Role of microsomal steroid hydroxylases in Δ7-steroid biosynthesis

The Carbon Monoxide-binding Pigment of Liver Microsomes

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HIGH-RESOLUTION CRYSTAL STRUCTURE OF CYTOCHROME P450-CAM

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Neuroendocrinology of the Skin1

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Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli.

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Neuroendocrinology of the Skin

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Chaperone Coexpression Plasmids: Differential and Synergistic Roles of DnaK-DnaJ-GrpE and GroEL-GroES in Assisting Folding of an Allergen of Japanese Cedar Pollen, Cryj2, in Escherichia coli

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Expression of Bovine 17α-Hydroxylase Cytochrome P-450 cDNA in Nonsteroidogenic (COS 1) Cells

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Smith-Lemli-Opitz Syndrome Is Caused by Mutations in the 7-Dehydrocholesterol Reductase Gene

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The Role of Cytochrome P450 17α-Hydroxylase and 3β-Hydroxysteroid Dehydrogenase in the Integration of Gonadal and Adrenal Steroidogenesis via the Δ5 and Δ4 Pathways of Steroidogenesis in Mammals

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A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin

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ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin.

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C21 steroid side chain cleavage enzyme from porcine adrenal microsomes. Purification and characterization of the 17 alpha-hydroxylase/C17,20-lyase cytochrome P-450.

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Molecular Modeling of Human P450c17 (17α-Hydroxylase/ 17,20-Lyase): Insights into Reaction Mechanisms and Effects of Mutations

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Studies on the steroid hydroxylation system in adrenal cortex microsomes. Purification and characterization of cytochrome P-450 specific for steroid C-21 hydroxylation.

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A pathway for the metabolism of vitamin D ₃ : Unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1)

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Rat P45017αfrom Testis: Characterization of a Full-Length cDNA Encoding a Unique Steroid Hydroxylase Capable of Catalyzing Both Δ4- and Δ5-Steroid-17,20-Lyase Reactions

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Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency.

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Modulation of the activity of human 17 α-hydroxylase-17,20-lyase (CYP17) by cytochrome <i>b</i>5: endocrinological and mechanistic implications

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Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest‐4‐en‐3‐one

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The cholesterol side-chain cleavage system of the adrenal cortex: A mixed-function oxidase

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The Structure of Mycobacterium tuberculosis CYP125

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Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase

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An alternative pathway of vitamin D₂ metabolism: Cytochrome P450scc (CYP11A1)‐mediated conversion to 20‐hydroxyvitamin D₂ and 17,20‐dihydroxyvitamin D₂

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Sequential metabolism of 7-dehydrocholesterol to steroidal 5, 7-dienes in adrenal glands and its biological implication in the skin

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Multiple catalytic properties of the purified and reconstituted cytochrome P-450 (P-450sccII) system of pig testis microsomes.

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5α-Reduced C21 steroids are substrates for human cytochrome P450c17

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Three-dimensional Structure of Steroid 21-Hydroxylase (Cytochrome P450 21A2) with Two Substrates Reveals Locations of Disease-associated Variants

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Expression of a functional 78,000 dalton mammalian flavoprotein, NADPH-cytochrome P-450 oxidoreductase, in Escherichia coli

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Cytochrome P-450 C21scc: One enzyme with two actions: Hydroxylase and lyase

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The Saga of the Ring B Unsaturated Equine Estrogens*

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Cytochrome b5 promotes the synthesis of Δ16-C19 steroids by homogeneous cytochrome P-450 C21 side-chain cleavage from pig testis

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Molecular Cloning and Expression of Guinea Pig Cytochrome P450C17 cDNA (Steroid 17α-Hydroxylase/17,20 Lyase): Tissue Distribution, Regulation, and Substrate Specificity of the Expressed Enzyme

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Cytochrome P450 17α Hydroxylase/17,20 Lyase (CYP17) Function in Cholesterol Biosynthesis: Identification of Squalene Monooxygenase (Epoxidase) Activity Associated with CYP17 in Leydig Cells

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Equine Type Estrogens Produced by a Pregnant Woman Carrying a Smith-Lemli-Opitz Syndrome Fetus

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Assessment of porcine and human 16‐ene‐synthase, a third activity of P450c17, in the formation of an androstenol precursor

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Molecular Cloning and Heterologous Expression in E. coli of Cytochrome P45017α. Comparison of Structural and Functional Properties of Substrate-Specific Cytochromes P450 from Different Species

Gilep, A. A., Estabrook, R. W., & Usanov, S. A. (2003) · Biochemistry (Moscow) · doi:10.1023/a:1022101703670 · Cited by 23 · see citing works

Characterization of the Adrenal Cytochrome P450C17 in the Hamster, a Small Animal Model for the Study of Adrenal Dehydroepiandrosterone Biosynthesis

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An Enzymatically Active Chimeric Protein Containing the Hydrophilic Form of NADPH-Cytochrome P450 Reductase Fused to the Membrane-Binding Domain of Cytochrome b5

Gilep, A. A., Guryev, O. L., Usanov, S. A., & Estabrook, R. W. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5075 · Cited by 21 · see citing works

