Contrasting strategies for sucrose utilization in a floral yeast clade
Open accessAbstract
Microbes usually have flexible metabolic capabilities and are able to use different compounds to meet their needs. The yeasts belonging to the Wickerhamiella and Starmerella genera (forming the so-called W/S clade) are usually found in flowers or insects that visit flowers and are known for having acquired many genes from bacteria by a process called horizontal gene transfer.
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Starmerella is considered a resource specialist organised in microbial consortia, capable of utilising a broad spectrum of carbohydrates, easily switching between respiration and fermentation depending on sugar and oxygen access.
“Starmerella is considered more as a resource specialist organised in microbial consortia, capable of utilising a broad spectrum of carbohydrates, easily switching between respiration and fermentation (reacquired in most species) depending on sugar and oxygen access whereas Wickerhammiella mostly lost fermentation ability and specialized in the utilization of a narrow spectrum of carbohydrates, rel”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Gonçalves et al. 2022
The Discussion (page unavailable) says Wickerhamiella has a somewhat broader niche than Starmerella and describes a broad-range pathway for using various disaccharides—the reverse of the claimed carbohydrate contrast. The Results (page unavailable) also report several Wickerhamiella species using maltose, melezitose and palatinose. The Introduction discusses switching between respiration and fermentation in yeasts generally, not the claimed easy switching by Starmerella according to sugar and oxygen access. (LLM, conf=0.85)
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Experimental — accuracy not yet measuredWickerhamiella mostly lost fermentation ability and specialized in the utilization of a narrow spectrum of carbohydrates, relying on intracellular sucrose metabolism.
“Starmerella is considered more as a resource specialist organised in microbial consortia, capable of utilising a broad spectrum of carbohydrates, easily switching between respiration and fermentation (reacquired in most species) depending on sugar and oxygen access whereas Wickerhammiella mostly lost fermentation ability and specialized in the utilization of a narrow spectrum of carbohydrates, rel”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Gonçalves et al. 2022
The Discussion (page unavailable) says Wickerhamiella species tend to be exclusively respiratory, and that several use an intracellular pathway for sucrose assimilation. But it describes that pathway as broad in substrate range and says Wickerhamiella may have a broader niche than Starmerella; intracellular sucrose metabolism also does not apply to all Wickerhamiella species. (LLM, conf=0.88)
Experimental — accuracy not yet measured
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Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
IQ-TREE: A Fast and Effective Stochastic Algorithm for Estimating Maximum-Likelihood Phylogenies
Nguyen, L.-T., Schmidt, H. A., von Haeseler, A., & Minh, B. Q. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msu300 · Cited by 26,046 · see citing works
SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing
Bankevich, A., Nurk, S., Antipov, D., Gurevich, A. A., Dvorkin, M. V., Kulikov, A. S., Lesin, V. M., Nikolenko, S., Pham, S., Prjibelski, A. D., et al. (2012) · Journal of Computational Biology · doi:10.1089/cmb.2012.0021 · Cited by 25,691 · see citing works
QUAST: quality assessment tool for genome assemblies
Gurevich, A., Saveliev, V., Vyahhi, N., & Tesler, G. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt086 · Cited by 11,172 · see citing works
Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences
Li, W.-Z., & Godzik, A. (2006) · Bioinform. · doi:10.1093/bioinformatics/btl158 · Cited by 10,994 · see citing works
UFBoot2: Improving the Ultrafast Bootstrap Approximation
Hoang, D. T., Chernomor, O., von Haeseler, A., Minh, B. Q., & Vinh, L. S. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msx281 · Cited by 10,881 · see citing works
Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation
Letunic, I., & Bork, P. (2021) · Nucleic Acids Res. · doi:10.1093/nar/gkab301 · Cited by 9,899 · see citing works
OrthoFinder: phylogenetic orthology inference for comparative genomics
Emms, D. M., & Kelly, S. (2019) · Genome Biology · doi:10.1186/s13059-019-1832-y · Cited by 7,676 · see citing works
Kurtzman, C. P., & Lodder, J. (1972) · Mycologia · doi:10.2307/3758036 · Cited by 3,441 · see citing works
The Black Queen Hypothesis: Evolution of Dependencies through Adaptive Gene Loss
Morris, J., Lenski, R. E., & Zinser, E. R. (2012) · mBio · doi:10.1128/mbio.00036-12 · Cited by 1,212 · see citing works
Snowdrift game dynamics and facultative cheating in yeast
