3979 · Cited by 337 · see citing works

Cis elements and Trans-acting factors involved in the RNA dimerization of the human immunodeficiency virus HIV-1

Darlix, J., Gabus, C., Nugeyre, M.-T., Clavel, F., & Barré‐Sinoussi, F. (1990) · Journal of Molecular Biology · doi:10.1016/0022-2836(90)90392-y · Cited by 333 · see citing works

Mechanism of action of regulatory proteins encoded by complex retroviruses

Cullen, B. R. (1992) · Microbiological Reviews · doi:10.1128/mr.56.3.375-394.1992 · Cited by 322 · see citing works

RNA secondary structure and binding sites for gag gene products in the 5’ packaging signal of human immunodeficiency virus type 1

Clever, J., Sassetti, C., & Parslow, T. G. (1995) · Journal of Virology · doi:10.1128/jvi.69.4.2101-2109.1995 · Cited by 307 · see citing works

Functional Sites in the 5′ Region of Human Immunodeficiency Virus Type 1 RNA Form Defined Structural Domains

Baudin, F., Marquet, R., Isel, C., Darlix, J., Ehresmann, B., & Ehresmann, C. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1041 · Cited by 302 · see citing works

RNA is a structural element in retrovirus particles

Muriaux, D. M., Mirro, J., Harvin, D., & Rein, A. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091000398 · Cited by 302 · see citing works

Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers.

de ROCQUIGNY, H., Gabus, C., Vincent, A., Fournié‐Zaluski, M., Roques, B. P., & Darlix, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6472 · Cited by 289 · see citing works

Mutant human immunodeficiency virus type 1 genomes with defects in RNA dimerization or encapsidation

Clever, J., & Parslow, T. (1997) · Journal of Virology · doi:10.1128/jvi.71.5.3407-3414.1997 · Cited by 287 · see citing works

The human immunodeficiency virus type 1 encapsidation site is a multipartite RNA element composed of functional hairpin structures

McBride, M., & Panganiban, A. (1996) · Journal of Virology · doi:10.1128/jvi.70.5.2963-2973.1996 · Cited by 277 · see citing works

Evidence for interstrand quadruplex formation in the dimerization of human immunodeficiency virus 1 genomic RNA.

Sundquist, W. I., & Heaphy, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3393 · Cited by 248 · see citing works

The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent

Gorelick, R. J., Chabot, D. J., Rein, A., Henderson, L. E., & Arthur, L. O. (1993) · Journal of Virology · doi:10.1128/jvi.67.7.4027-4036.1993 · Cited by 242 · see citing works

Mammalian Staufen Is a Double-Stranded-RNA- and Tubulin-Binding Protein Which Localizes to the Rough Endoplasmic Reticulum

Wickham, L., Duchaîne, T. F., Luo, M., Nabi, I. R., & DesGroseillers, L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2220 · Cited by 242 · see citing works

A 19-nucleotide sequence upstream of the 5’ major splice donor is part of the dimerization domain of human immunodeficiency virus 1 genomic RNA

Laughrea, M., & Jette, L. (1994) · Biochemistry · doi:10.1021/bi00249a035 · Cited by 237 · see citing works

Primer tRNAs for reverse transcription

Mak, J., & Kleiman, L. (1997) · Journal of Virology · doi:10.1128/jvi.71.11.8087-8095.1997 · Cited by 226 · see citing works

Basic Residues in Human Immunodeficiency Virus Type 1 Nucleocapsid Promote Virion Assembly via Interaction with RNA

Cimarelli, A., Sandin, S., Höglund, S., & Luban, J. (2000) · Journal of Virology · doi:10.1128/jvi.74.7.3046-3057.2000 · Cited by 220 · see citing works

Role of the DIS hairpin in replication of human immunodeficiency virus type 1

Berkhout, B., & van Wamel, J. L. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.6723-6732.1996 · Cited by 219 · see citing works

Retroviral nucleocapsid domains mediate the specific recognition of genomic viral RNAs by chimeric Gag polyproteins during RNA packaging in vivo

Berkowitz, R., Ohagen, A., Höglund, S., & Goff, S. (1995) · Journal of Virology · doi:10.1128/jvi.69.10.6445-6456.1995 · Cited by 215 · see citing works

The Leader of Human Immunodeficiency Virus Type 1 Genomic RNA Harbors an Internal Ribosome Entry Segment That Is Active during the G2/M Phase of the Cell Cycle

Brasey, A., López-Lastra, M., Ohlmann, T., Beerens, N., Berkhout, B., Darlix, J., & Sonenberg, N. (2003) · Journal of Virology · doi:10.1128/jvi.77.7.3939-3949.2003 · Cited by 213 · see citing works

Two alternating structures of the HIV-1 leader RNA

HUTHOFF, H., & BERKHOUT, B. (2001) · RNA · doi:10.1017/s1355838201001881 · Cited by 209 · see citing works

Specific binding of HIV‐1 nucleocapsid protein to PSI RNA in vitro requires N‐terminal zinc finger and flanking basic amino acid residues.

Dannull, J., Surovoy, A., Jung, G., & Moelling, K. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06414.x · Cited by 207 · see citing works

The human immunodeficiency virus type 1 packaging signal and major splice donor region have a conserved stable secondary structure

Harrison, G. P., & Lever, A. M. L. (1992) · Journal of Virology · doi:10.1128/jvi.66.7.4144-4153.1992 · Cited by 207 · see citing works

GENERATION OF DIVERSITY IN RETROVIRUSES

Katz, R. A., & Skalka, A. M. (1990) · Annual Review of Genetics · doi:10.1146/annurev.ge.24.120190.002205 · Cited by 201 · see citing works

Mutational analysis of the bipartite dimer linkage structure of human immunodeficiency virus type 1 genomic RNA

Paillart, J. C., Marquet, R., Skripkin, E., Ehresmann, B., & Ehresmann, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47011-1 · Cited by 201 · see citing works

Crystal structures of coaxially stacked kissing complexes of the HIV-1 RNA dimerization initiation site.

Ennifar, E., Walter, P., Ehresmann, B., Ehresmann, C., & Dumas, P. (2001) · Nature Structural Biology · doi:10.1038/nsb727 · Cited by 199 · see citing works

A dual role of the putative RNA dimerization initiation site of human immunodeficiency virus type 1 in genomic RNA packaging and proviral DNA synthesis

Paillart, J., Berthoux, L., Ottmann, M., Darlix, J., Marquet, R., Ehresmann, B., & Ehresmann, C. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8348-8354.1996 · Cited by 194 · see citing works

Role of Pr160gag-pol in mediating the selective incorporation of tRNA(Lys) into human immunodeficiency virus type 1 particles

Mak, J., Jiang, M., Wainberg, M. A., Hammarskjöld, M. L., Rekosh, D., & Kleiman, L. (1994) · Journal of Virology · doi:10.1128/jvi.68.4.2065-2072.1994 · Cited by 194 · see citing works

Specific binding of human immunodeficiency virus type 1 gag polyprotein and nucleocapsid protein to viral RNAs detected by RNA mobility shift assays

Berkowitz, R. D., Luban, J., & Goff, S. P. (1993) · Journal of Virology · doi:10.1128/jvi.67.12.7190-7200.1993 · Cited by 193 · see citing works

NCp7 Activates HIV-1Lai RNA Dimerization by Converting a Transient Loop-Loop Complex into a Stable Dimer

Muriaux, D. M., de ROCQUIGNY, H., Roques, B. P., & Paoletti, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33686 · Cited by 191 · see citing works

A mutant of human immunodeficiency virus with reduced RNA packaging and abnormal particle morphology

Clavel, F., & Orenstein, J. M. (1990) · Journal of Virology · doi:10.1128/jvi.64.10.5230-5234.1990 · Cited by 180 · see citing works

HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitro.

Feng, Y., Copeland, T. D., Henderson, L. E., Gorelick, R. J., Bosche, W. J., Levin, J. G., & Rein, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7577 · Cited by 180 · see citing works

The Human Immunodeficiency Virus Type 1gagGene Encodes an Internal Ribosome Entry Site

Buck, C. B., Shen, X.-F., Egan, M. A., Pierson, T. C., Walker, C. M., & Siliciano, R. F. (2001) · Journal of Virology · doi:10.1128/jvi.75.1.181-191.2001 · Cited by 178 · see citing works

Charged amino acid residues of human immunodeficiency virus type 1 nucleocapsid p7 protein involved in RNA packaging and infectivity

Poon, D. T. K., Wu, J. S., & Aldovini, A. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.6607-6616.1996 · Cited by 166 · see citing works

The crystal structure of the dimerization initiation site of genomic HIV-1 RNA reveals an extended duplex with two adenine bulges

Ennifar, E., Yusupov, M., Walter, P., Marquet, R., Ehresmann, B., Ehresmann, C., & Dumas, P. (1999) · Structure · doi:10.1016/s0969-2126(00)80033-7 · Cited by 163 · see citing works

Mutations in the kissing-loop hairpin of human immunodeficiency virus type 1 reduce viral infectivity as well as genomic RNA packaging and dimerization

Laughrea, M., Jetté, L. P., Mak, J., Kleiman, L., Liang, C., & Wainberg, M. A. (1997) · Journal of Virology · doi:10.1128/jvi.71.5.3397-3406.1997 · Cited by 162 · see citing works

The Double-Stranded RNA-Binding Protein Staufen Is Incorporated in Human Immunodeficiency Virus Type 1: Evidence for a Role in Genomic RNA Encapsidation

Mouland, A. J., Mercier, J., Luo, M., Bernier, L., DesGroseillers, L., & Cohen, É. A. (2000) · Journal of Virology · doi:10.1128/jvi.74.12.5441-5451.2000 · Cited by 162 · see citing works

Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA

Luban, J., & Goff, S. (1994) · Journal of Virology · doi:10.1128/jvi.68.6.3784-3793.1994 · Cited by 160 · see citing works

Identification of an Intracellular Trafficking and Assembly Pathway for HIV‐1 Gag

Perlman, M., & Resh, M. D. (2006) · Traffic · doi:10.1111/j.1398-9219.2006.00428.x · Cited by 160 · see citing works

Retroviral Genomic RNAs Are Transported to the Plasma Membrane by Endosomal Vesicles

