The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Phylogenetically Novel Uncultured Microbial Cells Dominate Earth Microbiomes
Open accessAbstract
In the past few decades, it has become apparent that most of the microbial diversity on Earth has never been characterized in laboratory cultures. We show that these unknown microbes, sometimes called “microbial dark matter,” are numerically dominant in all major environments on Earth, with the exception of the human body, where most of the microbes have been cultured. We also estimate that about one-quarter of the population of microbial cells on Earth belong to phyla with no cultured relatives, suggesting that these never-before-studied organisms may be important for ecosystem functions.
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Cites
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Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · cited 2×
“Marine sediment (48) NA NA NA NA Soil (49) 2,560 49 (2) 758 (30) 1,753 (69) Terrestrial subsurface (49) 2,500 45 (2) 597 (24) 1,858 (74) Seawater (49) 1,010 36 (4) 389 (38) 587 (58) Freshwater (49) 1.”
The SILVA and “All-species Living Tree Project (LTP)” taxonomic frameworks
Yilmaz, P., Parfrey, L. W., Yarza, P., Gerken, J., Pruesse, E., Quast, C., Schweer, T., Peplies, J., Ludwig, W., & Glöckner, F. O. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1209 · Cited by 3,952
Microbial diversity in the deep sea and the underexplored “rare biosphere”
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Isolation of an autotrophic ammonia-oxidizing marine archaeon
Könneke, M., Bernhard, A. E., de la Torre, J. R., Walker, C. B., Waterbury, J. B., & Stahl, D. A. (2005) · Nature · doi:10.1038/nature03911 · Cited by 2,857
Yarza, P., Yilmaz, P., Pruesse, E., Glöckner, F. O., Ludwig, W., Schleifer, K.-H., Whitman, W. B., Euzéby, J., Amann, R., & Rosselló-Móra, R. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3330 · Cited by 2,589
Insights into the phylogeny and coding potential of microbial dark matter
Rinke, C., Schwientek, P., Sczyrba, A., Ivanova, N. N., Anderson, I. J., Cheng, J.-F., Darling, A., Malfatti, S., Swan, B. K., Gies, E. A., et al. (2013) · Nature · doi:10.1038/nature12352 · Cited by 2,394
Microbiology of the Phyllosphere
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A new view of the tree of life
Hug, L. A., Baker, B. J., Anantharaman, K., Brown, C. T., Probst, A. J., Castelle, C. J., Butterfield, C. N., Hernsdorf, A. W., Amano, Y., Ise, K., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.48 · Cited by 2,039
Cited by
Computational methods for chromosome-scale haplotype reconstruction
Garg, S. (2021) · Genome Biology · doi:10.1186/s13059-021-02328-9 · Cited by 116
New technologies for developing phage-based tools to manipulate the human microbiome
Khan Mirzaei, M., & Deng, L. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2021.04.007 · Cited by 53
Sussfeld, D., Lannes, R., Corel, E., Bernard, G., Martin, P., Bapteste, E., Pelletier, E., & Lopez, P. (2025) · Environmental Microbiome · doi:10.1186/s40793-025-00697-3 · Cited by 3
Metadata
- Authors
- Lloyd, K. G., Steen, A. D., Ladau, J., Yin, J., & Crosby, L.
- Venue
- mSystems
- Publisher
- American Society for Microbiology
- Published
- 2018-10-30
- Volume
- 3
- Issue
- 5
- ISSN
- 2379-5077 (ISSN-L)
- OpenAlex
- W2798209956
- Cited by
- 459
- References
- 68
- FWCI
- 32.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lloyd, K. G., Steen, A. D., Ladau, J., Yin, J., & Crosby, L. (2018). Phylogenetically Novel Uncultured Microbial Cells Dominate Earth Microbiomes. mSystems. https://doi.org/10.1128/msystems.00055-18
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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