Gore, J., Youk, H., & van Oudenaarden, A. (2009) · Nature · doi:10.1038/nature07921 · Cited by 653 · see citing works
Tempo and Mode of Genome Evolution in the Budding Yeast Subphylum
Shen, X.-X., Opulente, D. A., Kominek, J., Zhou, X., Steenwyk, J. L., Buh, K. V., Haase, M. A. B., Wisecaver, J. H., Wang, M., Doering, D. T., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.023 · Cited by 619 · see citing works
MAFFT: Iterative Refinement and Additional Methods
Katoh, K., & Standley, D. M. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-646-7_8 · Cited by 520 · see citing works
The Prisoner's Dilemma and polymorphism in yeast SUC genes
Greig, D., & Travisano, M. (2004) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rsbl.2003.0083 · Cited by 282 · see citing works
Sucrose Utilization in Budding Yeast as a Model for the Origin of Undifferentiated Multicellularity
Koschwanez, J. H., Foster, K. R., & Murray, A. W. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001122 · Cited by 243 · see citing works
The birth, evolution and death of metabolic gene clusters in fungi
Rokas, A., Wisecaver, J. H., & Lind, A. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0075-3 · Cited by 222 · see citing works
Alberto, F., Bignon, C., Sulzenbacher, G., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313911200 · Cited by 214 · see citing works
Voordeckers, K., Brown, C. A., Vanneste, K., van der Zande, E., Voet, A. R. D., Maere, S., & Verstrepen, K. J. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001446 · Cited by 201 · see citing works
Hexose and pentose transport in ascomycetous yeasts: an overview
Leandro, M. J., Fonseca, C., & GonçAlves, P. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00509.x · Cited by 150 · see citing works
Self-citationSucrose andSaccharomyces cerevisiae: a relationship most sweet
Marques, W. L., Raghavendran, V., Stambuk, B. U., & Gombert, A. K. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov107 · Cited by 145 · see citing works
Driscoll, T., Verhoeve, V. I., Guillotte, M. L., Lehman, S. S., Rennoll, S. A., Beier‐Sexton, M., Rahman, M. S., Azad, A. F., & Gillespie, J. J. (2017) · mBio · doi:10.1128/mbio.00859-17 · Cited by 131 · see citing works
Fungal metabolic gene clusters—caravans traveling across genomes and environments
Wisecaver, J. H., & Rokas, A. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00161 · Cited by 128 · see citing works
Genome Diversity and Evolution in the Budding Yeasts (Saccharomycotina)
Dujon, B., & Louis, E. J. (2017) · Genetics · doi:10.1534/genetics.116.199216 · Cited by 127 · see citing works
Sugar Metabolism in Yeasts: an Overview of Aerobic and Anaerobic Glucose Catabolism
Rodrigues, F. J. S., Ludovico, P., & Leão, C. (2006) · Springer eBooks · doi:10.1007/3-540-30985-3_6 · Cited by 114 · see citing works
Three-dimensional Structure of Saccharomyces Invertase
Sainz-Polo, M. Á., Ramirez-Escudero, M., Lafraya, Á., González, B., Marín‐Navarro, J., Polaina, J., & Sanz‐Aparicio, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.446435 · Cited by 109 · see citing works
Eukaryotic Acquisition of a Bacterial Operon
Kominek, J., Doering, D. T., Opulente, D. A., Shen, X., Zhou, X., DeVirgilio, J. H., Hulfachor, A. B., Groenewald, M., Mcgee, M. A., Karlen, S. D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.034 · Cited by 109 · see citing works
Byrne, K. P., & Wolfe, K. H. (2006) · Genetics · doi:10.1534/genetics.106.066951 · Cited by 103 · see citing works
Prielhofer, R., Cartwright, S. P., Graf, A. B., Valli, M., Bill, R. M., Mattanovich, D., & Gasser, B. (2015) · BMC Genomics · doi:10.1186/s12864-015-1393-8 · Cited by 98 · see citing works
Wolff, D. (2006) · Annals of Botany · doi:10.1093/aob/mcl033 · Cited by 98 · see citing works
Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineage
Gonçalves, C., Wisecaver, J. H., Kominek, J., Salema‐Oom, M., Leandro, M. J., Shen, X., Opulente, D. A., Zhou, X., Peris, D., Kurtzman, C. P., et al. (2018) · eLife · doi:10.7554/elife.33034 · Cited by 91 · see citing works
Self-citationSalema‐Oom, M., Pinto, V. V., Gonçalves, P. M., et al. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.9.5044-5049.2005 · Cited by 87 · see citing works
Self-citationMaltose Transport by Brewer's Yeasts in Brewer's Wort
Rautio, J. J., & Londesborough, J. (2003) · Journal of the Institute of Brewing · doi:10.1002/j.2050-0416.2003.tb00166.x · Cited by 80 · see citing works
Genome reduction in prokaryotic obligatory intracellular parasites of humans: a comparative analysis
Sakharkar, K. R., Dhar, P. K., & Chow, V. T. K. (2004) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.63090-0 · Cited by 78 · see citing works
Mittelbach, M., Yurkov, A. M., Nocentini, D., Nepi, M., Weigend, M., & Begerow, D. (2015) · BMC Ecology · doi:10.1186/s12898-015-0036-x · Cited by 74 · see citing works
