Cited by 2,761COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchAutoimmune and Inflammatory Disorders Research

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

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Ye, Qing, Wang, Bili, Mao, Jianhua·2020·Journal of Infection

Abstract

Cytokine storm is an excessive immune response to external stimuli. The pathogenesis of the cytokine storm is complex. The disease progresses rapidly, and the mortality is high. Certain evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, the severe deterioration of some patients has been closely related to the cytokine storm in their bodies. This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment.

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  1. [31]Chien J.-Y. Hsueh P.-R. Cheng W.-C. Yu C.-J. Yang P.-C. Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome Respirol (Carlton, Vic) 11 6 2006 715 722 PubMed PMID: 17052299. eng PMC7192207 17052299
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Authors
Ye, Q., Wang, B., & Mao, J.
Affiliations
Children's Hospital of Zhejiang University (CN)
Corresponding author
Mao, Jianhua
Venue
Journal of Infection
Publisher
Elsevier BV
Published
2020-06
Volume
80
Issue
6
Pages
607-613
ISSN
0163-4453 (ISSN-L)
OpenAlex
W3015228903
Cited by
2,761
References
90
Citations by year
2026: 41 · 2025: 87 · 2024: 198 · 2023: 340 · 2022: 526 · 2021: 828 · 2020: 734 · 2019: 3 · 2018: 2
FWCI
28.68
Type
journal article
Language
en
Open access
Locations
  • Journal of Infection (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Zhejiang University
Topics
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords
cytokine storm, COVID-19 pandemic, SARS-CoV-2, inflammatory cytokines, pathogenesis, treatment options, hyperinflammation, mortality
MeSH terms
Betacoronavirus, Cytokine Release Syndrome, COVID-19, SARS-CoV-2, Anti-Inflammatory Agents, Humans, Pneumonia, Viral, Critical Illness, Coronavirus Infections, Pandemics

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