Comparison of the 17α-Hydroxylase/C17,20-Lyase Activities of Porcine, Guinea Pig and Bovine P450c17 Using Purified Recombinant Fusion Proteins Containing P450c17 Linked to NADPH-P450 Reductase

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Mechanism of intermolecular interactions of microsomal cytochrome P450s CYP17 and CYP21 involved in steroid hormone biosynthesis

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Investigations into the biosynthetic pathways for classical and ring B-unsaturated oestrogens in equine placental preparations and allantochorionic tissues

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Modulation of 17α-Hydroxylase/17,20-Lyase Activity of Guinea Pig Cytochrome P450c17 by Site-Directed Mutagenesis

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Novel activities of CYP11A1 and their potential physiological significance

Slominski, A. T., Li, W., Kim, T.-K., Semak, I., Wang, J., Zjawiony, J. K., & Tuckey, R. C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.010 · Cited by 292 · see citing works

Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders

Slominski, R. M., Tuckey, R. C., Manna, P. R., Jetten, A. M., Postlethwaite, A., Raman, C., & Slominski, A. T. (2020) · Genes &amp; Immunity · doi:10.1038/s41435-020-0096-6 · Cited by 155 · see citing works

Analysis of the transcriptome of Marsdenia tenacissima discovers putative polyoxypregnane glycoside biosynthetic genes and genetic markers

Zheng, K., Zhang, G., Jiang, N.-H., Yang, S., Li, C. L., Meng, Z., Guo, Q., & Long, G. (2014) · Genomics · doi:10.1016/j.ygeno.2014.07.013 · Cited by 24 · see citing works

New azole derivatives of [17(20)E]-21-norpregnene: Synthesis and inhibition of prostate carcinoma cell growth

Nikonovich, T., Hurski, A. L., Morozevich, G. E., Latysheva, А. S., Sushko, T. A., Strushkevich, N. V., Gilep, A. A., Misharin, A. Y., Zhabinskii, V. N., & Khripach, V. A. (2018) · Steroids · doi:10.1016/j.steroids.2018.08.004 · Cited by 18 · see citing works

Electron donation to an archaeal cytochrome P450 is enhanced by PCNA‐mediated selective complex formation with foreign redox proteins

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Novel alkylaminoethyl derivatives of androstane 3-oximes as anticancer candidates: synthesis and evaluation of cytotoxic effects

Ajduković, J. J., Jakimov, D., Rárová, L., Strnad, M., Dzichenka, Y. U., Usanov, S. A., Škorić, D., Jovanović-Šanta, S., & Sakač, M. N. (2021) · RSC Advances · doi:10.1039/d1ra07613b · Cited by 17 · see citing works

Selective ability of rat 7-Dehydrocholesterol reductase (DHCR7) to act on some 7-Dehydrocholesterol metabolites but not on lumisterol metabolites

Tuckey, R. C., Tang, E. K. Y., Chen, Y. A., & Slominski, A. T. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105929 · Cited by 15 · see citing works

Modified bile acids and androstanes—Novel promising inhibitors of human cytochrome P450 17A1

Dzichenka, Y. U., Shapira, M. A., Yantsevich, A., Cherkesova, T., Grbović, L. M., Savić, M. P., Usanov, S. A., & Jovanović-Šanta, S. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105777 · Cited by 10 · see citing works

Different inhibitory effects of azole-containing drugs and pesticides on CYP2C9 polymorphic forms: An in vitro study

Haidukevich, I. V., Sushko, T. A., Tumilovich, A. M., Grabovec, I. P., Usanov, S. A., & Gilep, A. A. (2018) · Toxicology in Vitro · doi:10.1016/j.tiv.2018.04.002 · Cited by 9 · see citing works

Design and synthesis of phosphoryl-substituted steroidal pyridazines (Pho-STPYRs) as potent estrogen receptor alpha inhibitors: targeted treatment of hormone-dependent breast cancer cells

Volkova, Y. A., Scherbakov, A. M., Dzichenka, Y. U., Komkov, A., Bogdanov, F. B., Salnikova, D. I., Dmitrenok, A. S., Sachanka, A. B., Sorokin, D. V., & Zavarzin, I. V. (2024) · RSC Medicinal Chemistry · doi:10.1039/d4md00153b · Cited by 5 · see citing works

At the crossroads of steroid hormone biosynthesis: The role, substrate specificity and evolutionary development of CYP17

Gilep, A. A., Sushko, T. A., & Usanov, S. A. (2010) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.06.021 · Cited by 137 · see citing works

At the crossroads of steroid hormone biosynthesis: The role, substrate specificity and evolutionary development of CYP17 Proteins and proteomics

Gilep, A. A., Sushko, T. A., & Usanov, S. A. (2011) · Biochimica et Biophysica Acta

Enzymatic Phenotyping and Evolutionary Relatedness of Species Specific Cytochromes P450 17α

Estabrook, R. W., Gilip, A., Guryev, O. L., & Usanov, S. A. (2004) · Endocrine Research · doi:10.1081/erc-200044012

Developmental and cAMP-Dependent Regulation of CYP17 Gene Expression

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17-Hydroxylase: an evaluation of the present view of its catalytic role in steroidogenesis

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