Maturation of caffeine elimination in infancy
Open accessAbstract
The developmental changes in caffeine elimination were studied in 7 infants aged between 2 1/2 weeks and 6 months. Adult plasma clearance rate of caffeine was achieved at 3 to 4 1/2 months of age. Plasma half-life and elimination rate reached adult levels after 3 to 4 1/2 months and seemed to exceed adult capacity thereafter. No significant changes in apparent volume of distribution were noted. Our data provide some indication of the age in infancy when the low rates of caffeine elimination in the neonate increase to the adult rate.
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- Authors
- Aranda, J. V., Collinge, J. M., Zinman, R., & Watters, G.
- Affiliations
- Montreal Children's Hospital (CA)
- Venue
- Archives of Disease in Childhood
- Publisher
- BMJ
- Published
- 1979-12-01
- Volume
- 54
- Issue
- 12
- Pages
- 946-949
- ISSN
- 0003-9888 (ISSN-L)
- 1468-2044
- PMC
- PMC1545746
- OpenAlex
- W2123141619
- Cited by
- 148
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 9 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 2
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Disease in Childhood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Keywords
- caffeine, infant development, plasma clearance, plasma half-life, volume of distribution, neonatal pharmacokinetics, age-related maturation, drug metabolism
- MeSH terms
- Adult, Aging, Caffeine, Half-Life, Humans, Infant, Infant, Newborn, Kinetics, Metabolic Clearance Rate
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