Alternative oxidase: distribution, induction, properties, structure, regulation, and functions
Abstract
The respiratory chain in the majority of organisms with aerobic type metabolism features the concomitant existence of the phosphorylating cytochrome pathway and the cyanide- and antimycin A-insensitive oxidative route comprising a so-called alternative oxidase (AOX) as a terminal oxidase. In this review, the history of AOX discovery is described. Considerable evidence is presented that AOX occurs widely in organisms at various levels of organization and is not confined to the plant kingdom. This enzyme has not been found only in Archaea, mammals, some yeasts and protists. Bioinformatics research revealed the sequences characteristic of AOX in representatives of various taxonomic groups. Based on multiple alignments of these sequences, a phylogenetic tree was constructed to infer their possible evolution. The ways of AOX activation, as well as regulatory interactions between AOX and the main respiratory chain are described. Data are summarized concerning the properties of AOX and the AOX-encoding genes whose expression is either constitutive or induced by various factors. Information is presented on the structure of AOX, its active center, and the ubiquinone-binding site. The principal functions of AOX are analyzed, including the cases of cell survival, optimization of respiratory metabolism, protection against excess of reactive oxygen species, and adaptation to variable nutrition sources and to biotic and abiotic stress factors. It is emphasized that different AOX functions complement each other in many instances and are not mutually exclusive. Examples are given to demonstrate that AOX is an important tool to overcome the adverse aftereffects of restricted activity of the main respiratory chain in cells and whole animals. This is the first comprehensive review on alternative oxidases of various organisms ranging from yeasts and protists to vascular plants.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CaAoxp is an enzyme protecting against ROS.
“CaAoxp is thought to be an enzyme protecting against ROS (Yan et al. 2009; Rogov et al. 2014), which might be relevant, as dysfunctional Cl and CIII generate more free oxygen radicals (Li et al. 2011).”
From <i>Candida albicans</i> PPR proteins are required for the expression of respiratory Complex I subunits (2024) · cites this paper as Rogov et al. 2014
Cites
VMD: visual molecular dynamics
Humphrey, W., Dalke, A., & Schulten, K. (1996) · Journal of Molecular Graphics · doi:10.1016/0263-7855(96)00018-5 · Cited by 66,952 · see citing works
Analysis Tool Web Services from the EMBL-EBI
McWilliam, H., Li, W., Uludağ, M., Squizzato, S., Park, Y. M., Buso, N., Cowley, A., & López, R. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt376 · Cited by 1,636 · see citing works
The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells
Maxwell, D. P., Wang, Y., & McIntosh, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8271 · Cited by 1,113 · see citing works
Cross Talk in Defense Signaling
Koornneef, A., & Pieterse, C. M. J. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.112029 · Cited by 1,016 · see citing works
Vanlerberghe, G. C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14046805 · Cited by 722 · see citing works
Organization and Regulation of Mitochondrial Respiration in Plants
Millar, A. H., Whelan, J., Soole, K. L., & Day, D. A. (2011) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042110-103857 · Cited by 653 · see citing works
A Fungal Family of Transcriptional Regulators: the Zinc Cluster Proteins
MacPherson, S., Larochelle, M., & Turcotte, B. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00015-06 · Cited by 612 · see citing works
Rhoads, D. M., Umbach, A. L., Subbaiah, C. C., & Siedow, J. N. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.079129 · Cited by 512 · see citing works
T-REX: a web server for inferring, validating and visualizing phylogenetic trees and networks
Boc, A., Diallo, A. B., & Makarenkov, V. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks485 · Cited by 474 · see citing works
Hill, W. R. (1996) · Elsevier eBooks · doi:10.1016/b978-012668450-6/50034-5 · Cited by 425 · see citing works
Schonbaum, G. R., Bonner, W. D., Storey, B. T., & Bahr, J. T. (1971) · PLANT PHYSIOLOGY · doi:10.1104/pp.47.1.124 · Cited by 415 · see citing works
[9] Applications of network BLAST server
Madden, T., Tatusov, R. L., & Zhang, J. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)66011-x · Cited by 412 · see citing works
Giraud, E., Ho, L. H. M., Clifton, R., Carroll, A. J., Estavillo, G. M., Tan, Y., Howell, K. A., Ivanova, A., Pogson, B. J., Millar, A. H., et al. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.115121 · Cited by 405 · see citing works
Clercq, I. D., Vermeirssen, V., Aken, O. V., Vandepoele, K., Murcha, M. W., Law, S. R., Inzé, A., Ng, S., Ivanova, A., Rombaut, D., et al. (2013) · The Plant Cell · doi:10.1105/tpc.113.117168 · Cited by 369 · see citing works
Ng, S., Ivanova, A., Duncan, O., Law, S. R., Aken, O. V., Clercq, I. D., Wang, Y., Carrie, C., Lin, X., Kmiec, B., et al. (2013) · The Plant Cell · doi:10.1105/tpc.113.113985 · Cited by 346 · see citing works
Clifton, R., Millar, A. H., & Whelan, J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.009 · Cited by 344 · see citing works
Monoclonal Antibodies to the Alternative Oxidase of Higher Plant Mitochondria
Elthon, T. E., Nickels, R. L., & McIntosh, L. (1989) · PLANT PHYSIOLOGY · doi:10.1104/pp.89.4.1311 · Cited by 341 · see citing works
Stress-induced co-expression of alternative respiratory chain components in Arabidopsis thaliana
Clifton, R., Lister, R., Parker, K. L., Sappl, P. G., Elhafez, D., Millar, A. H., Day, D. A., & Whelan, J. (2005) · Plant Molecular Biology · doi:10.1007/s11103-005-5514-7 · Cited by 339 · see citing works
Fungal respiration: a fusion of standard and alternative components
Joseph‐Horne, T., Hollomon, D. W., & Wood, P. M. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00251-6 · Cited by 331 · see citing works
Umbach, A. L., & Siedow, J. N. (1993) · PLANT PHYSIOLOGY · doi:10.1104/pp.103.3.845 · Cited by 316 · see citing works
Skirycz, A., Bodt, S. D., Obata, T., Clercq, I. D., Claeys, H., Rycke, R. M. D., Andriankaja, M., Aken, O. V., Breusegem, F. V., Fernie, A. R., et al. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.148965 · Cited by 308 · see citing works
Giraud, E., Aken, O. V., Ho, L. H. M., & Whelan, J. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.139782 · Cited by 276 · see citing works
Vanlerberghe, G. C., & Mclntosh, L. (1996) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.2.589 · Cited by 259 · see citing works
Alternative oxidase: a target and regulator of stress responses
Aken, O. V., Giraud, E., Clifton, R., & Whelan, J. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01240.x · Cited by 247 · see citing works
Robson, C. A., & Vanlerberghe, G. C. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.004853 · Cited by 215 · see citing works
Aken, O. V., Zhang, B., Law, S. R., Narsai, R., & Whelan, J. (2013) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.215996 · Cited by 204 · see citing works
Cyanide-insensitive Respiration in Plant Mitochondria
Bendall, D. S., & Bonner, W. D. (1971) · PLANT PHYSIOLOGY · doi:10.1104/pp.47.2.236 · Cited by 204 · see citing works
Oxidative stress response of filamentous fungi induced by hydrogen peroxide and paraquat
Angelova, M., Pashova, S. B., Spasova, B., Vassilev, S. V., & Slokoska, L. S. (2005) · Mycological Research · doi:10.1017/s0953756204001352 · Cited by 199 · see citing works
Molecular Distinction between Alternative Oxidase from Monocots and Dicots
Considine, M. J., Holtzapffel, R., Day, D. A., Whelan, J., & Millar, A. H. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.004150 · Cited by 194 · see citing works
Gupta, K. J., Shah, J. K., Brotman, Y., Jahnke, K., Willmitzer, L., Kaiser, W. M., Bauwe, H., & Igamberdiev, A. U. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/ers053 · Cited by 189 · see citing works
Structure of the trypanosome cyanide-insensitive alternative oxidase
Shiba, T., Kido, Y., Sakamoto, K., Inaoka, D. K., Tsuge, C., Tatsumi, R., Takahashi, G., Balogun, E. O., Nara, T., Aoki, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218386110 · Cited by 187 · see citing works
Ederli, L., Morettini, R., Borgogni, A., Wasternack, C. H., Miersch, O., Reale, L., Ferranti, F., Tosti, N., & Pasqualini, S. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.085472 · Cited by 186 · see citing works