Basyuk, E. I., Galli, T., Mougel, M., Blanchard, J., Sitbon, M., & Bertrand, É. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00188-6 · Cited by 159 · see citing works

Structure of the dimer a initiation complex of HIV-1 genomic RNA

Mujeeb, A., Clever, J. L., Billeci, T. M., James, T. L., & Parslow, T. G. (1998) · Nature Structural Biology · doi:10.1038/nsb0698-432 · Cited by 159 · see citing works

The human immunodeficiency virus type 1 Gag polyprotein has nucleic acid chaperone activity: possible role in dimerization of genomic RNA and placement of tRNA on the primer binding site

Feng, Y.-X., Campbell, S., Harvin, D., Ehresmann, B., Ehresmann, C., & Rein, A. (1999) · Journal of Virology · doi:10.1128/jvi.73.5.4251-4256.1999 · Cited by 159 · see citing works

Human Immunodeficiency Virus Type 1 Nucleocapsid Zn 2+ Fingers Are Required for Efficient Reverse Transcription, Initial Integration Processes, and Protection of Newly Synthesized Viral DNA

Buckman, J. S., Bosche, W. J., & Gorelick, R. J. (2002) · Journal of Virology · doi:10.1128/jvi.77.2.1469-1480.2003 · Cited by 157 · see citing works

Non-canonical interactions in a kissing loop complex: the dimerization initiation site of HIV-1 genomic RNA

Paillart, J., Westhof, É., Ehresmann, C., Ehresmann, B., & Marquet, R. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1096 · Cited by 151 · see citing works

Nucleocapsid protein effects on the specificity of retrovirus RNA encapsidation

Zhang, Y., & Barklis, E. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5716-5722.1995 · Cited by 151 · see citing works

Nucleic acid binding and chaperone properties of HIV-1 Gag and nucleocapsid proteins

Cruceanu, M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj458 · Cited by 149 · see citing works

First Snapshots of the HIV-1 RNA Structure in Infected Cells and in Virions

Paillart, J., Dettenhofer, M., Yu, X.-F., Ehresmann, C., Ehresmann, B., & Marquet, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408294200 · Cited by 147 · see citing works

Simian immunodeficiency virus RNA is efficiently encapsidated by human immunodeficiency virus type 1 particles

Rizvi, T. A., & Panganiban, A. (1993) · Journal of Virology · doi:10.1128/jvi.67.5.2681-2688.1993 · Cited by 145 · see citing works

Analysis in human immunodeficiency virus type 1 vectors of cis-acting sequences that affect gene transfer into human lymphocytes

Parolin, C., Dorfman, T., Palú, G., Göttlinger, H., & Sodroski, J. (1994) · Journal of Virology · doi:10.1128/jvi.68.6.3888-3895.1994 · Cited by 144 · see citing works

Retroviral mRNA nuclear export elements regulate protein function and virion assembly

Swanson, C. M., Puffer, B. A., Ahmad, K. M., Doms, R. W., & Malim, M. H. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600270 · Cited by 141 · see citing works

Nucleic Acid Sequence Discrimination by the HIV-1 Nucleocapsid Protein NCp7: A Fluorescence Study

Vuilleumier, C., Bombarda, E., Morellet, N., Gérard, D., Roques, B. P., & Mély, Y. (1999) · Biochemistry · doi:10.1021/bi991145p · Cited by 139 · see citing works

High Rates of Human Immunodeficiency Virus Type 1 Recombination: Near-Random Segregation of Markers One Kilobase Apart in One Round of Viral Replication

Rhodes, T. D., Wargo, H., & Hu, W.-S. (2003) · Journal of Virology · doi:10.1128/jvi.77.20.11193-11200.2003 · Cited by 139 · see citing works

Identification of a binding site for the human immunodeficiency virus type 1 nucleocapsid protein.

Sakaguchi, K., Zambrano, N., Baldwin, E. T., Shapiro, B. A., Erickson, J. W., Omichinski, J. G., Clore, G. M., Gronenborn, A. M., & Appella, E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5219 · Cited by 135 · see citing works

A conserved hairpin motif in the R-U5 region of the human immunodeficiency virus type 1 RNA genome is essential for replication

Das, A. T., Klaver, B., Klasens, B. I. F., van Wamel, J. L. B., & Berkhout, B. (1997) · Journal of Virology · doi:10.1128/jvi.71.3.2346-2356.1997 · Cited by 131 · see citing works

The nonmyristylated Pr160gag-pol polyprotein of human immunodeficiency virus type 1 interacts with Pr55gag and is incorporated into viruslike particles

Park, J., & Morrow, C. D. (1992) · Journal of Virology · doi:10.1128/jvi.66.11.6304-6313.1992 · Cited by 129 · see citing works

Nonreciprocal Packaging of Human Immunodeficiency Virus Type 1 and Type 2 RNA: a Possible Role for the p2 Domain of Gag in RNA Encapsidation

Kaye, J. F., & Lever, A. (1998) · Journal of Virology · doi:10.1128/jvi.72.7.5877-5885.1998 · Cited by 129 · see citing works

The retrovirus RNA trafficking granule: from birth to maturity

Cochrane, A., McNally, M. T., & Mouland, A. J. (2006) · Retrovirology · doi:10.1186/1742-4690-3-18 · Cited by 127 · see citing works

RNA Structure and packaging signals in the 5′ leader region of the human immunodeficiency virus Type 1 genome

Clever, J. L., Miranda, & Parslow, T. G. (2002) · Journal of Virology · doi:10.1128/jvi.76.23.12381-12387.2002 · Cited by 127 · see citing works

Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably?

Russell, R., Chen, L., & Wainberg, M. (2004) · Retrovirology · doi:10.1186/1742-4690-1-23 · Cited by 125 · see citing works

The HIV-1 leader RNA conformational switch regulates RNA dimerization but does not regulate mRNA translation

Abbink, T. E. M., Ooms, M., Haasnoot, P. C. J., & Berkhout, B. (2005) · Biochemistry · doi:10.1021/bi0502588 · Cited by 122 · see citing works

RNA packaging signal of human immunodeficiency virus type 1

Hayashi, T., Shioda, T., Iwakura, Y., & Shibuta, H. (1992) · Virology · doi:10.1016/0042-6822(92)90513-o · Cited by 119 · see citing works

HIV‐1 Gag–RNA Interaction Occurs at a Perinuclear/Centrosomal Site; Analysis by Confocal Microscopy and FRET

Poole, E. L., Strappe, P., Mok, H. P., Hicks, R., & Lever, A. M. L. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00312.x · Cited by 117 · see citing works

Synthesis of murine leukemia virus proteins associated with virions assembled in actinomycin D-treated cells: evidence for persistence of viral messenger RNA.

Levin, J. G., & Rosenak, M. J. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1154 · Cited by 117 · see citing works

Nuclear entry and CRM1-dependent nuclear export of the Rous sarcoma virus Gag polyprotein

Scheifele, L. Z., Garbitt, R. A., Rhoads, J. D., & Parent, L. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.062652199 · Cited by 114 · see citing works

Retroviral RNA packaging: a review

Rein, A. R. (1994) · Springer eBooks · doi:10.1007/978-3-7091-9326-6_49 · Cited by 114 · see citing works

Evidence that a Kissing Loop Structure Facilitates Genomic RNA Dimerisation in HIV-1

Haddrick, M., Lear, A. L., Cann, A. J., & Heaphy, S. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0301 · Cited by 113 · see citing works

Packaging of human immunodeficiency virus type 1 RNA requires cis-acting sequences outside the 5' leader region

Richardson, J. H., Child, L. A., & Lever, A. M. L. (1993) · Journal of Virology · doi:10.1128/jvi.67.7.3997-4005.1993 · Cited by 112 · see citing works

Trafficking of HIV‐1 RNA is Mediated by Heterogeneous Nuclear Ribonucleoprotein A2 Expression and Impacts on Viral Assembly

Lévesque, K., Halvorsen, M., Abrahamyan, L. G., Chatel‐Chaix, L., Poupon, V., Gordon, H., DesGroseillers, L., Gatignol, A., & Mouland, A. J. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00461.x · Cited by 112 · see citing works

Human Immunodeficiency Virus Types 1 and 2 Differ in the Predominant Mechanism Used for Selection of Genomic RNA for Encapsidation

Kaye, J. F., & Lever, A. (1999) · Journal of Virology · doi:10.1128/jvi.73.4.3023-3031.1999 · Cited by 111 · see citing works

In Vitro Evidence for a Long Range Pseudoknot in the 5′-Untranslated and Matrix Coding Regions of HIV-1 Genomic RNA

Paillart, J., Skripkin, E. A., Ehresmann, B., Ehresmann, C., & Marquet, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108972200 · Cited by 111 · see citing works

Structural requirement for the two-step dimerization of human immunodeficiency virus type 1 genome

Takahashi, K., Baba, S., CHATTOPADHYAY, P., Koyanagi, Y., Yamamoto, N., Takaku, H., & Kawai, G. (2000) · RNA · doi:10.1017/s1355838200991635 · Cited by 111 · see citing works

Lentiviral-mediated delivery of siRNAs for antiviral therapy

Morris, K. V., & Rossi, J. J. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302688 · Cited by 110 · see citing works

Dimerization of human immunodeficiency virus type 1 RNA involves sequences located upstream of the splice donor site

Marquet, R., Paillart, J., Skripkin, E. A., Ehresmann, C., & Ehresmann, B. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.2.145 · Cited by 110 · see citing works

The M-PMV cytoplasmic targeting-retention signal directs nascent Gag polypeptides to a pericentriolar region of the cell

Sfakianos, J. N., LaCasse, R. A., & Hunter, E. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00125.x · Cited by 110 · see citing works

Mapping the RNA binding sites for human immunodeficiency virus type-1 gag and NC proteins within the complete HIV-1 and -2 untranslated leader regions.

