ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin.

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458 · see citing works

Melanin pigmentation in mammalian skin and its hormonal regulation

Slominski, A., Tobin, D. J., Shibahara, S., & Wortsman, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00044.2003 · Cited by 2,015 · see citing works

Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress

Slominski, A., Wortsman, J., Luger, T., Paus, R., & Solomon, S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.979 · Cited by 776 · see citing works

Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol

Ito, N., Ito, T., Kromminga, A., Bettermann, A., Takigawa, M., Kees, F., Straub, R. H., & Paus, R. (2005) · The FASEB Journal · doi:10.1096/fj.04-1968fje · Cited by 498 · see citing works

Untitled work

Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461 · see citing works

Key role of CRF in the skin stress response system

Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400 · see citing works

Steroidogenesis in the skin: Implications for local immune functions

Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works

Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1)

Thiboutot, D., Gilliland, K., Cong, Z., Jabara, S., McAllister, J. M., Sivarajah, A., & Clawson, G. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12244.x · Cited by 301 · see citing works

Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function

Taves, M. D., Gomez-Sanchez, C. E., & Soma, K. K. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00100.2011 · Cited by 293 · see citing works

Novel activities of CYP11A1 and their potential physiological significance

Slominski, A. T., Li, W., Kim, T.-K., Semak, I., Wang, J., Zjawiony, J. K., & Tuckey, R. C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.010 · Cited by 292 · see citing works

Differential expression of HPA axis homolog in the skin

Slominski, A., Wortsman, J., Tuckey, R. C., & Paus, R. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.012 · Cited by 279 · see citing works

A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin

Slominski, A., Zjawiony, J., Wortsman, J., Semak, I., Stewart, J., Pisarchik, A., Sweatman, T., Marcos, J., Dunbar, C., & C. Tuckey, R. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04356.x · Cited by 243 · see citing works

CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH

Slominski, A., Zbytek, B., Szczesniewski, A., Semak, I., Kaminski, J., Sweatman, T., & Wortsman, J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00519.2004 · Cited by 211 · see citing works

Disorders in the initial steps of steroid hormone synthesis

Miller, W. L. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.009 · Cited by 205 · see citing works

Recent advances in the diagnosis and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Forest, M. G. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh047 · Cited by 200 · see citing works

The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions

Slominski, A. T., Kim, T.-K., Li, W., Yi, A.-K., Postlethwaite, A., & Tuckey, R. C. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.10.012 · Cited by 170 · see citing works

Corticotropin releasing hormone and the skin

Slominski, A. (2006) · Frontiers in bioscience · doi:10.2741/1966 · Cited by 157 · see citing works

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity

Slominski, A. T., Janjetovic, Z., Fuller, B. E., Zmijewski, M. A., Tuckey, R. C., Nguyen, M. N., Sweatman, T., Li, W., Zjawiony, J., Miller, D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009907 · Cited by 149 · see citing works

CRH stimulates POMC activity and corticosterone production in dermal fibroblasts

Slominski, A., Zbytek, B., Semak, I., Sweatman, T., & Wortsman, J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.01.014 · Cited by 143 · see citing works

Potential mechanism of skin response to stress

SLOMINSKI, A., & MIHM, M. C. (1996) · International Journal of Dermatology · doi:10.1111/j.1365-4362.1996.tb05049.x · Cited by 115 · see citing works

Skin as an endocrine organ: implications for its function

Slominski, A., Wortsman, J., Paus, R., Elias, P. M., Tobin, D. J., & Feingold, K. R. (2008) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2008.04.004 · Cited by 116 · see citing works

60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH

Gallo-Payet, N. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0257 · Cited by 98 · see citing works

Steroid synthesis by primary human keratinocytes; implications for skin disease

Hannen, R. F., Michael, A. E., Jaulim, A., Bhogal, R., Burrin, J. M., & Philpott, M. P. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.11.059 · Cited by 96 · see citing works

Stress-linked cortisol concentrations in hair: what we know and what we need to know