Fernández‐Ayala, D. J. M., Sanz, A., Vartiainen, S., Kemppainen, K. K., Babušiak, M., Mustalahti, E., Costa, R., Tuomela, T., Zeviani, M., Chung, J., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.004 · Cited by 181 · see citing works
Escobar, M. A., Geisler, D. A., & Rasmusson, A. G. (2006) · The Plant Journal · doi:10.1111/j.1365-313x.2005.02640.x · Cited by 179 · see citing works
Simons, B. H., Millenaar, F. F., Mulder, L., van Loon, L. C., & Lambers, H. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.120.2.529 · Cited by 174 · see citing works
Sieger, S. M., Kristensen, B. K., Robson, C. A., Amirsadeghi, S., Eng, E. W. Y., Abdel-Mesih, A., Møller, I. M., & Vanlerberghe, G. C. (2005) · Journal of Experimental Botany · doi:10.1093/jxb/eri146 · Cited by 173 · see citing works
Trypanosome alternative oxidase: from molecule to function
Chaudhuri, M., Ott, R. D., & Hill, G. C. (2006) · Trends in Parasitology · doi:10.1016/j.pt.2006.08.007 · Cited by 172 · see citing works
Ho, L. H. M., Giraud, E., Uggalla, V., Lister, R., Clifton, R., Glen, A., Thirkettle-Watts, D., Aken, O. V., & Whelan, J. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.121384 · Cited by 169 · see citing works
Alternative oxidase modulates leaf mitochondrial concentrations of superoxide and nitric oxide
Cvetkovska, M., & Vanlerberghe, G. C. (2012) · New Phytologist · doi:10.1111/j.1469-8137.2012.04166.x · Cited by 168 · see citing works
Vanlerberghe, G. C., & McIntosh, L. (1994) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.3.867 · Cited by 167 · see citing works
Vanlerberghe, G. C., Cvetkovska, M., & Wang, J. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01254.x · Cited by 158 · see citing works
Regulation of the Cyanide-resistant Alternative Oxidase of Plant Mitochondria
Rhoads, D. M., Umbach, A. L., Sweet, C. R., Lennon, A. M., Rauch, G. S., & Siedow, J. N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30750 · Cited by 157 · see citing works
The Expression of Alternative Oxidase and Uncoupling Protein during Fruit Ripening in Mango
Considine, M. J., Daley, D. O., & Whelan, J. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.126.4.1619 · Cited by 156 · see citing works
Salicylic Acid Regulation of Respiration in Higher Plants: Alternative Oxidase Expression.
Rhoads, D. M., & McIntosh, L. (1992) · The Plant Cell · doi:10.1105/tpc.4.9.1131 · Cited by 154 · see citing works
Alternative oxidase: a defence against metabolic fluctuations?
Rasmusson, A. G., Fernie, A. R., & van Dongen, J. T. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01252.x · Cited by 150 · see citing works
Identification of the alternative terminal oxidase of higher plant mitochondria
Elthon, T. E., & McIntosh, L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8399 · Cited by 150 · see citing works
Membrane-Bound Diiron Carboxylate Proteins
Berthold, D. A., & Stenmark, P. (2003) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.54.031902.134915 · Cited by 150 · see citing works
Parsons, H. L., Yip, J. Y. H., & Vanlerberghe, G. C. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.121.4.1309 · Cited by 144 · see citing works
Alternative oxidase in animals: unique characteristics and taxonomic distribution
McDonald, A. E., Vanlerberghe, G. C., & Staples, J. F. (2009) · Journal of Experimental Biology · doi:10.1242/jeb.032151 · Cited by 143 · see citing works
Unraveling the Heater: New Insights into the Structure of the Alternative Oxidase
Moore, A. L., Shiba, T., Young, L., Harada, S., Kita, K., & Ito, K. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105432 · Cited by 140 · see citing works
Siedow, J. N., Umbach, A. L., & Moore, A. L. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00196-g · Cited by 139 · see citing works
Hakkaart, G. A. J., Dassa, E. P., Jacobs, H. T., & Rustin, P. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400601 · Cited by 139 · see citing works
Alternative oxidase in higher plants.
Juszczuk, I. M., & Rychter, A. M. (2003) · Acta Biochimica Polonica · doi:10.18388/abp.2003_3649 · Cited by 128 · see citing works
McDonald, A. E., & Vanlerberghe, G. C. (2006) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2006.08.001 · Cited by 128 · see citing works
Strodtkötter, I., Padmasree, K., Challabathula, D., Speth, B., Niazi, P. S., Wojtera, J., Voß, I., Do, P. T., Nunes‐Nesi, A., Fernie, A. R., et al. (2009) · Molecular Plant · doi:10.1093/mp/ssn089 · Cited by 122 · see citing works
Minagawa, N., Koga, S., Nakano, M., Sakajo, S., & Yoshimoto, A. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80444-l · Cited by 122 · see citing works
Thirty years of protein translocation into mitochondria: Unexpectedly complex and still puzzling
Mokranjac, D., & Neupert, W. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.06.021 · Cited by 121 · see citing works
El‐Khoury, R., Dufour, É., Rak, M., Ramanantsoa, N., Grandchamp, N., Csaba, Z., Duvillié, B., Bénit, P., Gallego, J., Gressèns, P., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003182 · Cited by 116 · see citing works
Role of Alternative Oxidase Gene in Pathogenesis of <i>Cryptococcus neoformans</i>
Akhter, S., McDade, H. C., Gorlach, J. M., Heinrich, G., Cox, G. M., & Perfect, J. R. (2003) · Infection and Immunity · doi:10.1128/iai.71.10.5794-5802.2003 · Cited by 115 · see citing works
Characterization of the gene family encoding alternative oxidase from Candida albicans
HUH, W.-K., & KANG, S.-O. (2001) · Biochemical Journal · doi:10.1042/bj3560595 · Cited by 113 · see citing works
Manipulation of alternative oxidase can influence salt tolerance in Arabidopsis thaliana
Smith, C. A., Melino, V. J., Sweetman, C., & Soole, K. L. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01305.x · Cited by 111 · see citing works
Ivanova, A., Law, S. R., Narsai, R., Duncan, O., Lee, J., Zhang, B., Aken, O. V., Radomiljac, J., van der Merwe, M. J., Yi, K., et al. (2014) · PLANT PHYSIOLOGY · doi:10.1104/pp.114.237495 · Cited by 109 · see citing works
Regulation of alternative oxidase activity in higher plants
Day, D. A., & Wiskich, J. T. (1995) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf02110000 · Cited by 105 · see citing works
Yukioka, H., Inagaki, S., Tanaka, R., Katoh, K., Miki, N., Mizutani, A., & MASUKO, M. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00159-6 · Cited by 103 · see citing works
Andronis, E. A., Moschou, P. N., Toumi, I., & Roubelakis–Angelakis, K. A. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00132 · Cited by 99 · see citing works
Wang, J., Rajakulendran, N., Amirsadeghi, S., & Vanlerberghe, G. C. (2011) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2011.01471.x · Cited by 98 · see citing works
Moore, A. L., Umbach, A. L., & Siedow, J. N. (1995) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf02109999 · Cited by 95 · see citing works
Cloning and Analysis of the Alternative Oxidase Gene of Neurospora crassa
Li, Q., Ritzel, R. G., McLean, L. L. T., McIntosh, L., Ko, T., Bertrand, H., & Nargang, F. E. (1996) · Genetics · doi:10.1093/genetics/142.1.129 · Cited by 94 · see citing works
Dojcinovic, D., Krosting, J., Harris, A. J., Wagner, D. J., & Rhoads, D. M. (2005) · Plant Molecular Biology · doi:10.1007/s11103-005-5390-1 · Cited by 94 · see citing works
Fu, L., Shi, K., Gu, M. J., Zhou, Y., Dong, D., Liang, W., Song, F., & Yu, J. (2009) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-23-1-0039 · Cited by 93 · see citing works
Hiser, C., & McIntosh, L. (1990) · PLANT PHYSIOLOGY · doi:10.1104/pp.93.1.312 · Cited by 93 · see citing works
Zhang, D., Xu, F., Zhang, Z., Chen, Y., Du, J., Jia, S.-D., Yuan, S., & Lin, H. (2010) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2010.02211.x · Cited by 92 · see citing works
Cyanide-resistant respiration, a very frequent metabolic pathway in yeasts
Veiga, A., Arrabaça, J. D., & Loureiro-Dias, M. C. (2003) · FEMS Yeast Research · doi:10.1016/s1567-1356(03)00036-9 · Cited by 91 · see citing works
Sluse, F. E., & Jarmuszkiewicz, W. (1998) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1998000600003 · Cited by 91 · see citing works
Regulation of alternative oxidase gene expression in soybean
Djajanegara, I., Finnegan, P. M., Mathieu, C., McCabe, T. C., Whelan, J., & Day, D. A. (2002) · Plant Molecular Biology · doi:10.1023/a:1019942720636 · Cited by 90 · see citing works
Immunological identification of the alternative oxidase of Neurospora crassa mitochondria.
