Prevotella copri in individuals at risk for rheumatoid arthritis
Open accessAbstract
Objectives Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome composition and prevalence of Prevotella spp. in a group of individuals at increased risk for RA, but prior to the development of the disease.Methods In an ongoing cohort study of first-degree relatives (FDRs) of patients with RA, we identified 'FDR controls', asymptomatic and without autoantibodies, and individuals in pre-clinical RA stages, who had either developed anticitrullinated peptide antibodies or rheumatoid factor positivity and/or symptoms and signs associated with possible RA. Stool sampling and culture-independent microbiota analyses were performed followed by descriptive statistics and statistical analyses of community structures.Results A total of 133 participants were included, of which 50 were categorised as 'FDR controls' and 83 in 'pre-clinical RA stages'. The microbiota of individuals in 'pre-clinical RA stages' was significantly altered compared with FDR controls. We found a significant enrichment of the bacterial family Prevotellaceae, particularly Prevotella spp., in the 'pre-clinical RA' group (p=0.04).Conclusions Prevotella spp. enrichment in individuals in pre-clinical stages of RA, before the onset of RA, suggests a role of intestinal dysbiosis in the development of RA.
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Prevotella species associated with detrimental impacts on intestinal barrier integrity are enriched in IBS patients and in models of intestinal inflammation and may promote inflammatory arthritis.
“Prevotella species associated with detrimental impacts on intestinal barrier integrity are enriched in IBS patients and in models of intestinal inflammation [52, 113] and may promote inflammatory arthritis [3, 104, 126].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [3]
Increased abundance of Prevotella copri is reported in treatment-naïve new-onset RA patients and in individuals at high risk for RA.
“An increased abundance of Prevotella copri was reported in treatment-naïve new-onset RA patients168,169 and in individuals at high risk for RA.170”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [170]
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- Authors
- Alpizar-Rodriguez, D., Lesker, T. R., Gronow, A., Gilbert, B., Raemy, E., Lamacchia, C., Gabay, C., Finckh, A., & Strowig, T.
- Affiliations
- University Hospital of Geneva (CH)
- Helmholtz Centre for Infection Research (DE)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Finckh, Axel
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 78
- Issue
- 5
- Pages
- 590-593
- ISSN
- 0003-4967 (ISSN-L)
- OpenAlex
- W2913429571
- Cited by
- 449
- References
- 21
- Citations by year
- 2026: 42 · 2025: 55 · 2024: 84 · 2023: 62 · 2022: 67 · 2021: 67 · 2020: 49 · 2019: 21 · 2012: 1
- FWCI
- 16.87
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- PubMed (publishedVersion)
- HZI (Helmholtz Centre for Infection Research) (submittedVersion, cc-by-nc-sa)
- HighWire Press Open Archive (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Unrestricted research grant from AbbVie Switzerland (Abbvie Grant 2016)
- The Federal Commission for Scholarships for Foreign Students. (Swiss Government Excellence Scholarship for PhD st)
- Helmholtz-Gemeinschaft (VH-NG-933)
- EU (StG337251)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- Prevotella copri, rheumatoid arthritis, gut microbiota, Prevotellaceae, first-degree relatives, gut dysbiosis, anti-citrullinated protein antibodies, rheumatoid factor, fecal microbiota, disease risk
- MeSH terms
- Gastrointestinal Microbiome, Aged, Arthritis, Rheumatoid, Autoantibodies, Feces, Female, Humans, Male, Middle Aged, Pedigree, Rheumatoid Factor, Risk Factors, Case-Control Studies, Prevotella, Genetic Predisposition to Disease, Dysbiosis
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