Damgaard, C., Dyhr-Mikkelsen, H., & Kjems, J. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.16.3667 · Cited by 107 · see citing works

A Riboswitch Regulates RNA Dimerization and Packaging in Human Immunodeficiency Virus Type 1 Virions

Ooms, M., Huthoff, H. T., Russell, R. S., Liang, C., & Berkhout, B. (2004) · Journal of Virology · doi:10.1128/jvi.78.19.10814-10819.2004 · Cited by 107 · see citing works

Mode of dimerization of HIV-1 genomic RNA

Awang, G., & Sen, D. (1993) · Biochemistry · doi:10.1021/bi00093a024 · Cited by 106 · see citing works

The Major Human Immunodeficiency Virus Type 2 (HIV-2) Packaging Signal Is Present on All HIV-2 RNA Species: Cotranslational RNA Encapsidation and Limitation of Gag Protein Confer Specificity

Griffin, S., Allen, J. F., & Lever, A. (2001) · Journal of Virology · doi:10.1128/jvi.75.24.12058-12069.2001 · Cited by 106 · see citing works

In vitro selection of RNAs that bind to the human immunodeficiency virus type-1 gag polyprotein

Lochrie, M. A. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.14.2902 · Cited by 103 · see citing works

The human immunodeficiency virus type 1 5' packaging signal structure affects translation but does not function as an internal ribosome entry site structure

Miele, G., Mouland, A. J., Harrison, G. P., Cohen, É. A., & Lever, A. M. L. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.944-951.1996 · Cited by 103 · see citing works

Mutations of basic amino acids of NCp7 of human immunodeficiency virus type 1 affect RNA binding in vitro

Schmalzbauer, E., Strack, B., Dannull, J., Guehmann, S., & Moelling, K. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.771-777.1996 · Cited by 103 · see citing works

7SL RNA, but not the 54-kd signal recognition particle protein, is an abundant component of both infectious HIV-1 and minimal virus-like particles

Onafuwa-Nuga, A., Telesnitsky, A., & King, S. R. (2006) · RNA · doi:10.1261/rna.2306306 · Cited by 102 · see citing works

The leader of the HIV-1 RNA genome forms a compactly folded tertiary structure

Berkhout, B., & van Wamel, J. L. B. (2000) · RNA · doi:10.1017/s1355838200991684 · Cited by 102 · see citing works

1H NMR structure and biological studies of the His23 .fwdarw. Cys mutant nucleocapsid protein of HIV-1 indicate that the conformation of the first zinc finger is critical for virus infectivity

Déméné, H., Dong, C., Ottmann, M., Rouyez, M.-C., Jullian, N., Morellet, N., Mély, Y., Darlix, J., & Fournié‐Zaluski, M. (1994) · Biochemistry · doi:10.1021/bi00205a006 · Cited by 101 · see citing works

NMR structure of stem-loop SL2 of the HIV-1 Ψ RNA packaging signal reveals a novel A-U-A base-triple platform 1 1Edited by I. Tinoco

Amarasinghe, G. K., Guzman, R. N. D., Turner, R. B., & Summers, M. F. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3710 · Cited by 100 · see citing works

Analysis of Binding Elements in the Human Immunodeficiency Virus Type 1 Genomic RNA and Nucleocapsid Protein

Berkowitz, R. D., & Goff, S. P. (1994) · Virology · doi:10.1006/viro.1994.1339 · Cited by 97 · see citing works

Functional Analysis of the Core Human Immunodeficiency Virus Type 1 Packaging Signal in a Permissive Cell Line

Harrison, G. P., Miele, G., Hunter, E., & Lever, A. M. L. (1998) · Journal of Virology · doi:10.1128/jvi.72.7.5886-5896.1998 · Cited by 97 · see citing works

Dimerization of HIV-1 genomic RNA of subtypes A and B: RNA loop structure and magnesium binding

Jossinet, F., Paillart, J., Westhof, É., Hermann, T., Skripkin, E. A., Lodmell, J. S., Ehresmann, C., Ehresmann, B., & Marquet, R. (1999) · RNA · doi:10.1017/s1355838299990982 · Cited by 92 · see citing works

Involvement of HIV-I Nucleocapsid Protein in the Recruitment of Reverse Transcriptase into Nucleoprotein Complexes Formedin Vitro

Lener, D., Tanchou, V., Roques, B. P., Grice, S. F. J. L., & Darlix, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33781 · Cited by 91 · see citing works

Redundant Roles for Nucleocapsid and Matrix RNA-Binding Sequences in Human Immunodeficiency Virus Type 1 Assembly

Ott, D. E., Coren, L. V., & Gagliardi, T. D. (2005) · Journal of Virology · doi:10.1128/jvi.79.22.13839-13847.2005 · Cited by 90 · see citing works

Binding properties of the human immunodeficiency virus type 1 nucleocapsid protein p7 to a model RNA: elucidation of the structural determinants for function 1 1Edited by D. E. Draper

Urbaneja, M. A., Kane, B., Johnson, D. G., Gorelick, R. J., Henderson, L. E., & Casas‐Finet, J. R. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2521 · Cited by 89 · see citing works

Stem-loop SL4 of the HIV-1 psi RNA packaging signal exhibits weak affinity for the nucleocapsid protein. structural studies and implications for genome recognition.

Amarasinghe, G., Zhou, J., Miskimon, M., Chancellor, K. J., McDonald, J. A., Matthews, A. G., Miller, R. R., Rouse, M. D., & Summers, M. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.5182 · Cited by 88 · see citing works

Proteolytic Processing of the P2/Nucleocapsid Cleavage Site Is Critical for Human Immunodeficiency Virus Type 1 RNA Dimer Maturation

Shehu-Xhilaga, M., Kraeusslich, H.-G., Pettit, S. C., Swanstrom, R. I., Jy, L., Marshall, J. A., Crowe, S. M., & Mak, J. (2001) · Journal of Virology · doi:10.1128/jvi.75.19.9156-9164.2001 · Cited by 87 · see citing works

Affinities of Packaging Domain Loops in HIV-1 RNA for the Nucleocapsid Protein

Shubsda, M. F., Paoletti, A. C., Hudson, B. S., & Borer, P. N. (2002) · Biochemistry · doi:10.1021/bi016045+ · Cited by 87 · see citing works

In Vitro Evidence That the Untranslated Leader of the HIV-1 Genome Is an RNA Checkpoint That Regulates Multiple Functions through Conformational Changes

Berkhout, B., Ooms, M., Beerens, N., Huthoff, H. T., Southern, E. M., & Verhoef, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200950200 · Cited by 87 · see citing works

Helical structure determined by NMR of the HIV‐1 (345–392)Gag sequence, surrounding p2: Implications for particle assembly and RNA packaging

Morellet, N., Druillennec, S., Lenoir, C., Bouaziz, S., & Roques, B. P. (2005) · Protein Science · doi:10.1110/ps.041087605 · Cited by 86 · see citing works

Role of the Trans-activation Response Element in Dimerization of HIV-1 RNA

Andersen, E. S., Contera, S., Knudsen, B., Damgaard, C. K., Besenbacher, F., & Kjems, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314326200 · Cited by 86 · see citing works

Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Its Own Translation

Anderson, E. C., & Lever, A. (2006) · Journal of Virology · doi:10.1128/jvi.02596-05 · Cited by 84 · see citing works

The Kissing Hairpin Sequence Promotes Recombination within the HIV-I 5′ Leader Region

Balakrishnan, M., Fay, P. J., & Bambara, R. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102860200 · Cited by 84 · see citing works

An Intact TAR Element and Cytoplasmic Localization Are Necessary for Efficient Packaging of Human Immunodeficiency Virus Type 1 Genomic RNA

Helga-Maria, C., Hammarskjöld, M., & Rekosh, D. M. (1999) · Journal of Virology · doi:10.1128/jvi.73.5.4127-4135.1999 · Cited by 83 · see citing works

Impact of Human Immunodeficiency Virus Type 1 RNA Dimerization on Viral Infectivity and of Stem-Loop B on RNA Dimerization and Reverse Transcription and Dissociation of Dimerization from Packaging

Shen, N., Jetté, L., Liang, C., Wainberg, M. A., & Laughrea, M. (2000) · Journal of Virology · doi:10.1128/jvi.74.12.5729-5735.2000 · Cited by 83 · see citing works

Comparison of Viral Genomic RNA Sorting Mechanisms in Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Moloney Murine Leukemia Virus

Dorman, N., & Lever, A. M. L. (2000) · Journal of Virology · doi:10.1128/jvi.74.23.11413-11417.2000 · Cited by 82 · see citing works

5′ Regions of HIV-1 RNAs Are Not Sufficient for Encapsidation: Implications for the HIV-1 Packaging Signal

Berkowitz, R. D., Hammarskjöld, M., Helga-Maria, C., Rekosh, D. M., & Goff, S. P. (1995) · Virology · doi:10.1006/viro.1995.1530 · Cited by 80 · see citing works

Location of cis-acting signals important for RNA encapsidation in the leader sequence of human immunodeficiency virus type 2

McCann, E., & Lever, A. (1997) · Journal of Virology · doi:10.1128/jvi.71.5.4133-4137.1997 · Cited by 75 · see citing works

Structure of the intact stem and bulge of HIV-1 Psi-RNA stem-loop SL1.

Lawrence, D. C., Stover, C., Noznitsky, J., Wu, Z.-R., & Summers, M. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)01305-0 · Cited by 75 · see citing works

Genetic Dissociation of the Encapsidation and Reverse Transcription Functions in the 5′ R Region of Human Immunodeficiency Virus Type 1

Clever, J. L., Eckstein, D. A., & Parslow, T. G. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.101-109.1999 · Cited by 72 · see citing works

The major HIV-1 packaging signal is an extended bulged stem loop whose structure is altered on interaction with the Gag polyprotein.