Lambowitz, A. M., Sabourin, J. R., Bertrand, H., Nickels, R. L., & McIntosh, L. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.3.1362 · Cited by 89 · see citing works
Restoration of electron transport without proton pumping in mammalian mitochondria
Perales‐Clemente, E., Bayona‐Bafaluy, M. P., Martos, A. P., Barrientos, A., Fernández‐Silva, P., & Enrı́quez, J. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810518105 · Cited by 89 · see citing works
The alternative oxidase of Candida albicans causes reduced fluconazole susceptibility
Yan, L., Li, M., Cao, Y., Gao, P., Cao, Y., Wang, Y., & Jiang, Y. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp273 · Cited by 89 · see citing works
Kunova, A., Pizzatti, C., & Cortesi, P. (2012) · Pest Management Science · doi:10.1002/ps.3386 · Cited by 89 · see citing works
Aox gene structure, transcript variation and expression in plants
Polidoros, A. N., Mylona, P. V., & Arnholdt‐Schmitt, B. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01284.x · Cited by 88 · see citing works
Plant mitochondria under pathogen attack: A sigh of relief or a last breath?
Colombatti, F., González, D. H., & Welchen, E. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.03.006 · Cited by 85 · see citing works
An Inducible Alternate Terminal Oxidase in Euglena gracilis Mitochondria
Sharpless, T., & Butow, R. A. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63422-2 · Cited by 82 · see citing works
Isolation, Purification, and Characterization of Mitochondria from Chlamydomonas reinhardtii
Eriksson, M., Gardeström, P., & Samuelsson, G. S. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.2.479 · Cited by 82 · see citing works
Liu, J., Li, Z., Wang, Y., & Xing, D. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru222 · Cited by 81 · see citing works
Yip, J. Y. H., & Vanlerberghe, G. C. (2001) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2001.1120305.x · Cited by 80 · see citing works
Almeida, A. M., Jarmuszkiewicz, W., Khomsi, H., Arruda, P., Vercesi, A. E., & Sluse, F. E. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.119.4.1323 · Cited by 79 · see citing works
EPR Studies of the Mitochondrial Alternative Oxidase
Berthold, D. A., Voevodskaya, N. V., Stenmark, P., Gräslund, A., & Nordlund, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206724200 · Cited by 78 · see citing works
Functions of Alternative Terminal Oxidases
(1978) · Elsevier eBooks · doi:10.1016/c2013-0-03004-6 · Cited by 76 · see citing works
Zhang, L., Oh, Y., Li, H., Baldwin, I. T., & Gális, I. (2012) · PLANT PHYSIOLOGY · doi:10.1104/pp.112.200865 · Cited by 76 · see citing works
Wang, J., & Vanlerberghe, G. C. (2013) · Physiologia Plantarum · doi:10.1111/ppl.12059 · Cited by 75 · see citing works
Ruy, F., Vercesi, A. E., & Kowaltowski, A. J. (2006) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-006-9012-7 · Cited by 74 · see citing works
Yoshida, K., WATANABE, C. K., Hachiya, T., Tholen, D., Shibata, M., Terashima, I., & Noguchi, K. (2011) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2010.02267.x · Cited by 73 · see citing works
Dinamarco, T. M., Soriani, F. M., Martins, V. D. P., Nascimento, A. M., Tudella, V. G., Curti, C., & Uyemura, S. A. (2007) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2007.00716.x · Cited by 72 · see citing works
Vanlerberghe, G. C., Vanlerberghe, A. E., & McIntosh, L. (1997) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.2.657 · Cited by 72 · see citing works
Characterization and Solubilization of the Alternative Oxidase of Sauromatum guttatum Mitochondria
Elthon, T. E., & McIntosh, L. (1986) · PLANT PHYSIOLOGY · doi:10.1104/pp.82.1.1 · Cited by 71 · see citing works
The complete mitochondrial genome of Yarrowia lipolytica
Kerscher, S., Durstewitz, G., Casarégola, S., Gaillardin, C. M., & Brandt, U. (2001) · Comparative and Functional Genomics · doi:10.1002/cfg.72 · Cited by 71 · see citing works
Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila
Humphrey, D. M., Parsons, R. B., Ludlow, Z. N., Riemensperger, T. D., Esposito, G., Verstreken, P., Jacobs, H. T., Birman, S., & Hirth, F. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds096 · Cited by 71 · see citing works
Stumpferl, S. W., Stephan, O., & Osiewacz, H. D. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.1.200-211.2004 · Cited by 70 · see citing works
Kemppainen, K. K., Rinne, J., Sriram, A., Lakanmaa, M., Zeb, A., Tuomela, T., Popplestone, A., Singh, S., Sanz, A., Rustin, P., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt601 · Cited by 70 · see citing works
Towards a structural elucidation of the alternative oxidase in plants
Albury, M. S., Elliott, C., & Moore, A. L. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01270.x · Cited by 69 · see citing works
Cyanide-resistant respiration is frequent, but confined to yeasts incapable of aerobic fermentation
Veiga, A., Arrabaça, J. D., & Loureiro-Dias, M. C. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09268.x · Cited by 69 · see citing works
Costa, J. H., Jolivet, Y., Hasenfratz‐Sauder, M., Orellano, E. G., Lima, M. D. G. S., Dizengremel, P., & de Melo, D. F. (2006) · Journal of Plant Physiology · doi:10.1016/j.jplph.2006.04.001 · Cited by 68 · see citing works
SHAM‐sensitive alternative respiration in the xylose‐metabolizing yeast Pichia stipitis
Shi, N., Cruz, J. M., Sherman, F., & Jeffries, T. W. (2002) · Yeast · doi:10.1002/yea.915 · Cited by 67 · see citing works
Signals Required for the Import and Processing of the Alternative Oxidase into Mitochondria
Tanudji, M., Sjöling, S., Glaser, E. G., & Whelan, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.3.1286 · Cited by 67 · see citing works
Molecular Cloning and Functional Expression of Alternative Oxidase from <i>Candida albicans</i>
Huh, W.-K., & Kang, S.-O. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.13.4098-4102.1999 · Cited by 66 · see citing works
Disruption of the Alternative Oxidase Gene in Magnaporthe grisea and Its Impact on Host Infection
Avila‐Adame, C., & Köller, W. (2002) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi.2002.15.5.493 · Cited by 65 · see citing works
