The DOI matches its Crossref record.
Cerebral blood flow during vasovagal syncope induced by active standing or head up tilt
Open accessAbstract
BACKGROUND: Vasovagal syncope is usually associated with a sudden drop of blood pressure and/or heart rate. However, occasionally the symptoms of syncope induced by orthostatic stress testing are not associated with obvious haemodynamic changes. The mechanisms of syncope in these patients are not clear. AIM: To evaluate changes in cerebral blood flow velocities during orthostatic stress testing in children and adolescents with vasovagal syncope. METHODS: Electrocardiogram, instantaneous arterial blood pressure, and right middle cerebral artery blood flow velocity were recorded at rest, during active standing, and 80 degrees head up tilt. 32 children and adolescents aged between 7 and 18 years with a history of repeated vasovagal syncope and 23 healthy control subjects were studied. RESULTS: Presyncope occurred in 10 patients during standing, and 13 patients during head up tilt. None of the controls had symptoms during the test. The transcranial Doppler study showed that the symptoms were associated with significant decreases of diastolic cerebral blood flow velocity and an increase of pulsatility. There was no significant change of the systolic cerebral blood flow velocity. The changes of cerebral blood flow velocities occurred in all episodes of presyncope, including those not associated with severe drop of blood pressure or heart rate. CONCLUSIONS: Diastolic cerebral blood flow velocity decreased significantly during episodes of presyncope induced by orthostatic stress. Impairment of autoregulation of cerebral blood flow might play an important role in the pathophysiology of syncope.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Studies also suggest that patients may show reduced CBF before syncope despite a lack of notable reductions in HR and BP (Sung et al., 2000).”
From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Sung et al., 2000
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 20
- Ruckmann RN. Cardiac causes of syncope. Pediatr Rev 1987;9:101-8.
- Driscoll DJ, Jacobsen SJ, Porter CJ, et al. Syncope in children and adolescents. J Am Coll Cardiol 1997;29:1039- 45.
- Benditt DG, Ferguson DW, Grubb BP, et al. Tilt table test- ing for assessing syncope (ACC expert consensus docu- ment). J Am Coll Cardiol 1996;28:263-75.
- Kapoor WE, Smith MA, Miller NL. Upright tilt testing in evaluating syncope: a comprehensive literature review. Am J Med 1994;97:78-88.
- Tanaka H, Thulesius O, Yamaguchi O, Mino M. Circulatory responses in children with unexplained syncope evaluated by continuous non-invasive finger blood pressure monitor- ing. Acta Paediatr 1994;83:754-61.
- Grubb BP, Samoil D, Kosinski D, et al. Cerebral syncope: loss of consciousness associated with cerebral vasoconstric- tion in the absence of systemic hypotension. Pacing Clin Electrophysiol 1998;21:652-8.
- Fredman CS, Biermann KM, Patel V, Uppstrom EL, Auer AI. Transcranial Doppler ultrasonography during head- upright tilt-table testing. Ann Intern Med 1995;23:848-9.
- Grubb BP, Gerard G, Roush K, et al. Cerebral vasoconstric- tion during head-upright tilt-induced vasovagal syncope: a paradoxic and unexpected response. Circulation 1991;84: 1157-64.
- Stephenson JBP. Specific syncopes and anoxic seizure types. In: Stephenson JBP, ed. Fits and faints. London: Mackeith Press, 1990:67-70.
- Bondar RL, Kassam MS, Stein F, Dunphy PT, Fortney S, Riedesel ML. Simultaneous cerebrovascular and cardiovas- cular responses during presyncope. Stroke 1995;26:1794- 800.
- Imholz BPM, Wieling W, van Montfrans GA, Wesseling KH. Fifteen years experience with finger arterial pressure monitoring: assessment of the technology. Cardiovasc Res 1998;38:605-16.
- Kosinsky D, Grubb BP, Temesy-Armos P. Pathophysiologi- cal aspects of neurocardiogenic syncope: current concepts and new perspectives. Pacing Clin Electrophysiol 1995;18: 716-24.
- Henderson MC, Prabhu SD. Syncope: current diagnosis and treatment. Curr Probl Cardiol 1997;22:244-51.
- Vanderheyden M, Goethals M, Nellens P, Andries E, Brugada P. DiVerent humoral responses during head-up tilt testing among patients with neurocardiogenic syncope. Am Heart J 1998;135:67-73.
- Sorteberg W. Cerebral artery blood velocity and cerebral blood flow. In: Newell DW, Aaslid R, eds. Transcranial Dop- pler. New York: Raven Press, 1992:57-66.
- Tiecks FP, Lam AM, Aaslid R, Newell DW. Comparison of static and dynamic cerebral autoregulation measurements. Stroke 1995;26:1014-19.
- Kawai K, Murthy G, Watenpaugh DE, Breit GA, Deroshia CW, Hargens AR. Cerebral blood flow velocity in humans exposed to 24 hours of head-down tilt. J Appl Physiol 1993; 74:3046-51.
- Lindegaard KF, Lundar T, Wiberg J, Sjoberg D, Aaslid U, Nornes H. Variations in middle cerebral artery blood flow investigated with noninvasive transcranial blood velocity measurements. Stroke 1987;18:1025-30.
- Ladwig S, Ries S, Henning O, Valikovics A, DaVertshofer M, Pohlmann-Eden B. Combined electroencephalography and measurements of transcranial blood flow velocity dur- ing orthostatic testing-a new approach to assess syncope of unknown origin? Clin Auton Res 1997;7:305-9.
- Grossi D, Nozzoli C, Roca ME, Santostasi R, Simone F. Head-up tilt for triggering and diagnosing syncope. Funct Neurol 1987;2:457-64.
Cited by
The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm
Ritz, T., Meuret, A. E., & Ayala, E. S. (2010) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.05.007 · Cited by 74
“Studies also suggest that patients may show reduced CBF before syncope despite a lack of notable reductions in HR and BP (Sung et al., 2000).”
BackgroundChanges in cerebral blood oxygenation induced by active standing test in children with pots and nms
Endo, A., Fujita, Y., Fuchigami, T., Takahashi, S., Mugishima, H., & Skatani, K. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0620-8_34 · Cited by 15
Metadata
- Authors
- Sung, R. Y. T.
- Affiliations
- Prince of Wales Hospital (CN)
- Corresponding author
- Sung, R Y T
- Venue
- Archives of Disease in Childhood
- Publisher
- BMJ
- Published
- 2000-02-01
- Volume
- 82
- Issue
- 2
- Pages
- 154-158
- ISSN
- 0003-9888 (ISSN-L)
- PMC
- PMC1718216
- OpenAlex
- W2161717099
- Cited by
- 40
- References
- 0
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Disease in Childhood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- vasovagal syncope, cerebral blood flow velocity, head-up tilt, active standing, presyncope, cerebral autoregulation, middle cerebral artery, children and adolescents, transcranial Doppler
- MeSH terms
- Adolescent, Blood Flow Velocity, Cerebrovascular Circulation, Child, Female, Hemodynamics, Homeostasis, Humans, Male, Posture, Ultrasonography, Doppler, Transcranial, Tilt-Table Test, Syncope, Vasovagal, Middle Cerebral Artery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cerebral blood flow during vasovagal syncope induced by active standing or head up tilt. https://app.cochat.ai/papers/10.1136/adc.82.2.154
- The paper
- Sung, R. Y. T. (2000). Cerebral blood flow during vasovagal syncope induced by active standing or head up tilt. Archives of Disease in Childhood. https://doi.org/10.1136/adc.82.2.154
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