Zeffman, A., Hassard, S., Varani, G., & Lever, A. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3611 · Cited by 71 · see citing works

Sequences Downstream of the 5′ Splice Donor Site Are Required for both Packaging and Dimerization of Human Immunodeficiency Virus Type 1 RNA

Russell, R. S., Hu, J., Bériault, V., Mouland, A. J., Kleiman, L., Wainberg, M. A., & Liang, C. (2002) · Journal of Virology · doi:10.1128/jvi.77.1.84-96.2003 · Cited by 70 · see citing works

Possible Role of Dimerization in Human Immunodeficiency Virus Type 1 Genome RNA Packaging

Sakuragi, J.-I., Ueda, S., Iwamoto, A., & Shioda, T. (2003) · Journal of Virology · doi:10.1128/jvi.77.7.4060-4069.2003 · Cited by 69 · see citing works

Duplication of the Primary Encapsidation and Dimer Linkage Region of Human Immunodeficiency Virus Type 1 RNA Results in the Appearance of Monomeric RNA in Virions

Sakuragi, J.-I., Shioda, T., & Panganiban, A. T. (2001) · Journal of Virology · doi:10.1128/jvi.75.6.2557-2565.2001 · Cited by 66 · see citing works

The retroviral RNA dimer linkage: different structures may reflect different roles

Greatorex, J. S. (2004) · Retrovirology · doi:10.1186/1742-4690-1-22 · Cited by 64 · see citing works

Translation Is Not Required To Generate Virion Precursor RNA in Human Immunodeficiency Virus Type 1-Infected T Cells

Butsch, M., & Boris‐Lawrie, K. (2000) · Journal of Virology · doi:10.1128/jvi.74.24.11531-11537.2000 · Cited by 63 · see citing works

Human Immunodeficiency Virus Type 1 Preferentially Encapsidates Genomic RNAs That Encode Pr55Gag: Functional Linkage between Translation and RNA Packaging

Poon, D. T. K., Chertova, E. N., & Ott, D. E. (2002) · Virology · doi:10.1006/viro.2001.1283 · Cited by 60 · see citing works

Variant Effects of Non-Native Kissing-Loop Hairpin Palindromes on HIV Replication and HIV RNA Dimerization: Role of Stem−Loop B in HIV Replication and HIV RNA Dimerization

Laughrea, M., Shen, N., Jetté, L., & Wainberg, M. A. (1998) · Biochemistry · doi:10.1021/bi981728j · Cited by 60 · see citing works

Dimer Initiation Sequence of HIV-1LaiGenomic RNA: NMR Solution Structure of the Extended Duplex

Girard, F. C., Barbault, F., Gouyette, C., Huynh‐Dinh, T., Paoletti, J., & Lancelot, G. (1999) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.1999.10508323 · Cited by 58 · see citing works

Structure and Stability of Wild-type and Mutant RNA Internal Loops from the SL-1 Domain of the HIV-1 Packaging Signal

Greatorex, J. S., Gallego, J., Varani, G., & Lever, A. M. L. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00776-3 · Cited by 57 · see citing works

HIV-1 Genome Dimerization: Kissing-Loop Hairpin Dictates Whether Nucleotides Downstream of the 5‘ Splice Junction Contribute to Loose and Tight Dimerization of Human Immunodeficiency Virus RNA

Laughrea, M., & Jetté, L. (1997) · Biochemistry · doi:10.1021/bi970862l · Cited by 57 · see citing works

NMR Structure of the Full-length Linear Dimer of Stem-Loop-1 RNA in the HIV-1 Dimer Initiation Site

Ulyanov, N. B., Mujeeb, A., Du, Z., Tonelli, M., Parslow, T. G., & James, T. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601711200 · Cited by 56 · see citing works

Effects of Mutations in the Human Immunodeficiency Virus Type 1 gag Gene on RNA Packaging and Recombination

Nikolaitchik, O. A., Rhodes, T. D., Ott, D. E., & Hu, W.-S. (2006) · Journal of Virology · doi:10.1128/jvi.80.10.4691-4697.2006 · Cited by 56 · see citing works

NMR structure of the mature dimer initiation complex of HIV‐1 genomic RNA

Mujeeb, A., Parslow, T. G., Zarrinpar, A., Das, C., & James, T. L. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01183-7 · Cited by 56 · see citing works

RNA Incorporation Is Critical for Retroviral Particle Integrity after Cell Membrane Assembly of Gag Complexes

Wang, S.-W., & Aldovini, A. (2002) · Journal of Virology · doi:10.1128/jvi.76.23.11853-11865.2002 · Cited by 55 · see citing works

The Human Immunodeficiency Virus Type 1 TAR RNA Upper Stem-Loop Plays Distinct Roles in Reverse Transcription and RNA Packaging

Harrich, D., Hooker, C. W., & Parry, E. (2000) · Journal of Virology · doi:10.1128/jvi.74.12.5639-5646.2000 · Cited by 55 · see citing works

Three-dimensional folding of an RNA hairpin required for packaging HIV-1.

Pappalardo, L., Kerwood, D., Pelczer, I., & Borer, P. N. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2046 · Cited by 53 · see citing works

Affinities of the Nucleocapsid Protein for Variants of SL3 RNA in HIV-1

Paoletti, A. C., Shubsda, M. F., Hudson, B. S., & Borer, P. N. (2002) · Biochemistry · doi:10.1021/bi026307n · Cited by 53 · see citing works

A new NMR solution structure of the SL1 HIV-1Lai loop-loop dimer

Kieken, F. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj427 · Cited by 53 · see citing works

Murine Leukemia Virus Nucleocapsid Mutant Particles Lacking Viral RNA Encapsidate Ribosomes

Muriaux, D. M., Mirro, J., Nagashima, K., Harvin, D., & Rein, A. R. (2002) · Journal of Virology · doi:10.1128/jvi.76.22.11405-11413.2002 · Cited by 51 · see citing works

Autogenous regulation of RNA translation and packaging by Rous sarcoma virus Pr76gag

Sonstegard, T., & Hackett, P. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.6542-6552.1996 · Cited by 51 · see citing works

RNA interference as an antiviral approach: targeting HIV-1.

Berkhout, B. (2004) · PubMed · Cited by 51 · see citing works

Mechanism of Hairpin-Duplex Conversion for the HIV-1 Dimerization Initiation Site

Bernacchi, S., Ennifar, E., Tóth, K., Walter, P., Langowski, J., & Dumas, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503230200 · Cited by 50 · see citing works

Analysis of Human Immunodeficiency Virus Type 1 Gag Dimerization-Induced Assembly

Alfadhli, A., Dhenub, T. C., Still, A., & Barklis, E. (2005) · Journal of Virology · doi:10.1128/jvi.79.23.14498-14506.2005 · Cited by 50 · see citing works

Elucidation of a conserved RNA stem‐loop structure in the packaging signal of human immunodeficiency virus type 1

Hayashi, T., Ueno, Y., & Okamoto, T. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80172-q · Cited by 48 · see citing works

Nonrandom Dimerization of Murine Leukemia Virus Genomic RNAs

Flynn, J. A., An, W., King, S. R., & Telesnitsky, A. (2004) · Journal of Virology · doi:10.1128/jvi.78.22.12129-12139.2004 · Cited by 47 · see citing works

Anti-HIV Inhibitors Based on Nucleic Acids: Emergence of Aptamers as Potent Antivirals

Joshi, P., Fisher, T. S., & Prasad, V. R. (2003) · Current Drug Targets - Infectious Disorders · doi:10.2174/1568005033481060 · Cited by 47 · see citing works

Proline Residues within Spacer Peptide p1 Are Important for Human Immunodeficiency Virus Type 1 Infectivity, Protein Processing, and Genomic RNA Dimer Stability

Hill, M. K., Shehu-Xhilaga, M., Crowe, S. M., & Mak, J. (2002) · Journal of Virology · doi:10.1128/jvi.76.22.11245-11253.2002 · Cited by 45 · see citing works

Analysis of NCp7-dependent Activation of HIV-1 cDNA Integration and its Conservation Among Retroviral Nucleocapsid Proteins

Poljak, L. G., Batson, S. M., Ficheux, D., Roques, B. P., Darlix, J., & Käs, E. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00472-8 · Cited by 45 · see citing works

Dissociation of Genome Dimerization from Packaging Functions and Virion Maturation of Human Immunodeficiency Virus Type 1

Sakuragi, J.-I., Iwamoto, A., & Shioda, T. (2002) · Journal of Virology · doi:10.1128/jvi.76.3.959-967.2002 · Cited by 44 · see citing works

Insights into the Regioselectivity and RNA-binding Affinity of HIV-1 Nucleocapsid Protein from Linear-scaling Quantum Methods

Khandogin, J., Musier‐Forsyth, K., & York, D. M. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00658-2 · Cited by 43 · see citing works

The Conformation of the Mature Dimeric Human Immunodeficiency Virus Type 1 RNA Genome Requires Packaging of Pol Protein

Shehu-Xhilaga, M., Hill, M. K., Marshall, J. A., Kappes, J. C., Crowe, S. M., & Mak, J. (2002) · Journal of Virology · doi:10.1128/jvi.76.9.4331-4340.2002 · Cited by 43 · see citing works

Packaging and reverse transcription of snRNAs by retroviruses may generate pseudogenes

Giles, K. E., Caputi, M., & BEEMON, K. L. (2004) · RNA · doi:10.1261/rna.2150604 · Cited by 43 · see citing works

Stem of SL1 RNA in HIV-1: Structure and Nucleocapsid Protein Binding for a 1 × 3 Internal Loop,

Yuan, Y., Kerwood, D. J., Paoletti, A. C., Shubsda, M. F., & Borer, P. N. (2003) · Biochemistry · doi:10.1021/bi034084a · Cited by 42 · see citing works

A structural linkage between the dimerization and encapsidation signals in HIV-2 leader RNA

Lanchy, J.-M., Ivanovitch, J. D., & Lodmell, J. S. (2003) · RNA · doi:10.1261/rna.5590603 · Cited by 42 · see citing works

Effects of a Single Amino Acid Substitution within thep2 Region of Human Immunodeficiency Virus Type 1 on Packagingof Spliced ViralRNA

Russell, R. S., Roldán, A., Detorio, M., Hu, J., Wainberg, M. A., & Liang, C. (2003) · Journal of Virology · doi:10.1128/jvi.77.24.12986-12995.2003 · Cited by 41 · see citing works

Role of Distal Zinc Finger of Nucleocapsid Protein in Genomic RNA Dimerization of Human Immunodeficiency Virus Type 1; No Role for the Palindrome Crowning the R-U5 Hairpin

Laughrea, M., Shen, N., Jetté, L., Darlix, J., Kleiman, L., & Wainberg, M. A. (2001) · Virology · doi:10.1006/viro.2000.0778 · Cited by 41 · see citing works

Antisense RNA sequences targeting the 5′ leader packaging signal region of human immunodeficiency virus type-1 inhibits viral replication at post-transcriptional stages of the life cycle

