Cited by 1,256SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesViral Infections and Outbreaks Research

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Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus

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Weiss, Susan R., Navas-Martin, Sonia·2005·Microbiology and Molecular Biology Reviews

DOI 10.1128/mmbr.69.4.635-664.2005PMC PMC1306801

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Abstract

SUMMARY: Coronaviruses are a family of enveloped, single-stranded, positive-strand RNA viruses classified within the Nidovirales order. This coronavirus family consists of pathogens of many animal species and of humans, including the recently isolated severe acute respiratory syndrome coronavirus (SARS-CoV). This review is divided into two main parts; the first concerns the animal coronaviruses and their pathogenesis, with an emphasis on the functions of individual viral genes, and the second discusses the newly described human emerging pathogen, SARS-CoV. The coronavirus part covers (i) a description of a group of coronaviruses and the diseases they cause, including the prototype coronavirus, murine hepatitis virus, which is one of the recognized animal models for multiple sclerosis, as well as viruses of veterinary importance that infect the pig, chicken, and cat and a summary of the human viruses; (ii) a short summary of the replication cycle of coronaviruses in cell culture; (iii) the development and application of reverse genetics systems; and (iv) the roles of individual coronavirus proteins in replication and pathogenesis. The SARS-CoV part covers the pathogenesis of SARS, the developing animal models for infection, and the progress in vaccine development and antiviral therapies. The data gathered on the animal coronaviruses continue to be helpful in understanding SARS-CoV.

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Receptor Homologue Scanning Functions in the Maintenance of MHV-A59 Persistence in Vitro
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Targets of a protease inhibitor, KNI-272, in HIV-1-infected cells
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Vitamin supplements do not reduce incidence of cancer or heart disease
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Mutation of the Immunodominant CD8+ Epitope in the MHV-4 Spike Protein
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Nidovirus Genome Replication and Subgenomic mRNA Synthesis
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More frequent screening would improve detection of colon cancer
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Sorted by citations

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
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“Four common coronavirus genera (alpha, beta, gamma, and delta) circulate among vertebrates and cause mild upper respiratory tract illnesses in humans and gastroenteritis in animals (Weiss and Navas-Martin, 2005).”
Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses
Su, S., Wong, G., Shi, W., Liu, J., Lai, A. C.-K., Zhou, J., Liu, W., Bi, Y., & Gao, G. F. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.03.003 · Cited by 2,956
Evidence for gastrointestinal infection of SARS-CoV-2
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Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology
Channappanavar, R., & Perlman, S. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0629-x · Cited by 2,524
“Coronaviruses infecting the respiratory tract have long been recognized as significant pathogens in domestic and companion animals and as the cause of mild and severe respiratory illness in humans [4, 5].”
Background

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Authors: Weiss, S. R., & Navas-Martin, S.
Affiliations: University of Pennsylvania (US)
Department of Microbiology and Immunology, Center for Molecular Medicine and Infectious Disease, Drexel College of Medicine, Philadelphia, Pennsylvania
Corresponding author: Weiss, Susan R.
ORCID: Weiss, Susan R.
Venue: Microbiology and Molecular Biology Reviews
Publisher: American Society for Microbiology
Published: 2005-12
Volume: 69
Issue: 4
Pages: 635-664
ISSN: 1092-2172 (ISSN-L)
1098-5557
DOI: 10.1128/mmbr.69.4.635-664.2005
PMC: PMC1306801
OpenAlex: W2131988685
Cited by: 1,256
References: 391
Citations by year: 2026: 14 · 2025: 39 · 2024: 69 · 2023: 80 · 2022: 149 · 2021: 253 · 2020: 352 · 2019: 18 · 2018: 12 · 2017: 19 · 2016: 24 · 2015: 14 · 2014: 33 · 2013: 23 · 2012: 18
FWCI: 3.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Microbiology and Molecular Biology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Multiple Sclerosis Society
Drexel University
Multiple Sclerosis Society
National Institutes of Health
National Institute of Allergy and Infectious Diseases (AI 17418, AI-47800, N01 AI060021, R01AI047800, R01AI060021, R01AI017418, AI60021)
National Institute of Neurological Disorders and Stroke (R01NS021954, NS-21954, NS-30606, P01NS030606)
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
Keywords: coronavirus pathogenesis, severe acute respiratory syndrome coronavirus, SARS-CoV, animal coronaviruses, mouse hepatitis virus, reverse genetics, coronavirus proteins, SARS, animal models of infection, vaccine development, antiviral therapy, emerging pathogens
MeSH terms: Animals, Cats, Cattle, Disease Models, Animal, Humans, Viral Proteins, Viral Vaccines, Virion, Coronavirus, Coronavirus Infections, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, Mice

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Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus

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