Searle, S., Thomas, S., Griffin, K. L., Horton, T. W., Kornfeld, A., Yakir, D., Hurry, V., & Turnbull, M. H. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03557.x · Cited by 65 · see citing works
Milani, G., Jarmuszkiewicz, W., Sluse-Goffart, C. M., Schreiber, A. Z., Vercesi, A. E., & Sluse, F. E. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03060-5 · Cited by 65 · see citing works
Martins, V. P., Dinamarco, T. M., Soriani, F. M., Tudella, V. G., Oliveira, S. C., Goldman, G. H., Curti, C., & Uyemura, S. A. (2011) · Eukaryotic Cell · doi:10.1128/ec.00194-10 · Cited by 64 · see citing works
Pichia pastoris ‘just in time’ alternative respiration
Kern, A., Hartner, F. S., Freigaßner, M. E., Spielhofer, J., Rumpf, C., Leitner, L., Fröhlich, K., & Glieder, A. (2007) · Microbiology · doi:10.1099/mic.0.2006/001404-0 · Cited by 64 · see citing works
Isolation of a cyanide‐resistant duroquinol oxidase from arum maculatum mitochondria
Huq, S., & Palmer, J. M. (1978) · FEBS Letters · doi:10.1016/0014-5793(78)80997-1 · Cited by 63 · see citing works
Mayer, I. A. (1999) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/43.5.651 · Cited by 63 · see citing works
Kido, Y., Sakamoto, K., Nakamura, K., Harada, M., Suzuki, T., Yabu, Y., Saimoto, H., Yamakura, F., Ohmori, D., Moore, A. L., et al. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.12.021 · Cited by 62 · see citing works
Watanabe, C. K., Hachiya, T., Takahara, K., Kawai‐Yamada, M., Uchimiya, H., Uesono, Y., Terashima, I., & Noguchi, K. (2010) · Plant and Cell Physiology · doi:10.1093/pcp/pcq033 · Cited by 61 · see citing works
Chaudhuri, M., Ajayi, W. U., TEMPLE, S., & Hill, G. C. (1995) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.1995.tb05892.x · Cited by 61 · see citing works
Vanlerberghe, G. C., Yip, J. Y. H., & Parsons, H. L. (1999) · PLANT PHYSIOLOGY · doi:10.1104/pp.121.3.793 · Cited by 61 · see citing works
Zhu, Y. J., Lu, J., Wang, J., Chen, F., Leng, F., & Li, H. (2010) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2010.01004.x · Cited by 60 · see citing works
Borghouts, C., Scheckhuber, C. Q., Stephan, O., & Osiewacz, H. D. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00078-x · Cited by 60 · see citing works
A prokaryotic alternative oxidase present in the bacterium Novosphingobium aromaticivorans
Stenmark, P., & Nordlund, P. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00920-7 · Cited by 60 · see citing works
Dinant, M., Baurain, D., Coosemans, N., Joris, B., & Matagne, R. F. (2001) · Current Genetics · doi:10.1007/s002940000183 · Cited by 60 · see citing works
Stress-induced co-expression of two alternative oxidase (VuAox1 and 2b) genes in Vigna unguiculata
Costa, J. H., Mota, É. F., Cambursano, M. V., Lauxmann, M. A., de Oliveira, L. M. N., Lima, M. D. G. S., Orellano, E. G., & de Melo, D. F. (2009) · Journal of Plant Physiology · doi:10.1016/j.jplph.2009.11.001 · Cited by 59 · see citing works
Florez‐Sarasa, I., Lambers, H., Wang, X., Finnegan, P. M., & Ribas‐Carbó, M. (2013) · Plant Cell & Environment · doi:10.1111/pce.12208 · Cited by 57 · see citing works
Sequencing of a Soybean Alternative Oxidase cDNA Clone
Whelan, J., McIntosh, L., & Day, D. A. (1993) · PLANT PHYSIOLOGY · doi:10.1104/pp.103.4.1481 · Cited by 57 · see citing works
Whelan, J., Hugosson, M., Glaser, E. G., & Day, D. A. (1995) · Plant Molecular Biology · doi:10.1007/bf00020229 · Cited by 57 · see citing works
Alternative oxidase expression in Neurospora crassa
Tanton, L. L., Nargang, C. E., Kessler, K. E., Li, Q., & Nargang, F. E. (2003) · Fungal Genetics and Biology · doi:10.1016/s1087-1845(03)00002-1 · Cited by 55 · see citing works
Compelling EPR evidence that the alternative oxidase is a diiron carboxylate protein
Moore, A. L., Carré, J. E., Affourtit, C., Albury, M. S., Crichton, P. G., Kita, K., & Heathcote, P. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.01.004 · Cited by 54 · see citing works
Thomazella, D. P. D. T., Teixeira, P. J. P. L., Oliveira, H. C., Saviani, E. E., Rincones, J., Toni, I. M., Reis, O., Garcia, O., Meinhardt, L. W., Salgado, I., et al. (2012) · New Phytologist · doi:10.1111/j.1469-8137.2012.04119.x · Cited by 54 · see citing works
Grant, N. M., Onda, Y., Kakizaki, Y., Ito, K., Watling, J. R., & Robinson, S. A. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.139394 · Cited by 53 · see citing works
The expression, function and regulation of mitochondrial alternative oxidase under biotic stresses
Hanqing, F., KUN, S., Li, M., HONGYU, L., XIN, L., Li, Y., & YIFENG, W. (2010) · Molecular Plant Pathology · doi:10.1111/j.1364-3703.2010.00615.x · Cited by 53 · see citing works
Cvetkovska, M., Dahal, K., Alber, N. A., Jin, C., Cheung, M., & Vanlerberghe, G. C. (2014) · New Phytologist · doi:10.1111/nph.12773 · Cited by 53 · see citing works
Alternative Oxidase Mediates Pathogen Resistance in Paracoccidioides brasiliensis Infection
Ruiz, O. H., González, Á., Almeida, A. J., Tamayo, D. P., Garcı́a, A. M., Restrepo, Á., & McEwen, J. G. (2011) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001353 · Cited by 52 · see citing works
Liao, Y., Shi, K., Fu, L.-J., Zhang, S., Li, X., Dong, D.-K., Jiang, Y.-P., Zhou, Y., Xia, X., Liang, W.-S., et al. (2011) · Planta · doi:10.1007/s00425-011-1483-z · Cited by 51 · see citing works
Helmerhorst, E. J., Stan, M., Murphy, M. P., Sherman, F., & Oppenheim, F. G. (2005) · Mitochondrion · doi:10.1016/j.mito.2005.04.001 · Cited by 50 · see citing works
The mitochondrial respiratory chain of Ustilago maydis
Juárez, O. X., Guerra, G., Martı́nez, F., & Pardo, J. P. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.06.005 · Cited by 50 · see citing works
Mhadhbi, H., Fotopoulos, V., Mylona, P. V., Jebara, M., Aouani, M. E., & Polidoros, A. N. (2012) · Journal of Plant Physiology · doi:10.1016/j.jplph.2012.08.017 · Cited by 49 · see citing works
Essential role of ferrous iron in cyanide‐resistant respiration in Hansenula anomala
Minagawa, N., Sakajo, S., Komiyama, T., & Yoshimoto, A. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80302-y · Cited by 48 · see citing works
Purification of active recombinant trypanosome alternative oxidase
