The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Physical mechanisms of the therapeutic effect of ultrasound (a review)
Abstract
Therapeutic ultrasound is an emerging field with many medical applications. High intensity focused ultrasound (HIFU) provides the ability to localize the deposition of acoustic energy within the body, which can cause tissue necrosis and hemostasis. Similarly, shock waves from a lithotripter penetrate the body to comminute kidney stones, and transcutaneous ultrasound enhances the transport of chemotherapy agents. New medical applications have required advances in transducer design and advances in numerical and experimental studies of the interaction of sound with biological tissues and fluids. The primary physical mechanism in HIFU is the conversion of acoustic energy into heat, which is often enhanced by nonlinear acoustic propagation and nonlinear scattering from bubbles. Other mechanical effects from ultrasound appear to stimulate an immune response, and bubble dynamics play an important role in lithotripsy and ultrasound-enhanced drug delivery. A dramatic shift to understand and exploit these nonlinear and mechanical mechanisms has occurred over the last few years. Specific challenges remain, such as treatment protocol planning and real-time treatment monitoring. An improved understanding of the physical mechanisms is essential to meet these challenges and to further advance therapeutic ultrasound.
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Cites
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Cited by
Applications of Acoustics and Cavitation to Noninvasive Therapy and Drug Delivery
Coussios, C. C., & Roy, R. A. (2008) · Annual Review of Fluid Mechanics · doi:10.1146/annurev.fluid.40.111406.102116 · Cited by 532
Schroeder, A., Kost, J., & Barenholz, Y. (2009) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2009.08.003 · Cited by 485
A Review of Acoustic Impedance Matching Techniques for Piezoelectric Sensors and Transducers
Rathod, V. T. (2020) · Sensors · doi:10.3390/s20144051 · Cited by 328
Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications
Khokhlova, V. A., Fowlkes, J. B., Roberts, W. W., Schade, G. R., Xu, Z., Khokhlova, T. D., Hall, T. L., Maxwell, A. D., Wang, Y.-N., & Cain, C. A. (2015) · International Journal of Hyperthermia · doi:10.3109/02656736.2015.1007538 · Cited by 317
Self-citationActivating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine
Choi, V., Rajora, M. A., & Zheng, G. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00029 · Cited by 237
Metadata
- Authors
- Bailey, M. R., Khokhlova, V. A., Sapozhnikov, O. A., Kargl, S. G., & Crum, L. A.
- Venue
- Acoustical Physics
- Publisher
- Pleiades Publishing Ltd
- Published
- 2003-07
- Volume
- 49
- Issue
- 4
- Pages
- 369-388
- ISSN
- 1063-7710 (ISSN-L)
- 1562-6865
- OpenAlex
- W1979921670
- Cited by
- 465
- References
- 27
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bailey, M. R., Khokhlova, V. A., Sapozhnikov, O. A., Kargl, S. G., & Crum, L. A. (2003). Physical mechanisms of the therapeutic effect of ultrasound (a review). Acoustical Physics. https://doi.org/10.1134/1.1591291
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