Sharpley, C. F., McFarlane, J. R., & Slominski, A. (2012) · revneuro · doi:10.1515/rns.2011.058 · Cited by 92 · see citing works

The melanocortin receptors and their accessory proteins

Ramachandrappa, S., Gorrigan, R. J., Clark, A. J. L., & Chan, L. F. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00009 · Cited by 87 · see citing works

Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes

Slominski, A. T., Kim, T.-K., Chen, J., Nguyen, M. N., Li, W., Yates, C. R., Sweatman, T., Janjetovic, Z., & Tuckey, R. C. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.07.027 · Cited by 81 · see citing works

Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity

Slominski, A. T., Manna, P. R., & Tuckey, R. C. (2014) · Experimental Dermatology · doi:10.1111/exd.12376 · Cited by 79 · see citing works

Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation

Slominski, A. T., Janjetovic, Z., Kim, T.-K., Wasilewski, P., Rosas, S., Hanna, S., Sayre, R. M., Dowdy, J. C., Li, W., & Tuckey, R. C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.01.014 · Cited by 77 · see citing works

Skin steroidogenesis in health and disease

Nikolakis, G., Stratakis, C. A., Kanaki, T., Slominski, A., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9390-z · Cited by 76 · see citing works

Novel vitamin D photoproducts and their precursors in the skin

Slominski, A., Kim, T.-K., Zmijewski, M. A., Janjetovic, Z., Li, W., Chen, J., Kusniatsova, E. I., Semak, I., Postlethwaite, A., Miller, D. D., et al. (2013) · Dermato-Endocrinology · doi:10.4161/derm.23938 · Cited by 76 · see citing works

Cultured human dermal fibroblasts do produce cortisol

Slominski, A., Zbytek, B., Szczesniewski, A., & Wortsman, J. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700204 · Cited by 66 · see citing works

CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds

Tongkao-on, W., Carter, S., Reeve, V. E., Dixon, K. M., Gordon-Thomson, C., Halliday, G. M., Tuckey, R. C., & Mason, R. S. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.015 · Cited by 63 · see citing works

Sex steroid synthesis in human skin in situ: the roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin

Inoue, T., Miki, Y., Abe, K., Hatori, M., Hosaka, M., Kariya, Y., Kakuo, S., Fujimura, T., Hachiya, A., Honma, S., et al. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.05.005 · Cited by 62 · see citing works

Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells

Slominski, A., Gomez-Sanchez, C. E., Foecking, M. F., & Wortsman, J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00889-3 · Cited by 60 · see citing works

Drug-induced and genetic alterations in stress-responsive systems: implications for specific addictive diseases

Zhou, Y., Proudnikov, D., Yuferov, V., & Kreek, M. J. (2010) · Brain Research · doi:10.1016/j.brainres.2009.11.015 · Cited by 58 · see citing works

Lumisterol is metabolized by CYP11A1: discovery of a new pathway

Tuckey, R. C., Slominski, A. T., Cheng, C. Y. S., Chen, J., Kim, T.-K., Xiao, M., & Li, W. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.08.004 · Cited by 43 · see citing works

Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses

Skobowiat, C., Nejati, R., Lu, L., Williams, R. W., & Slominski, A. T. (2013) · Gene · doi:10.1016/j.gene.2013.08.035 · Cited by 42 · see citing works

Gas chromatography/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes

Slominski, A., Wortsman, J., Foecking, M. F., Shackleton, C., Gomez-Sanchez, C., & Szczesniewski, A. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01648.x · Cited by 41 · see citing works

Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia

Chen, W., Tsai, S.-J., Liao, C.-Y., Tsai, R.-Y., Chen, Y.-J., Pan, B.-J., Hung, C.-L., & Zouboulis, C. C. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700442 · Cited by 25 · see citing works

Role of microsomal steroid hydroxylases in Δ7-steroid biosynthesis

Sushko, T. A., Gilep, A. A., Yantsevich, A. V., & Usanov, S. A. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913030103 · Cited by 10 · see citing works