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Cited by 28Antifungal resistance and susceptibilityInfection Control in HealthcareFungal Infections and Studies

First patient-to-patient intrahospital transmission of clade I Candida auris in France revealed after a two-month incubation period

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Alanio, Alexandre, Snell, Hannah Marie, Cordier, Camille, Desnos-Olivier, Marie, Dellière, Sarah, Aissaoui, Nesrine, Sturny-Leclère, Aude, Da Silva, Elodie +12 more·2022·Microbiology Spectrum
DOI 10.1128/spectrum.01833-22PMC PMC9604096
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Abstract

While large outbreaks of C. auris in hospital settings have been described, few clear cases of direct transmission have been documented. We here investigated the transmission of C. auris clade I between two patients with a 41- to 61-day delay between exposure and the development of colonization. This may lead to changes in the recommendations concerning treatment of C. auris cases, as an incubation period of this length is one of the first to be reported.

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Crossref · 10.1128/spectrum.01833-22

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  • C. auris displays unique skin tropism and can persist on human skin for a long time.

    “Unlike most Candida species, C. auris displays unique skin tropism and can persist on the human skin for a long time.”

    From The <i>Candida auris</i> Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence (2024) · cites this paper as [16]

    The Results (Investigation of contact patients; page unavailable) report C. auris-positive skin samples in P1, supporting human skin colonization. The Discussion reports detection more than 41 days after possible exposure, but does not establish that C. auris persisted on the skin throughout that period. Our copy also does not establish that its skin tropism is unique compared with most Candida species. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • C. auris skin tropism and persistence are thought to be important factors for C. auris outbreaks in healthcare settings.

    “This attribute is thought to be an important factor for C. auris outbreaks in healthcare settings (16)”

    From The <i>Candida auris</i> Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence (2024) · cites this paper as [16]

    The Results (Investigation of contact patients; page unavailable) report C. auris on the transmitted case’s skin, and the Discussion describes delayed detection after patient-to-patient transmission. However, the paper does not identify skin tropism and persistence as important drivers of healthcare outbreaks; it considers persistent environmental contamination in this case less likely. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

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Cites

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Research works printed but not linked: 24

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Authors
Alanio, A., Snell, H. M., Cordier, C., Desnos-Olivier, M., Dellière, S., Aissaoui, N., Sturny-Leclère, A., Da Silva, E., Eblé, C., Rouveau, M., Thégat, M., Zebiche, W., Lafaurie, M., Denis, B., Touratier, S., Benyamina, M., Dudoignon, E., Hamane, S., Cuomo, C. A., & Dépret, F.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Broad Institute (US)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Institut Pasteur, Université Paris Cité, CNRS, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, UMR2000, Paris, France
  • Laboratoire de parasitologie-mycologie, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France
  • Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
  • Inserm (FR)
Corresponding author
Alanio, Alexandre
ORCID
Venue
Microbiology Spectrum
Publisher
American Society for Microbiology
Published
2022-10-26
Volume
10
Issue
5
Pages
e0183322-e0183322
ISSN
2165-0497 (ISSN-L)
DOI
10.1128/spectrum.01833-22
PMC
PMC9604096
OpenAlex
W4295279939
Cited by
28
References
3
Citations by year
2026: 7 · 2025: 8 · 2024: 10 · 2023: 3
FWCI
2.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Microbiology Spectrum (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Agence Nationale de la Recherche (20CE350007)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
Candida auris, clade 1, patient-to-patient transmission, incubation period, fungal colonization, hospital outbreak
MeSH terms
Whole Genome Sequencing, Candida auris, Antifungal Agents, Candida, Candidiasis, Humans, Microbial Sensitivity Tests, Infectious Disease Incubation Period

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