Nihei, C., Fukai, Y., Kawai, K., Osanai, A., Yabu, Y., Suzuki, T., Ohta, N., Minagawa, N., Nagai, K., & Kita, K. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00120-0 · Cited by 48 · see citing works
The physiologic role of alternative oxidase in Ustilago maydis
Juárez, O. X., Guerra, G., Velázquez‐López, I., Flores-Herrera, Ó., Rivera‐Pérez, R. E., & Pardo, J. P. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05463.x · Cited by 47 · see citing works
Suzuki, Y., Murray, S. L., Wong, K. H., Davis, M. A., & Hynes, M. J. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08067.x · Cited by 46 · see citing works
Tudella, V. G., Curti, C., Soriani, F. M., dos Santos, A. C., & Uyemura, S. A. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(03)00194-8 · Cited by 45 · see citing works
Response of mitochondrial alternative oxidase (AOX) to light signals
Xu, F., Yuan, S., & Lin, H. (2011) · Plant Signaling & Behavior · doi:10.4161/psb.6.1.14192 · Cited by 44 · see citing works
Sakajo, S., Minagawa, N., & Yoshimoto, A. (1997) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.61.396 · Cited by 43 · see citing works
Differential expression and co‐regulation of carrot AOX genes (Daucus carota)
Campos, M. D., Cardoso, H. G., Linke, B., Costa, J. H., de Melo, D. F., Justo, L., Frederico, A. M., & Arnholdt‐Schmitt, B. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01282.x · Cited by 42 · see citing works
Joseph‐Horne, T., Babij, J., Wood, P. M., Hollomon, D. W., & Sessions, R. B. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01943-8 · Cited by 42 · see citing works
Alternative Oxidase Inhibitors Potentiate the Activity of Atovaquone against Plasmodium falciparum
Murphy, A., & Lang-Unnasch, N. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.3.651 · Cited by 42 · see citing works
Xu, T., Yao, F., Liang, W., Li, Y., Li, D., Wang, H., & Wang, Z. (2012) · The Journal of Microbiology · doi:10.1007/s12275-012-2015-7 · Cited by 41 · see citing works
A glucocorticoid-inducible gene expression system can cause growth defects in tobacco
Amirsadeghi, S., McDonald, A. E., & Vanlerberghe, G. C. (2007) · Planta · doi:10.1007/s00425-007-0495-1 · Cited by 41 · see citing works
Characterization of an alternative oxidase activity of Histoplasma capsulatum
Johnson, C. H., Prigge, J. T., Warren, A. D., & McEwen, J. E. (2003) · Yeast · doi:10.1002/yea.968 · Cited by 40 · see citing works
Dolgikh, V. V., Senderskiy, I. V., Pavlova, O. A., Naumov, A. M., & Beznoussenko, G. V. (2011) · Eukaryotic Cell · doi:10.1128/ec.00283-10 · Cited by 40 · see citing works
Xu, T., Wang, Y., Liang, W., Yao, F., Li, Y., Li, D., Wang, H., & Wang, Z. (2013) · The Journal of Microbiology · doi:10.1007/s12275-013-2534-x · Cited by 40 · see citing works
Cyanide-insensitive respiration of Candida lipolytica
Mf, H., Hamaide-Deplus, M. C., & Nyns, E. J. (1974) · Antonie van Leeuwenhoek · doi:10.1007/bf00394556 · Cited by 39 · see citing works
Alternative oxidase: what information can protein sequence comparisons give us?
McDonald, A. E. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01242.x · Cited by 38 · see citing works
Medentsev, A. G., Arinbasarova, A. Y., Golovchenko, N. P., & Akimenko, V. K. (2002) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2002.tb00118.x · Cited by 38 · see citing works
Albury, M. S., Dudley, P., Watts, F. Z., & Moore, A. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17062 · Cited by 38 · see citing works
Guerrero‐Castillo, S., Cabrera‐Orefice, A., Vázquez‐Acevedo, M., González‐Halphen, D., & Uribe‐Carvajal, S. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.11.007 · Cited by 38 · see citing works
Matos, A. R., Mendes, A. T., Scotti‐Campos, P., & Arrabaça, J. D. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01250.x · Cited by 37 · see citing works
Mathy, G., Cardol, P., Dinant, M., Blomme, A., Gérin, S., Cloes, M., Ghysels, B., Pauw, E. D., Leprince, P., Remacle, C., et al. (2010) · Journal of Proteome Research · doi:10.1021/pr900866e · Cited by 37 · see citing works
Gray, G. R., Villarimo, A. R., Whitehead, C. L., & McIntosh, L. (2004) · Plant and Cell Physiology · doi:10.1093/pcp/pch162 · Cited by 37 · see citing works
Costa, J. H., de Melo, D. F., Gouveia, Z. L., Cardoso, H. G., Peixe, A., & Arnholdt‐Schmitt, B. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01267.x · Cited by 36 · see citing works
The alternative oxidase, a tool for compensating cytochrome c oxidase deficiency in human cells
Dassa, E. P., Dufour, É., Gonçalves, S., Jacobs, H. T., & Rustin, P. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01248.x · Cited by 35 · see citing works
Honda, Y., Hattori, T., & Kirimura, K. (2011) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2011.10.026 · Cited by 34 · see citing works
Crichton, P. G., Albury, M. S., Affourtit, C., & Moore, A. L. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.12.010 · Cited by 34 · see citing works
Alternative oxidase involvement in Daucus carota somatic embryogenesis
Frederico, A. M., Campos, M. D., Cardoso, H. G., Imani, J., & Arnholdt‐Schmitt, B. (2009) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2009.01278.x · Cited by 34 · see citing works
Metabolism and aging in the filamentous fungus Podospora anserina
Osiewacz, H. D., & Stumpferl, S. W. (2001) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(01)00096-6 · Cited by 33 · see citing works
The alternative oxidases: simple oxidoreductase proteins with complex functions
Young, L., Shiba, T., Harada, S., Kita, K., Albury, M. S., & Moore, A. L. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130073 · Cited by 33 · see citing works
Integrative response of plant mitochondrial electron transport chain to nitrogen source
Hachiya, T., & Noguchi, K. (2010) · Plant Cell Reports · doi:10.1007/s00299-010-0955-0 · Cited by 33 · see citing works
Cavalcanti, J. H. F., Oliveira, G. M., Saraiva, K. D. D. C., Torquato, J. P. P., Maia, I. G., de Melo, D. F., & Costa, J. H. (2013) · Journal of Plant Physiology · doi:10.1016/j.jplph.2013.06.012 · Cited by 33 · see citing works
Regulation and physiological role of cyanide-resistant oxidases in fungi and plants.
