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Multicenter Study of Colistin Heteroresistance in Carbapenem-Resistant Klebsiella pneumoniae Strains in China
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The problem of CRKP has raised alarms concerning global health. Our study enriches the epidemiological study of colistin heteroresistance among CRKP strains in China, where the prevalence of this phenomenon was previously unknown.
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Specific sequence types linked to neonatal infections were identified, such as E. coli ST1193, ST73 and ST95, and K. pneumoniae ST432, which are typically drug-resistant and of clinical significance.
“Indeed, we identified specific STs linked to neonatal infections, such as E. coli ST119347, ST73 and ST9547,48, and K. pneumoniae ST43249 strains, which are typically drug-resistant strains and of clinical significance.”
From Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants. (2025) · cites this paper as [49]
The Observation section reports one K. pneumoniae ST432 isolate, and Table 1 identifies it as a blood isolate carrying the KPC-2 carbapenemase gene. The paper does not link that isolate to a neonatal infection or establish that ST432 strains are typically drug-resistant; it studies one resistant ST432 isolate. The E. coli sequence types are attached to other citations, not this one. (LLM, conf=0.88)
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Metadata
- Authors
- Weng, Y., Wang, T., Huang, B., Yu, H., Jia, W., Shan, B., Qu, F., Tang, Y., Chen, L., & Du, H.
- Affiliations
- Ningbo University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- Ningxia Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Aviation General Hospital (CN)
- Department of Medical Affairs, Danaher Diagnostic Platform/Cepheid (China), New York, New York, USA
- Hackensack Meridian Health (US)
- Corresponding author
- Du, Hong
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2023-08-17
- Volume
- 11
- Issue
- 4
- Pages
- e0221822-e0221822
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC10434274
- OpenAlex
- W4383710411
- Cited by
- 20
- References
- 19
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 6 · 2023: 1
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiology Spectrum (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- The Science Foundation of Jiangsu Province Health Department (ZDB2020014)
- The Science Foundation of Suzhou Health Department (LCZX202106)
- The Discipline Construction Program of the Second Affiliated Hospital of Soochow University (XKTJ-TD202001)
- Science and Technology Program of Suzhou (SLJ2022003)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Microbiology › Enterobacteriaceae and Cronobacter Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- colistin heteroresistance, carbapenem-resistant Klebsiella pneumoniae, colistin resistance, efflux pumps, efflux pump inhibitors, prevalence, genetic mechanisms, China
- MeSH terms
- Carbapenem-Resistant Enterobacteriaceae, Anti-Bacterial Agents, Colistin, Humans, Klebsiella Infections, Klebsiella pneumoniae, Microbial Sensitivity Tests, Carbapenems
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