Synovial immunopathology in haemochromatosis arthropathy
Abstract
Background Hereditary haemochromatosis (HH) is a common autosomal recessive inherited disorder that frequently causes arthritis. The pathophysiology of musculoskeletal involvement is, however, unclear.Objective To analyse synovial tissue obtained at surgery from patients with HH arthropathy and compare it qualitatively and quantitatively with specimens from patients with rheumatoid arthritis (RA) and osteoarthritis (OA).Methods Synovial tissue from 15 patients with HH, 20 with RA and 39 with OA was obtained during surgery. A synovitis grading system was used to determine the severity of synovial inflammation. Using immunohistochemistry, synovial neovascularisation and infiltration of macrophages, neutrophils and lymphocytes were quantitatively assessed.Results Synovitis in HH arthropathy largely resembles OA with mild infiltration of mononuclear cells and lymphocytes, formation of synovial microvessels and a low degree of synovial hyperplasia. While many features of HH arthropathy are reminiscent of OA, macrophage and especially neutrophil invasion is clearly more prominent in HH arthropathy than in primary OA and mimics features of RA. This finding was observed particularly in synovial tissue of HH samples with marked haemosiderin deposition.Discussion The histological picture of the synovium in HH arthropathy largely resembles a process reminiscent of OA. Neutrophil invasion is, however, markedly increased in HH arthropathy, especially in joints with iron deposition. Accumulation of neutrophils may be crucial for the production of matrix enzymes, which enables cartilage degradation and more rapidly progressive articular damage.
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Arthropathy of the second and third metacarpophalangeal joints is a typical manifestation of type I hemochromatosis.
“Arthropathy of the second and third metacarpophalangeal joints is a typical manifestation of type I hemochromatosis [94].”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [94]
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“Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels
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Self-citationVCAM-1 serum levels are associated with arthropathy in hereditary haemochromatosis
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- Authors
- Heiland, G. R., Aigner, E., Dallos, T., Sahinbegovic, E., Krenn, V., Thaler, C., Weiss, G., Distler, J. H., Datz, C., Schett, G., & Zwerina, J.
- Affiliations
- Krankenhaus Oberndorf (AT)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universität Trier (DE)
- University of Salzburg (AT)
- Innsbruck Medical University (AT)
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 69
- Issue
- 6
- Pages
- 1214-1219
- ISSN
- 0003-4967 (ISSN-L)
- OpenAlex
- W2169182592
- Cited by
- 64
- References
- 22
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 7 · 2013: 6 · 2012: 3
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Rheumatology › Musculoskeletal synovial abnormalities and treatments
- Keywords
- hereditary hemochromatosis, synovitis, neutrophil infiltration, macrophage infiltration, lymphocyte infiltration, hemosiderin deposition, osteoarthritis, rheumatoid arthritis, cartilage degeneration, synovial hyperplasia
- MeSH terms
- Adult, Aged, Aged, 80 and over, Arthritis, Arthritis, Rheumatoid, Female, Hemochromatosis, Humans, Macrophages, Male, Middle Aged, Neovascularization, Pathologic, Osteoarthritis, Synovial Membrane, Synovitis, Lymphocyte Subsets, Neutrophil Infiltration
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