Dietary management of D-lactic acidosis in short bowel syndrome.
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Manipulation of carbohydrate intake was used to treat severe, recurrent D-lactic acidosis in a patient with short bowel syndrome. Dietary carbohydrate composition was determined after assessment of D-lactic acid production from various carbohydrate substrates by faecal flora in vitro. This approach may be preferable to repeated courses of antibiotics.
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In a single case report, restriction of monosaccharides and sucrose decreased D-lactate production in a patient with short bowel syndrome, preventing neurotoxicity.
“In a single case report, restriction of monosaccharides and sucrose was shown to decrease D-lactate production in a patient with short bowel syndrome, preventing neurotoxicity.150”
From The Gut Microbiome and the Brain (2014) · cites this paper as [150]
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- Authors
- Mayne, A. J., Handy, D. J., Preece, M. A., George, R. H., & Booth, I. W.
- Affiliations
- University of Birmingham (GB)
- ORCID
- Booth, I W
- Venue
- Archives of Disease in Childhood
- Publisher
- BMJ
- Published
- 1990-02-01
- Volume
- 65
- Issue
- 2
- Pages
- 229-231
- ISSN
- 0003-9888 (ISSN-L)
- 1468-2044
- PMC
- PMC1792240
- OpenAlex
- W2167200219
- Cited by
- 80
- References
- 6
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 4
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Disease in Childhood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- D-lactic acidosis, short bowel syndrome, dietary management, carbohydrate intake, carbohydrate composition, fecal microbiota, D-lactate production, antibiotics
- MeSH terms
- Acidosis, Lactic, Child, Colon, Dietary Carbohydrates, Female, Humans, Lactates, Lactobacillus, Malabsorption Syndromes, Short Bowel Syndrome, Lactic Acid, Carbohydrate Metabolism
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