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PqsE Is Essential for RhlR-Dependent Quorum Sensing Regulation in Pseudomonas aeruginosa

Groleau, Marie-Christine, de Oliveira Pereira, Thays, Dekimpe, Valérie, Déziel, Eric·2020·mSystems
DOI 10.1128/msystems.00194-20
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Abstract

Pseudomonas aeruginosa is a versatile bacterium found in various environments. It can cause severe infections in immunocompromised patients and naturally resists many antibiotics. The World Health Organization listed it among the top priority pathogens for research and development of new antimicrobial compounds. Quorum sensing (QS) is a cell-cell communication mechanism, which is important for P. aeruginosa adaptation and pathogenesis. Here, we validate the central role of the PqsE protein in QS particularly by its impact on the regulator RhlR. This study challenges the traditional dogmas of QS regulation in P. aeruginosa and ties loose ends in our understanding of the traditional QS circuit by confirming RhlR to be the main QS regulator in P. aeruginosa . PqsE could represent an ideal target for the development of new control methods against the virulence of P. aeruginosa . This is especially important when considering that LasR-defective mutants frequently arise, e.g., in chronic infections.

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Metadata

Authors
Groleau, M.-C., de Oliveira Pereira, T., Dekimpe, V., & Déziel, E.
Affiliations
Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique (INRS), Laval, Quebec, Canada
ORCID
Venue
mSystems
Publisher
American Society for Microbiology
Published
2020-06-30
Volume
5
Issue
3
ISSN
2379-5077
DOI
10.1128/msystems.00194-20
Cited by
71
References
0
Language
en
Licence
Funders
Gouvernement du Canada | Canadian Institutes of Health Research (MOP-142466, MOP-97888)

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CoChat. (2026). Citation check: PqsE Is Essential for RhlR-Dependent Quorum Sensing Regulation in Pseudomonas aeruginosa. https://app.cochat.ai/papers/10.1128/msystems.00194-20
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Groleau, M.-C., de Oliveira Pereira, T., Dekimpe, V., & Déziel, E. (2020). PqsE Is Essential for RhlR-Dependent Quorum Sensing Regulation in Pseudomonas aeruginosa. mSystems. https://doi.org/10.1128/msystems.00194-20

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.