Chadwick, D., & Lever, A. M. L. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301254 · Cited by 41 · see citing works

Rev Binds Specifically to a Purine Loop in the SL1 Region of the HIV-1 Leader RNA

Gallego, J., Greatorex, J. S., Zhang, H., Yang, B., Arunachalam, S., Fang, J., Seamons, J., Lea, S. M., Pomerantz, R. J., & Lever, A. M. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301041200 · Cited by 40 · see citing works

Deficient Dimerization of Human Immunodeficiency Virus Type 1 RNA Caused by Mutations of the U5 RNA Sequences

Russell, R. S., Hu, J., Laughrea, M., Wainberg, M. A., & Liang, C. (2002) · Virology · doi:10.1006/viro.2002.1592 · Cited by 40 · see citing works

Retrovirus Translation Initiation: Issues and Hypotheses Derived from Study of HIV-1

Yılmaz, A., Bolinger, C., & Boris‐Lawrie, K. (2006) · Current HIV Research · doi:10.2174/157016206776055039 · Cited by 40 · see citing works

Role of Stem B, Loop B, and Nucleotides next to the Primer Binding Site and the Kissing-Loop Domain in Human Immunodeficiency Virus Type 1 Replication and Genomic-RNA Dimerization

Shen, N., Jetté, L., Wainberg, M. A., & Laughrea, M. (2001) · Journal of Virology · doi:10.1128/jvi.75.21.10543-10549.2001 · Cited by 40 · see citing works

Rational development of a HIV‐1 gene therapy vector

Anson, D. S., & Fuller, M. (2003) · The Journal of Gene Medicine · doi:10.1002/jgm.415 · Cited by 39 · see citing works

Evidence for preferential copackaging of Moloney murine leukemia virus genomic RNAs transcribed in the same chromosomal site

Kharytonchyk, S. A., Kireyeva, A. I., Osipovich, A. B., & Fomin, I. K. (2005) · Retrovirology · doi:10.1186/1742-4690-2-3 · Cited by 39 · see citing works

Elements Located Upstream and Downstream of the Major Splice Donor Site Influence the Ability of HIV-2 Leader RNA To Dimerize in Vitro

Lanchy, J.-M., Rentz, C. A., Ivanovitch, J. D., & Lodmell, J. S. (2003) · Biochemistry · doi:10.1021/bi0271190 · Cited by 37 · see citing works

trans-acting proteins involved in RNA encapsidation and viral assembly in human immunodeficiency virus type 1

Kaye, J. F., & Lever, A. M. L. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.880-886.1996 · Cited by 36 · see citing works

Distinct Roles for Nucleic Acid in In Vitro Assembly of Purified Mason-Pfizer Monkey Virus CANC Proteins

Ulbrich, P., Haubova, S., Nermut, M. V., Hunter, E., Rumlová, M., & Ruml, T. (2006) · Journal of Virology · doi:10.1128/jvi.02694-05 · Cited by 35 · see citing works

Deletion Mutagenesis within the Dimerization Initiation Site of Human Immunodeficiency Virus Type 1 Results in Delayed Processing of the p2 Peptide from Precursor Proteins

Liang, C., Rong, L., Cherry, E., Kleiman, L., Laughrea, M., & Wainberg, M. (1999) · Journal of Virology · doi:10.1128/jvi.73.7.6147-6151.1999 · Cited by 32 · see citing works

Mutations within Four Distinct Gag Proteins Are Required To Restore Replication of Human Immunodeficiency Virus Type 1 after Deletion Mutagenesis within the Dimerization Initiation Site

Liang, C., Rong, L., Quan, Y., Laughrea, M., Kleiman, L., & Wainberg, M. A. (1999) · Journal of Virology · doi:10.1128/jvi.73.8.7014-7020.1999 · Cited by 32 · see citing works

Two Basic Regions of NCp7 Are Sufficient for Conformational Conversion of HIV-1 Dimerization Initiation Site from Kissing-loop Dimer to Extended-duplex Dimer

Takahashi, K., Baba, S., Koyanagi, Y., Yamamoto, N., Takaku, H., & Kawai, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104577200 · Cited by 32 · see citing works

Alternate Usage of Two Dimerization Initiation Sites in HIV-2 Viral RNA In Vitro

Lanchy, J.-M., & Lodmell, J. S. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00369-8 · Cited by 31 · see citing works

HIV RNA packaging and lentivirus-based vectors

Lever, A. M. L. (2000) · Advances in pharmacology · doi:10.1016/s1054-3589(00)48002-6 · Cited by 30 · see citing works

In Vitro Identification and Characterization of an Early Complex Linking HIV-1 Genomic RNA Recognition and Pr55Gag Multimerization

Roldán, A., Russell, R. S., Marchand, B., Götte, M., Liang, C., & Wainberg, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405632200 · Cited by 30 · see citing works

Structure of SL4 RNA from the HIV-1 Packaging Signal,

Kerwood, D. J., Cavaluzzi, M. J., & Borer, P. N. (2001) · Biochemistry · doi:10.1021/bi0111909 · Cited by 29 · see citing works

Reduced Mobilization of Rev-Responsive Element-Deficient Lentiviral Vectors

Lucke, S., Grünwald, T., & Überla, K. (2005) · Journal of Virology · doi:10.1128/jvi.79.14.9359-9362.2005 · Cited by 26 · see citing works

Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage

Strappe, P., Hampton, D. W., Brown, D., Cachón-González, B., Caldwell, M. A., Fawcett, J. W., & Lever, A. M. L. (2005) · Retrovirology · doi:10.1186/1742-4690-2-55 · Cited by 26 · see citing works

Co-localization of gammaretroviral RNAs at their transcription site favours co-packaging

Rasmussen, S. V., & Pedersen, F. S. (2006) · Journal of General Virology · doi:10.1099/vir.0.81759-0 · Cited by 25 · see citing works

The packaging signal of simian immunodeficiency virus is upstream of the major splice donor at a distance from the RNA cap site similar to that of human immunodeficiency virus types 1 and 2

Strappe, P., Greatorex, J. S., Thomas, J. A., Biswas, P., McCann, E., & Lever, A. M. L. (2003) · Journal of General Virology · doi:10.1099/vir.0.19185-0 · Cited by 25 · see citing works

Conformational Pathway for the Kissing Complex→Extended Dimer Transition of the SL1 Stem-Loop from Genomic HIV-1 RNA as Monitored by Targeted Molecular Dynamics Techniques

Aci‐Sèche, S., Mazier, S., & Genest, D. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.06.009 · Cited by 24 · see citing works

Incorporation of tRNA into normal and mutant HIV-1

Kleiman, L., Caudry, S. D., Boulerice, F., Wainberg, M. A., & Parniak, M. A. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91559-u · Cited by 24 · see citing works

Deletion of stem-loop 3 is compensated by second-site mutations within the Gag protein of human immunodeficiency virus type 1.

Rong, L., Russell, R., Hu, J., Laughrea, M., Wainberg, M., & Liang, C. (2003) · Virology · doi:10.1016/s0042-6822(03)00405-7 · Cited by 21 · see citing works

Mutation of the Rev-binding loop in the human immunodeficiency virus 1 leader causes a replication defect characterized by altered RNA trafficking and packaging

Greatorex, J. S., Palmer, E. A., Pomerantz, R. J., Dangerfield, J. A., & Lever, A. M. L. (2006) · Journal of General Virology · doi:10.1099/vir.0.81658-0 · Cited by 21 · see citing works

Monomer−Dimer Equilibrium Constants of RNA in the Dimer Initiation Site of Human Immunodeficiency Virus Type 1

Shubsda, M. F., McPike, M. P., Goodisman, J., & Dabrowiak, J. C. (1999) · Biochemistry · doi:10.1021/bi990744t · Cited by 20 · see citing works

ANTIVIRAL ACTIVITY OF STERIC-BLOCK OLIGONUCLEOTIDES TARGETING THE HIV-1 TRANS-ACTIVATION RESPONSE AND PACKAGING SIGNAL STEM-LOOP RNAS

Brown, D., Arzumanov, A. A., Turner, J. J., Stetsenko, D. A., Lever, A. M. L., & Gait, M. J. (2005) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1081/ncn-200059813 · Cited by 16 · see citing works

Human Immunodeficiency Virus Type 2 Gag Interacts Specifically with PRP4, a Serine-Threonine Kinase, and Inhibits Phosphorylation of Splicing Factor SF2

Bennett, E. M., Lever, A. M. L., & Allen, J. F. (2004) · Journal of Virology · doi:10.1128/jvi.78.20.11303-11312.2004 · Cited by 15 · see citing works

Properties of Visna Virus Particles Harvested at Short Time Intervals: RNA Content, Infectivity, and Ultrastructure

Brahic, M., & Vigne, R. (1975) · Journal of Virology · doi:10.1128/jvi.15.5.1222-1230.1975 · Cited by 13 · see citing works

Translation of Pr55 gag Augments Packaging of Human Immunodeficiency Virus Type 1 RNA in a Cis -Acting Manner

Liang, C., Hu, J., Russell, R. S., & Wainberg, M. A. (2002) · AIDS Research and Human Retroviruses · doi:10.1089/088922202320567851 · Cited by 12 · see citing works

Splicing affects presentation of RNA dimerization signals in HIV-2 in vitro

Lanchy, J.-M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh800 · Cited by 11 · see citing works

RNA‐based gene therapy for HIV infection

Dorman, N., & Lever, A. M. L. (2001) · HIV Medicine · doi:10.1046/j.1468-1293.2001.00052.x · Cited by 10 · see citing works

Anti‐HIV Activity of Steric Block Oligonucleotides

Ivanova, G. D., Arzumanov, A. A., Turner, J. J., Reigadas, S., Toulmé, J., BROWN, D. E., Lever, A. M. L., & Gait, M. J. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1348.033 · Cited by 9 · see citing works

Inhibition of HIV-1 Replication by Oligonucleotide Analogues Directed to the Packaging Signal and Trans-Activating Response Region

Brown, D. E., Arzumanov, A. A., Syed, S., Gait, M. J., & Lever, A. M. L. (2006) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020601700101 · Cited by 8 · see citing works

