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Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.
Open accessAbstract
Repression of yeast a cell-specific genes by the global repressor Ssn6/Tup1 has been linked to a specific organization of chromatin. We report here that Tup1 directly interacts with the amino-terminal tails of histones H3 and H4, providing a molecular basis for this connection. This interaction appears to be required for Tup1 function because amino-terminal mutations in H3 and H4 that weaken interactions with Tup1 cause derepression of both a cell-specific and DNA damage-inducible genes. Moreover, the Tup1 histone-binding domain coincides with the previously defined Tup1 repression domain. Tup1/histone interactions are negatively influenced by high levels of histone acetylation, suggesting a mechanism whereby the organization of chromatin may be modulated in response to changing environmental signals.
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Citations
Cited by
The language of covalent histone modifications
Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
Histone acetylation and transcriptional regulatory mechanisms
Struhl, K. (1998) · Genes & Development · doi:10.1101/gad.12.5.599 · Cited by 1,815
Relationship between Secondary Metabolism and Fungal Development
Calvo, A. M., Wilson, R. A., Bok, J. W., & Keller, N. P. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.447-459.2002 · Cited by 1,123
Grant, P. A., Duggan, L., Côté, J., Roberts, S. M., Brownell, J. E., Candau, R., Ohba, R., Owen-Hughes, T., Allis, C. D., Winston, F., et al. (1997) · Genes & Development · doi:10.1101/gad.11.13.1640 · Cited by 1,085
Metadata
- Authors
- Edmondson, D. G., Smith, M. M., & Roth, S. Y.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1996-05-15
- Volume
- 10
- Issue
- 10
- Pages
- 1247-1259
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2159952125
- Cited by
- 450
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Edmondson, D. G., Smith, M. M., & Roth, S. Y. (1996). Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4. Genes & Development. https://doi.org/10.1101/gad.10.10.1247
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