The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
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Cytokine storm is an excessive immune response to external stimuli. The pathogenesis of the cytokine storm is complex. The disease progresses rapidly, and the mortality is high. Certain evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, the severe deterioration of some patients has been closely related to the cytokine storm in their bodies. This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment.
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Cytokine storms have been reported in several viral infections, including SARS-CoV-2.
“Cytokine storms have been reported in several viral infections [96], including SARS-CoV-2 [9, 97].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [97]
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- Authors
- Ye, Q., Wang, B., & Mao, J.
- Affiliations
- Children's Hospital of Zhejiang University (CN)
- Corresponding author
- Mao, Jianhua
- Venue
- Journal of Infection
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 80
- Issue
- 6
- Pages
- 607-613
- ISSN
- 0163-4453 (ISSN-L)
- PMC
- PMC7194613
- OpenAlex
- W3015228903
- Cited by
- 2,761
- References
- 90
- Citations by year
- 2026: 41 · 2025: 87 · 2024: 198 · 2023: 340 · 2022: 526 · 2021: 828 · 2020: 734 · 2019: 3 · 2018: 2
- FWCI
- 28.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Infection (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Zhejiang University
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- cytokine storm, COVID-19 pandemic, SARS-CoV-2, inflammatory cytokines, pathogenesis, treatment options, hyperinflammation, mortality
- MeSH terms
- Betacoronavirus, Cytokine Release Syndrome, COVID-19, SARS-CoV-2, Anti-Inflammatory Agents, Humans, Pneumonia, Viral, Critical Illness, Coronavirus Infections, Pandemics
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