Inhibition of HIV-1 replication by 5'LTR decoy RNA

Nishitsuji, H., Tamura, Y., Fuse, T., Habu, Y., Miyano‐Kurosaki, N., & TAKAKU, H. (2001) · Nucleic Acids Symposium Series · doi:10.1093/nass/1.1.141 · Cited by 4 · see citing works

HIV-1 assembly, budding, and maturation

Sundquist, W. I., & Krausslich, H.-G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006924 · Cited by 814 · see citing works

Structure of the HIV-1 RNA packaging signal

Keane, S. C., Heng, X., Lu, K., Kharytonchyk, S., Ramakrishnan, V., Carter, G., Barton, S., Hosic, A., Florwick, A., Santos, J., et al. (2015) · Science · doi:10.1126/science.aaa9266 · Cited by 278 · see citing works

NMR Detection of Structures in the HIV-1 5′-Leader RNA That Regulate Genome Packaging

Lu, K., Heng, X., Garyu, L., Monti, S., Garcia, E. L., Kharytonchyk, S., Dorjsuren, B., Kulandaivel, G., Jones, S., Hiremath, A., et al. (2011) · Science · doi:10.1126/science.1210460 · Cited by 260 · see citing works

Application of Aptamers in Virus Detection and Antiviral Therapy

Zou, X., Wu, J., Gu, J., Shen, L., & Mao, L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01462 · Cited by 260 · see citing works

HIV Gag polyprotein: processing and early viral particle assembly

Bell, N. M., & Lever, A. M. L. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2012.11.006 · Cited by 222 · see citing works

The Remarkable Frequency of Human Immunodeficiency Virus Type 1 Genetic Recombination

Onafuwa-Nuga, A., & Telesnitsky, A. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00012-09 · Cited by 174 · see citing works

Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome

Kharytonchyk, S., Monti, S., Smaldino, P. J., Van, V., Bolden, N. C., Brown, J. D., Russo, E., Swanson, C., Shuey, A., Telesnitsky, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616627113 · Cited by 123 · see citing works

Structural basis for transcriptional start site control of HIV-1 RNA fate

Brown, J. D., Kharytonchyk, S., Chaudry, I., Iyer, A. S., Carter, H., Becker, G., Desai, Y., Glang, L., Choi, S. H., Singh, K., et al. (2020) · Science · doi:10.1126/science.aaz7959 · Cited by 118 · see citing works

HIV-1 RNA dimerization: It takes two to tango.

Moore, M. D., & Hu, W. S. (2009) · PubMed · Cited by 114 · see citing works

Dimeric RNA Recognition Regulates HIV-1 Genome Packaging

Nikolaitchik, O. A., Dilley, K. A., Fu, W., Gorelick, R. J., Tai, S.-H. S., Soheilian, F., Ptak, R. G., Nagashima, K., Pathak, V. K., & Hu, W.-S. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003249 · Cited by 106 · see citing works

Identification of a Minimal Region of the HIV-1 5′-Leader Required for RNA Dimerization, NC Binding, and Packaging

Heng, X., Kharytonchyk, S., Garcia, E. L., Lu, K., Divakaruni, S. S., LaCotti, C., Edme, K., Telesnitsky, A., & Summers, M. F. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.01.033 · Cited by 106 · see citing works

Implications of recombination for HIV diversity

Ramírez, B. C., Simon‐Lorière, E., Galetto, R., & Negroni, M. (2008) · Virus Research · doi:10.1016/j.virusres.2008.01.007 · Cited by 97 · see citing works

Dimerization of oskar 3′ UTRs promotes hitchhiking for RNA localization in the Drosophila oocyte

Jambor, H. K., Brunel, C., & Ephrussi, A. (2011) · RNA · doi:10.1261/rna.2686411 · Cited by 91 · see citing works

Tumultuous Relationship between the Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) and the Human APOBEC-3G and APOBEC-3F Restriction Factors

Henriet, S., Mercenne, G., Bernacchi, S., Paillart, J., & Marquet, R. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00040-08 · Cited by 81 · see citing works

Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal

Ding, P., Kharytonchyk, S., Waller, A., Mbaekwe, U., Basappa, S., Kuo, N., Frank, H. M., Quasney, C., Kidane, A., Swanson, C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008519117 · Cited by 69 · see citing works

Wrapping up the bad news – HIV assembly and release

Meng, B., & Lever, A. M. (2013) · Retrovirology · doi:10.1186/1742-4690-10-5 · Cited by 68 · see citing works

Rev: beyond nuclear export.

Groom, H. C. T., Anderson, E. C., & Lever, A. (2009) · Journal of General Virology · doi:10.1099/vir.0.011460-0 · Cited by 69 · see citing works

A new type of IRES within gag coding region recruits three initiation complexes on HIV-2 genomic RNA

Weill, L., James, L., Ulryck, N., Chamond, N., Herbreteau, C. H., Ohlmann, T., & Sargueil, B. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1109 · Cited by 65 · see citing works

Multiple, Switchable Protein:RNA Interactions Regulate Human Immunodeficiency Virus Type 1 Assembly

Bieniasz, P. D., & Telesnitsky, A. (2018) · Annual Review of Virology · doi:10.1146/annurev-virology-092917-043448 · Cited by 62 · see citing works

In-gel probing of individual RNA conformers within a mixed population reveals a dimerization structural switch in the HIV-1 leader

Kenyon, J. C., Prestwood, L. J., Grice, S. F. J. L., & Lever, A. M. L. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt690 · Cited by 60 · see citing works

Genomic analysis of codon, sequence and structural conservation with selective biochemical-structure mapping reveals highly conserved and dynamic structures in rotavirus RNAs with potential cis -acting functions

Li, W., Manktelow, E., von Kirchbach, J. C., Gog, J. R., Desselberger, U., & Lever, A. M. L. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq663 · Cited by 58 · see citing works

Role of HIV-1 RNA and protein determinants for the selective packaging of spliced and unspliced viral RNA and host U6 and 7SL RNA in virus particles

Didierlaurent, L., Racine, P. J., Houzet, L., Chamontin, C., Berkhout, B., & Mougel, M. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr577 · Cited by 57 · see citing works

Cell biology of retroviral RNA packaging

Jouvenet, N., Lainé, S., Pessel-Vivares, L., & Mougel, M. (2011) · RNA Biology · doi:10.4161/rna.8.4.16030 · Cited by 53 · see citing works

Dual Roles for an Arginine-Rich Motif in Specific Genome Recognition and Localization of Viral Coat Protein to RNA Replication Sites in Flock House Virus-Infected Cells

Venter, P. A., Marshall, D., & Schneemann, A. (2009) · Journal of Virology · doi:10.1128/jvi.01780-08 · Cited by 46 · see citing works

Efficient support of virus-like particle assembly by the HIV-1 packaging signal

Comas‐García, M., Kroupa, T., Datta, S. A., Harvin, D., Hu, W.-S., & Rein, A. R. (2018) · eLife · doi:10.7554/elife.38438 · Cited by 46 · see citing works

Advances in HIV-1 Assembly

Lerner, G., Weaver, N. C., Anokhin, B., & Spearman, P. W. (2022) · Viruses · doi:10.3390/v14030478 · Cited by 43 · see citing works

Retrospective on the all-in-one retroviral nucleocapsid protein

Darlix, J., de ROCQUIGNY, H., Mauffret, O., & Mély, Y. (2014) · Virus Research · doi:10.1016/j.virusres.2014.05.011 · Cited by 43 · see citing works

Dynamics of HIV-1 RNA Near the Plasma Membrane during Virus Assembly

Sardo, L., Hatch, S. C., Chen, J., Nikolaitchik, O. A., Burdick, R. C., Chen, D., Westlake, C. J., Lockett, S., Pathak, V. K., & Hu, W.-S. (2015) · Journal of Virology · doi:10.1128/jvi.01146-15 · Cited by 42 · see citing works

SHAPE analysis of the FIV Leader RNA reveals a structural switch potentially controlling viral packaging and genome dimerization

Kenyon, J. C., Tanner, S. J., Łęgiewicz, M., Phillip, P. S., Rizvi, T. A., Grice, S. F. J. L., & Lever, A. M. L. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr252 · Cited by 42 · see citing works

Conserved determinants of lentiviral genome dimerization

Tran, T., Liu, Y., Marchant, J., Monti, S., Seu, M. Y., Zaki, J., Yang, A. L., Bohn, J. A., Ramakrishnan, V., Singh, R., et al. (2015) · Retrovirology · doi:10.1186/s12977-015-0209-x · Cited by 41 · see citing works

NMR Studies of the Structure and Function of the HIV-1 5′-Leader

Keane, S. C., & Summers, M. F. (2016) · Viruses · doi:10.3390/v8120338 · Cited by 41 · see citing works

Understanding retroviral life cycle and its genomic RNA packaging

Chameettachal, A., Mustafa, F., & Rizvi, T. A. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167924 · Cited by 41 · see citing works

The Molecular Biology of Feline Immunodeficiency Virus (FIV)

Kenyon, J. C., & Lever, A. M. L. (2011) · Viruses · doi:10.3390/v3112192 · Cited by 41 · see citing works

Identification of a Heterogeneous Nuclear Ribonucleoprotein-recognition Region in the HIV Rev Protein

Hadian, K., Vincendeau, M., Mäusbacher, N., Nagel, D., Hauck, S. M., Ueffing, M., Loyter, A., Werner, T., Wolff, H., & Brack‐Werner, R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021659 · Cited by 38 · see citing works

A novel combined RNA-protein interaction analysis distinguishes HIV-1 Gag protein binding sites from structural change in the viral RNA leader

Kenyon, J. C., Prestwood, L. J., & Lever, A. M. L. (2015) · Scientific Reports · doi:10.1038/srep14369 · Cited by 35 · see citing works

The basal translation rate of authentic HIV-1 RNA is regulated by 5’UTR nt-pairings at junction of R and U5

Boeraș, I., Seufzer, B. J., Brady, S., Rendahl, A., Heng, X., & Boris‐Lawrie, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-06883-9 · Cited by 36 · see citing works

Targeting RNA–Protein Interactions within the Human Immunodeficiency Virus Type 1 Lifecycle

Bell, N. M., L’Hernault, A., Murat, P., Richards, J. E., Lever, A. M. L., & Balasubramanian, S. (2013) · Biochemistry · doi:10.1021/bi401270d · Cited by 36 · see citing works

