VCAM-1 serum levels are associated with arthropathy in hereditary haemochromatosis
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OBJECTIVES: The aim of this study was to assess the role of vascular adhesion molecule 1 (VCAM-1) in patients with hereditary haemochromatosis (HH) with or without arthropathy. METHODS: Sera from a large cross-sectional cohort of unselected HH patients (n=147) were obtained and compared to an age-matched and sex-matched control group. Serum levels of VCAM-1 were measured by ELISA and were correlated with clinical measures. RESULTS: VCAM-1 serum levels were elevated in HH patients as compared to matched controls (mean 913±456 vs 654±451 ng/ml, p<0.0001). Within the HH patient group, VCAM-1 levels were much higher in patients with arthropathy and joint replacement surgery. VCAM-1 levels correlated well with radiographic measures of HH arthropathy (r=0.36, p<0.0001). Multivariate regression analysis confirmed a highly significant association of VCAM-1 serum levels and the presence of HH arthropathy, independent from diabetes, body mass index and age. CONCLUSIONS: VCAM-1 serum levels emerge as a biomarker for haemochromatosis arthropathy.
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Elevated VCAM1 levels are an accurate biomarker to diagnose arthropathy of type I hemochromatosis.
“Elevated vascular cell adhesion molecule 1 (VCAM1) levels are an accurate biomarker to diagnose this condition, but whether the adhesion molecule is also involved in its pathogenesis remains unclear [170].”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [170]
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Cites
Osborn, L., Hession, C. A., Tizard, R., Vassallo, C., Luhowskyj, S., Rosso, G. C., & Lobb, R. R. (1989) · Cell · doi:10.1016/0092-8674(89)90775-7 · Cited by 1,690 · see citing works
Iron-Overload–Related Disease inHFEHereditary Hemochromatosis
Allen, K. J., Gurrin, L. C., Constantine, C. C., Osborne, N. J., Delatycki, M. B., Nicoll, A., McLaren, C. E., Bahlo, M., Nisselle, A. E., Vulpe, C. D., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa073286 · Cited by 730 · see citing works
Paleolog, E. M., Young, S., Stark, A. C., McCloskey, R. V., Feldmann, M., & Maini, R. N. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199807)41:7 · Cited by 318 · see citing works
Grogan, S. P., Miyaki, S., Asahara, H., DʼLima, D. D., & Lotz, M. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2719 · Cited by 265 · see citing works
Schumacher, H. R. (1964) · Arthritis & Rheumatism · doi:10.1002/art.1780070106 · Cited by 210 · see citing works
A survey of 2,851 patients with hemochromatosis:
McDonnell, S. M., Preston, B. L., Jewell, S., Barton, J. C., Edwards, C. Q., Adams, P. C., & Yip, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00120-5 · Cited by 208 · see citing works
Nonalcoholic fatty liver disease: an independent risk factor for colorectal neoplasia
Stadlmayr, A., Aigner, E. S., Steger, B., Scharinger, L., Lederer, D., Mayr, A., Straßer, M., Brunner, E., Heuberger, A., Hohla, F., et al. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02377.x · Cited by 127 · see citing works
Self-citationMusculoskeletal disease burden of hereditary hemochromatosis
Sahinbegovic, E., Dallos, T., Aigner, E. S., Axmann, R., Manger, B., Englbrecht, M., Schöniger–Hekele, M., Karonitsch, T., Stamm, T., Farkas, M., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27712 · Cited by 93 · see citing works
Self-citationVascular cell adhesion molecule 1 as a predictor of severe osteoarthritis of the hip and knee joints
Schett, G. A., Kiechl, S. J., Bonora, E., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24757 · Cited by 84 · see citing works
Self-citationPredominance of the HLA-H Cys282Tyr mutation in Austrian patients with genetic haemochromatosis
Datz, C., Lalloz, M. R. A., Vogel, W., Graziadei, I. W., Hackl, F., Vautier, G., Layton, D. M., Maier-Dobersberger, T., Ferenci, P., Penner, E., et al. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80312-1 · Cited by 81 · see citing works
Self-citationMarazuela, M., Postigo, A. A., Acevedo, A., et al. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241034 · Cited by 68 · see citing works
Synovial immunopathology in haemochromatosis arthropathy
Heiland, G. R., Aigner, E., Dallos, T., Sahinbegovic, E., Krenn, V., Thaler, C., Weiss, G., Distler, J. H., Datz, C., Schett, G., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.120204 · Cited by 64 · see citing works
Self-citationThe hand arthropathy of hereditary hemochromatosis is strongly associated with iron overload.