Medentsev, A. G., Ay, A., & Akimenko, V. K. (1999) · PubMed · Cited by 33 · see citing works
Seasonal variation of leaf respiration and the alternative pathway in field‐grown Populus×canadensis
Searle, S., & Turnbull, M. H. (2010) · Physiologia Plantarum · doi:10.1111/j.1399-3054.2010.01442.x · Cited by 32 · see citing works
Enhancement and repression of cyanide-insensitive respiration in Aspergillus niger
Kirimura, K., Matsui, T., SUGANO, S., & Usami, S. (1996) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1996.tb08393.x · Cited by 32 · see citing works
Maréchal, A., Kido, Y., Kita, K., Moore, A. L., & Rich, P. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.059980 · Cited by 30 · see citing works
Functional properties of the Ustilago maydis alternative oxidase under oxidative stress conditions
Sierra‐Campos, E., Velázquez‐López, I., Matuz‐Mares, D., Villavicencio‐Queijeiro, A., & Pardo, J. P. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.01.003 · Cited by 29 · see citing works
Descheneau, A. T., Cleary, I. A., & Nargang, F. E. (2004) · Genetics · doi:10.1534/genetics.104.034017 · Cited by 29 · see citing works
Observations on certain Cestodes of Rats, with an Account of a New Species of Hymenolepis
Baylis, H. A. (1922) · Parasitology · doi:10.1017/s0031182000009860 · Cited by 29 · see citing works
Neimanis, K., Staples, J. F., Hüner, N. P. A., & McDonald, A. E. (2013) · Gene · doi:10.1016/j.gene.2013.04.072 · Cited by 29 · see citing works
Hattori, T., Kino, K., & Kirimura, K. (2009) · Current Microbiology · doi:10.1007/s00284-009-9369-z · Cited by 28 · see citing works
The alternative oxidase of Candida parapsilosis
Guérin, M., & Camougrand, N. M. (1986) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1986.tb09917.x · Cited by 28 · see citing works
Ito, K., Ogata, T., Kakizaki, Y., Elliott, C., Albury, M. S., & Moore, A. L. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.186932 · Cited by 28 · see citing works
Mitochondrial Electron Transport Regulation of Nuclear Gene Expression
Vanlerberghe, C. C., & Mclntosh, L. (1994) · Cited by 28 · see citing works
Sellem, C. H., Bovier, E., Lorin, S., & Sainsard-Chanet, A. (2009) · Genetics · doi:10.1534/genetics.109.100834 · Cited by 27 · see citing works
Interaction of purified alternative oxidase from thermogenic Arum maculatum with pyruvate
Carré, J. E., Affourtit, C., & Moore, A. L. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.12.026 · Cited by 27 · see citing works
Ito‐Inaba, Y., Hida, Y., & Inaba, T. (2009) · Planta · doi:10.1007/s00425-009-1034-z · Cited by 27 · see citing works
Conserved Active Site Sequences in Arabidopsis Plastid Terminal Oxidase (PTOX)
Fu, A., Aluru, M. R., & Rodermel, S. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.017905 · Cited by 27 · see citing works
Albury, M. S., Elliott, C., & Moore, A. L. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.013 · Cited by 26 · see citing works
Cabrera‐Orefice, A., Chiquete‐Félix, N., Espinasa-Jaramillo, J., Rosas‐Lemus, M., Guerrero‐Castillo, S., Peña, A., & Uribe‐Carvajal, S. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.07.011 · Cited by 26 · see citing works
Young, L., May, B., Pendlebury-Watt, A., Shearman, J., Elliott, C., Albury, M. S., Shiba, T., Inaoka, D. K., Harada, S., Kita, K., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.01.027 · Cited by 26 · see citing works
Affourtit, C., & Moore, A. L. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2003.12.002 · Cited by 25 · see citing works
Suzuki, T., Hashimoto, T., Yabu, Y., Majiwa, P. A. O., Ohshima, S., Suzuki, M., Lu, S., Hato, M., Kido, Y., Sakamoto, K., et al. (2005) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2005.00050.x · Cited by 24 · see citing works
Scheckhuber, C. Q., Houthoofd, K., Weil, A. C., Werner, A., Vreese, A. D., Vanfleteren, J. R., & Osiewacz, H. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016620 · Cited by 24 · see citing works
Mitochondria from the salt-tolerant yeast Debaryomyces hansenii (halophilic organelles?)
Cabrera‐Orefice, A., Guerrero‐Castillo, S., Luévano‐Martínez, L. A., Peña, A., & Uribe‐Carvajal, S. (2010) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9264-0 · Cited by 24 · see citing works
Gérin, S., Mathy, G., Blomme, A., Franck, F., & Sluse, F. E. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.034 · Cited by 24 · see citing works
Williams, S., Saha, L., Singha, U. K., & Chaudhuri, M. (2007) · Experimental Parasitology · doi:10.1016/j.exppara.2007.10.008 · Cited by 23 · see citing works
Uribe, D., & Khachatourians, G. G. (2008) · Canadian Journal of Microbiology · doi:10.1139/w07-127 · Cited by 23 · see citing works
Respiratory System of Rhodotorula glutinis I. Inhibitor Tolerance and Cytochrome Components
MATSUNAKA, S., Morita, S., & Conti, S. F. (1966) · PLANT PHYSIOLOGY · doi:10.1104/pp.41.8.1364 · Cited by 23 · see citing works
Elliott, C., Young, L., May, B., Shearman, J., Albury, M. S., Kido, Y., Kita, K., & Moore, A. L. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.03.002 · Cited by 22 · see citing works
Costa‐de‐Oliveira, S., Sampaio‐Marques, B., Barbosa, M., Ricardo, E., Pina‐Vaz, C., Ludovico, P., & Rodrigues, A. G. (2012) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2012.00789.x · Cited by 22 · see citing works
Figueira, T. R. E. S., & Arruda, P. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9333-z · Cited by 21 · see citing works
Walker, R., Saha, L., Hill, G. C., & Chaudhuri, M. (2004) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2004.11.003 · Cited by 21 · see citing works
Lei, T., Yan, Y.-C., Xi, D., Feng, H., Sun, X., Zhang, F., Xu, W., Liang, H., & Lin, H. (2008) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2008-9-1016 · Cited by 21 · see citing works
Gene expression during activation of Paracoccidioides brasiliensis conidia
Hernández, O., Garcı́a, A. M., Almeida, A. J., Tamayo, D. P., González, Á., Restrepo, Á., & McEwen, J. G. (2011) · Yeast · doi:10.1002/yea.1902 · Cited by 20 · see citing works
Flagged first, then by citations
3 of the 236 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Hossain, M. S., & Dietz, K. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00548 · Cited by 327 · see citing works
Challabathula, D., Analin, B., Mohanan, A., & Bakka, K. (2021) · Journal of Plant Physiology · doi:10.1016/j.jplph.2021.153583 · Cited by 110 · see citing works
Plant defense signals: Players and pawns in plant-virus-vector interactions
Carr, J. P., Murphy, A. M., Tungadi, T., & Yoon, J.-Y. (2018) · Plant Science · doi:10.1016/j.plantsci.2018.04.011 · Cited by 89 · see citing works
An update on salicylic acid biosynthesis, its induction and potential exploitation by plant viruses
Murphy, A. M., Zhou, T., & Carr, J. P. (2020) · Current Opinion in Virology · doi:10.1016/j.coviro.2020.02.008 · Cited by 86 · see citing works
Alternative NAD(P)H dehydrogenase and alternative oxidase: Proposed physiological roles in animals
McDonald, A. E., & Gospodaryov, D. V. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.01.009 · Cited by 67 · see citing works
Yarrowia lipolytica: a multitalented yeast species of ecological significance
Mamaev, D. V., & Zvyagilskaya, R. A. (2021) · FEMS Yeast Research · doi:10.1093/femsyr/foab008 · Cited by 60 · see citing works
Characterization of the mechanism of action of the fungicide fenpicoxamid and its metabolite UK‐2A
Young, D. H., Wang, N. X., Meyer, S. T., & Avila‐Adame, C. (2017) · Pest Management Science · doi:10.1002/ps.4743 · Cited by 57 · see citing works
Rocha, M. C., de Godoy, K. F., Bannitz-Fernandes, R., Fabri, J. H. T. M., Barbosa, M. M. F., de Castro, P. A., Almeida, F. B. D. R., Goldman, G. H., da Cunha, A. F., Netto, L. E. S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-30108-2 · Cited by 52 · see citing works
Structural insights into the alternative oxidases: are all oxidases made equal?