Reinders, A., & Ward, J. M. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02237.x · Cited by 68 · see citing works
Extensive Intra-Kingdom Horizontal Gene Transfer Converging on a Fungal Fructose Transporter Gene
Coelho, M. A., Gonçalves, C., Sampaio, J. P., & Gonçalves, P. M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003587 · Cited by 65 · see citing works
Self-citationLincoln, L., & More, S. S. (2017) · Journal of Basic Microbiology · doi:10.1002/jobm.201700269 · Cited by 65 · see citing works
Gonçalves, P. M., Gonçalves, C., Brito, P. H., & Sampaio, J. P. (2020) · Yeast · doi:10.1002/yea.3463 · Cited by 62 · see citing works
Self-citationCanto, A., Herrera, C. M., & Rodríguez, R. (2017) · PeerJ · doi:10.7717/peerj.3517 · Cited by 60 · see citing works
Factors driving metabolic diversity in the budding yeast subphylum
Opulente, D. A., Rollinson, E. J., Bernick-Roehr, C., Hulfachor, A. B., Rokas, A., Kurtzman, C. P., & Hittinger, C. T. (2018) · BMC Biology · doi:10.1186/s12915-018-0498-3 · Cited by 58 · see citing works
Thermostable extracellular ?-amylase and ?-glucosidase ofLipomyces starkeyi
Kelly, C. T., Moriarty, M. E., & Fogarty, W. M. (1985) · Applied Microbiology and Biotechnology · doi:10.1007/bf00582419 · Cited by 56 · see citing works
Pontes, A., Hutzler, M., Brito, P. H., & Sampaio, J. P. (2020) · Microorganisms · doi:10.3390/microorganisms8060903 · Cited by 54 · see citing works
de Vega, C., Albaladejo, R. G., Guzmán, B., et al. (2017) · FEMS Yeast Research · doi:10.1093/femsyr/fox054 · Cited by 49 · see citing works
Stepwise Functional Evolution in a Fungal Sugar Transporter Family
Gonçalves, C., Coelho, M. A., Salema‐Oom, M., et al. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv220 · Cited by 48 · see citing works
Self-citationTwo Different Signals Regulate Repression and Induction of Gene Expression by Glucose
Özcan, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208726200 · Cited by 46 · see citing works
Gonçalves, C., & Gonçalves, P. M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909844116 · Cited by 45 · see citing works
Self-citationPomraning, K., Collett, J. R., Kim, J., et al. (2019) · Biotechnology for Biofuels · doi:10.1186/s13068-019-1510-z · Cited by 43 · see citing works
Loureiro-Dias, M. C. (1988) · Antonie van Leeuwenhoek · doi:10.1007/bf00393524 · Cited by 31 · see citing works
Jansen, M. L. A., Krook, D. J. J., Graaf, K. D., et al. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00091.x · Cited by 21 · see citing works
Viigand, K., Visnapuu, T., Ernits, K., Aasamets, A., & Alamäe, T. (2016) · Yeast · doi:10.1002/yea.3157 · Cited by 20 · see citing works
Intra- and extracellular forms of α-Glucosidase from Aspergillus niger
Rudick, M. J., Fitzgerald, Z. E., & Rudick, V. L. (1979) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(79)90058-4 · Cited by 16 · see citing works
Reiser, V., & Gašperı́k, J. (1995) · Biochemical Journal · doi:10.1042/bj3080753 · Cited by 15 · see citing works
Genome Mining of Non-Conventional Yeasts: Search and Analysis of MAL Clusters and Proteins
Viigand, K., Põšnograjeva, K., Visnapuu, T., & Alamäe, T. (2018) · Genes · doi:10.3390/genes9070354 · Cited by 14 · see citing works
Visnapuu, T., Meldre, A., Põšnograjeva, K., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010297 · Cited by 10 · see citing works
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Gonçalves, C., Steenwyk, J. L., Rinker, D. C., Opulente, D. A., LaBella, A. L., Harrison, M.-C., Wolters, J. F., Zhou, X., Shen, X.-X., Covo, S., et al. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf285 · Cited by 4 · see citing works
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Łabędzka-Dmoch, K., Bui, T. H. D., Piątkowski, J., Dilling, M., Jagiełło, P., Kabza, W., & Golik, P. (2026) · Molecular Biology and Evolution · doi:10.1093/molbev/msag005 · Cited by 1 · see citing works
- Authors
- Gonçalves, C., Marques, M., & Gonçalves, P.
- Affiliations
- Unidade em Ciências Biomoleculares Aplicadas (PT)
- Corresponding author
- Gonçalves, Carla
- Gonçalves, Paula
- Venue
- mSphere
- Publisher
- American Society for Microbiology
- Published
- 2022-04-27
- Volume
- 7
- Issue
- 2
- Pages
- e0003522-e0003522
- ISSN
- 2379-5042 (ISSN-L)
- PMC
- PMC9044934
- OpenAlex
- W4221120990
- Cited by
- 23
- References
- 54
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 14 · 2022: 1
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mSphere (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- MEC | Fundação para a Ciência e a Tecnologia (PTDC/BIA-MIC/29529/2017, PTDC/BIA-EVL/1100/2020, LA/P/0140/2020, UIDB/04378/2020)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- sucrose utilization, Starmerella, horizontal gene transfer, yeast metabolism
- MeSH terms
- Saccharomycetales, Glucose, Glucosides, Humans, Maltose, Saccharomyces cerevisiae, Sucrose
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