The secondary structure of the 5′ end of the FIV genome reveals a long-range interaction between R/U5 and gag sequences, and a large, stable stem–loop

Kenyon, J. C., Ghazawi, A., Cheung, W., Phillip, P. S., Rizvi, T. A., & Lever, A. M. L. (2008) · RNA · doi:10.1261/rna.1284908 · Cited by 36 · see citing works

Structural basis of genomic RNA (gRNA) dimerization and packaging determinants of mouse mammary tumor virus (MMTV)

Aktar, S. J., Vivet-Boudou, V., Ali, L. M., Jabeen, A., Kalloush, R. M., Richer, D., Mustafa, F., Marquet, R., & Rizvi, T. A. (2014) · Retrovirology · doi:10.1186/s12977-014-0096-6 · Cited by 35 · see citing works

The A-rich RNA sequences of HIV-1 pol are important for the synthesis of viral cDNA

Keating, C. P., Hill, M. K., Hawkes, D. J., Smyth, R. P., Isel, C., Le, S.-Y., Palmenberg, A. C., Marshall, J. A., Marquet, R., Nabel, G. J., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn1015 · Cited by 35 · see citing works

From promoting to inhibiting: diverse roles of helicases in HIV-1 Replication

Lorgeoux, R.-P., Guo, F., & Liang, C. (2012) · Retrovirology · doi:10.1186/1742-4690-9-79 · Cited by 35 · see citing works

Unpaired Guanosines in the 5′ Untranslated Region of HIV-1 RNA Act Synergistically To Mediate Genome Packaging

Nikolaitchik, O. A., Somoulay, X., Rawson, J. M. O., Yoo, J. A., Pathak, V. K., & Hu, W.-S. (2020) · Journal of Virology · doi:10.1128/jvi.00439-20 · Cited by 33 · see citing works

Targeting the HIV RNA Genome: High-Hanging Fruit Only Needs a Longer Ladder

Grice, S. F. J. L. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_434 · Cited by 34 · see citing works

Characterization of the interaction between the HIV-1 Gag structural polyprotein and the cellular ribosomal protein L7 and its implication in viral nucleic acid remodeling

Mekdad, H. E., Boutant, E., Karnib, H., Biedma, M. E., Sharma, K. K., Malytska, I., Laumond, G., Roy, M., Réal, É., Paillart, J., et al. (2016) · Retrovirology · doi:10.1186/s12977-016-0287-4 · Cited by 32 · see citing works

HIV-1 Sequence Necessary and Sufficient to Package Non-viral RNAs into HIV-1 Particles

Liu, Y., Nikolaitchik, O. A., Rahman, S. A., Chen, J., Pathak, V. K., & Hu, W.-S. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.06.018 · Cited by 32 · see citing works

Cytoplasmic Utilization of Human Immunodeficiency Virus Type 1 Genomic RNA Is Not Dependent on a Nuclear Interaction with Gag

Grewe, B., Hoffmann, B., Ohs, I., Blißenbach, M., Brandt, S., Tippler, B. G., Grünwald, T., & Überla, K. (2012) · Journal of Virology · doi:10.1128/jvi.06874-11 · Cited by 31 · see citing works

Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp)

Vincendeau, M., Kramer-Hämmerle, S., Hadian, K., Rothenaigner, I., Bell, J. E., Hauck, S. M., Bickel, C., Nagel, D., Kremmer, E., Werner, T., et al. (2010) · AIDS · doi:10.1097/qad.0b013e32833e8758 · Cited by 29 · see citing works

Optimal Packaging of FIV Genomic RNA Depends upon a Conserved Long-range Interaction and a Palindromic Sequence within gag

Rizvi, T. A., Kenyon, J. C., Ali, J., Aktar, S. J., Phillip, P. S., Ghazawi, A., Mustafa, F., & Lever, A. M. L. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.08.019 · Cited by 29 · see citing works

The HIV-1 Rev/RRE system is required for HIV-1 5' UTR cis elements to augment encapsidation of heterologous RNA into HIV-1 viral particles

Cockrell, A. S., van Praag, H., Santistevan, N. J., Ma, H., & Kafri, T. (2011) · Retrovirology · doi:10.1186/1742-4690-8-51 · Cited by 29 · see citing works

Cross- and Co-Packaging of Retroviral RNAs and Their Consequences

Ali, L. M., Rizvi, T. A., & Mustafa, F. (2016) · Viruses · doi:10.3390/v8100276 · Cited by 28 · see citing works

Influence of gag and RRE Sequences on HIV-1 RNA Packaging Signal Structure and Function

Kharytonchyk, S., Brown, J. D., Stilger, K. L., Yasin, S., Iyer, A. S., Collins, J. T., Summers, M. F., & Telesnitsky, A. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.05.029 · Cited by 26 · see citing works

Beyond Plasma Membrane Targeting: Role of the MA domain of Gag in Retroviral Genome Encapsidation

Parent, L. J., & Gudleski-O'Regan, N. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.04.072 · Cited by 28 · see citing works

SHAPE analysis of the 5′ end of the Mason-Pfizer monkey virus (MPMV) genomic RNA reveals structural elements required for genome dimerization

Aktar, S. J., Jabeen, A., Ali, L. M., Vivet-Boudou, V., Marquet, R., & Rizvi, T. A. (2013) · RNA · doi:10.1261/rna.040931.113 · Cited by 25 · see citing works

An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation

Ingemarsdotter, C. K., Zeng, J., Long, Z., Lever, A. M. L., & Kenyon, J. C. (2018) · Retrovirology · doi:10.1186/s12977-018-0407-4 · Cited by 25 · see citing works

Overview of the Nucleic-Acid Binding Properties of the HIV-1 Nucleocapsid Protein in Its Different Maturation States

Mouhand, A., Pasi, M., Catala, M., Zargarian, L., Belfetmi, A., Barraud, P., Mauffret, O., & Tisné, C. (2020) · Viruses · doi:10.3390/v12101109 · Cited by 24 · see citing works

RNA secondary structure of the feline immunodeficiency virus 5′UTR and Gag coding region

James, L., & Sargueil, B. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn447 · Cited by 24 · see citing works

A G–C-Rich Palindromic Structural Motif and a Stretch of Single-Stranded Purines Are Required for Optimal Packaging of Mason–Pfizer Monkey Virus (MPMV) Genomic RNA

Jaballah, S. A., Aktar, S. J., Ali, J., Phillip, P. S., AlDhaheri, N. S., Jabeen, A., & Rizvi, T. A. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.06.043 · Cited by 23 · see citing works

Role of a heterologous retroviral transport element in the development of genetic complementation assay for mouse mammary tumor virus (MMTV) replication

Rizvi, T. A., Ali, J., Phillip, P. S., Ghazawi, A., Jayanth, P., & Mustafa, F. (2009) · Virology · doi:10.1016/j.virol.2008.12.027 · Cited by 21 · see citing works

Deciphering the Role of the Gag-Pol Ribosomal Frameshift Signal in HIV-1 RNA Genome Packaging

Nikolaitchik, O. A., & Hu, W.-S. (2014) · Journal of Virology · doi:10.1128/jvi.03745-13 · Cited by 20 · see citing works

Comparative Structural Effects of HIV-1 Gag and Nucleocapsid Proteins in Binding to and Unwinding of the Viral RNA Packaging Signal

Bell, N. M., Kenyon, J. C., Balasubramanian, S., & Lever, A. M. L. (2012) · Biochemistry · doi:10.1021/bi2017969 · Cited by 18 · see citing works

Zinc Fingers in HIV-1 Gag Precursor Are Not Equivalent for gRNA Recruitment at the Plasma Membrane

Boutant, E., Bonzi, J., Anton, H., Nasim, M. B., Cathagne, R., Réal, É., Dujardin, D., Carl, P., Didier, P., Paillart, J., et al. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.05.035 · Cited by 16 · see citing works

Packaging of Mason-Pfizer monkey virus (MPMV) genomic RNA depends upon conserved long-range interactions (LRIs) between U5 and <i>gag</i> sequences

Kalloush, R. M., Vivet-Boudou, V., Ali, L. M., Mustafa, F., Marquet, R., & Rizvi, T. A. (2016) · RNA · doi:10.1261/rna.055731.115 · Cited by 17 · see citing works

A purine loop and the primer binding site are critical for the selective encapsidation of mouse mammary tumor virus genomic RNA by Pr77Gag

Chameettachal, A., Vivet-Boudou, V., Pitchai, F. N. N., Pillai, V. N., Ali, L. M., Krishnan, A., Bernacchi, S., Mustafa, F., Marquet, R., & Rizvi, T. A. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab223 · Cited by 15 · see citing works

Cross-packaging of genetically distinct mouse and primate retroviral RNAs

AlDhaheri, N. S., Phillip, P. S., Ghazawi, A., Ali, J., Beebi, E., Jaballah, S. A., & Rizvi, T. A. (2009) · Retrovirology · doi:10.1186/1742-4690-6-66 · Cited by 15 · see citing works

Potential inhibition of HIV-1 encapsidation by oligoribonucleotide–dendrimer nanoparticle complexes

Parboosing, R., Chonco, L., de la Mata, J., Govender, T., Maguire, G. E. M., & Kruger, G. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s114446 · Cited by 14 · see citing works

The bifurcated stem loop 4 (SL4) is crucial for efficient packaging of mouse mammary tumor virus (MMTV) genomic RNA

Mustafa, F., Vivet‐Boudou, V., Jabeen, A., Ali, L. M., Kalloush, R. M., Marquet, R., & Rizvi, T. A. (2018) · RNA Biology · doi:10.1080/15476286.2018.1486661 · Cited by 14 · see citing works

Conformational transitions of the HIV-1 Gag polyprotein upon multimerization and gRNA binding

Banerjee, P., & Voth, G. A. (2023) · Biophysical Journal · doi:10.1016/j.bpj.2023.11.017 · Cited by 14 · see citing works

Reciprocal cross-packaging of primate lentiviral (HIV-1 and SIV) RNAs by heterologous non-lentiviral MPMV proteins