May, B., Young, L., & Moore, A. L. (2017) · Biochemical Society Transactions · doi:10.1042/bst20160178 · Cited by 49 · see citing works
Ebiloma, G. U., Balogun, E. O., Cueto-Diaz, E. J., de Koning, H. P., & Dardonville, C. Y. (2019) · Medicinal Research Reviews · doi:10.1002/med.21560 · Cited by 48 · see citing works
Cárdenas-Monroy, C. A., Pohlmann, T., Piñón-Zárate, G., Matus‐Ortega, G., Guerra, G., Feldbrügge, M., & Pardo, J. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173389 · Cited by 47 · see citing works
Lighting the way: Compelling open questions in photosynthesis research
Eckardt, N. A., Allahverdiyeva, Y., Álvarez, C. E., Büchel, C., Burlacot, A., Cardona, T., Chaloner, E., Engel, B. D., Grossman, A. R., Harris, D., et al. (2024) · The Plant Cell · doi:10.1093/plcell/koae203 · Cited by 39 · see citing works
Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls
Saari, S., Garcia, G. S., Bremer, K., Chioda, M. M., Andjelković, A., Debes, P. V., Nikinmaa, M., Szibor, M., Dufour, É., Rustin, P., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.012 · Cited by 39 · see citing works
Mohanapriya, G., Bharadwaj, R., Noceda, C., Costa, J. H., Kumar, S. R., Sathishkumar, R., Thiers, K. L. L., Santos Macedo, E., Silva, S., Annicchiarico, P., et al. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01134 · Cited by 32 · see citing works
Development of an industrial yeast strain for efficient production of 2,3-butanediol
Huo, G., Foulquié-Moreno, M. R., & Thevelein, J. M. (2022) · Microbial Cell Factories · doi:10.1186/s12934-022-01924-z · Cited by 32 · see citing works
The transcriptomic responses of the ark shell, Anadara broughtonii, to sulfide and hypoxia exposure
Wang, Y., Zhou, S., Liu, T., Chen, M., Li, W., & Zhang, X. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-04879-4 · Cited by 29 · see citing works
Oxygen and Nitrate Respiration in Streptomyces coelicolor A3(2)
Sawers, R. G., Falke, D., & Fischer, M. (2016) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2016.02.004 · Cited by 28 · see citing works
Aziz, S., Germano, T. A., Thiers, K. L. L., Batista, M. C., Miranda, R. D. S., Arnholdt‐Schmitt, B., & Costa, J. H. (2022) · Plants · doi:10.3390/plants11162145 · Cited by 26 · see citing works
Cyanide resistant respiration and the alternative oxidase pathway: A journey from plants to mammals
El‐Khoury, R., Rak, M., Bénit, P., Jacobs, H. T., & Rustin, P. (2022) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2022.148567 · Cited by 24 · see citing works
Tward, C. E., Singh, J., Cygelfarb, W., & McDonald, A. E. (2018) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2018.11.003 · Cited by 23 · see citing works
Hypothesized Evolutionary Consequences of the Alternative Oxidase (AOX) in Animal Mitochondria
Weaver, R. J. (2019) · Integrative and Comparative Biology · doi:10.1093/icb/icz015 · Cited by 22 · see citing works
Raven, J. A., & Beardall, J. (2017) · Journal of Experimental Botany · doi:10.1093/jxb/erx149 · Cited by 22 · see citing works
Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration
Andjelković, A., Mordas, A., Bruinsma, L., Ketola, A. E., Cannino, G., Giordano, L., Dhandapani, P. K., Szibor, M., Dufour, É., & Jacobs, H. T. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00110-18 · Cited by 19 · see citing works
High Osmolarity Environments Activate the Mitochondrial Alternative Oxidase in Debaryomyces Hansenii
Garcia-Neto, W., Cabrera‐Orefice, A., Uribe‐Carvajal, S., Kowaltowski, A. J., & Luévano‐Martínez, L. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169621 · Cited by 21 · see citing works
Barsottini, M. R., Pires, B. A., Vieira, M. L., Pereira, J. G., Costa, P. C., Sanitá, J., Coradini, A., Mello, F., Marschalk, C., Silva, E. M., et al. (2019) · Pest Management Science · doi:10.1002/ps.5243 · Cited by 19 · see citing works
Weaver, R. J., & McDonald, A. E. (2023) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2023.149003 · Cited by 18 · see citing works
Ding, C., Ng, S., Wang, L., Wang, Y.-C., Li, N.-N., Hao, X., Zeng, J.-M., Wang, X., & Yang, Y. (2018) · Planta · doi:10.1007/s00425-018-2974-y · Cited by 18 · see citing works
The mitochondrial respiratory chain from Rhodotorula mucilaginosa, an extremophile yeast
Castañeda-Támez, P., Chiquete‐Félix, N., Uribe‐Carvajal, S., & Cabrera‐Orefice, A. (2024) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2024.149035 · Cited by 17 · see citing works
Alternative Oxidase: From Molecule and Function to Future Inhibitors
Li, J., Yang, S., Wu, Y., Wang, R., Liu, Y., Liu, J., Ye, Z., Tang, R., Whiteway, M. S., Lv, Q., et al. (2024) · ACS Omega · doi:10.1021/acsomega.3c09339 · Cited by 17 · see citing works
Retrograde Signaling as a Mechanism of Yeast Adaptation to Unfavorable Factors
Trendeleva, T. A., & Zvyagilskaya, R. A. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918020025 · Cited by 16 · see citing works
Barsottini, M. R. D. O., Copsey, A. C., Young, L., Baroni, R. M., Cordeiro, A. T., Pereira, G. A. G., & Moore, A. L. (2020) · Communications Biology · doi:10.1038/s42003-020-0981-6 · Cited by 16 · see citing works
Szibor, M., Schenkl, C., Barsottini, M. R. D. O., Young, L., & Moore, A. L. (2022) · Biochemical Journal · doi:10.1042/bcj20180192 · Cited by 15 · see citing works
Bremer, K., Yasuo, H., Debes, P. V., & Jacobs, H. T. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.242985 · Cited by 15 · see citing works
Moretti-Almeida, G., Thomazella, D. P. D. T., Pereira, G. A. G., & Monteiro, G. (2019) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2019.02.006 · Cited by 13 · see citing works
Jiang, N., Li, S., Zhang, Y.-W.-Q., Habib, M. R., Xiong, T., Xu, S., Dong, H., & Zhao, Q.-P. (2022) · Parasites & Vectors · doi:10.1186/s13071-022-05227-5 · Cited by 13 · see citing works
Ding, C., Chen, C., Su, N. Y., Lyu, W., Yang, J., Hu, Z., & Zhang, M. (2020) · Plant Science · doi:10.1016/j.plantsci.2020.110735 · Cited by 12 · see citing works
Functional Relationship of Arabidopsis AOXs and PTOX Revealed via Transgenic Analysis
Wang, D., Wang, C., Li, C., Song, H., Qin, J., Chang, H., Fu, W., Wang, Y., Wang, F., Li, B., et al. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.692847 · Cited by 12 · see citing works
Weaver, R. J., Carrion, G., Nix, R., Maeda, G. P., Rabinowitz, S., Iverson, E. N. K., Thueson, K., & Havird, J. C. (2020) · Biology Letters · doi:10.1098/rsbl.2020.0450 · Cited by 11 · see citing works
Alternative oxidase confers nutritional limitation on Drosophila development
Saari, S., Kemppainen, E., Tuomela, T., Oliveira, M. T., Dufour, É., & Jacobs, H. T. (2019) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.2274 · Cited by 11 · see citing works
