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Cited by 24Oral microbiology and periodontitis researchBacterial Infections and VaccinesOral and gingival health research

Porphyromonas gingivalis Gingipains Destroy the Vascular Barrier and Reduce CD99 and CD99L2 Expression To Regulate Transendothelial Migration

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Zou, Zhaolei, Fang, Juan, Ma, Wanting, Guo, Junyi, Shan, Zhongyan, Ma, Da, Hu, Qiannan, Wen, Liling +1 more·2023·Microbiology Spectrum
DOI 10.1128/spectrum.04769-22PMC PMC10269447
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Abstract

P. gingivalis is associated with a variety of systemic diseases and colonizes in distal locations in the body. Here, we found that P. gingivalis gingipains degrade PECAM-1 to promote bacterial penetration while simultaneously reducing leukocyte TEM capacity.

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  • Gingipains are potent proteolytic enzymes produced by Pg that degrade tight junction proteins of human endothelial cells.

    “Gingipains are potent proteolytic enzymes produced by Pg that degrade tight junction proteins of human endothelial cells [3,4].”

    From Oral Microbially-Induced Small Extracellular Vesicles Cross the Blood–Brain Barrier (2024) · cites this paper as [4]

    The Introduction identifies gingipains as proteases produced by P. gingivalis. The Results section on PECAM-1 reports that gingipains reduced this endothelial junction protein in human umbilical vein endothelial cells, but it does not establish degradation of tight-junction proteins specifically. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Zou, Z., Fang, J., Ma, W., Guo, J., Shan, Z., Ma, D., Hu, Q., Wen, L., & Wang, Z.
Affiliations
  • Sun Yat-sen University (CN)
  • Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China
Corresponding author
Wang, Zhi
ORCID
Venue
Microbiology Spectrum
Publisher
American Society for Microbiology
Published
2023-06-15
Volume
11
Issue
3
Pages
e0476922-e0476922
ISSN
2165-0497 (ISSN-L)
DOI
10.1128/spectrum.04769-22
PMC
PMC10269447
OpenAlex
W4377011901
Cited by
24
References
1
Citations by year
2026: 15 · 2025: 4 · 2024: 5
FWCI
6.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Microbiology Spectrum (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (82101017, U22A20315, 31670001, 81972532)
  • Sun Yat-sen University
  • Natural Science Foundation of Guangdong Province
  • National Key Research and Development Program of China (2022YFC2402900)
  • Fundamental Research Funds for the Central Universities (87000–31670001)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
Keywords
Porphyromonas gingivalis, gingipains, CD31, CD99, transendothelial migration, bacterial virulence factors, systemic disease, periodontal pathogens
MeSH terms
Gingipain Cysteine Endopeptidases, Animals, Porphyromonas gingivalis, Adhesins, Bacterial, Platelet Endothelial Cell Adhesion Molecule-1, Phosphatidylinositol 3-Kinases, Endothelial Cells, Mice, Transendothelial and Transepithelial Migration

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