Shamsi, I. R. A., AlDhaheri, N. S., Phillip, P. S., Mustafa, F., & Rizvi, T. A. (2010) · Virus Research · doi:10.1016/j.virusres.2010.09.018 · Cited by 13 · see citing works

Biochemical and functional characterization of mouse mammary tumor virus full-length Pr77Gag expressed in prokaryotic and eukaryotic cells

Chameettachal, A., Pillai, V. N., Ali, L. M., Pitchai, F. N. N., Ardah, M. T., Mustafa, F., Marquet, R., & Rizvi, T. A. (2018) · Viruses · doi:10.3390/v10060334 · Cited by 13 · see citing works

Identification and characterization of a new type of inhibitor against the human immunodeficiency virus type-1 nucleocapsid protein

Kim, M.-J., Kim, S. H., Park, J. A., Yu, K. L., Jang, S. I., Kim, B., Lee, E. S., & You, J. C. (2015) · Retrovirology · doi:10.1186/s12977-015-0218-9 · Cited by 12 · see citing works

Mutations in the Basic Region of the Mason-Pfizer Monkey Virus Nucleocapsid Protein Affect Reverse Transcription, Genomic RNA Packaging, and the Virus Assembly Site

Dostálková, A., Kaufman, F., Křížová, I., Kultová, A., Strohalmová, K., Hadravová, R., Ruml, T., & Rumlová, M. (2018) · Journal of Virology · doi:10.1128/jvi.00106-18 · Cited by 12 · see citing works

Identification of Pr78Gag Binding Sites on the Mason-Pfizer monkey virus genomic RNA packaging determinants

Pitchai, F. N. N., Chameettachal, A., Vivet-Boudou, V., Ali, L. M., Pillai, V. N., Krishnan, A., Bernacchi, S., Mustafa, F., Marquet, R., & Rizvi, T. A. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.166923 · Cited by 12 · see citing works

Expression, purification, and characterization of biologically active full-length Mason-Pfizer monkey virus (MPMV) Pr78Gag

Pitchai, F. N. N., Ali, L. M., Pillai, V. N., Chameettachal, A., Ashraf, S. M., Mustafa, F., Marquet, R., & Rizvi, T. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-30142-0 · Cited by 12 · see citing works

Purification and functional characterization of a biologically active full-length feline immunodeficiency virus (FIV) Pr50Gag

Krishnan, A., Pillai, V. N., Chameettachal, A., Mohamed Ali, L., Nuzra Nagoor Pitchai, F., Tariq, S., Mustafa, F., Marquet, R., & A. Rizvi, T. (2019) · Viruses · doi:10.3390/v11080689 · Cited by 12 · see citing works

Role of Purine-Rich Regions in Mason-Pfizer Monkey Virus (MPMV) Genomic RNA Packaging and Propagation

Ali, L. M., Pitchai, F. N. N., Vivet‐Boudou, V., Chameettachal, A., Jabeen, A., Pillai, V. N., Mustafa, F., Marquet, R., & Rizvi, T. A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.595410 · Cited by 9 · see citing works

NMR Studies of Retroviral Genome Packaging

Boyd, P. S., Brown, J. B., Brown, J. D., Catazaro, J., Chaudry, I., Ding, P., Dong, X., Marchant, J., O’Hern, C., Singh, K., et al. (2020) · Viruses · doi:10.3390/v12101115 · Cited by 9 · see citing works

A Stretch of Unpaired Purines in the Leader Region of Simian Immunodeficiency Virus (SIV) Genomic RNA is Critical for its Packaging into Virions

Pillai, V. N., Ali, L. M., Prabhu, S., Krishnan, A., Chameettachal, A., Pitchai, F. N. N., Mustafa, F., & Rizvi, T. A. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167293 · Cited by 8 · see citing works

Multi-Faceted Post-Transcriptional Functions of HIV-1 Rev

Jeang, K. (2012) · Biology · doi:10.3390/biology1020165 · Cited by 7 · see citing works

Quantitative analysis of the formation of nucleoprotein complexes between HIV-1 Gag protein and genomic RNA using transmission electron microscopy

Durand, S., Seigneuret, F., Burlaud‐Gaillard, J., Lemoine, R., Tassi, M., Moreau, A., Mougel, M., Roingeard, P., Tauber, C., & de ROCQUIGNY, H. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101500 · Cited by 7 · see citing works

Identification of a putative Gag binding site critical for feline immunodeficiency virus genomic RNA packaging

Krishnan, A., Ali, L. M., Prabhu, S. G., Pillai, V. N., Chameettachal, A., Vivet-Boudou, V., Bernacchi, S., Mustafa, F., Marquet, R., & Rizvi, T. A. (2024) · RNA · doi:10.1261/rna.079840.123 · Cited by 6 · see citing works

Stabilizing role of structural elements within the 5´ Untranslated Region (UTR) and gag sequences in Mason-Pfizer monkey virus (MPMV) genomic RNA packaging

Kalloush, R. M., Vivet‐Boudou, V., Ali, L. M., Pillai, V. N., Mustafa, F., Marquet, R., & Rizvi, T. A. (2019) · RNA Biology · doi:10.1080/15476286.2019.1572424 · Cited by 6 · see citing works

Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication

Jehad, M. A., Ali, L. M., Pillai, V. N., Prabhu, S. G., Mustafa, F., & Rizvi, T. A. (2026) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf066 · Cited by 5 · see citing works

Expression, purification, and functional characterization of soluble recombinant full-length simian immunodeficiency virus (SIV) Pr55Gag

Pillai, V. N., Ali, L. M., Prabhu, S. G., Krishnan, A., Tariq, S., Mustafa, F., & Rizvi, T. A. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e12892 · Cited by 4 · see citing works

6thInternational Symposium on Retroviral Nucleocapsid

Berkhout, B., Gorelick, R. J., Summers, M. F., Mély, Y., & Darlix, J. (2008) · Retrovirology · doi:10.1186/1742-4690-5-21 · Cited by 4 · see citing works

RNA ‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Jehad, M. A., Prabhu, S., Ali, L. M., Pillai, V. N., Mustafa, F., & Rizvi, T. A. (2026) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1002/brv.70188 · Cited by 2 · see citing works

MMTV RNA packaging requires an extended long-range interaction for productive Gag binding to packaging signals

Prabhu, S. G., Pillai, V. N., Ali, L. M., Vivet-Boudou, V., Chameettachal, A., Bernacchi, S., Mustafa, F., Marquet, R., & Rizvi, T. A. (2024) · PLOS Biology · doi:10.1371/journal.pbio.3002827 · Cited by 2 · see citing works

Aptamers for Personalized Therapeutics

Irfan, M., Khan, R. U., & Qu, F. (2021) · Springer eBooks · doi:10.1007/978-981-33-4838-7_7 · Cited by 2 · see citing works

Funktionelle Charakterisierung der HERV-K Proteine Env und Rec

Hanke, K. (2010) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-8920 · Cited by 1 · see citing works

STUDIES OF THE DIMERIZATION AND PACKAGING SIGNALS IN HIV-2 RNA

Baig, T. T. (2008) · The Mathematics Enthusiast · Cited by 1 · see citing works

HIV-1 Rev Expression and Functions

Grewe, B., & Überla, K. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7101-5_63

HIV-1 virus cycle replication: a review of RNA polymerase II transcription, alternative splicing and protein synthesisPreprint

Pascual, M. R. (2019) · arXiv (Cornell University) · doi:10.48550/arxiv.1903.05067

Insights into the mechanisms of HIV-1 cis elements and trans factors required for RNA encapsidation and transduction

Cockrell, A. S. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/t9n9-ct90

HIV-1 Rev Expression and Functions

Grewe, B., & Überla, K. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9610-6_63-1

Molecular Biology of HIV-2

Lever, A. M. L. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9610-6_43-1

Molecular Biology of HIV-2

Lever, A. M. L. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7101-5_43

Elements in the 5′ Untranslated Region of Viral RNA Important for HIV Gag Recognition and Cross-Packaging

Cheng, Z., Nikolaitchik, O. A., Duchon, A. A., Rawson, J. M. O., Pathak, V. K., & Hu, W.-S. (2025) · Viruses · doi:10.3390/v17040551

Étude de l'émergence in vivo d'un variant de virus de l'immunodéficience humaine de type 1 portant des glycoprotéines d'enveloppe naturellement tronquées dans leur domaine cytoplasmique

Beaumont, É. (2009) · theses.fr (ABES) · doi:10.70675/e2a38c00z7838z4dddza10czd0cebef906c0

Etude du contrôle spatiotemporel de la rétrotranscription au cours des phases tardives de la réplication du VIH-1

Racine, P. (2012) · theses.fr (ABES) · doi:10.70675/c500e39bzb544z45aczb2e4z18c4c5ec42e2

Etude des mécanismes contrôlant la spécificité d'encapsidation des ARN dans le VIH-1

Didierlaurent, L. (2010) · theses.fr (ABES) · doi:10.70675/6af45cb6z95b9z414cz94fbzdcd9c17fde4a

Etude de la régulation de l’export nucléaire de l’ARN non-épissé du virus de la leucémie murine

Pessel-Vivares, L. (2014) · theses.fr (ABES) · doi:10.70675/61e764aez358dz4511zb2abz00c501f8506b

Packaging of the HIV-1 RNA Genome

Chen, J., Nikolaitchik, O. A., Dilley, K. A., & Hu, W.-S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7729-7_3

HIV-1 RNA genome packaging: it’s G-rated

Duchon, A. A., & Hu, W.-S. (2024) · mBio · doi:10.1128/mbio.00861-23 · Cited by 27 · see citing works

Cellular Factors Involved in HIV-1 RNA Transport

Williams, C. A. L., Lever, A. M. L., & Abbink, T. E. M. (2010) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814295314_0006 · Cited by 3 · see citing works

On the Selective Packaging of Genomic RNA by HIV-1

Comas‐García, M., Davis, S. R., & Rein, A. R. (2016) · Viruses · doi:10.3390/v8090246 · Cited by 79 · see citing works

HIV-1 specifically encapsidates other nucleic acids than its genomic RNA

Didierlaurent, L., Houzet, L., Paillart, J., Morichaud, Z., Smagulova, F. O., Maurel, S., Marquet, R., & Mougel, M. (2009) · Retrovirology · doi:10.1186/1742-4690-6-s2-p31