Arnholdt‐Schmitt, B., Mohanapriya, G., Bharadwaj, R., Noceda, C., Macedo, E. S., Ramalingam, S., Gupta, K. J., Sircar, D., Kumar, S. R., Srivastava, S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.673723 · Cited by 11 · see citing works
Fakhimi, N., & Grossman, A. R. (2024) · Plants · doi:10.3390/plants13213015 · Cited by 11 · see citing works
Streptomyces strains producing mitochondriotoxic antimycin A found in cereal grains
Rasimus, S., Mikkola, R., Andersson, M. A., Jestoi, M. N., & Salkinoja-Salonen, M. S. (2015) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2015.11.007 · Cited by 9 · see citing works
Bourgeade, P., Bourioug, M., Macor, S., Alaoui-Sossé, L., Alaoui-Sossé, B., & Aleya, L. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-0893-2 · Cited by 8 · see citing works
Wang, M., Yuan, Y., Zhao, Y., Hu, Z., Zhang, S., Luo, J., Jiang, C., Zhang, Y., & Sun, D. (2025) · Horticulture Research · doi:10.1093/hr/uhaf013 · Cited by 7 · see citing works
To die or not to die – How mitochondrial processes affect lifespan of Podospora anserina
Hamann, A., & Osiewacz, H. D. (2022) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2022.148568 · Cited by 7 · see citing works
Folgueira, I., Lamas, J., Sueiro, R. A., & Leiro, J. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-68791-9 · Cited by 7 · see citing works
Warnsmann, V., Meisterknecht, J., Wittig, I., & Osiewacz, H. D. (2021) · Cells · doi:10.3390/cells10123319 · Cited by 6 · see citing works
Xu, S., Zhang, Y.-W.-Q., Habib, M. R., Li, S., Yuan, Y., Ke, W. H., Jiang, N., Dong, H., & Zhao, Q.-P. (2023) · Parasites & Vectors · doi:10.1186/s13071-022-05642-8 · Cited by 5 · see citing works
On the use of n-octyl gallate and salicylhydroxamic acid to study the alternative oxidase role
Romero‐Aguilar, L., Cárdenas-Monroy, C. A., Garrido-Bazán, V., Aguirre, J., Guerra‐Sánchez, G., & Pardo, J. P. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108603 · Cited by 4 · see citing works
The response of Naegleria gruberi to oxidative stress
Malych, R., Füssy, Z., Ženíšková, K., Arbon, D., Hampl, V., Hrdý, I., & Šuťák, R. (2022) · Metallomics · doi:10.1093/mtomcs/mfac009 · Cited by 4 · see citing works
Wen, Y., & Zhang, D. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.07.080 · Cited by 3 · see citing works
RetractedKalacheva, N. V., Gubskaya, V. P., Fazleeva, G. M., Igtisamova, G. R., Nuretdinov, I. A., Rizvanov, A. A., & Черепнев, Г. В. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.09.054 · Cited by 3 · see citing works
Photosynthesis and Oxygen Uptake Rate in Winter Rape Plants Treated with 5-Aminolevulinic Acid
Averina, N. G., Yemelyanava, H. V., Sherbakov, R. A., Kozel, N. V., Obukhovskaya, L. V., & Usatov, A. V. (2019) · Russian Journal of Plant Physiology · doi:10.1134/s1021443719060037 · Cited by 3 · see citing works
Wenda, J. M., Drzewicka, K., Mulica, P., Tetaud, E., di Rago, J. P., Golik, P., & Łabędzka-Dmoch, K. (2024) · GENETICS · doi:10.1093/genetics/iyae124 · Cited by 2 · see citing works
Batjuka, A., & Škute, N. (2021) · Journal of Central European Agriculture · doi:10.5513/jcea01/22.2.2816 · Cited by 2 · see citing works
Garcia, G. S., Othonicar, M. F., Campos, A. T. P., Kilbourn, E. A., Bícego, K. C., Lerchner, J., Tennessen, J. M., & Oliveira, M. T. (2025) · eLife · doi:10.7554/elife.106202.1 · Cited by 2 · see citing works
Zhang, M., Zhang, L., Hu, L. H., Li, J., Luan, W., Li, Z., & Liu, J. (2025) · Physiologia Plantarum · doi:10.1111/ppl.70302 · Cited by 1 · see citing works
Krylova, V. V., & Григорьевич, Ш. А. (2025) · Russian Journal of Plant Physiology · doi:10.1134/s1021443725603039 · Cited by 1 · see citing works
Vaali, K., Sulyok, M., Louhelainen, J., Mannerström, M., Heinonen, T., Krska, R., Räsänen, L. A., Visala, A., Harmo, P., & Salkinoja-Salonen, M. S. (2026) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2026.182020 · Cited by 1 · see citing works
Garcia, G. S., Othonicar, M. F., Campos, A. T. P., Kilbourn, E. A., Bícego, K. C., Lerchner, J., Tennessen, J. M., & Oliveira, M. T. (2025) · eLife · doi:10.7554/elife.106202 · Cited by 1 · see citing works
BIOBLASTS, CYTOMIKROSOMEN AND CHONDRIOSOMES
Logan, D. C., & Scott, I. (2017) · Wiley eBooks · doi:10.1002/9781118906583.ch1
Potential application of alternative oxidase (AOX) in neurodegenerative diseases
Zhuang, Y. (2018) · Työväentutkimus Vuosikirja
Application of abscisic acid prevents leaf senescence at decreased irradiance
Kupis, W., Tomal, E., & Niewiadomska, E. (2019) · Biologia Plantarum · doi:10.32615/bp.2019.052
Logan, D. C., & Scott, I. (2018) · Annual Plant Reviews online · doi:10.1002/9781119312994.apr0543
Hong, D. P. (2020) · Eötvös Loránd Tudományegyetem · doi:10.15476/elte.2020.219
Romero‐Aguilar, L., Sánchez, G. G., Herrera, Ó. F., Rendón, J. L., Vázquez‐Meza, H., & Pardo, J. P. (2025) · Archives of Microbiology · doi:10.1007/s00203-025-04505-x
Keresztes, Á., Sárvári, É., Nyitrai, P., Pham, H.-D., Mihailova, G., Szalai, G., Sass, L., Georgieva, K., Vass, I., & Solti, Á. (2025) · Plant Stress · doi:10.1016/j.stress.2025.101093
Xu, S., Zhang, Y.-W.-Q., Habib, M. R., Li, S.-Z., Yuan, Y., Ke, W. H., Jiang, N., Dong, H., & Zhao, Q.-P. (2024) · Figshare · doi:10.6084/m9.figshare.26569525
Xu, S., Zhang, Y.-W.-Q., Habib, M. R., Li, S.-Z., Yuan, Y., Ke, W. H., Jiang, N., Dong, H., & Zhao, Q.-P. (2024) · Figshare · doi:10.6084/m9.figshare.26569531
Xu, S., Zhang, Y.-W.-Q., Habib, M. R., Li, S.-Z., Yuan, Y., Ke, W. H., Jiang, N., Dong, H., & Zhao, Q.-P. (2024) · Figshare · doi:10.6084/m9.figshare.26569528
Water Leakage in a Timber Building: How to Rescue a Short-Term Flood?
Vaali, K. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1017797
- Authors
- Rogov, A. G., Sukhanova, E. I., Uralskaya, L. A., Aliverdieva, D. A., & Zvyagilskaya, R. A.
- Affiliations
- Russian Academy of Sciences (RU)
- Corresponding author
- Rogov, A. G.
- Venue
- Biochemistry (Moscow)
- Publisher
- Pleiades Publishing Ltd
- Published
- 2014-12
- Volume
- 79
- Issue
- 13
- Pages
- 1615-1634
- ISSN
- 0006-2979 (ISSN-L)
- 1608-3040
- OpenAlex
- W2135673284
- Cited by
- 73
- References
- 236
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 11 · 2017: 7 · 2016: 2 · 2015: 2 · 2013: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biochemistry (Moscow) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Keywords
- alternative oxidase, electron transport chain, terminal oxidase, active site, ubiquinone binding site, stress adaptation, cytochrome pathway, cyanide-resistant respiration
- MeSH terms
- Alternative Oxidase, Bacteria, Electron Transport, Nutritional Physiological Phenomena, Oxidoreductases, Phylogeny, Plant Proteins, Protein Conformation, Mitochondrial Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review