Potential Fifth Clade of Candida auris, Iran, 2018

Chow, Nancy A.; de Groot, Theun; Badali, Hamid; Abastabar, Mahdi; Chiller, Tom M.; Meis, Jacques F.

doi:10.3201/eid2509.190686

Cited by 356Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

Potential Fifth Clade of Candida auris, Iran, 2018

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Chow, Nancy A., de Groot, Theun, Badali, Hamid, Abastabar, Mahdi, Chiller, Tom M., Meis, Jacques F.·2019·Emerging Infectious Diseases

DOI 10.3201/eid2509.190686PMC PMC6711235

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Abstract

Four major clades of Candida auris have been described, and all infections have clustered in these 4 clades. We identified an isolate representative of a potential fifth clade, separated from the other clades by >200,000 single-nucleotide polymorphisms, in a patient in Iran who had never traveled outside the country.

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Whole-genome sequencing and epidemiologic investigations have revealed near simultaneous emergence of genetically distinct clades of C. auris on different continents: East Asia, South Asia, South America, and Africa, with a potential fifth Iranian clade.
“Whole-genome sequencing and epidemiologic investigations have revealed near simultaneous emergence of genetically distinct clades of C. auris on different continents: East Asia, South Asia, South America, and Africa (Lockhart et al., 2017), with a potential fifth Iranian clade (Chow et al., 2019).”
From Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies (2021) · cites this paper as Chow et al., 2019

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Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally
Chowdhary, A., Sharma, C., & Meis, J. F. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006290 · Cited by 750 · see citing works
Self-citation
Multiple introductions and subsequent transmission of multidrug-resistant Candida auris in the USA: a molecular epidemiological survey.
Chow, N. A., Gade, L., Tsay, S. V., Forsberg, K., Greenko, J. A., Southwick, K. L., Barrett, P. M., Kerins, J. L., Lockhart, S. R., Chiller, T. M., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30597-8 · Cited by 289 · see citing works
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[2]Saris K, Meis JF, Voss A. Candida auris. Curr Opin Infect Dis. 2018; 31: 334– 40. 29878905
[3]Welsh RM, Bentz ML, Shams A, Houston H, Lyons A, Rose LJ, et al. Survival, persistence, and isolation of the emerging multidrug-resistant pathogenic yeast Candida auris on a plastic healthcare surface. J Clin Microbiol. 2017; 55: 2996– 3005. 10.1128/JCM.00921-17 28747370 PMC5625385 · DOI · Paper page
[4]Lockhart SR, Etienne KA, Vallabhaneni S, Farooqi J, Chowdhary A, Govender NP, et al. Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses. Clin Infect Dis. 2017; 64: 134– 40. 10.1093/cid/ciw691 27988485 PMC5215215 · DOI · Paper page
[6]Escandón P, Chow NA, Caceres DH, Gade L, Berkow EL, Armstrong P, et al. Molecular epidemiology of Candida auris in Colombia reveals a highly related, countrywide colonization with regional patterns in amphotericin B resistance. Clin Infect Dis. 2019; 68: 15– 21. 29788045
[7]Rhodes J, Abdolrasouli A, Farrer RA, Cuomo CA, Aanensen DM, Armstrong-James D, et al. Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris. Emerg Microbes Infect. 2018; 7: 43. 10.1038/s41426-018-0045-x 29593275 PMC5874254 · DOI · Paper page
[8]Abastabar M, Haghani I, Ahangarkani F, Rezai MS, Taghizadeh Armaki M, Roodgari S, et al. Candida auris otomycosis in Iran and review of recent literature. Mycoses. 2019; 62: 101– 5. 10.1111/myc.12886 30585653 · DOI
[9]Welsh RM, Sexton DJ, Forsberg K, Vallabhaneni S, Litvintseva A. Insights into the unique nature of the East Asian clade of the emerging pathogenic yeast Candida auris. J Clin Microbiol. 2019; 57: e00007– 00019. 10.1128/JCM.00007-19 30760535 PMC6440783 · DOI
[10]Kwon YJ, Shin JH, Byun SA, Choi MJ, Won EJ, Lee D, et al. Candida auris clinical isolates from South Korea: Identification, antifungal susceptibility, and genotyping. J Clin Microbiol. 2019; 57: e01624– 18. 10.1128/JCM.01624-18 30728190 PMC6440790 · DOI

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Authors: Chow, N. A., de Groot, T., Badali, H., Abastabar, M., Chiller, T. M., & Meis, J. F.
Affiliations: Centers for Disease Control and Prevention (US)
Corresponding author: Meis, Jacques F.
ORCID: Chow, Nancy A.
Badali, Hamid
Abastabar, Mahdi
Chiller, Tom M.
Meis, Jacques F.
Venue: Emerging Infectious Diseases
Publisher: Centers for Disease Control and Prevention (CDC)
Published: 2019-09
Volume: 25
Issue: 9
Pages: 1780-1781
ISSN: 1080-6040 (ISSN-L)
1080-6059
DOI: 10.3201/eid2509.190686
PMC: PMC6711235
OpenAlex: W2956528092
Cited by: 356
References: 2
Citations by year: 2026: 28 · 2025: 43 · 2024: 52 · 2023: 61 · 2022: 47 · 2021: 61 · 2020: 48 · 2019: 16
FWCI: 32.97
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by
Locations: Emerging infectious diseases (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: Candida auris, clade identification, single nucleotide polymorphisms, fungal genotyping, nosocomial fungal infections, Iran
MeSH terms: Whole Genome Sequencing, Adolescent, Candida, Candidiasis, Female, Humans, Iran, Travel, Otomycosis

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Potential Fifth Clade of Candida auris, Iran, 2018

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