Valenti, L. V. C., Fracanzani, A. L., Rossi, V., Rampini, C., Pulixi, E. A., VARENNA, M., Fargion, S. R., & SINIGAGLIA, L. (2008) · PubMed · Cited by 63 · see citing works
CARTER, R. A., Campbell, I. K., O'DONNEL, K. L., & Wicks, I. P. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01794.x · Cited by 54 · see citing works
Cross-Linking of CD44 on Rheumatoid Synovial Cells Up-Regulates VCAM-1
Fujii, K., Tanaka, Y., Hübscher, S. G., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.4.2391 · Cited by 51 · see citing works
Hereditary Hemochromatosis as a Risk Factor for Joint Replacement Surgery
Sahinbegovic, E., Dallos, T., Aigner, E. S., Axmann, R., Engelbrecht, M., Schöniger–Hekele, M., Karonitsch, T., Farkas, M., Karger, T., Willeit, J., et al. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.01.024 · Cited by 41 · see citing works
Self-citationRadiological features of the visceral and skeletal involvement of hemochromatosis
Jäger, H. J., Mehring, U.-M., Götz, G. F., et al. (1997) · European Radiology · doi:10.1007/s003300050274 · Cited by 39 · see citing works
Validation of a radiographic scoring system for haemochromatosis arthropathy
Dallos, T., Sahinbegovic, E., Aigner, E. S., Axmann, R., Schöniger–Hekele, M., Karonitsch, T., Stamm, T., Farkas, M., Karger, T., Cavallaro, A., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.122119 · Cited by 32 · see citing works
Self-citationSynovial Iron Deposition in Rheumatoid Arthritis
Bennett, R. M., Williams, E. D., Lewis, S. M., & Holt, P. J. L. (1973) · Arthritis & Rheumatism · doi:10.1002/art.1780160303 · Cited by 27 · see citing works
Association between vascular cell adhesion molecule 1 and radiographic hand osteoarthritis.
Kalichman, L., Pantsulaia, I., & Kobyliansky, E. (2011) · PubMed · Cited by 20 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Dallos T, Sahinbegovic E, Aigner E, et al. Validation of a radiographic scoring system for hemochromatosis. Ann Rheum Dis 2010;69:2145-51.
- Kienzle G, von Kempis J. Vascular cell adhesion molecule 1 (CD106) on primary human articular chondrocytes: functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 (CD54) and very late activation antigen 2. Arthritis Rheum 1998;41:1296-305.
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“Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels
Nairz, M., Theurl, I., Swirski, F. K., & Weiss, G. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1944-8 · Cited by 178 · see citing works
- Authors
- Nell-Duxneuner, V., Axmann, R., Husar-Memmer, E., Dallos, T., Datz, C., Stadlmayr, A., Aigner, E., Englbrecht, M., Schett, G., & Zwerina, J.
- Affiliations
- Hanusch Hospital (AT)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Krankenhaus Oberndorf (AT)
- Paracelsus Medical University (AT)
- Corresponding author
- Zwerina, Jochen
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 72
- Issue
- 12
- Pages
- 2006-2010
- ISSN
- 0003-4967 (ISSN-L)
- OpenAlex
- W2109668031
- Cited by
- 10
- References
- 20
- Citations by year
- 2023: 1 · 2019: 1 · 2017: 4 · 2015: 3 · 2013: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- green
- open.fau.de
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universitätsbibliothek Erlangen-Nürnberg) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- VCAM-1, hereditary hemochromatosis, serum biomarkers, joint replacement, radiographic damage, iron overload
- MeSH terms
- Adult, Aged, Arthritis, Female, Hemochromatosis, Humans, Liver Diseases, Male, Middle Aged, Biomarkers, Confounding Factors, Epidemiologic, Case-Control Studies, Vascular Cell Adhesion Molecule-1, Arthroplasty, Replacement
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